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The map label for this gene is pdhA [H]

Identifier: 88607434

GI number: 88607434

Start: 87566

End: 88603

Strand: Reverse

Name: pdhA [H]

Synonym: APH_0082

Alternate gene names: 88607434

Gene position: 88603-87566 (Counterclockwise)

Preceding gene: 88607297

Following gene: 88607651

Centisome position: 6.02

GC content: 46.24

Gene sequence:

>1038_bases
ATGCGCTTGAAAAGGGAAGCTTTGCAGAGTAGTATAGCAGGCACTAAAGACATCGGGCGTAAGGAGGTTTTGCACGTGAA
TTTGACTAACGAATCTGTACTGTCCGCCTATAAGCACATGCTATTTATGCGTCGACTGGAAGAGAAAGTTGGCCAATTGT
ACGGTATGGGCTTGATTCGAGGGTTCTGCCATCTATATATTGGCCAAGAAGCCGTCGCTGCTGGAATGTATAGCGTATTA
CAACCTTCGGATTCCGTAATCACAAGTTACAGAGAACATGGGTTTGCGTTATCATCTGGCGAAAGCCCAGGGAAGATAAT
CGCGGAACTACTGGGAAGAAGCGCAGGTTCTTCCAAAGGAAAGGGTGGTTCCATGCATATTTTCAACGTGCAGAAAAACT
TCTACGGTGGCCATGGAATCGTGGGAGCCCAGGTTCCCATAGGTACAGGAATAGCATTCGCCAATAAGTATAAAGCGAAC
GGTGGAGTCGTGTTCACTTGCTTAGGTGACGGCGCTATAAACCAAGGACAAGTGTACGAGGCCTTTAACATGGCAGCACT
GTGGAAATTGCCTGTTGTATACGTAGTAGAAAATAATGAATATGCCATGGGGACTTCAGTAGCCAGATCTTCCTATGTTT
CTGATTTGTATAAACGTGGTGAAAGCTGTGGCGTACCGGGTCGCAGAGTTGATGGCATGGACTTGTTTGAAGTAATACGC
GAGGTTTCGCAAGCTGCTGCGCATTGCCGTGAGGGCAATGGACCGATTTTACTGGAGATGAAAACCTACCGTTACAGGGG
GCACTCTATGTCTGATCCTGCGAAGTATCGTACACGGGAAGAAGTGGAAGAGATACGAAATAATAGAGATCCCCTATGCA
TTGTAAAGAGCCACATATTAGAGCATAACATGGCTTCAGAAGAGGTTCTTACAACGTGGGAAAAGGAAATACGAGACGAG
ATAAAGAAGGCCGTTGAGTTTGCAGAAGGTTGCCCTGAACCCAGTGTAGAAGAGCTATATACCGACGTATACAAATAG

Upstream 100 bases:

>100_bases
CCCGCACTTTTTCAGCAAAACAGAATAGATGACGTTTTGCACTGGCTTAACAAAACGTCTACTATCCACAATATGTAGTA
TTAGAAAGCGTCGGGGTGGA

Downstream 100 bases:

>100_bases
CTGTAACTCTGAGCTCTACCTGTACGTGAAAGACATGTTCTTTACTCGCTGCGGGCAATCTTGATGCCCAGTTCAGTGCT
GAGTGGTAGCTTTTTCTCAC

Product: pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MRLKREALQSSIAGTKDIGRKEVLHVNLTNESVLSAYKHMLFMRRLEEKVGQLYGMGLIRGFCHLYIGQEAVAAGMYSVL
QPSDSVITSYREHGFALSSGESPGKIIAELLGRSAGSSKGKGGSMHIFNVQKNFYGGHGIVGAQVPIGTGIAFANKYKAN
GGVVFTCLGDGAINQGQVYEAFNMAALWKLPVVYVVENNEYAMGTSVARSSYVSDLYKRGESCGVPGRRVDGMDLFEVIR
EVSQAAAHCREGNGPILLEMKTYRYRGHSMSDPAKYRTREEVEEIRNNRDPLCIVKSHILEHNMASEEVLTTWEKEIRDE
IKKAVEFAEGCPEPSVEELYTDVYK

Sequences:

>Translated_345_residues
MRLKREALQSSIAGTKDIGRKEVLHVNLTNESVLSAYKHMLFMRRLEEKVGQLYGMGLIRGFCHLYIGQEAVAAGMYSVL
QPSDSVITSYREHGFALSSGESPGKIIAELLGRSAGSSKGKGGSMHIFNVQKNFYGGHGIVGAQVPIGTGIAFANKYKAN
GGVVFTCLGDGAINQGQVYEAFNMAALWKLPVVYVVENNEYAMGTSVARSSYVSDLYKRGESCGVPGRRVDGMDLFEVIR
EVSQAAAHCREGNGPILLEMKTYRYRGHSMSDPAKYRTREEVEEIRNNRDPLCIVKSHILEHNMASEEVLTTWEKEIRDE
IKKAVEFAEGCPEPSVEELYTDVYK
>Mature_345_residues
MRLKREALQSSIAGTKDIGRKEVLHVNLTNESVLSAYKHMLFMRRLEEKVGQLYGMGLIRGFCHLYIGQEAVAAGMYSVL
QPSDSVITSYREHGFALSSGESPGKIIAELLGRSAGSSKGKGGSMHIFNVQKNFYGGHGIVGAQVPIGTGIAFANKYKAN
GGVVFTCLGDGAINQGQVYEAFNMAALWKLPVVYVVENNEYAMGTSVARSSYVSDLYKRGESCGVPGRRVDGMDLFEVIR
EVSQAAAHCREGNGPILLEMKTYRYRGHSMSDPAKYRTREEVEEIRNNRDPLCIVKSHILEHNMASEEVLTTWEKEIRDE
IKKAVEFAEGCPEPSVEELYTDVYK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=53.1446540880503, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=53.1446540880503, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=53.1446540880503, Blast_Score=324, Evalue=8e-89,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=52, Blast_Score=317, Evalue=8e-87,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=47.7987421383648, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI258645172, Length=320, Percent_Identity=29.0625, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI11386135, Length=320, Percent_Identity=28.4375, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=322, Percent_Identity=49.3788819875776, Blast_Score=314, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17536047, Length=322, Percent_Identity=49.3788819875776, Blast_Score=314, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI86563355, Length=320, Percent_Identity=28.75, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI86563357, Length=320, Percent_Identity=28.75, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321026, Length=324, Percent_Identity=46.9135802469136, Blast_Score=310, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24639744, Length=361, Percent_Identity=44.3213296398892, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI28571106, Length=361, Percent_Identity=44.3213296398892, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24639740, Length=320, Percent_Identity=48.4375, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=49.0196078431373, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24639748, Length=329, Percent_Identity=46.8085106382979, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=26.9113149847095, Blast_Score=114, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38181; Mature: 38181

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKREALQSSIAGTKDIGRKEVLHVNLTNESVLSAYKHMLFMRRLEEKVGQLYGMGLIR
CCCHHHHHHHHHCCCHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFCHLYIGQEAVAAGMYSVLQPSDSVITSYREHGFALSSGESPGKIIAELLGRSAGSSKG
HHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHCCCCCCCCC
KGGSMHIFNVQKNFYGGHGIVGAQVPIGTGIAFANKYKANGGVVFTCLGDGAINQGQVYE
CCCCEEEEEECCCCCCCCCEEECCCCCCCCCHHHCCEECCCCEEEEEECCCCCCCCCHHH
AFNMAALWKLPVVYVVENNEYAMGTSVARSSYVSDLYKRGESCGVPGRRVDGMDLFEVIR
HHHHHHHHHCCEEEEEECCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
EVSQAAAHCREGNGPILLEMKTYRYRGHSMSDPAKYRTREEVEEIRNNRDPLCIVKSHIL
HHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHH
EHNMASEEVLTTWEKEIRDEIKKAVEFAEGCPEPSVEELYTDVYK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRLKREALQSSIAGTKDIGRKEVLHVNLTNESVLSAYKHMLFMRRLEEKVGQLYGMGLIR
CCCHHHHHHHHHCCCHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFCHLYIGQEAVAAGMYSVLQPSDSVITSYREHGFALSSGESPGKIIAELLGRSAGSSKG
HHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHCCCCCCCCC
KGGSMHIFNVQKNFYGGHGIVGAQVPIGTGIAFANKYKANGGVVFTCLGDGAINQGQVYE
CCCCEEEEEECCCCCCCCCEEECCCCCCCCCHHHCCEECCCCEEEEEECCCCCCCCCHHH
AFNMAALWKLPVVYVVENNEYAMGTSVARSSYVSDLYKRGESCGVPGRRVDGMDLFEVIR
HHHHHHHHHCCEEEEEECCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
EVSQAAAHCREGNGPILLEMKTYRYRGHSMSDPAKYRTREEVEEIRNNRDPLCIVKSHIL
HHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHH
EHNMASEEVLTTWEKEIRDEIKKAVEFAEGCPEPSVEELYTDVYK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA