Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 88607036

GI number: 88607036

Start: 244680

End: 246068

Strand: Direct

Name: fumC [H]

Synonym: APH_0247

Alternate gene names: 88607036

Gene position: 244680-246068 (Clockwise)

Preceding gene: 88607528

Following gene: 88607946

Centisome position: 16.63

GC content: 44.42

Gene sequence:

>1389_bases
ATGGGTGTTAGGGTAGAACATGATAGTATGGGCAGTGTTGAGGTATCAGGTGAGCATTACTGGGGTGCTCAAACGCAGCG
TTCGCTTGTGAATTTTAAAATCGGTGAGGAGAAGATGCCTTTGCCATTGATTAGGGCATTGGGCATAGTTAAGCTCGCTG
CAGCGCGCGTCAACATGGCTAATGGCAGCATTGATGAGTCTGTGGGGAAAGCAATATGTGCAGCGGCTCAAGAGGTTGTA
GAGGGCAGATTCGACGGAGAGTTTCCTCTGGTAGTGTGGCAGACTGGCTCCGGAACGCAGACTAACATGAATGCCAATGA
GGTGATTGCAAATAGGGCAATAGAAATGCTGGGTGGTGAGATAGGAAGTAAGTCGCCTGTGCATCCTAATGATCACGTAA
ACTGTTCGCAATCTTCAAATGATGTATTTCCCACTGCGATGCACATTGCGGTAGTTTTGGAAGTGACAAAGAACTTATTA
CCTAATTTATGTATATTGCAAGAAGCCCTCAAGGCAAAGGTAGAGGAATTTTCTGGCATAGTGAAAGTAGGGCGTACTCA
CTTACAAGATGCTACTCCGTTATTTTTAAGTCAGGAGTTCTCAGGGTATGAATACCAAGTTAAGCAGAGTATAGAACGTA
TTAAGTCGTCCATTAGTAGCCTTTACCAGCTTGCACAAGGGGGTACAGCTGTGGGCACCGGACTAAATGCGAAGAAGGGT
TTTGCTGAGAGCTTTGCTGCAGAAGTTGCAGGTATTACTGGATGTCCGTTTGTGACAGCAGAGAACAAGTTTGAGGCTTT
GGCTACGCATGATGCCTTAGTCGAGTTTAGTGGTACTTTGAATACTTTAGCAGTCAGCTGCATGAAAATAGCGAATGATA
TAAGGATGCTGGCTTCAGGGCCTAGATGCGGTATAGGTGAGATTATTCTCCCAGCTAATGAGCCTGGATCTTCTATTATG
CCTGGTAAAGTTAATCCTACACAGTGTGAAGCGATGACTATGGTCTGTGCGCAGGTTATGGGTAACCATGTTGCAGTTTC
TGTCGGTGGATCGAATGGTCATTTTGAACTCAATGTATTCAAACCTGTAATAGCATACAATGTGTTGCAGTCTGTTCGGC
TTTTATCTGACGCATCACTGAGTTTCGCACAAAAATGTGTAGTTGGGATAAAGCCAGATGTAGAACGTATAGAAACTTTG
CTAGGTGCATCGCTGATGTTGGTGACTGCGCTGAATCGTCATATCGGTTATGATAATGCAGCAAAAGTAGCTAAATTTGC
ATTTGAAAATCGTGTGACCTTAAAAGAAGCTGCAGTTACCCTGAAGCTTGTCGATGCTGAAGAGTTCGACAGAATTGTGG
ATCCTGTCAAAATGGTCACACCAAACTAA

Upstream 100 bases:

>100_bases
TTCAGTCTTGCAAATTCTCTGCAATTTAAAAATTTCCTAATGATGGACGCGCTCTAAAAGCGGCTGTAGAATTTCTGCGC
TATGTATTTTGGGTGGTGCT

Downstream 100 bases:

>100_bases
TGATTTAGACTTTAGTTTATGTACCAATTTCAAAGTTGTACTTTCCTGCTTGCGGGTGTTTATAGATGACATGTCTATAG
GCACCCTGTTTTTTTAAATG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MGVRVEHDSMGSVEVSGEHYWGAQTQRSLVNFKIGEEKMPLPLIRALGIVKLAAARVNMANGSIDESVGKAICAAAQEVV
EGRFDGEFPLVVWQTGSGTQTNMNANEVIANRAIEMLGGEIGSKSPVHPNDHVNCSQSSNDVFPTAMHIAVVLEVTKNLL
PNLCILQEALKAKVEEFSGIVKVGRTHLQDATPLFLSQEFSGYEYQVKQSIERIKSSISSLYQLAQGGTAVGTGLNAKKG
FAESFAAEVAGITGCPFVTAENKFEALATHDALVEFSGTLNTLAVSCMKIANDIRMLASGPRCGIGEIILPANEPGSSIM
PGKVNPTQCEAMTMVCAQVMGNHVAVSVGGSNGHFELNVFKPVIAYNVLQSVRLLSDASLSFAQKCVVGIKPDVERIETL
LGASLMLVTALNRHIGYDNAAKVAKFAFENRVTLKEAAVTLKLVDAEEFDRIVDPVKMVTPN

Sequences:

>Translated_462_residues
MGVRVEHDSMGSVEVSGEHYWGAQTQRSLVNFKIGEEKMPLPLIRALGIVKLAAARVNMANGSIDESVGKAICAAAQEVV
EGRFDGEFPLVVWQTGSGTQTNMNANEVIANRAIEMLGGEIGSKSPVHPNDHVNCSQSSNDVFPTAMHIAVVLEVTKNLL
PNLCILQEALKAKVEEFSGIVKVGRTHLQDATPLFLSQEFSGYEYQVKQSIERIKSSISSLYQLAQGGTAVGTGLNAKKG
FAESFAAEVAGITGCPFVTAENKFEALATHDALVEFSGTLNTLAVSCMKIANDIRMLASGPRCGIGEIILPANEPGSSIM
PGKVNPTQCEAMTMVCAQVMGNHVAVSVGGSNGHFELNVFKPVIAYNVLQSVRLLSDASLSFAQKCVVGIKPDVERIETL
LGASLMLVTALNRHIGYDNAAKVAKFAFENRVTLKEAAVTLKLVDAEEFDRIVDPVKMVTPN
>Mature_461_residues
GVRVEHDSMGSVEVSGEHYWGAQTQRSLVNFKIGEEKMPLPLIRALGIVKLAAARVNMANGSIDESVGKAICAAAQEVVE
GRFDGEFPLVVWQTGSGTQTNMNANEVIANRAIEMLGGEIGSKSPVHPNDHVNCSQSSNDVFPTAMHIAVVLEVTKNLLP
NLCILQEALKAKVEEFSGIVKVGRTHLQDATPLFLSQEFSGYEYQVKQSIERIKSSISSLYQLAQGGTAVGTGLNAKKGF
AESFAAEVAGITGCPFVTAENKFEALATHDALVEFSGTLNTLAVSCMKIANDIRMLASGPRCGIGEIILPANEPGSSIMP
GKVNPTQCEAMTMVCAQVMGNHVAVSVGGSNGHFELNVFKPVIAYNVLQSVRLLSDASLSFAQKCVVGIKPDVERIETLL
GASLMLVTALNRHIGYDNAAKVAKFAFENRVTLKEAAVTLKLVDAEEFDRIVDPVKMVTPN

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=66.304347826087, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=63.4920634920635, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=59.7374179431072, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=38.961038961039, Blast_Score=306, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=64.8590021691974, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=65.9509202453988, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=60.6521739130435, Blast_Score=551, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=61.3882863340564, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=61.3882863340564, Blast_Score=583, Evalue=1e-166,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=59.3073593073593, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=58.8362068965517, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.9157667386609, Blast_Score=485, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49377; Mature: 49246

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRVEHDSMGSVEVSGEHYWGAQTQRSLVNFKIGEEKMPLPLIRALGIVKLAAARVNMA
CCCEECCCCCCCEEECCCCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
NGSIDESVGKAICAAAQEVVEGRFDGEFPLVVWQTGSGTQTNMNANEVIANRAIEMLGGE
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
IGSKSPVHPNDHVNCSQSSNDVFPTAMHIAVVLEVTKNLLPNLCILQEALKAKVEEFSGI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VKVGRTHLQDATPLFLSQEFSGYEYQVKQSIERIKSSISSLYQLAQGGTAVGTGLNAKKG
HHHHHHHHCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
FAESFAAEVAGITGCPFVTAENKFEALATHDALVEFSGTLNTLAVSCMKIANDIRMLASG
HHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
PRCGIGEIILPANEPGSSIMPGKVNPTQCEAMTMVCAQVMGNHVAVSVGGSNGHFELNVF
CCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEH
KPVIAYNVLQSVRLLSDASLSFAQKCVVGIKPDVERIETLLGASLMLVTALNRHIGYDNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
AKVAKFAFENRVTLKEAAVTLKLVDAEEFDRIVDPVKMVTPN
HHHHHHHHHCCCCHHHHEEEEEEECHHHHHHHHCCHHHCCCC
>Mature Secondary Structure 
GVRVEHDSMGSVEVSGEHYWGAQTQRSLVNFKIGEEKMPLPLIRALGIVKLAAARVNMA
CCEECCCCCCCEEECCCCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
NGSIDESVGKAICAAAQEVVEGRFDGEFPLVVWQTGSGTQTNMNANEVIANRAIEMLGGE
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
IGSKSPVHPNDHVNCSQSSNDVFPTAMHIAVVLEVTKNLLPNLCILQEALKAKVEEFSGI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
VKVGRTHLQDATPLFLSQEFSGYEYQVKQSIERIKSSISSLYQLAQGGTAVGTGLNAKKG
HHHHHHHHCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
FAESFAAEVAGITGCPFVTAENKFEALATHDALVEFSGTLNTLAVSCMKIANDIRMLASG
HHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
PRCGIGEIILPANEPGSSIMPGKVNPTQCEAMTMVCAQVMGNHVAVSVGGSNGHFELNVF
CCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEH
KPVIAYNVLQSVRLLSDASLSFAQKCVVGIKPDVERIETLLGASLMLVTALNRHIGYDNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
AKVAKFAFENRVTLKEAAVTLKLVDAEEFDRIVDPVKMVTPN
HHHHHHHHHCCCCHHHHEEEEEEECHHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]