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The map label for this gene is gltP [C]

Identifier: 88607314

GI number: 88607314

Start: 437776

End: 438966

Strand: Direct

Name: gltP [C]

Synonym: APH_0424

Alternate gene names: 88607314

Gene position: 437776-438966 (Clockwise)

Preceding gene: 88607423

Following gene: 88606979

Centisome position: 29.75

GC content: 40.13

Gene sequence:

>1191_bases
ATGTTGAAGTTTTTTCTTATTTTCCTTGCTGTAGGTTTTGCATTTTTAACCAAGTATCTGGATATTCCTGTACTATTAGA
AGCAGCTCAGGGCGTCAGTTCCATGTTCATAGGTTTGCTGAAACTCGTGGGTATTCCCATGATATTTCTGTCCGTAATGT
CGACTTTTTCTGGGTTAAGCGGCTTAAAAGATGCTAAGAGTCTTATAGGTAGCACTATCTTTTATGCGCTAGCAACGACT
ACAGTAGCAGCGTTGATCGGGTTATGCTTGTACATAGTCATAGCGCCTGCTCAAGGTATAAACATCTCTGAAGTATCCGA
TTCGTCTAGTGTTATGGACTGGGATTATGGTGCACACCTTATGTCAGTATTTCCAGACAATTTCGTGCGAATTTTTCTCG
ATAATAATGTAATAGGCTGTATAGGAGTCTCTTTTTTGTTAGGGGCGGGGTGCTTATTTATTGAAGACGAACAGCGTGCA
TTTCTGAGCAAATTTTTCTCTGCGATGTTTGAGGTATTTTTACGAGCTGCAGGTTTTCTTACATATCTTATGCCACTGGC
GGTGTGGGGATTTATGACTGTGTTTTTGTGCATGCCTCAGGGACAAGATTTTTCTAATGGGCTTACAAAGTATGTACTAT
GCGTTATGTTGGCCAACGCCATACAAGCGGTTATAGTATTGCCCGGGTTACTGATGGCAAAGGGTATACCGGTGATACCC
ACATTGAAAGCTGTTTTACCATCGTTAGTAACTGCGTTTTTTTCCAGATCATCCGTAGTTGCGTTACCAGTGACCATTAA
GTGTGTCAATGAAGGTTTAGGTGAATCAAAAAGAGTAACGTCTTTTGTATTGCCGCTGTGCGCAAGCATAAACATGAATG
CATGTGCTTCATTCATCTTGATAACAGTACTTTTTGTATGTGAAGTTAATTTGCATTCTTTTTCATTTATGGAAATCTTA
ATATGGGTTATTTTCGCTATAGGAGGAGCTGTAGGTAATGCGGGCGTGCCTATGGGATGTTATTTTATGGTCATGAGTTA
CCTTACTTATATGAAGGTGCCCTTGCATGTTATGGGTTTGATATTGCCCATGTATTCTATCCTTGACATGTTTGAAACTG
CATTAAATGTGTGGTCAGACATATGTGTTACTCGAGTCATAGGAAGAAAGCATCAGGCGATAAGCTCATAG

Upstream 100 bases:

>100_bases
GGTTTTCTGGTTTATAGAGTGGTTTTATTTTTGTAAAGTGTTAGCAAAGGTGGTGTGCTTTATGGTTTTGAACTGAAGTA
CTGGAATTGTTGAGAGTAGT

Downstream 100 bases:

>100_bases
GTGTGGTACTTTTAAGCATGGCGCACAAACGGATTAACCACCTTGTCGTCGAGCTCTTGTATTAGCTGCTTCAAGTGCTC
TTTGTCATGGCATTATGATT

Product: sodium:dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLKFFLIFLAVGFAFLTKYLDIPVLLEAAQGVSSMFIGLLKLVGIPMIFLSVMSTFSGLSGLKDAKSLIGSTIFYALATT
TVAALIGLCLYIVIAPAQGINISEVSDSSSVMDWDYGAHLMSVFPDNFVRIFLDNNVIGCIGVSFLLGAGCLFIEDEQRA
FLSKFFSAMFEVFLRAAGFLTYLMPLAVWGFMTVFLCMPQGQDFSNGLTKYVLCVMLANAIQAVIVLPGLLMAKGIPVIP
TLKAVLPSLVTAFFSRSSVVALPVTIKCVNEGLGESKRVTSFVLPLCASINMNACASFILITVLFVCEVNLHSFSFMEIL
IWVIFAIGGAVGNAGVPMGCYFMVMSYLTYMKVPLHVMGLILPMYSILDMFETALNVWSDICVTRVIGRKHQAISS

Sequences:

>Translated_396_residues
MLKFFLIFLAVGFAFLTKYLDIPVLLEAAQGVSSMFIGLLKLVGIPMIFLSVMSTFSGLSGLKDAKSLIGSTIFYALATT
TVAALIGLCLYIVIAPAQGINISEVSDSSSVMDWDYGAHLMSVFPDNFVRIFLDNNVIGCIGVSFLLGAGCLFIEDEQRA
FLSKFFSAMFEVFLRAAGFLTYLMPLAVWGFMTVFLCMPQGQDFSNGLTKYVLCVMLANAIQAVIVLPGLLMAKGIPVIP
TLKAVLPSLVTAFFSRSSVVALPVTIKCVNEGLGESKRVTSFVLPLCASINMNACASFILITVLFVCEVNLHSFSFMEIL
IWVIFAIGGAVGNAGVPMGCYFMVMSYLTYMKVPLHVMGLILPMYSILDMFETALNVWSDICVTRVIGRKHQAISS
>Mature_396_residues
MLKFFLIFLAVGFAFLTKYLDIPVLLEAAQGVSSMFIGLLKLVGIPMIFLSVMSTFSGLSGLKDAKSLIGSTIFYALATT
TVAALIGLCLYIVIAPAQGINISEVSDSSSVMDWDYGAHLMSVFPDNFVRIFLDNNVIGCIGVSFLLGAGCLFIEDEQRA
FLSKFFSAMFEVFLRAAGFLTYLMPLAVWGFMTVFLCMPQGQDFSNGLTKYVLCVMLANAIQAVIVLPGLLMAKGIPVIP
TLKAVLPSLVTAFFSRSSVVALPVTIKCVNEGLGESKRVTSFVLPLCASINMNACASFILITVLFVCEVNLHSFSFMEIL
IWVIFAIGGAVGNAGVPMGCYFMVMSYLTYMKVPLHVMGLILPMYSILDMFETALNVWSDICVTRVIGRKHQAISS

Specific function: This Carrier Protein Is Part Of The Na(+)-Independent, Binding-Protein-Independent Glutamate-Aspartate Transport System. [C]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=227, Percent_Identity=30.8370044052863, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4827012, Length=222, Percent_Identity=30.1801801801802, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI5032093, Length=175, Percent_Identity=33.1428571428571, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI223468564, Length=175, Percent_Identity=33.1428571428571, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI223468566, Length=175, Percent_Identity=33.1428571428571, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI21314632, Length=253, Percent_Identity=26.4822134387352, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI66773030, Length=235, Percent_Identity=25.9574468085106, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI194239697, Length=139, Percent_Identity=31.6546762589928, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI262359914, Length=168, Percent_Identity=31.547619047619, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI301601644, Length=119, Percent_Identity=32.7731092436975, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40254478, Length=131, Percent_Identity=32.824427480916, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790514, Length=376, Percent_Identity=26.5957446808511, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1789947, Length=395, Percent_Identity=20.253164556962, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206505, Length=428, Percent_Identity=25, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17537407, Length=385, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=403, Percent_Identity=24.5657568238213, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71983099, Length=403, Percent_Identity=24.5657568238213, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71996953, Length=415, Percent_Identity=25.5421686746988, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=394, Percent_Identity=24.3654822335025, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193206654, Length=446, Percent_Identity=24.6636771300448, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583025, Length=390, Percent_Identity=27.4358974358974, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137668, Length=390, Percent_Identity=27.4358974358974, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583023, Length=390, Percent_Identity=27.4358974358974, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43005; Mature: 43005

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]