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The map label for this gene is pyrC

Identifier: 88607405

GI number: 88607405

Start: 242513

End: 243856

Strand: Reverse

Name: pyrC

Synonym: APH_0245

Alternate gene names: 88607405

Gene position: 243856-242513 (Counterclockwise)

Preceding gene: 88606820

Following gene: 88606980

Centisome position: 16.57

GC content: 46.8

Gene sequence:

>1344_bases
GTGGTTAGTGAAAGACAGACTTGGTCTCTCTTACAGGGTGGTCAGTGTAATGAGTATACGGTTGCATACATAAATGCGCG
GATCATCGACCCAGCATCTGGCACAGACTATAAGGGTTATCTCCTTACTAGAGGCAAAGAAATTCTGGACTTTGGACCAG
GTTTTTTTGACCCTAACGGAGCAGCTTTCGCGGCTAGTGAAGTTGTAGATTGTAATGGGCATGTGTTGATGCCCGGTATT
GTCGATCTGCACGTTCACTTAAGAGAACCAGGAGGAGAGCATAAAGAAACCGTAGATACTGGAAGTCGGGCAGCTGCAGC
AGGTGGTGTTACTACCGTTGTGTGCCAACCAAATACTATCCCTCGCCTAGAGAATGTATTGGTAGCAAAGTATCTCAAGA
TGAGAGCCTTGGAGAGCTCTTGTGTAAACATAGAATTCTACGGGGCAGTTACAAAGTCCGATGGTGAGCTATGCGACATG
GCGTCTCTCAAGGATGCAGGTGCACTTGGCTTCACGGATGATGGATTGCCCGTCATGAACGCGCTGTATATGAAGCGAGC
CTTCGAATACGCTCAAGATTTGGATGTTGTCGTGGCGCAACATGCAGAAGACTGCAATCTCTCCGATGGAGGGTGCATCA
ATGAAGGACTGGTATCGCGAGAATTAGGCTTAAAGGGCATACCAGATATATCTGAGAGCATAATGGTCAGCAGAGATATA
CAGTTGCTACGTGAAGTACCTGGTGCGCACTATCACGTATTGCATATCTCAACAAAAAAGGCTTTAGATATTGTACGTGC
TGCAAAACGTGAAGGGCTGCGTGTCACGTGTGAAGTTACTCCACACCATTTTCTGCTCAATGAGAGTGCAGTTTTAGAAC
ATGGCACAATGGCGAAAATGAATCCTCCTCTGCGAACAGAAGAGGATCGTCTGAGTATGATTTCTGGCTTGGAAGACGGC
ACTATAGACTGCATAGCTACTGACCATGCTCCTCACGCTGCTCAGGAGAAAACGCGTCCTATATCATGCTGTGCGTTTGG
TATAGTAGGGCTCGAAACTCTGCTGCCTCTATCACTGGAACTGTACCACAATGCAGGTATGAGCCTCATGGACGTTCTCT
CCAAACTTACAAGCAAACCGGCAGAGATAGTAAGGCTTCCTAGGGGTAAGATAGCCAAAGGGCTAGTGGCAGATTTGGTG
ATATTTGATTTAGAACATGTGTGGACTATAGACACAGCAAAATTCTCCAGTAAATCGAAAAACTCCCCTTTCCAAGGAAG
AAAAGTGAAGGGCAAAGTACTCCGCACTGTAGTGTCAGGCAAGACAGTATACAGGGCCGAATAG

Upstream 100 bases:

>100_bases
GACGAAAGTAGAGGTAGCTAAGCTATTAACGGAAGAAATAATTGACTATCTCAATAGGTTAGATATACCCTAACTGTGTG
TTGTATCCTGCGTAATTGTT

Downstream 100 bases:

>100_bases
AAGAGTGTTATACCTGTTTAAAGCAACCTACTTAGTGCCCTGCTGAAAATACGTAAGGAAGAAGATAGGTAAAGTGCAGG
GCGATCGTACTATAGTACCA

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MVSERQTWSLLQGGQCNEYTVAYINARIIDPASGTDYKGYLLTRGKEILDFGPGFFDPNGAAFAASEVVDCNGHVLMPGI
VDLHVHLREPGGEHKETVDTGSRAAAAGGVTTVVCQPNTIPRLENVLVAKYLKMRALESSCVNIEFYGAVTKSDGELCDM
ASLKDAGALGFTDDGLPVMNALYMKRAFEYAQDLDVVVAQHAEDCNLSDGGCINEGLVSRELGLKGIPDISESIMVSRDI
QLLREVPGAHYHVLHISTKKALDIVRAAKREGLRVTCEVTPHHFLLNESAVLEHGTMAKMNPPLRTEEDRLSMISGLEDG
TIDCIATDHAPHAAQEKTRPISCCAFGIVGLETLLPLSLELYHNAGMSLMDVLSKLTSKPAEIVRLPRGKIAKGLVADLV
IFDLEHVWTIDTAKFSSKSKNSPFQGRKVKGKVLRTVVSGKTVYRAE

Sequences:

>Translated_447_residues
MVSERQTWSLLQGGQCNEYTVAYINARIIDPASGTDYKGYLLTRGKEILDFGPGFFDPNGAAFAASEVVDCNGHVLMPGI
VDLHVHLREPGGEHKETVDTGSRAAAAGGVTTVVCQPNTIPRLENVLVAKYLKMRALESSCVNIEFYGAVTKSDGELCDM
ASLKDAGALGFTDDGLPVMNALYMKRAFEYAQDLDVVVAQHAEDCNLSDGGCINEGLVSRELGLKGIPDISESIMVSRDI
QLLREVPGAHYHVLHISTKKALDIVRAAKREGLRVTCEVTPHHFLLNESAVLEHGTMAKMNPPLRTEEDRLSMISGLEDG
TIDCIATDHAPHAAQEKTRPISCCAFGIVGLETLLPLSLELYHNAGMSLMDVLSKLTSKPAEIVRLPRGKIAKGLVADLV
IFDLEHVWTIDTAKFSSKSKNSPFQGRKVKGKVLRTVVSGKTVYRAE
>Mature_447_residues
MVSERQTWSLLQGGQCNEYTVAYINARIIDPASGTDYKGYLLTRGKEILDFGPGFFDPNGAAFAASEVVDCNGHVLMPGI
VDLHVHLREPGGEHKETVDTGSRAAAAGGVTTVVCQPNTIPRLENVLVAKYLKMRALESSCVNIEFYGAVTKSDGELCDM
ASLKDAGALGFTDDGLPVMNALYMKRAFEYAQDLDVVVAQHAEDCNLSDGGCINEGLVSRELGLKGIPDISESIMVSRDI
QLLREVPGAHYHVLHISTKKALDIVRAAKREGLRVTCEVTPHHFLLNESAVLEHGTMAKMNPPLRTEEDRLSMISGLEDG
TIDCIATDHAPHAAQEKTRPISCCAFGIVGLETLLPLSLELYHNAGMSLMDVLSKLTSKPAEIVRLPRGKIAKGLVADLV
IFDLEHVWTIDTAKFSSKSKNSPFQGRKVKGKVLRTVVSGKTVYRAE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=32.8165374677003, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4503375, Length=421, Percent_Identity=24.4655581947743, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI19923821, Length=433, Percent_Identity=25.1732101616628, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786722, Length=411, Percent_Identity=28.9537712895377, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87082175, Length=400, Percent_Identity=25.5, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193204318, Length=370, Percent_Identity=30.8108108108108, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322218, Length=384, Percent_Identity=31.25, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24642586, Length=379, Percent_Identity=32.1899736147757, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI18859883, Length=414, Percent_Identity=27.2946859903382, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_ANAPZ (Q2GL89)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_504862.1
- ProteinModelPortal:   Q2GL89
- SMR:   Q2GL89
- STRING:   Q2GL89
- GeneID:   3931083
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_0245
- NMPDR:   fig|212042.5.peg.233
- TIGR:   APH_0245
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- PhylomeDB:   Q2GL89
- ProtClustDB:   CLSK749639
- BioCyc:   APHA212042:APH_0245-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 48529; Mature: 48529

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSERQTWSLLQGGQCNEYTVAYINARIIDPASGTDYKGYLLTRGKEILDFGPGFFDPNG
CCCCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCEEEECCCHHHHCCCCCCCCCC
AAFAASEVVDCNGHVLMPGIVDLHVHLREPGGEHKETVDTGSRAAAAGGVTTVVCQPNTI
CEEEECCEEECCCCEECCCEEEEEEEEECCCCCCCHHHCCCCCCCCCCCCEEEEECCCCC
PRLENVLVAKYLKMRALESSCVNIEFYGAVTKSDGELCDMASLKDAGALGFTDDGLPVMN
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEECHHHCCCCCCCCCCCCCHHHHH
ALYMKRAFEYAQDLDVVVAQHAEDCNLSDGGCINEGLVSRELGLKGIPDISESIMVSRDI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
QLLREVPGAHYHVLHISTKKALDIVRAAKREGLRVTCEVTPHHFLLNESAVLEHGTMAKM
HHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHCCCCCCCC
NPPLRTEEDRLSMISGLEDGTIDCIATDHAPHAAQEKTRPISCCAFGIVGLETLLPLSLE
CCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHE
LYHNAGMSLMDVLSKLTSKPAEIVRLPRGKIAKGLVADLVIFDLEHVWTIDTAKFSSKSK
EHHCCCCHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCC
NSPFQGRKVKGKVLRTVVSGKTVYRAE
CCCCCCCCHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MVSERQTWSLLQGGQCNEYTVAYINARIIDPASGTDYKGYLLTRGKEILDFGPGFFDPNG
CCCCCCCHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCEEEECCCHHHHCCCCCCCCCC
AAFAASEVVDCNGHVLMPGIVDLHVHLREPGGEHKETVDTGSRAAAAGGVTTVVCQPNTI
CEEEECCEEECCCCEECCCEEEEEEEEECCCCCCCHHHCCCCCCCCCCCCEEEEECCCCC
PRLENVLVAKYLKMRALESSCVNIEFYGAVTKSDGELCDMASLKDAGALGFTDDGLPVMN
HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEECHHHCCCCCCCCCCCCCHHHHH
ALYMKRAFEYAQDLDVVVAQHAEDCNLSDGGCINEGLVSRELGLKGIPDISESIMVSRDI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHH
QLLREVPGAHYHVLHISTKKALDIVRAAKREGLRVTCEVTPHHFLLNESAVLEHGTMAKM
HHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCHHHCCCCCCCC
NPPLRTEEDRLSMISGLEDGTIDCIATDHAPHAAQEKTRPISCCAFGIVGLETLLPLSLE
CCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHE
LYHNAGMSLMDVLSKLTSKPAEIVRLPRGKIAKGLVADLVIFDLEHVWTIDTAKFSSKSK
EHHCCCCHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCC
NSPFQGRKVKGKVLRTVVSGKTVYRAE
CCCCCCCCHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA