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The map label for this gene is ppiD [C]

Identifier: 88607320

GI number: 88607320

Start: 635244

End: 637049

Strand: Reverse

Name: ppiD [C]

Synonym: APH_0608

Alternate gene names: 88607320

Gene position: 637049-635244 (Counterclockwise)

Preceding gene: 88607362

Following gene: 88607876

Centisome position: 43.3

GC content: 39.87

Gene sequence:

>1806_bases
ATGGGTAAGTTGTCTAATTCTGGCAACGGACAGTGCGTTGCAATGTTGGGTAATAAATGTCTACCATTGCGGGATTACCG
TATAATGTACCGCAACGAGTTGGCAGAACTAGAGAAGATGTTACAACACAAATTGTCTGATGCTCAAATTAATCAGTTTG
GTATTAAGGAAGTTGTCCTCAAGAACATGATAGCCGACATGGTCGTTGAAAAGTTTGCTCATGACTTAGGCATACGTGTT
GGCTCAAATAGCTTACGGAGTCTGATCAAAAATATAAGAATATTTCAGGATGCTAATGGTGTCTTCGACCAGGAGAGATA
TGAAGCCGTATTGGCTGACAGCGGAATGACTGAGTCGTCCTATGTGAATAAAATTCGCAATGCTTTACCTTCTACTATTC
TAATGGAGTGTTTATTCCCTAATAGGGCGGAATTACATATTCCTTATTATGATGCATTAGCAAAAGATGTTGTGTTGGGA
TTGCTGCAGCATCGTGTGGCAGACATAGTGGAAATATCTTCTGATGCCGTAGACATTTCAGGAAGTGATATATCTGATGA
TGAATTGCAAAAATTGTTTGAGGAGCAGTACAAGAATTCTCTAAATTTCCCTGAATATCGCAGTGCTGATTATATAATCA
TGGCAGAAGACGACTTGCTTGCTGATGTCATTGTTTCGGATCAAGAGGTAGACGTTGAGATTAAAAACAGTGAACTACAT
GATCAAAGAGATGTTCTAAATTTAGTATTTACAGACAAAAATGAAGCTGAGCTAGCTTACAAAGCTTACCAAGAGGGTAA
GTCTTTTGAGGAATTGGTTAGTGATGCTGGCTACACCATAGAGGATATTGCACTCAATAATATCTCTAAGGATGTTCTTC
CGGTAGGTGTGCGAAATGTGGTGTTTGCACTAAATGAAGGAGAAGTCAGTGAAATGTTCCGTAGCGTTGTCGGCTGGCAT
ATCATGAAGGTAATAAGGAAGCATGAGATCACTAAGGAAGACCTAGAAAAGCTGAAAGAGAAGATATCTTCAAATATTAG
AAGGCAGAAGGCAGGTGAGTTGCTAGTTAGCAATGTGAAAAAAGCAAACGATATGATCAGCCGCGGGGCATCGCTGAATG
AACTAAAGGATATGTTTGGTGCGCGGATCAGTGGTGTTTTGACGAATTTTGATATGCATGGGCTCGATAAATCTGGCAAC
TTAGTGAAAGACTTTCCGTTGCAGCTTGGTATAAACGCCTTTACTACTTTGGCGTTTTCATCTGCCGTAGGAAAACCGTC
TCATCTGGTTAGCAATGGTGACGCTTATTTCGGCGTTCTTGTTACTGAAGTAGTGCCTCCAAGACCAAGGACACTTGAAG
AAAGCAGGTCTATTCTTACTGAAGAATGGAAGAGTGCATTACGTATGAAGAAAATACGTGAATTTGCTGTGGAGTTGCGC
TCGAAGCTACAAAATGGCACTGAATTGTCCGTTGTAAATGGAGTTTCTTTTAAAAAGAATGTCACGGTAAAAAAGTCAGA
TGGCTCTACCGACAATGATAGCAAGTATCCTGAACGCTTAGTCGATGAGATATTCGCCATTAACATTGGTGGAGTAACGA
AAGAAGTTATAGATTCTGAATCTGAGACTGTATACATTGCTCTGCTTAAAGAAATAAAAGATGCTGAAATAAGTGAGGAG
GATCTAGAGAGCTACAAGGCACATTTTGTTAGTAGTGGCATCCTATCTATAAGAGAGCAGCTCTTAGGTTATTTGATGAA
AAAATACGGAGTAACGATCGAAAATAGTTTGCTAGAGAAAGTGTAA

Upstream 100 bases:

>100_bases
TGGGCGTTCTGTTATGCGATCAAGGAAGATTTATGTTTGGGTGGTCATGGCAACGGTTTTAGGTGCCATGGCTTTTGTCA
CTTTTGGAAGCATGATACCA

Downstream 100 bases:

>100_bases
TTACGTACTTTCCTAAGGCTATTTTGTTTTTAGGATGAAGCGCGTTAGTGGATTTTAGTATCCTGTGTGTGCATCGTATA
TGTACAGTATATGCTTCGTT

Product: ppiC/parvulin rotamase family protein

Products: peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerse D; Peptidyl-Prolyl Cis-Trans Isomerase D; Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerse; Peptidyl-Prolyl Cis-Trans Isomerase Protein; Rotamase Family Protein; Parvulin-Like Peptidyl-Prolyl Isomerase; Parvulin-Like Peptidyl-Prolyl Isomerase PPID; Peptidyl-Prolyl Isomerase; PpiC/Parvulin Rotamase Family Protein; Peptidyl-Prolyl Cis-Trans Isomerase PpiD; Peptidylprolyl Isomerase

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MGKLSNSGNGQCVAMLGNKCLPLRDYRIMYRNELAELEKMLQHKLSDAQINQFGIKEVVLKNMIADMVVEKFAHDLGIRV
GSNSLRSLIKNIRIFQDANGVFDQERYEAVLADSGMTESSYVNKIRNALPSTILMECLFPNRAELHIPYYDALAKDVVLG
LLQHRVADIVEISSDAVDISGSDISDDELQKLFEEQYKNSLNFPEYRSADYIIMAEDDLLADVIVSDQEVDVEIKNSELH
DQRDVLNLVFTDKNEAELAYKAYQEGKSFEELVSDAGYTIEDIALNNISKDVLPVGVRNVVFALNEGEVSEMFRSVVGWH
IMKVIRKHEITKEDLEKLKEKISSNIRRQKAGELLVSNVKKANDMISRGASLNELKDMFGARISGVLTNFDMHGLDKSGN
LVKDFPLQLGINAFTTLAFSSAVGKPSHLVSNGDAYFGVLVTEVVPPRPRTLEESRSILTEEWKSALRMKKIREFAVELR
SKLQNGTELSVVNGVSFKKNVTVKKSDGSTDNDSKYPERLVDEIFAINIGGVTKEVIDSESETVYIALLKEIKDAEISEE
DLESYKAHFVSSGILSIREQLLGYLMKKYGVTIENSLLEKV

Sequences:

>Translated_601_residues
MGKLSNSGNGQCVAMLGNKCLPLRDYRIMYRNELAELEKMLQHKLSDAQINQFGIKEVVLKNMIADMVVEKFAHDLGIRV
GSNSLRSLIKNIRIFQDANGVFDQERYEAVLADSGMTESSYVNKIRNALPSTILMECLFPNRAELHIPYYDALAKDVVLG
LLQHRVADIVEISSDAVDISGSDISDDELQKLFEEQYKNSLNFPEYRSADYIIMAEDDLLADVIVSDQEVDVEIKNSELH
DQRDVLNLVFTDKNEAELAYKAYQEGKSFEELVSDAGYTIEDIALNNISKDVLPVGVRNVVFALNEGEVSEMFRSVVGWH
IMKVIRKHEITKEDLEKLKEKISSNIRRQKAGELLVSNVKKANDMISRGASLNELKDMFGARISGVLTNFDMHGLDKSGN
LVKDFPLQLGINAFTTLAFSSAVGKPSHLVSNGDAYFGVLVTEVVPPRPRTLEESRSILTEEWKSALRMKKIREFAVELR
SKLQNGTELSVVNGVSFKKNVTVKKSDGSTDNDSKYPERLVDEIFAINIGGVTKEVIDSESETVYIALLKEIKDAEISEE
DLESYKAHFVSSGILSIREQLLGYLMKKYGVTIENSLLEKV
>Mature_600_residues
GKLSNSGNGQCVAMLGNKCLPLRDYRIMYRNELAELEKMLQHKLSDAQINQFGIKEVVLKNMIADMVVEKFAHDLGIRVG
SNSLRSLIKNIRIFQDANGVFDQERYEAVLADSGMTESSYVNKIRNALPSTILMECLFPNRAELHIPYYDALAKDVVLGL
LQHRVADIVEISSDAVDISGSDISDDELQKLFEEQYKNSLNFPEYRSADYIIMAEDDLLADVIVSDQEVDVEIKNSELHD
QRDVLNLVFTDKNEAELAYKAYQEGKSFEELVSDAGYTIEDIALNNISKDVLPVGVRNVVFALNEGEVSEMFRSVVGWHI
MKVIRKHEITKEDLEKLKEKISSNIRRQKAGELLVSNVKKANDMISRGASLNELKDMFGARISGVLTNFDMHGLDKSGNL
VKDFPLQLGINAFTTLAFSSAVGKPSHLVSNGDAYFGVLVTEVVPPRPRTLEESRSILTEEWKSALRMKKIREFAVELRS
KLQNGTELSVVNGVSFKKNVTVKKSDGSTDNDSKYPERLVDEIFAINIGGVTKEVIDSESETVYIALLKEIKDAEISEED
LESYKAHFVSSGILSIREQLLGYLMKKYGVTIENSLLEKV

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 67407; Mature: 67275

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLSNSGNGQCVAMLGNKCLPLRDYRIMYRNELAELEKMLQHKLSDAQINQFGIKEVVL
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KNMIADMVVEKFAHDLGIRVGSNSLRSLIKNIRIFQDANGVFDQERYEAVLADSGMTESS
HHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHH
YVNKIRNALPSTILMECLFPNRAELHIPYYDALAKDVVLGLLQHRVADIVEISSDAVDIS
HHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GSDISDDELQKLFEEQYKNSLNFPEYRSADYIIMAEDDLLADVIVSDQEVDVEIKNSELH
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCEEEEEECCCCCC
DQRDVLNLVFTDKNEAELAYKAYQEGKSFEELVSDAGYTIEDIALNNISKDVLPVGVRNV
HHHHHHHHEECCCCHHHHHHHHHHCCCCHHHHHHCCCCEEHHHHHHCCCHHHHCCCHHHH
VFALNEGEVSEMFRSVVGWHIMKVIRKHEITKEDLEKLKEKISSNIRRQKAGELLVSNVK
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANDMISRGASLNELKDMFGARISGVLTNFDMHGLDKSGNLVKDFPLQLGINAFTTLAFS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHCHHHHHHHHHH
SAVGKPSHLVSNGDAYFGVLVTEVVPPRPRTLEESRSILTEEWKSALRMKKIREFAVELR
HHCCCCHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLQNGTELSVVNGVSFKKNVTVKKSDGSTDNDSKYPERLVDEIFAINIGGVTKEVIDSE
HHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCC
SETVYIALLKEIKDAEISEEDLESYKAHFVSSGILSIREQLLGYLMKKYGVTIENSLLEK
CCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
V
C
>Mature Secondary Structure 
GKLSNSGNGQCVAMLGNKCLPLRDYRIMYRNELAELEKMLQHKLSDAQINQFGIKEVVL
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KNMIADMVVEKFAHDLGIRVGSNSLRSLIKNIRIFQDANGVFDQERYEAVLADSGMTESS
HHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHH
YVNKIRNALPSTILMECLFPNRAELHIPYYDALAKDVVLGLLQHRVADIVEISSDAVDIS
HHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
GSDISDDELQKLFEEQYKNSLNFPEYRSADYIIMAEDDLLADVIVSDQEVDVEIKNSELH
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCEEEEEECCCCCC
DQRDVLNLVFTDKNEAELAYKAYQEGKSFEELVSDAGYTIEDIALNNISKDVLPVGVRNV
HHHHHHHHEECCCCHHHHHHHHHHCCCCHHHHHHCCCCEEHHHHHHCCCHHHHCCCHHHH
VFALNEGEVSEMFRSVVGWHIMKVIRKHEITKEDLEKLKEKISSNIRRQKAGELLVSNVK
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KANDMISRGASLNELKDMFGARISGVLTNFDMHGLDKSGNLVKDFPLQLGINAFTTLAFS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHCHHHHHHHHHH
SAVGKPSHLVSNGDAYFGVLVTEVVPPRPRTLEESRSILTEEWKSALRMKKIREFAVELR
HHCCCCHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLQNGTELSVVNGVSFKKNVTVKKSDGSTDNDSKYPERLVDEIFAINIGGVTKEVIDSE
HHHCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCC
SETVYIALLKEIKDAEISEEDLESYKAHFVSSGILSIREQLLGYLMKKYGVTIENSLLEK
CCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA