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The map label for this gene is coaBC [H]

Identifier: 88606820

GI number: 88606820

Start: 243884

End: 244603

Strand: Reverse

Name: coaBC [H]

Synonym: APH_0246

Alternate gene names: 88606820

Gene position: 244603-243884 (Counterclockwise)

Preceding gene: 88606862

Following gene: 88607405

Centisome position: 16.63

GC content: 41.94

Gene sequence:

>720_bases
TTGCAGAGAATTTGCAAGACTGAATGTGCGGGGCTATATTTATCGCAGTTTCTAATAGAGATTATCTGTGTGGTTAGCGT
ACTCATAACAGCTGGTTCTACTAGAGAGTATATCGACCCGGTTCGATATATAAGCAGTGGTTCTTCTGGAAAACAAGGTT
ATGCTCTGGCAGAATGCATGGGAAAGATGGGCTGGGATGTAAAGTTAGTGTCTTGCCCAGTAGCCCTTGCACCCAGGCAA
GACCTATATCAGACGTACCATGTAAATACCTCAGCGGATATGCTCAATACCTGCTTATCGCTATTACCCGTAGATGTGGC
CATTCTCACCGCTGCTATTACGGATTGGGTACCCTATCGTTGCAAACACAAGTTGAAAAAGCACGCTGTGGATCGAATAG
ACATGCTACATAGCCCAGACATAGCAAAATGTATCAGCATGAATAAAGATAGACCGAAACTCGTTATAGGGTTTTGCCTG
GAATCAGAAAACTTAATCGAATCTGCAAAAAATAAATTGGCTTACAAGGGATGCGACTGGATAATCGCCAACCACTACTA
TGTAAACGAGCACGAACCCGTAATGCATAGCAACTATAATCAAGTATCTATAGTCACCAGAGATTCCGTAAGACCCTTTC
AGATGATGACGAAAGTAGAGGTAGCTAAGCTATTAACGGAAGAAATAATTGACTATCTCAATAGGTTAGATATACCCTAA

Upstream 100 bases:

>100_bases
ATCATGTTCTACCCTAACACCCATAGCACCACCCAAAATACATAGCGCAGAAATTCTACAGCCGCTTTTAGAGCGCGTCC
ATCATTAGGAAATTTTTAAA

Downstream 100 bases:

>100_bases
CTGTGTGTTGTATCCTGCGTAATTGTTGTGGTTAGTGAAAGACAGACTTGGTCTCTCTTACAGGGTGGTCAGTGTAATGA
GTATACGGTTGCATACATAA

Product: DNA / pantothenate metabolism flavoprotein family protein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQRICKTECAGLYLSQFLIEIICVVSVLITAGSTREYIDPVRYISSGSSGKQGYALAECMGKMGWDVKLVSCPVALAPRQ
DLYQTYHVNTSADMLNTCLSLLPVDVAILTAAITDWVPYRCKHKLKKHAVDRIDMLHSPDIAKCISMNKDRPKLVIGFCL
ESENLIESAKNKLAYKGCDWIIANHYYVNEHEPVMHSNYNQVSIVTRDSVRPFQMMTKVEVAKLLTEEIIDYLNRLDIP

Sequences:

>Translated_239_residues
MQRICKTECAGLYLSQFLIEIICVVSVLITAGSTREYIDPVRYISSGSSGKQGYALAECMGKMGWDVKLVSCPVALAPRQ
DLYQTYHVNTSADMLNTCLSLLPVDVAILTAAITDWVPYRCKHKLKKHAVDRIDMLHSPDIAKCISMNKDRPKLVIGFCL
ESENLIESAKNKLAYKGCDWIIANHYYVNEHEPVMHSNYNQVSIVTRDSVRPFQMMTKVEVAKLLTEEIIDYLNRLDIP
>Mature_239_residues
MQRICKTECAGLYLSQFLIEIICVVSVLITAGSTREYIDPVRYISSGSSGKQGYALAECMGKMGWDVKLVSCPVALAPRQ
DLYQTYHVNTSADMLNTCLSLLPVDVAILTAAITDWVPYRCKHKLKKHAVDRIDMLHSPDIAKCISMNKDRPKLVIGFCL
ESENLIESAKNKLAYKGCDWIIANHYYVNEHEPVMHSNYNQVSIVTRDSVRPFQMMTKVEVAKLLTEEIIDYLNRLDIP

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=220, Percent_Identity=33.6363636363636, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 27023; Mature: 27023

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRICKTECAGLYLSQFLIEIICVVSVLITAGSTREYIDPVRYISSGSSGKQGYALAECM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
GKMGWDVKLVSCPVALAPRQDLYQTYHVNTSADMLNTCLSLLPVDVAILTAAITDWVPYR
HHCCCCEEEEECCCEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
CKHKLKKHAVDRIDMLHSPDIAKCISMNKDRPKLVIGFCLESENLIESAKNKLAYKGCDW
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCE
IIANHYYVNEHEPVMHSNYNQVSIVTRDSVRPFQMMTKVEVAKLLTEEIIDYLNRLDIP
EEECCEEECCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQRICKTECAGLYLSQFLIEIICVVSVLITAGSTREYIDPVRYISSGSSGKQGYALAECM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHH
GKMGWDVKLVSCPVALAPRQDLYQTYHVNTSADMLNTCLSLLPVDVAILTAAITDWVPYR
HHCCCCEEEEECCCEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
CKHKLKKHAVDRIDMLHSPDIAKCISMNKDRPKLVIGFCLESENLIESAKNKLAYKGCDW
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCE
IIANHYYVNEHEPVMHSNYNQVSIVTRDSVRPFQMMTKVEVAKLLTEEIIDYLNRLDIP
EEECCEEECCCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]