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The map label for this gene is algD [H]

Identifier: 87201232

GI number: 87201232

Start: 3437998

End: 3439263

Strand: Direct

Name: algD [H]

Synonym: Saro_3220

Alternate gene names: 87201232

Gene position: 3437998-3439263 (Clockwise)

Preceding gene: 87201230

Following gene: 87201233

Centisome position: 96.53

GC content: 62.64

Gene sequence:

>1266_bases
TTGAAGATCGCAATTCTCGGCCTTGGCTATGTTGGTTGCACCGCAGCAGGGTGCATTGCCAGCCAGGGCCATCACGTGGT
CGGGATCGACGTGAACCTGGGCAAGGTCGAAACGCTGAACACGGGCAAATCGCCAGTCTATGAACCGGGTCTCGACGACC
TGATCGCCAAAGCTCGCGCGGAAGGCCGATTGCATGCGGTTACCGAGATCGGCTCGGCGCTCGACGATTGCGACATCGCG
ATCGTCTGCGTCGGCACGCCAAGCGGCGTCGATGGCGCGCACAACATGAGCTTCATCGTACAGGTATCGCGGGCAATCGC
GGCATCCGTGCGACCCGACCGCAAGACGCCCCTTACGGTCGTGTACCGATCGACCATGCGCCCCGGCACGACCGAGCAAA
TGATCCTTCCGATCTTCCGTTCGGTGATCGGCGAGGACTGCGAAAAGCTTATCGAGCTGGTCTACAACCCGGAGTTCCTG
CGCGAGGCCACTGCGATCGAGGACTATTTCCACCCGCCCAAGATCGTCCTCGGAACGATCGATGGCGCCCCGTCCGAGAA
GATGGTGGCGCTTCATGAAGGCATCGAAGCGCCGATCTTCCACGTGGGCATTCGCGAAGCAGAAATCACGAAGTTCGTGG
ACAACACCTGGCACGCCGTGAAGGTCGCTTTCGCCAACGAGGTCGGCCGGGTGTGCCAGAACCTGGGCATTTCGGCAAAG
CAGGTGCACGAGATCTTCGTCTCGGACACAAAGCTCAACATCTCGGCCTACTACACGCGTCCCGGCGGCCCCTTCGGAGG
ATCTTGCCTGCCCAAGGACGTCCGCGCGCTGCAGCATATCGCGGCCGATACCGGTGCGCAGACCCATCTCGTCGATTCCT
TGCTGCGCAGCAATGATGCGCACAAGCACCACCAGTTCCTGCAGGTGACCAAGGATCTCCAGCCGGGCGCAAGGGTCCTG
CTGGTCGGCCTTGCGTTCAAGGCGGACACCGACGACCTGCGCGAGAGCCCTGCGGTGGACATGGCCCGCAAGCTGCTCGA
CGCGGGCTACGCGCTCGACATCTACGATCCGCAACTGCGGCCCGAGAGCCTGGTCGGCCAGAACCTCGGCTATGCCTATG
CGATCCTTCCGTCCATCGACGGGCTGCTGGTGGACAAGACGACCGCGGAAGCGCGCGACTACGGCGTGGTGATTGCGACC
AATCGCCTCATTCGCGACCTCGCGCTTCCGGGCCGCCGTATCGTCGACGTGAGCGCCATTGCATGA

Upstream 100 bases:

>100_bases
TGCAAGGCTCTGATTTGACCGCCTAAGCAAATGTTTTTCCGAAACTTTCCCCTGAACCTCCAGTCCCAGCCCGGTTAAAT
CCCTGCCTCAGGAGAACACT

Downstream 100 bases:

>100_bases
ACGCGCCGGTTCCCGCAGCTGACTTCGAGTTCCCCACCGAAATCCCCGGCCTGCCGCTGGCGGGCAGGAAAGTCCTGATC
GTCGTCGAGAACCTGCCGCT

Product: GDP-mannose 6-dehydrogenase

Products: NA

Alternate protein names: GMD [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKIAILGLGYVGCTAAGCIASQGHHVVGIDVNLGKVETLNTGKSPVYEPGLDDLIAKARAEGRLHAVTEIGSALDDCDIA
IVCVGTPSGVDGAHNMSFIVQVSRAIAASVRPDRKTPLTVVYRSTMRPGTTEQMILPIFRSVIGEDCEKLIELVYNPEFL
REATAIEDYFHPPKIVLGTIDGAPSEKMVALHEGIEAPIFHVGIREAEITKFVDNTWHAVKVAFANEVGRVCQNLGISAK
QVHEIFVSDTKLNISAYYTRPGGPFGGSCLPKDVRALQHIAADTGAQTHLVDSLLRSNDAHKHHQFLQVTKDLQPGARVL
LVGLAFKADTDDLRESPAVDMARKLLDAGYALDIYDPQLRPESLVGQNLGYAYAILPSIDGLLVDKTTAEARDYGVVIAT
NRLIRDLALPGRRIVDVSAIA

Sequences:

>Translated_421_residues
MKIAILGLGYVGCTAAGCIASQGHHVVGIDVNLGKVETLNTGKSPVYEPGLDDLIAKARAEGRLHAVTEIGSALDDCDIA
IVCVGTPSGVDGAHNMSFIVQVSRAIAASVRPDRKTPLTVVYRSTMRPGTTEQMILPIFRSVIGEDCEKLIELVYNPEFL
REATAIEDYFHPPKIVLGTIDGAPSEKMVALHEGIEAPIFHVGIREAEITKFVDNTWHAVKVAFANEVGRVCQNLGISAK
QVHEIFVSDTKLNISAYYTRPGGPFGGSCLPKDVRALQHIAADTGAQTHLVDSLLRSNDAHKHHQFLQVTKDLQPGARVL
LVGLAFKADTDDLRESPAVDMARKLLDAGYALDIYDPQLRPESLVGQNLGYAYAILPSIDGLLVDKTTAEARDYGVVIAT
NRLIRDLALPGRRIVDVSAIA
>Mature_421_residues
MKIAILGLGYVGCTAAGCIASQGHHVVGIDVNLGKVETLNTGKSPVYEPGLDDLIAKARAEGRLHAVTEIGSALDDCDIA
IVCVGTPSGVDGAHNMSFIVQVSRAIAASVRPDRKTPLTVVYRSTMRPGTTEQMILPIFRSVIGEDCEKLIELVYNPEFL
REATAIEDYFHPPKIVLGTIDGAPSEKMVALHEGIEAPIFHVGIREAEITKFVDNTWHAVKVAFANEVGRVCQNLGISAK
QVHEIFVSDTKLNISAYYTRPGGPFGGSCLPKDVRALQHIAADTGAQTHLVDSLLRSNDAHKHHQFLQVTKDLQPGARVL
LVGLAFKADTDDLRESPAVDMARKLLDAGYALDIYDPQLRPESLVGQNLGYAYAILPSIDGLLVDKTTAEARDYGVVIAT
NRLIRDLALPGRRIVDVSAIA

Specific function: Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and ant

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=383, Percent_Identity=25.8485639686684, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI296040443, Length=228, Percent_Identity=26.7543859649123, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI296040438, Length=227, Percent_Identity=26.431718061674, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI1788340, Length=394, Percent_Identity=26.3959390862944, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI48994968, Length=363, Percent_Identity=28.099173553719, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560350, Length=389, Percent_Identity=27.5064267352185, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17136908, Length=383, Percent_Identity=26.8929503916449, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.132 [H]

Molecular weight: Translated: 45383; Mature: 45383

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILGLGYVGCTAAGCIASQGHHVVGIDVNLGKVETLNTGKSPVYEPGLDDLIAKARA
CEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHC
EGRLHAVTEIGSALDDCDIAIVCVGTPSGVDGAHNMSFIVQVSRAIAASVRPDRKTPLTV
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
VYRSTMRPGTTEQMILPIFRSVIGEDCEKLIELVYNPEFLREATAIEDYFHPPKIVLGTI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECC
DGAPSEKMVALHEGIEAPIFHVGIREAEITKFVDNTWHAVKVAFANEVGRVCQNLGISAK
CCCCCCCHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCHH
QVHEIFVSDTKLNISAYYTRPGGPFGGSCLPKDVRALQHIAADTGAQTHLVDSLLRSNDA
HHHHHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
HKHHQFLQVTKDLQPGARVLLVGLAFKADTDDLRESPAVDMARKLLDAGYALDIYDPQLR
HHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PESLVGQNLGYAYAILPSIDGLLVDKTTAEARDYGVVIATNRLIRDLALPGRRIVDVSAI
CHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEECHHHHHHHCCCCCEEEEEECC
A
C
>Mature Secondary Structure
MKIAILGLGYVGCTAAGCIASQGHHVVGIDVNLGKVETLNTGKSPVYEPGLDDLIAKARA
CEEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHC
EGRLHAVTEIGSALDDCDIAIVCVGTPSGVDGAHNMSFIVQVSRAIAASVRPDRKTPLTV
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
VYRSTMRPGTTEQMILPIFRSVIGEDCEKLIELVYNPEFLREATAIEDYFHPPKIVLGTI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECC
DGAPSEKMVALHEGIEAPIFHVGIREAEITKFVDNTWHAVKVAFANEVGRVCQNLGISAK
CCCCCCCHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCCHH
QVHEIFVSDTKLNISAYYTRPGGPFGGSCLPKDVRALQHIAADTGAQTHLVDSLLRSNDA
HHHHHHHCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
HKHHQFLQVTKDLQPGARVLLVGLAFKADTDDLRESPAVDMARKLLDAGYALDIYDPQLR
HHHHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PESLVGQNLGYAYAILPSIDGLLVDKTTAEARDYGVVIATNRLIRDLALPGRRIVDVSAI
CHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCEEEEECHHHHHHHCCCCCEEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]