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The map label for this gene is rnd [H]

Identifier: 88607542

GI number: 88607542

Start: 141529

End: 142674

Strand: Direct

Name: rnd [H]

Synonym: APH_0137

Alternate gene names: 88607542

Gene position: 141529-142674 (Clockwise)

Preceding gene: 88607475

Following gene: 88606736

Centisome position: 9.62

GC content: 39.97

Gene sequence:

>1146_bases
GTGTTTATTTGTTCAACAAATGATCTATCTAGGTTTTGTACGGAGTTATTACGTGATAACCCCGAAAGTGTGGCAATAGA
CACGGAGTTTTTGCGTAGCTTCAACGACTATTACCCAAAATTGTGTTTACTGCAGATAGCTTATGAGAATAAGCAGTGTG
TAATTGATGCTTTAGCAGAGGGTATTGATCTTACTCCTCTGCAGGAAATTTTTGATAACACACAGATTTTCAAGGTTTTT
CACGATTGTAGGCAGGATCTTGACGCGTTATCCCTGTTATTTGAGTCTCTCCCTAGGCCTATATTTGATACGCAAATAGC
GGCTATGCTGTGTGAGTATCACGAAAATTCAGTGGGATACTCTAAATTAGTTGAGCAGTTTCTAGGCGTGAAACTGAATA
AGATGCCCTTCAAGCGTGTGGATTGGTCAAAAAGGCCTTTAACGGAAAGTGAGGTACGTTACGCACTTGATGATGTTATT
TATCTATATAAGCTGTACGGAATCCTTCGGGATATTTTGACGTCCAAGGGTAGGTTATCGTGGTATATGGAGGAGATGGA
TTGCATTGTAGATTCGGTATCCGATAACTACACTACGATTTTAGAGAGTATGGAGTGTTATGCAGACTTAACTGAGCAAG
AAGCTAATATAGCAAGATCGGTGGTAGAGTGGAGAGAGCGTGTAGCACGTCTACTAAATATAAATCGAAATATTATCATG
AATGCCAGAGATGTCTTGAATATTACAAAAGACTTTATAGCGGATGGCAGCGACAGTACCCTCAGAAAATACGTGCGCGA
GCTATATCTACAAGACCTTCCATTCAGTTTGACTGAGATAGTGGAGAATAACAAGCATATAAAGCAAGATGTGTATAATA
AAGCGAGTCAAGAACGTGATACTCTAAGTTTACTGTCTATATTGCTGCATAGCGTGTGCATAGAAGATGGTGTGTCACAG
AAATTAGTAGCATCTAAGAGAGATTTGGTTAGAGCCATAAGTCGCCTTCCTAGCAACATAATGCGTGGGTGGAGATATGA
GTTTTTTGGCCATAAGGTTAAAGCTTTTATCGAAGGACAAGCCAAGTTGGTGTTTTCTGTCGATACCAATGGAGGCGATG
TACAGCTTCTTGTAGACAGTCATTAA

Upstream 100 bases:

>100_bases
ATAGTAGAGAAGATCCTGCAAGAGCATGGCGCATCTATAGGTTTCCGTAACTCAGAGGAAGGTGGTGTGGTACGGATTAC
TTTTTTGAAATGAGAAAAAT

Downstream 100 bases:

>100_bases
TTTGCCTGTAGATTAAGCGGCTAACGTAAGCGACGGCTCTTGATTTGCGGATTTTTTAGATGCACACAGCACCATATGCT
CCATAGTAAATAAGAAGACA

Product: putative ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MFICSTNDLSRFCTELLRDNPESVAIDTEFLRSFNDYYPKLCLLQIAYENKQCVIDALAEGIDLTPLQEIFDNTQIFKVF
HDCRQDLDALSLLFESLPRPIFDTQIAAMLCEYHENSVGYSKLVEQFLGVKLNKMPFKRVDWSKRPLTESEVRYALDDVI
YLYKLYGILRDILTSKGRLSWYMEEMDCIVDSVSDNYTTILESMECYADLTEQEANIARSVVEWRERVARLLNINRNIIM
NARDVLNITKDFIADGSDSTLRKYVRELYLQDLPFSLTEIVENNKHIKQDVYNKASQERDTLSLLSILLHSVCIEDGVSQ
KLVASKRDLVRAISRLPSNIMRGWRYEFFGHKVKAFIEGQAKLVFSVDTNGGDVQLLVDSH

Sequences:

>Translated_381_residues
MFICSTNDLSRFCTELLRDNPESVAIDTEFLRSFNDYYPKLCLLQIAYENKQCVIDALAEGIDLTPLQEIFDNTQIFKVF
HDCRQDLDALSLLFESLPRPIFDTQIAAMLCEYHENSVGYSKLVEQFLGVKLNKMPFKRVDWSKRPLTESEVRYALDDVI
YLYKLYGILRDILTSKGRLSWYMEEMDCIVDSVSDNYTTILESMECYADLTEQEANIARSVVEWRERVARLLNINRNIIM
NARDVLNITKDFIADGSDSTLRKYVRELYLQDLPFSLTEIVENNKHIKQDVYNKASQERDTLSLLSILLHSVCIEDGVSQ
KLVASKRDLVRAISRLPSNIMRGWRYEFFGHKVKAFIEGQAKLVFSVDTNGGDVQLLVDSH
>Mature_381_residues
MFICSTNDLSRFCTELLRDNPESVAIDTEFLRSFNDYYPKLCLLQIAYENKQCVIDALAEGIDLTPLQEIFDNTQIFKVF
HDCRQDLDALSLLFESLPRPIFDTQIAAMLCEYHENSVGYSKLVEQFLGVKLNKMPFKRVDWSKRPLTESEVRYALDDVI
YLYKLYGILRDILTSKGRLSWYMEEMDCIVDSVSDNYTTILESMECYADLTEQEANIARSVVEWRERVARLLNINRNIIM
NARDVLNITKDFIADGSDSTLRKYVRELYLQDLPFSLTEIVENNKHIKQDVYNKASQERDTLSLLSILLHSVCIEDGVSQ
KLVASKRDLVRAISRLPSNIMRGWRYEFFGHKVKAFIEGQAKLVFSVDTNGGDVQLLVDSH

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI50301240, Length=263, Percent_Identity=26.615969581749, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788105, Length=381, Percent_Identity=25.9842519685039, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324574, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 44107; Mature: 44107

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFICSTNDLSRFCTELLRDNPESVAIDTEFLRSFNDYYPKLCLLQIAYENKQCVIDALAE
CEEECCCHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GIDLTPLQEIFDNTQIFKVFHDCRQDLDALSLLFESLPRPIFDTQIAAMLCEYHENSVGY
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
SKLVEQFLGVKLNKMPFKRVDWSKRPLTESEVRYALDDVIYLYKLYGILRDILTSKGRLS
HHHHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WYMEEMDCIVDSVSDNYTTILESMECYADLTEQEANIARSVVEWRERVARLLNINRNIIM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEE
NARDVLNITKDFIADGSDSTLRKYVRELYLQDLPFSLTEIVENNKHIKQDVYNKASQERD
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
TLSLLSILLHSVCIEDGVSQKLVASKRDLVRAISRLPSNIMRGWRYEFFGHKVKAFIEGQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AKLVFSVDTNGGDVQLLVDSH
EEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MFICSTNDLSRFCTELLRDNPESVAIDTEFLRSFNDYYPKLCLLQIAYENKQCVIDALAE
CEEECCCHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GIDLTPLQEIFDNTQIFKVFHDCRQDLDALSLLFESLPRPIFDTQIAAMLCEYHENSVGY
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCH
SKLVEQFLGVKLNKMPFKRVDWSKRPLTESEVRYALDDVIYLYKLYGILRDILTSKGRLS
HHHHHHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
WYMEEMDCIVDSVSDNYTTILESMECYADLTEQEANIARSVVEWRERVARLLNINRNIIM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEE
NARDVLNITKDFIADGSDSTLRKYVRELYLQDLPFSLTEIVENNKHIKQDVYNKASQERD
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
TLSLLSILLHSVCIEDGVSQKLVASKRDLVRAISRLPSNIMRGWRYEFFGHKVKAFIEGQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AKLVFSVDTNGGDVQLLVDSH
EEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]