Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 88607852

GI number: 88607852

Start: 44756

End: 46243

Strand: Direct

Name: nuoN [H]

Synonym: APH_0044

Alternate gene names: 88607852

Gene position: 44756-46243 (Clockwise)

Preceding gene: 88606722

Following gene: 88606966

Centisome position: 3.04

GC content: 43.62

Gene sequence:

>1488_bases
ATGAAAGATCATTTGGTGATATTACAGGTATTGTTGCCGTTATTATCCGCAACTGTGTGCTCCTTGTTACGCTGCAGGGT
GAGTCTTATACAGATGTTCACTTGCGGGGTGGTTACAGGCTCTTTTTTGATATCTCTTCTGTTGTTCTTCCAGGTTTATT
CGGGACAACCCATAGTATATAAGGTTGGGGGATGGGGTTTGCCTTATGGCATAGAGCTTCGAGTAGATTTACTAAGCGCT
ACTATGATGTTGTTAGTTACCTTTATAGGGGTGATGAGCACGATTTACGGTATTTATCCTAGCCGAAAAGAAATACCGGC
TGAAAAGGTCTCAAAGTTTTATGCAGCCTTTTTATTATCGTTTGGCGGCCTACTAGGCATTTTGGTTTCCAATGATGCTT
TTAATGTCTATGTGTTTTTAGAGGTAGCATCAATATCTGCGTACGTACTAGTTGCAATGGGGGTGCACAAAGGGTCTCTG
GTATCGTCGTTTGAGTACTTGATCATAGGAACTGTAGGTGCAACCTTTTACCTACTGGGTATAGGCTTCTTGTATGCAGC
TACCGGCACGCTAAACATGGGAAATATGTTTATGATGCTGCAGGAGTTACCGGTAGATAGGACTGTATATATTGGTGTTT
TTTTCGTGATGCTTGGCTTGGTGATGAAGGCGGCTTTGTATCCGTTTCACGGCTGGTTGGTTAGAGCATATTCATCATCA
CCGGCATTTATTGCGGTGTTTTTATCAGGCACTGCAACAAAGGTGATGATTTACCTTATGATAAGGATAGTATACGGCGT
ATTTGGAGCGAATCTGGTATTTACAGAGTTACCTTTTGGCAAGATGCTGTTGGCTGTTGCTGCGTTGGCAATTATTGTTG
CCTCGGTATTGGCAGCGATGAGCAAGGGCATAAGTGATGTGTTGTCTTATTCCAGTGTGGCGAATATAGCATGTGTCATA
TTTGCGATTAGCGTAAATACGTATGCGGGGTTAGCTGCTGCGGTAACTTATATGGTTAGCCATAGCGTGGCAAAGTCGGC
ATTATTTATGGTATCTGGAGGGATATCCTATCACTTTGGTCGGGGCAATGTTGAGAAATGTTTGAGTTTGAGCCGAGTGC
TTCCGGGCATTACTGCGGCTTATGTGCTGCTTTCTCTTAGTTTGGTGGGGATGCCTCCTACCATGGGGTTTGTAGCCAAG
TGGCATATGCTTAGTTCGTTTGTCAGCGCACGGGCATGGGAGGGTATATTGGCATTGTCTGTTGGATCTGTGTGTTCTGT
AATATACACATGGAAGGTGATAGAATACTTGTATTTCACCCCTCGTATGGTAGAGAAATGCGCTAACGATATTGCGATAA
AAACCCCCAAGGCAATGACCTTATGTATGTGGGTAATGGCATGTATTGGGTTAGCCGTAGGGGCATATCCTATACCTCTA
ACAGCCATATCAGAACAAATAGCAATTACTCTGTGTCAGATTAGCTAG

Upstream 100 bases:

>100_bases
AAGAAGTACAAAAAGTAATATATTGTAGAAGCTTTTCTTTTTCAGTATAACTGCAGCGATGCTTGTTGTTATCAGGTGAA
AGGAACGTGTGATTTACGCT

Downstream 100 bases:

>100_bases
GCAAAAAAAGCAGCAAACACCCATTCTGCGCGGGTAACACAACAGAATTTACGTAGATTACGAGGCAACACGCTTACACG
ACAAACTTCTCAAAGCAAAC

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKDHLVILQVLLPLLSATVCSLLRCRVSLIQMFTCGVVTGSFLISLLLFFQVYSGQPIVYKVGGWGLPYGIELRVDLLSA
TMMLLVTFIGVMSTIYGIYPSRKEIPAEKVSKFYAAFLLSFGGLLGILVSNDAFNVYVFLEVASISAYVLVAMGVHKGSL
VSSFEYLIIGTVGATFYLLGIGFLYAATGTLNMGNMFMMLQELPVDRTVYIGVFFVMLGLVMKAALYPFHGWLVRAYSSS
PAFIAVFLSGTATKVMIYLMIRIVYGVFGANLVFTELPFGKMLLAVAALAIIVASVLAAMSKGISDVLSYSSVANIACVI
FAISVNTYAGLAAAVTYMVSHSVAKSALFMVSGGISYHFGRGNVEKCLSLSRVLPGITAAYVLLSLSLVGMPPTMGFVAK
WHMLSSFVSARAWEGILALSVGSVCSVIYTWKVIEYLYFTPRMVEKCANDIAIKTPKAMTLCMWVMACIGLAVGAYPIPL
TAISEQIAITLCQIS

Sequences:

>Translated_495_residues
MKDHLVILQVLLPLLSATVCSLLRCRVSLIQMFTCGVVTGSFLISLLLFFQVYSGQPIVYKVGGWGLPYGIELRVDLLSA
TMMLLVTFIGVMSTIYGIYPSRKEIPAEKVSKFYAAFLLSFGGLLGILVSNDAFNVYVFLEVASISAYVLVAMGVHKGSL
VSSFEYLIIGTVGATFYLLGIGFLYAATGTLNMGNMFMMLQELPVDRTVYIGVFFVMLGLVMKAALYPFHGWLVRAYSSS
PAFIAVFLSGTATKVMIYLMIRIVYGVFGANLVFTELPFGKMLLAVAALAIIVASVLAAMSKGISDVLSYSSVANIACVI
FAISVNTYAGLAAAVTYMVSHSVAKSALFMVSGGISYHFGRGNVEKCLSLSRVLPGITAAYVLLSLSLVGMPPTMGFVAK
WHMLSSFVSARAWEGILALSVGSVCSVIYTWKVIEYLYFTPRMVEKCANDIAIKTPKAMTLCMWVMACIGLAVGAYPIPL
TAISEQIAITLCQIS
>Mature_495_residues
MKDHLVILQVLLPLLSATVCSLLRCRVSLIQMFTCGVVTGSFLISLLLFFQVYSGQPIVYKVGGWGLPYGIELRVDLLSA
TMMLLVTFIGVMSTIYGIYPSRKEIPAEKVSKFYAAFLLSFGGLLGILVSNDAFNVYVFLEVASISAYVLVAMGVHKGSL
VSSFEYLIIGTVGATFYLLGIGFLYAATGTLNMGNMFMMLQELPVDRTVYIGVFFVMLGLVMKAALYPFHGWLVRAYSSS
PAFIAVFLSGTATKVMIYLMIRIVYGVFGANLVFTELPFGKMLLAVAALAIIVASVLAAMSKGISDVLSYSSVANIACVI
FAISVNTYAGLAAAVTYMVSHSVAKSALFMVSGGISYHFGRGNVEKCLSLSRVLPGITAAYVLLSLSLVGMPPTMGFVAK
WHMLSSFVSARAWEGILALSVGSVCSVIYTWKVIEYLYFTPRMVEKCANDIAIKTPKAMTLCMWVMACIGLAVGAYPIPL
TAISEQIAITLCQIS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788831, Length=344, Percent_Identity=26.453488372093, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788827, Length=353, Percent_Identity=24.3626062322946, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=23.0582524271845, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693160, Length=390, Percent_Identity=27.9487179487179, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788613, Length=432, Percent_Identity=24.3055555555556, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788614, Length=463, Percent_Identity=23.5421166306695, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=288, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53388; Mature: 53388

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDHLVILQVLLPLLSATVCSLLRCRVSLIQMFTCGVVTGSFLISLLLFFQVYSGQPIVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
KVGGWGLPYGIELRVDLLSATMMLLVTFIGVMSTIYGIYPSRKEIPAEKVSKFYAAFLLS
EECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FGGLLGILVSNDAFNVYVFLEVASISAYVLVAMGVHKGSLVSSFEYLIIGTVGATFYLLG
HHHHHEEEECCCCEEEEEEEEEHHHHHHHHHHHCCCCCHHHHCCHHHEEEHHHHHHHHHH
IGFLYAATGTLNMGNMFMMLQELPVDRTVYIGVFFVMLGLVMKAALYPFHGWLVRAYSSS
HHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCC
PAFIAVFLSGTATKVMIYLMIRIVYGVFGANLVFTELPFGKMLLAVAALAIIVASVLAAM
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
SKGISDVLSYSSVANIACVIFAISVNTYAGLAAAVTYMVSHSVAKSALFMVSGGISYHFG
HHCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEC
RGNVEKCLSLSRVLPGITAAYVLLSLSLVGMPPTMGFVAKWHMLSSFVSARAWEGILALS
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
VGSVCSVIYTWKVIEYLYFTPRMVEKCANDIAIKTPKAMTLCMWVMACIGLAVGAYPIPL
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCH
TAISEQIAITLCQIS
HHHHHHHEEEEEECC
>Mature Secondary Structure
MKDHLVILQVLLPLLSATVCSLLRCRVSLIQMFTCGVVTGSFLISLLLFFQVYSGQPIVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
KVGGWGLPYGIELRVDLLSATMMLLVTFIGVMSTIYGIYPSRKEIPAEKVSKFYAAFLLS
EECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FGGLLGILVSNDAFNVYVFLEVASISAYVLVAMGVHKGSLVSSFEYLIIGTVGATFYLLG
HHHHHEEEECCCCEEEEEEEEEHHHHHHHHHHHCCCCCHHHHCCHHHEEEHHHHHHHHHH
IGFLYAATGTLNMGNMFMMLQELPVDRTVYIGVFFVMLGLVMKAALYPFHGWLVRAYSSS
HHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCC
PAFIAVFLSGTATKVMIYLMIRIVYGVFGANLVFTELPFGKMLLAVAALAIIVASVLAAM
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
SKGISDVLSYSSVANIACVIFAISVNTYAGLAAAVTYMVSHSVAKSALFMVSGGISYHFG
HHCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEC
RGNVEKCLSLSRVLPGITAAYVLLSLSLVGMPPTMGFVAKWHMLSSFVSARAWEGILALS
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
VGSVCSVIYTWKVIEYLYFTPRMVEKCANDIAIKTPKAMTLCMWVMACIGLAVGAYPIPL
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCH
TAISEQIAITLCQIS
HHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA