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The map label for this gene is tmk

Identifier: 88607927

GI number: 88607927

Start: 98947

End: 99606

Strand: Direct

Name: tmk

Synonym: APH_0093

Alternate gene names: 88607927

Gene position: 98947-99606 (Clockwise)

Preceding gene: 88607175

Following gene: 88607674

Centisome position: 6.73

GC content: 42.42

Gene sequence:

>660_bases
ATGTTCATAACTTTTGAGGGAATAGATGGGTGTGGTAAGACCACGCAGTCTATTTTACTAGCGAAGTATATGTCTGATCT
GTACGGAGAAGACAATGTGGTGTTGACTAGAGAACCTGGGGGCACTTCTTTTAATGAACTGCTGCGTAGCGTGTTTTTGT
CAGTTTCAGACTACAAGGTTGATAAGCTCACAGAGTTATTTCTATTTCTAGCAATGCGCAGAGAGAGCTTTGTTAAGGTG
GTAGAGAGTGCTCTGAGAGCGAATAAGATAGTAATTAGTGACCGCTGTGTAGACTCTACTGTGGCTTACCAAGGGTACGG
TTGTGGTATTGACCTGGATCTAATATACAAGCTTAATTCCCTGGTTATGGGAATAGTTCCAGATATGACGTTCATCATAG
ACATCGATATAGAAAAGGCCTTATCAAGGGCTACTCGTAATGGCTATGAGAGCAATAGCATGGATTTTTATCACAAGGTG
CGGAAGGGCTTTCAACGTATAGCTGAGGAAGAGAAACATAGATGTGTATTGCTCCGTTGTGATGATTACGAGGAGAATGG
TATCTGTGATGTTTATTCCGTACACAACAAAATAGTGGGGCTTTTGCAGGGGGTGCTTCATAACAAGATGGATGCCGCCT
CCTCTAGTGTAAAGGTTTAG

Upstream 100 bases:

>100_bases
AGGACTGTGCGTTGTGTTAGTGTTTGTGCAGTAGATGCGATGCGAGAGTTATCGCAATATGCTGAAGTTCGTGAGTTTTG
CTAGAGTGTCCTTGGGTAAT

Downstream 100 bases:

>100_bases
TATATCCATACAATGCTTCTAAGGGTTTTTTAGAGAGATGCGCTGTACTAATGCGGTGTTATGAATTACCATGTCCCTAC
GTTTATTTTTGATGGTGGAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MFITFEGIDGCGKTTQSILLAKYMSDLYGEDNVVLTREPGGTSFNELLRSVFLSVSDYKVDKLTELFLFLAMRRESFVKV
VESALRANKIVISDRCVDSTVAYQGYGCGIDLDLIYKLNSLVMGIVPDMTFIIDIDIEKALSRATRNGYESNSMDFYHKV
RKGFQRIAEEEKHRCVLLRCDDYEENGICDVYSVHNKIVGLLQGVLHNKMDAASSSVKV

Sequences:

>Translated_219_residues
MFITFEGIDGCGKTTQSILLAKYMSDLYGEDNVVLTREPGGTSFNELLRSVFLSVSDYKVDKLTELFLFLAMRRESFVKV
VESALRANKIVISDRCVDSTVAYQGYGCGIDLDLIYKLNSLVMGIVPDMTFIIDIDIEKALSRATRNGYESNSMDFYHKV
RKGFQRIAEEEKHRCVLLRCDDYEENGICDVYSVHNKIVGLLQGVLHNKMDAASSSVKV
>Mature_219_residues
MFITFEGIDGCGKTTQSILLAKYMSDLYGEDNVVLTREPGGTSFNELLRSVFLSVSDYKVDKLTELFLFLAMRRESFVKV
VESALRANKIVISDRCVDSTVAYQGYGCGIDLDLIYKLNSLVMGIVPDMTFIIDIDIEKALSRATRNGYESNSMDFYHKV
RKGFQRIAEEEKHRCVLLRCDDYEENGICDVYSVHNKIVGLLQGVLHNKMDAASSSVKV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=179, Percent_Identity=36.8715083798883, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_ANAPZ (Q2GLN0)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504721.1
- HSSP:   P65248
- ProteinModelPortal:   Q2GLN0
- SMR:   Q2GLN0
- STRING:   Q2GLN0
- GeneID:   3930763
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0093
- NMPDR:   fig|212042.5.peg.87
- TIGR:   APH_0093
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q2GLN0
- ProtClustDB:   PRK13976
- BioCyc:   APHA212042:APH_0093-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24687; Mature: 24687

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITFEGIDGCGKTTQSILLAKYMSDLYGEDNVVLTREPGGTSFNELLRSVFLSVSDYKV
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCH
DKLTELFLFLAMRRESFVKVVESALRANKIVISDRCVDSTVAYQGYGCGIDLDLIYKLNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHEECCCCCCCCHHHHHHHHH
LVMGIVPDMTFIIDIDIEKALSRATRNGYESNSMDFYHKVRKGFQRIAEEEKHRCVLLRC
HHHHHCCCEEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
DDYEENGICDVYSVHNKIVGLLQGVLHNKMDAASSSVKV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFITFEGIDGCGKTTQSILLAKYMSDLYGEDNVVLTREPGGTSFNELLRSVFLSVSDYKV
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCH
DKLTELFLFLAMRRESFVKVVESALRANKIVISDRCVDSTVAYQGYGCGIDLDLIYKLNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHEECCCCCCCCHHHHHHHHH
LVMGIVPDMTFIIDIDIEKALSRATRNGYESNSMDFYHKVRKGFQRIAEEEKHRCVLLRC
HHHHHCCCEEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEE
DDYEENGICDVYSVHNKIVGLLQGVLHNKMDAASSSVKV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA