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The map label for this gene is lspA [H]

Identifier: 88657909

GI number: 88657909

Start: 1088126

End: 1088566

Strand: Reverse

Name: lspA [H]

Synonym: ECH_1060

Alternate gene names: 88657909

Gene position: 1088566-1088126 (Counterclockwise)

Preceding gene: 88658244

Following gene: 88658337

Centisome position: 92.55

GC content: 27.66

Gene sequence:

>441_bases
ATGAAAAAATATGTATTGATAATATGTATATTAGTTCTTGTAGATCAACTTAGTAAGTGGTACGTAATGAGTTTAGTAGG
AGATACAAGAATAATAGAGATATTTAGTTTTTTGCGATTTTCTACAGTATGGAATACTGGAATAAGCTTCGGTATGTTAC
ATGATTTCATGTATAGTAACCTTATTTTCTGTAGTATTTCCATCTTAATTACGTTTGTTTTGTTTTATTTTTTAGTAATA
CGTTTATCACATAGATTACCTCTTGCTATTATTATTGGGGGGTCAGTAGGGAATATAGTAGACAGAGTAAAATATGGAGC
TGTCTATGATTTTATAGATTTCTATATTAATAAATGGCACTGGCCTGCATTCAACTTAGCAGATTCTTTTATATTCTTAG
GTATTATAATAATGGTAAGAGCTAATAATTTTACAAAATAA

Upstream 100 bases:

>100_bases
GCTTATAAGTCAACTTACTGAATTACGTGGATAGGCATATAGGGTTTTATACTCAGTTAATGTGGTAAGTTGATAAAGGT
ATTGCCAAGTAGCAGAGTTT

Downstream 100 bases:

>100_bases
CTTACTAACTTTATCATTCTTTAACTTGTATAACTTTATAATATAGATGAAAGAACTACTTAAAGATGCTATTAACAAAG
AATGAAAACCAACAACAAGA

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKKYVLIICILVLVDQLSKWYVMSLVGDTRIIEIFSFLRFSTVWNTGISFGMLHDFMYSNLIFCSISILITFVLFYFLVI
RLSHRLPLAIIIGGSVGNIVDRVKYGAVYDFIDFYINKWHWPAFNLADSFIFLGIIIMVRANNFTK

Sequences:

>Translated_146_residues
MKKYVLIICILVLVDQLSKWYVMSLVGDTRIIEIFSFLRFSTVWNTGISFGMLHDFMYSNLIFCSISILITFVLFYFLVI
RLSHRLPLAIIIGGSVGNIVDRVKYGAVYDFIDFYINKWHWPAFNLADSFIFLGIIIMVRANNFTK
>Mature_146_residues
MKKYVLIICILVLVDQLSKWYVMSLVGDTRIIEIFSFLRFSTVWNTGISFGMLHDFMYSNLIFCSISILITFVLFYFLVI
RLSHRLPLAIIIGGSVGNIVDRVKYGAVYDFIDFYINKWHWPAFNLADSFIFLGIIIMVRANNFTK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=144, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17013; Mature: 17013

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYVLIICILVLVDQLSKWYVMSLVGDTRIIEIFSFLRFSTVWNTGISFGMLHDFMYSN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LIFCSISILITFVLFYFLVIRLSHRLPLAIIIGGSVGNIVDRVKYGAVYDFIDFYINKWH
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
WPAFNLADSFIFLGIIIMVRANNFTK
CCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKYVLIICILVLVDQLSKWYVMSLVGDTRIIEIFSFLRFSTVWNTGISFGMLHDFMYSN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LIFCSISILITFVLFYFLVIRLSHRLPLAIIIGGSVGNIVDRVKYGAVYDFIDFYINKWH
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
WPAFNLADSFIFLGIIIMVRANNFTK
CCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA