| Definition | Anaplasma phagocytophilum HZ, complete genome. |
|---|---|
| Accession | NC_007797 |
| Length | 1,471,282 |
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The map label for this gene is virB4-1 [H]
Identifier: 88607176
GI number: 88607176
Start: 365309
End: 367714
Strand: Direct
Name: virB4-1 [H]
Synonym: APH_0373
Alternate gene names: 88607176
Gene position: 365309-367714 (Clockwise)
Preceding gene: 88607882
Following gene: 88607323
Centisome position: 24.83
GC content: 42.27
Gene sequence:
>2406_bases ATGTTAAAGCTAGGTTGGTCTTCGGCTACGAGAAAGCGCAAGATTGTTAATAGGGAATACCATCAGTCGAACTTTTTGCC ATATCAGGAGCACTGGAATAGCACTACTCTTGTTACGAAGGATGGTTCGTTGCTTAAGGTAATCAAGCTTTCAGGCTACG CTTTCGAGACAGCAGATGATGAAGATCTTTCTATACAAAACTCGATCAGGAATCAGACTCTGCGAAGTATGTCGTCTGCG GCGTTTGGTCTGTATTTTCACATTATAAGGCGCAGGCGGAACGCGTTTTCTGAGGGTTTTGCTGGTAAGCAATTTTCTAG TGCGTTTGCTGATGCTGTGAATATGCAGTGGCGCAATAAGCATATGACCAAGCAATCTTTCACGAATGATCTTTATATAA CGATTGTGAGGGAAGGTAGTAATAAAAGTACCGAGCTATTCGTTAATCTATTACAAAAAATCAACAAAAAGGCAGCGACT GAGAGTTGGAAAAACGATATGCGGGCTGCTTTTGAGGATTTAGAGGAGGTTACCAATCGGGTAGTCACTAGCTTGCGTAA TTATGCGCCTAGGGAATTGGGTATTAGGAGTACTCCGGCTGGGGATTTTTCAGAGATTATGGAGTTTTTGCTCCAGATTG TGAATTGCGGTGCAGTGCATAATGTTGCGGTAGATCTTGGTGATATTTCTAAATATCTACCCATGCACAGGTTGTATTTT GGTCATAAAGTTGTGCAGGTAGTCTGTCATGATGGTTCGAAATACGCTGGTTTAATTAGTCTCAAGGAGTACGGGCAGAC GACTTCAGCTGGGATGTTGGATGCGTTTTTGCAGTTACCTTATGAGTTTATAATAACGCAGTCGTTTAAGTTTACCAATC GTCAGGCTGCTATTACAAAGATGCAGATTCAGCAGAATCGAATGATACAGTCTTCGGATAAGGCTGTATCTCAGATTTAT GAAATCTCTAAAGCGCTTGATGATGCTATGAGTGGTAAGATAGCTTTTGGGCATCATCATCTCACTGTTTTATGCATAGA GAAAACTCCCAAGAATTTGGAAAATGCTCTCTCTTTAGTAGAAGCAGAGTTGTCGAATTGTGGGGTATATCCTGTAAGAG AAAAAGTGAATCTAGAGCCGGCATTTTGGGCGCAATTGCCTGGTAATTTCTCTTATGTTGTACGTAAAGCTGTAATAAGT ACTCTCAACATGGCAGGTTTTGCGTCGCAGCATAACTATCCAAGTGGCCAGAAATTTGGCAATCACTGGGGAGAAGCGGT TACTGTATTTGATACGACGTCAGGCACGCCGTTCTTTTTCAGTTTTCACATGCGTGATGTTGGGCATACAGCAATCATTG GGCCAACTGGTGCGGGAAAGACAGTACTGATGAACTTTTTGTGTGTTCAGGCGATGAAGTTTTCTCCGCGGGTGTTCTTT TTTGACAAAGATCATGGTGCTGAGATATTCATCAGGGCTTTGAAGGGGGTATACAGCATTATAGAGACAAGAGGCTCCAC TGGGTTAAATCCGCTGCACTTAGACGATACTCCTGACAATAGGGGTTTTCTCATGGAGTGGTTTAAGTTATTGGCTACTA CTCTGTCAGATAAGCTTACGCCTGACGATATATTGCGCATTGATGATGCTATAGAGGGTAATTTCAAGCTCAAAAAGGAA GACAGAAAGTTACGTAATCTGGTTCCTTTTTTGGGTATAGGTGGAGAAGATACTCTAGCGAGTCGCATGATGATGTGGCA TTCAGAAGGGTCGCACGCGGCGCTTTTTGATAATGACGAAGATGTATTAGACTTCACTAAGTCTAGAGTATTTGGATTTG AGATGGGATATTTGCTAAAAGATCCCATGGCTCTTGCTCCGACGCTTTTGTATTTGTTTCACAAGATAAGTATTTCTCTC GATGGAACTCCTTCTATGATTATCTTGGACGAAGCGTGGGCGCTGATAGATAATCCTGTTTTTGCGCCTAGGATTAAAGA CTGGCTAAAAGTTCTTAGGAAGCTCAATACTTTTGTCATATTTGCGACACAGAGTGTTGAGGATGCTAGTAAAAGTCAGA TAAGTGATACCTTAGTTCAGCAGACTGCCACTCAGATATTTTTGCCTAATCTTAAGGCTACTAGTGCTTACAGGGATGTT TTCATGCTGACTGAGCGGGAGTATTCTTTAATAAAATATACAGATCCTGGCACTAGGTTTTTCCTAGTCAAGCAGGGGGT CAGTGCTGTTGTGGCCAGGATAGATTTACGAGGGCTCGATGACACGATAAACGTTTTGTCAGGTAGGGCCGAGACCGTTG CCATACTTCGTGAAATTATGGAAGAAGTAGGGGATGATCCAAATGTGTGGTTGCCTATTTTTTATCAAAGGGTGAAAAAT GCATAG
Upstream 100 bases:
>100_bases GGATCCTTTGTTCATGGATTTGCTAATCATAAGAATGCAGAAGTGCAGTAAGTGCCTTAATCGGTTCTATCACAATTCTA ATTCCTATGATGTGATGTAG
Downstream 100 bases:
>100_bases GGTAGCAAGGGCATTGGTATTTTTGATGTTTCTTGTTGTTACAGTTCCTTTAACGTCATACGCGGCGGGCGATGCTACTG CTAGTACACCAACAGAGGAA
Product: type IV secretion system ATPase VirB4
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 801; Mature: 801
Protein sequence:
>801_residues MLKLGWSSATRKRKIVNREYHQSNFLPYQEHWNSTTLVTKDGSLLKVIKLSGYAFETADDEDLSIQNSIRNQTLRSMSSA AFGLYFHIIRRRRNAFSEGFAGKQFSSAFADAVNMQWRNKHMTKQSFTNDLYITIVREGSNKSTELFVNLLQKINKKAAT ESWKNDMRAAFEDLEEVTNRVVTSLRNYAPRELGIRSTPAGDFSEIMEFLLQIVNCGAVHNVAVDLGDISKYLPMHRLYF GHKVVQVVCHDGSKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQAAITKMQIQQNRMIQSSDKAVSQIY EISKALDDAMSGKIAFGHHHLTVLCIEKTPKNLENALSLVEAELSNCGVYPVREKVNLEPAFWAQLPGNFSYVVRKAVIS TLNMAGFASQHNYPSGQKFGNHWGEAVTVFDTTSGTPFFFSFHMRDVGHTAIIGPTGAGKTVLMNFLCVQAMKFSPRVFF FDKDHGAEIFIRALKGVYSIIETRGSTGLNPLHLDDTPDNRGFLMEWFKLLATTLSDKLTPDDILRIDDAIEGNFKLKKE DRKLRNLVPFLGIGGEDTLASRMMMWHSEGSHAALFDNDEDVLDFTKSRVFGFEMGYLLKDPMALAPTLLYLFHKISISL DGTPSMIILDEAWALIDNPVFAPRIKDWLKVLRKLNTFVIFATQSVEDASKSQISDTLVQQTATQIFLPNLKATSAYRDV FMLTEREYSLIKYTDPGTRFFLVKQGVSAVVARIDLRGLDDTINVLSGRAETVAILREIMEEVGDDPNVWLPIFYQRVKN A
Sequences:
>Translated_801_residues MLKLGWSSATRKRKIVNREYHQSNFLPYQEHWNSTTLVTKDGSLLKVIKLSGYAFETADDEDLSIQNSIRNQTLRSMSSA AFGLYFHIIRRRRNAFSEGFAGKQFSSAFADAVNMQWRNKHMTKQSFTNDLYITIVREGSNKSTELFVNLLQKINKKAAT ESWKNDMRAAFEDLEEVTNRVVTSLRNYAPRELGIRSTPAGDFSEIMEFLLQIVNCGAVHNVAVDLGDISKYLPMHRLYF GHKVVQVVCHDGSKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQAAITKMQIQQNRMIQSSDKAVSQIY EISKALDDAMSGKIAFGHHHLTVLCIEKTPKNLENALSLVEAELSNCGVYPVREKVNLEPAFWAQLPGNFSYVVRKAVIS TLNMAGFASQHNYPSGQKFGNHWGEAVTVFDTTSGTPFFFSFHMRDVGHTAIIGPTGAGKTVLMNFLCVQAMKFSPRVFF FDKDHGAEIFIRALKGVYSIIETRGSTGLNPLHLDDTPDNRGFLMEWFKLLATTLSDKLTPDDILRIDDAIEGNFKLKKE DRKLRNLVPFLGIGGEDTLASRMMMWHSEGSHAALFDNDEDVLDFTKSRVFGFEMGYLLKDPMALAPTLLYLFHKISISL DGTPSMIILDEAWALIDNPVFAPRIKDWLKVLRKLNTFVIFATQSVEDASKSQISDTLVQQTATQIFLPNLKATSAYRDV FMLTEREYSLIKYTDPGTRFFLVKQGVSAVVARIDLRGLDDTINVLSGRAETVAILREIMEEVGDDPNVWLPIFYQRVKN A >Mature_801_residues MLKLGWSSATRKRKIVNREYHQSNFLPYQEHWNSTTLVTKDGSLLKVIKLSGYAFETADDEDLSIQNSIRNQTLRSMSSA AFGLYFHIIRRRRNAFSEGFAGKQFSSAFADAVNMQWRNKHMTKQSFTNDLYITIVREGSNKSTELFVNLLQKINKKAAT ESWKNDMRAAFEDLEEVTNRVVTSLRNYAPRELGIRSTPAGDFSEIMEFLLQIVNCGAVHNVAVDLGDISKYLPMHRLYF GHKVVQVVCHDGSKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQAAITKMQIQQNRMIQSSDKAVSQIY EISKALDDAMSGKIAFGHHHLTVLCIEKTPKNLENALSLVEAELSNCGVYPVREKVNLEPAFWAQLPGNFSYVVRKAVIS TLNMAGFASQHNYPSGQKFGNHWGEAVTVFDTTSGTPFFFSFHMRDVGHTAIIGPTGAGKTVLMNFLCVQAMKFSPRVFF FDKDHGAEIFIRALKGVYSIIETRGSTGLNPLHLDDTPDNRGFLMEWFKLLATTLSDKLTPDDILRIDDAIEGNFKLKKE DRKLRNLVPFLGIGGEDTLASRMMMWHSEGSHAALFDNDEDVLDFTKSRVFGFEMGYLLKDPMALAPTLLYLFHKISISL DGTPSMIILDEAWALIDNPVFAPRIKDWLKVLRKLNTFVIFATQSVEDASKSQISDTLVQQTATQIFLPNLKATSAYRDV FMLTEREYSLIKYTDPGTRFFLVKQGVSAVVARIDLRGLDDTINVLSGRAETVAILREIMEEVGDDPNVWLPIFYQRVKN A
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 90484; Mature: 90484
Theoretical pI: Translated: 7.99; Mature: 7.99
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLKLGWSSATRKRKIVNREYHQSNFLPYQEHWNSTTLVTKDGSLLKVIKLSGYAFETADD CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCCCEEEEEEECCEEEECCCC EDLSIQNSIRNQTLRSMSSAAFGLYFHIIRRRRNAFSEGFAGKQFSSAFADAVNMQWRNK CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHH HMTKQSFTNDLYITIVREGSNKSTELFVNLLQKINKKAATESWKNDMRAAFEDLEEVTNR HCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VVTSLRNYAPRELGIRSTPAGDFSEIMEFLLQIVNCGAVHNVAVDLGDISKYLPMHRLYF HHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHHH GHKVVQVVCHDGSKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQAAITK HHHHHHHEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCHHHEEECCCCCCCCHHHHHH MQIQQNRMIQSSDKAVSQIYEISKALDDAMSGKIAFGHHHLTVLCIEKTPKNLENALSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEEECCCCHHHHHHHHH EAELSNCGVYPVREKVNLEPAFWAQLPGNFSYVVRKAVISTLNMAGFASQHNYPSGQKFG HHHHHCCCCCCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH NHWGEAVTVFDTTSGTPFFFSFHMRDVGHTAIIGPTGAGKTVLMNFLCVQAMKFSPRVFF HCCCCEEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE FDKDHGAEIFIRALKGVYSIIETRGSTGLNPLHLDDTPDNRGFLMEWFKLLATTLSDKLT EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCC PDDILRIDDAIEGNFKLKKEDRKLRNLVPFLGIGGEDTLASRMMMWHSEGSHAALFDNDE HHHHHHHCCCCCCCEEECHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCCEEEECCCCH DVLDFTKSRVFGFEMGYLLKDPMALAPTLLYLFHKISISLDGTPSMIILDEAWALIDNPV HHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECHHHHHCCCC FAPRIKDWLKVLRKLNTFVIFATQSVEDASKSQISDTLVQQTATQIFLPNLKATSAYRDV CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH FMLTEREYSLIKYTDPGTRFFLVKQGVSAVVARIDLRGLDDTINVLSGRAETVAILREIM HEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHH EEVGDDPNVWLPIFYQRVKNA HHHCCCCCEEHHHHHHHHCCC >Mature Secondary Structure MLKLGWSSATRKRKIVNREYHQSNFLPYQEHWNSTTLVTKDGSLLKVIKLSGYAFETADD CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCCCEEEEEEECCEEEECCCC EDLSIQNSIRNQTLRSMSSAAFGLYFHIIRRRRNAFSEGFAGKQFSSAFADAVNMQWRNK CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHH HMTKQSFTNDLYITIVREGSNKSTELFVNLLQKINKKAATESWKNDMRAAFEDLEEVTNR HCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VVTSLRNYAPRELGIRSTPAGDFSEIMEFLLQIVNCGAVHNVAVDLGDISKYLPMHRLYF HHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHHH GHKVVQVVCHDGSKYAGLISLKEYGQTTSAGMLDAFLQLPYEFIITQSFKFTNRQAAITK HHHHHHHEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCHHHEEECCCCCCCCHHHHHH MQIQQNRMIQSSDKAVSQIYEISKALDDAMSGKIAFGHHHLTVLCIEKTPKNLENALSLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEEECCCCHHHHHHHHH EAELSNCGVYPVREKVNLEPAFWAQLPGNFSYVVRKAVISTLNMAGFASQHNYPSGQKFG HHHHHCCCCCCCHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH NHWGEAVTVFDTTSGTPFFFSFHMRDVGHTAIIGPTGAGKTVLMNFLCVQAMKFSPRVFF HCCCCEEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE FDKDHGAEIFIRALKGVYSIIETRGSTGLNPLHLDDTPDNRGFLMEWFKLLATTLSDKLT EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHCCCC PDDILRIDDAIEGNFKLKKEDRKLRNLVPFLGIGGEDTLASRMMMWHSEGSHAALFDNDE HHHHHHHCCCCCCCEEECHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCCEEEECCCCH DVLDFTKSRVFGFEMGYLLKDPMALAPTLLYLFHKISISLDGTPSMIILDEAWALIDNPV HHHHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCEEEEECHHHHHCCCC FAPRIKDWLKVLRKLNTFVIFATQSVEDASKSQISDTLVQQTATQIFLPNLKATSAYRDV CCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH FMLTEREYSLIKYTDPGTRFFLVKQGVSAVVARIDLRGLDDTINVLSGRAETVAILREIM HEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHH EEVGDDPNVWLPIFYQRVKNA HHHCCCCCEEHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]