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The map label for this gene is pepA [H]

Identifier: 88607014

GI number: 88607014

Start: 228020

End: 229552

Strand: Reverse

Name: pepA [H]

Synonym: APH_0231

Alternate gene names: 88607014

Gene position: 229552-228020 (Counterclockwise)

Preceding gene: 88607892

Following gene: 88607914

Centisome position: 15.6

GC content: 46.77

Gene sequence:

>1533_bases
ATGGTGGGTTGTATGGTCGGCATATCCTTCTTGAGCTTGGCTTCGGGTGTTTCTGCGCTGCTAAAAACAGCAGTAATTGT
TGTGGGAGTTTTTGAGGGAAGCAATACGCTGGAAGATAACGGTGTACTGCATGGTCCAGAGGTCAAGGCCATTCTCGAGG
CTAAGGCTGCATCATCTTTCTCAGGAACTTTTGCAAGCACAATGCCTGTAGTGTATACACCAGAAAGCAGAGCAGTCCTT
CTTGTAGGTCTGGGTAAAAAATCAGATACAATCTTGGAGCACATGGCAATGGAGCTCGGGGGAGCCATTTATACGCGTCT
CGAAGAGATAAAAGCATCCAAAGCCGTGATTGTAGCGCCGCAGCAAGTAGAGGCAAGGTTAGCGTACGGTGCCTTCTTGC
GTAGTTTTATGTTTAACAAGTACTTTCATAGTAAGAAGTCCGAGCACACTGCAAAAGTAGAAGAGTTAACAATAGCGGTA
AGTAAGGATCCTGTTACGATCAGCAAGGATTTTGAATTGTTAAAGACAGAGGGAGAATCCATATTTTTCACTCGTTCTTT
GATATCGGAGCCAGCCAACGTTCTTTATCCTGAAGAGTACGCAAAAAGGGTTCATGCCGAGCTCACTCCTCTGGGCGTAG
AAGTAGAAATATTGGATGAAGAGCGCATAAGGGCTGAAGGTATGATGGCGCTCCTAGGTGTAGGGCAAGGTAGTAGTAAG
CGCTCACAACTGGTGGTGATGAAGTGGAATGGTGCGCGCAACAACAGTGATACTCTAGCCTTTATCGGGAAGGGCGTGAC
TTTCGACACAGGAGGTGTATCACTGAAGCCCTCCAAAGGTATGTGGGATATGAAATATGACATGGGCGGTTCCGCAGTTG
TAGTAGGGTTGATGCGTGCTTTAGCTGCGAGAAAAGCCAATGTTAATGTCGTCGGAGTGATCGGGCTTGTAGAAAATGCT
GTAGACGGAAATGCGCAGCGTCCAGGAGATGTAGTAACCTCTATGTCTGGTCAGACTATAGAAGTCTTAAACACTGATGC
TGAAGGTAGGCTGGTTCTTGCCGATGCACTTTGGTATACACAGAAGATGTTTGCTCCTAAGTTTATGGTTGATCTCGCTA
CTCTGACCGGAGCTATAGTAGTAGCGCTTGGAGAGGGACCATATGCGGGGCTTTTCTCCAATGATGATGCTCTTTCCGAA
CAGTTGATAGATTCTGGAAATGAGGTCAATGAGAAGTTGTGGCGCATGCCTATGGGAGATGCTTACGACAAGATGATTGA
TTCTTCTATCGCCGATGTAAAGAACATATCAACGGCTGGACACGGTGCTGATAGCATAACTGCGGCACAGTTCTTACAGC
GCTTCGTGAATGGTTTACCTTGGGCTCACCTTGACATTGCAGGTGTTACGTGGAGCGACTCAGGGTCTAAAATTGCCGAA
AAGGGAGCTACGGGTTATGGCGTGATGTTGCTGAATAGGTTTATCCAGAAATATCATGAGGGAACTGCTCATCAAAAACC
TTCAGGGAAGTAG

Upstream 100 bases:

>100_bases
CACTGGGTATTTCATTATGCAGCAACATAGTCAACACAATGCATTACCACCTTGATATAAATGCCAAATGGGATTAGTAT
TCAACAGCGTTTGTGCTTTA

Downstream 100 bases:

>100_bases
CTTCTGTGAAGAAGGAACTACGCGTAGGTGTATTGATTTCTGGTAGGGGTTCTAATCTTGAAGCGTTAGCTAAGGCGTTT
TCGACTGAAGAGTCCTCTGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MVGCMVGISFLSLASGVSALLKTAVIVVGVFEGSNTLEDNGVLHGPEVKAILEAKAASSFSGTFASTMPVVYTPESRAVL
LVGLGKKSDTILEHMAMELGGAIYTRLEEIKASKAVIVAPQQVEARLAYGAFLRSFMFNKYFHSKKSEHTAKVEELTIAV
SKDPVTISKDFELLKTEGESIFFTRSLISEPANVLYPEEYAKRVHAELTPLGVEVEILDEERIRAEGMMALLGVGQGSSK
RSQLVVMKWNGARNNSDTLAFIGKGVTFDTGGVSLKPSKGMWDMKYDMGGSAVVVGLMRALAARKANVNVVGVIGLVENA
VDGNAQRPGDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFAPKFMVDLATLTGAIVVALGEGPYAGLFSNDDALSE
QLIDSGNEVNEKLWRMPMGDAYDKMIDSSIADVKNISTAGHGADSITAAQFLQRFVNGLPWAHLDIAGVTWSDSGSKIAE
KGATGYGVMLLNRFIQKYHEGTAHQKPSGK

Sequences:

>Translated_510_residues
MVGCMVGISFLSLASGVSALLKTAVIVVGVFEGSNTLEDNGVLHGPEVKAILEAKAASSFSGTFASTMPVVYTPESRAVL
LVGLGKKSDTILEHMAMELGGAIYTRLEEIKASKAVIVAPQQVEARLAYGAFLRSFMFNKYFHSKKSEHTAKVEELTIAV
SKDPVTISKDFELLKTEGESIFFTRSLISEPANVLYPEEYAKRVHAELTPLGVEVEILDEERIRAEGMMALLGVGQGSSK
RSQLVVMKWNGARNNSDTLAFIGKGVTFDTGGVSLKPSKGMWDMKYDMGGSAVVVGLMRALAARKANVNVVGVIGLVENA
VDGNAQRPGDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFAPKFMVDLATLTGAIVVALGEGPYAGLFSNDDALSE
QLIDSGNEVNEKLWRMPMGDAYDKMIDSSIADVKNISTAGHGADSITAAQFLQRFVNGLPWAHLDIAGVTWSDSGSKIAE
KGATGYGVMLLNRFIQKYHEGTAHQKPSGK
>Mature_510_residues
MVGCMVGISFLSLASGVSALLKTAVIVVGVFEGSNTLEDNGVLHGPEVKAILEAKAASSFSGTFASTMPVVYTPESRAVL
LVGLGKKSDTILEHMAMELGGAIYTRLEEIKASKAVIVAPQQVEARLAYGAFLRSFMFNKYFHSKKSEHTAKVEELTIAV
SKDPVTISKDFELLKTEGESIFFTRSLISEPANVLYPEEYAKRVHAELTPLGVEVEILDEERIRAEGMMALLGVGQGSSK
RSQLVVMKWNGARNNSDTLAFIGKGVTFDTGGVSLKPSKGMWDMKYDMGGSAVVVGLMRALAARKANVNVVGVIGLVENA
VDGNAQRPGDVVTSMSGQTIEVLNTDAEGRLVLADALWYTQKMFAPKFMVDLATLTGAIVVALGEGPYAGLFSNDDALSE
QLIDSGNEVNEKLWRMPMGDAYDKMIDSSIADVKNISTAGHGADSITAAQFLQRFVNGLPWAHLDIAGVTWSDSGSKIAE
KGATGYGVMLLNRFIQKYHEGTAHQKPSGK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=438, Percent_Identity=35.3881278538813, Blast_Score=222, Evalue=8e-58,
Organism=Homo sapiens, GI47155554, Length=455, Percent_Identity=27.9120879120879, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1790710, Length=505, Percent_Identity=34.4554455445545, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI87082123, Length=315, Percent_Identity=37.1428571428571, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=363, Percent_Identity=31.9559228650138, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=357, Percent_Identity=25.2100840336134, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=35.2201257861635, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24661038, Length=330, Percent_Identity=33.9393939393939, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24662227, Length=469, Percent_Identity=29.637526652452, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20129969, Length=297, Percent_Identity=32.6599326599327, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161077148, Length=402, Percent_Identity=28.6069651741293, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI20130057, Length=402, Percent_Identity=28.6069651741293, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI20129963, Length=403, Percent_Identity=29.7766749379653, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355645, Length=331, Percent_Identity=29.607250755287, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24662223, Length=331, Percent_Identity=29.607250755287, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922386, Length=402, Percent_Identity=29.3532338308458, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21357381, Length=338, Percent_Identity=31.9526627218935, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=338, Percent_Identity=31.9526627218935, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=338, Percent_Identity=31.9526627218935, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646701, Length=152, Percent_Identity=32.2368421052632, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646703, Length=152, Percent_Identity=32.2368421052632, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358201, Length=152, Percent_Identity=32.2368421052632, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54646; Mature: 54646

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGCMVGISFLSLASGVSALLKTAVIVVGVFEGSNTLEDNGVLHGPEVKAILEAKAASSF
CCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEECCCHHHHHHHHHCCCC
SGTFASTMPVVYTPESRAVLLVGLGKKSDTILEHMAMELGGAIYTRLEEIKASKAVIVAP
CCCHHHCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECC
QQVEARLAYGAFLRSFMFNKYFHSKKSEHTAKVEELTIAVSKDPVTISKDFELLKTEGES
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEECCCCEEECCCHHHHHCCCCE
IFFTRSLISEPANVLYPEEYAKRVHAELTPLGVEVEILDEERIRAEGMMALLGVGQGSSK
EEEEHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHCCEEEEEECCCCCCC
RSQLVVMKWNGARNNSDTLAFIGKGVTFDTGGVSLKPSKGMWDMKYDMGGSAVVVGLMRA
CCEEEEEEECCCCCCCCEEEEEECCEEECCCCEEECCCCCCEEEEECCCCHHHHHHHHHH
LAARKANVNVVGVIGLVENAVDGNAQRPGDVVTSMSGQTIEVLNTDAEGRLVLADALWYT
HHHHCCCCEEEEEEEHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHH
QKMFAPKFMVDLATLTGAIVVALGEGPYAGLFSNDDALSEQLIDSGNEVNEKLWRMPMGD
HHHCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCH
AYDKMIDSSIADVKNISTAGHGADSITAAQFLQRFVNGLPWAHLDIAGVTWSDSGSKIAE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHH
KGATGYGVMLLNRFIQKYHEGTAHQKPSGK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVGCMVGISFLSLASGVSALLKTAVIVVGVFEGSNTLEDNGVLHGPEVKAILEAKAASSF
CCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEECCCHHHHHHHHHCCCC
SGTFASTMPVVYTPESRAVLLVGLGKKSDTILEHMAMELGGAIYTRLEEIKASKAVIVAP
CCCHHHCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCEEEECC
QQVEARLAYGAFLRSFMFNKYFHSKKSEHTAKVEELTIAVSKDPVTISKDFELLKTEGES
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEEECCCCEEECCCHHHHHCCCCE
IFFTRSLISEPANVLYPEEYAKRVHAELTPLGVEVEILDEERIRAEGMMALLGVGQGSSK
EEEEHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHCCEEEEEECCCCCCC
RSQLVVMKWNGARNNSDTLAFIGKGVTFDTGGVSLKPSKGMWDMKYDMGGSAVVVGLMRA
CCEEEEEEECCCCCCCCEEEEEECCEEECCCCEEECCCCCCEEEEECCCCHHHHHHHHHH
LAARKANVNVVGVIGLVENAVDGNAQRPGDVVTSMSGQTIEVLNTDAEGRLVLADALWYT
HHHHCCCCEEEEEEEHHHHHCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEHHHHHH
QKMFAPKFMVDLATLTGAIVVALGEGPYAGLFSNDDALSEQLIDSGNEVNEKLWRMPMGD
HHHCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCH
AYDKMIDSSIADVKNISTAGHGADSITAAQFLQRFVNGLPWAHLDIAGVTWSDSGSKIAE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHH
KGATGYGVMLLNRFIQKYHEGTAHQKPSGK
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA