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The map label for this gene is fabH

Identifier: 87200379

GI number: 87200379

Start: 2513945

End: 2514922

Strand: Reverse

Name: fabH

Synonym: Saro_2366

Alternate gene names: 87200379

Gene position: 2514922-2513945 (Counterclockwise)

Preceding gene: 87200380

Following gene: 87200378

Centisome position: 70.61

GC content: 64.83

Gene sequence:

>978_bases
ATGAGCGTGCGGTCCGTAATCCGTGGCAGCGGTTCGGCCCTGCCGCGTCGCGCGGTATCGAATGCCGAAATGACCACCAT
GGTCGACACGACCGATGAATGGATCGTCGAGCGCACCGGTATCCGCAACCGCTACATCGCGGGCGAAGGTGAAACCACCT
CGACGCTTGCCACCGAAGCGGCGCGCAAGGCGCTCGAAGCCGCCGGCGTAGACGCCTCGCGCATCGACCTTATCGTTCTG
GCAACGGCGACGCCCGACCAGACCTTCCCGGCGACCGCAACGATCGTCCAGCACAACCTCGGGTGCAACGGCGGCATCGC
CTTTGACGTGGCGGCGGTCTGCTCGGGCTTCCTTTATGCGCTCGCCACTGCGGATTCGATGATCCGTTCCGGCATGGCGC
GCTGCGCGCTGGTGATCGGCGCCGAGACCATGAGCCGGCTGCTCGACTGGGAAGATCGCACGACCTGCGTCCTTTTCGGC
GATGGTGCCGGTGCGGTCGTGCTTGAAGCTGTCGATGTCGACGAAACGGACCCGAAGGCGCCCGGCATTCTGGCAACGCG
CCTCCACGCCGACGGCGCGCACAACGAGCTGCTCTATGTCGATGGCGGTCCCTCCACGACGGGGACGGTCGGCAAGCTGC
GCATGAAGGGCCGTGAGGTCTTCCGTCACGCCGTCACCAACCTTGCGAATGTCCTGAAGGAAGTTCTTGAGACGACGGGG
CATGACGCGGAAGAAATCGATTGGGTCGTACCACATCAGGCGAACTTCCGCATTCTCGACGCTACCGCGCGCAAGCTCGA
TCTTCCCGCGGACAAGGTGATCGTCACGGTCGACCATCACGCCAACACCAGTGCTGCCTCGGTTCCGCTCGCCTATGACA
CCGCTGTGCGGGACGGGCGGATCAAGCCCGGCGACCTCGTCATGTTCGAGGCGATGGGCGGTGGATTCACCTGGGGCGCC
AGTTTGGCCCGGGTGTGA

Upstream 100 bases:

>100_bases
TCAAGGCCGACCTTGCCCGCGTGGGCGCGGAGGCTATTCGCACCTCGGGCCGCAGCGGAGGGAAGTCGAAGTCTTCCGCC
GCCCGCGAGGATGGCGCGGC

Downstream 100 bases:

>100_bases
ACCGTTCCATCCCGGAATGGACGCATTCTAATCCTTTGTCCCCAAGGCATTGCATTGCGTTCCGTAGAAACACCGTTATT
CTCGGACGCCTTGGTAGGTC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSVRSVIRGSGSALPRRAVSNAEMTTMVDTTDEWIVERTGIRNRYIAGEGETTSTLATEAARKALEAAGVDASRIDLIVL
ATATPDQTFPATATIVQHNLGCNGGIAFDVAAVCSGFLYALATADSMIRSGMARCALVIGAETMSRLLDWEDRTTCVLFG
DGAGAVVLEAVDVDETDPKAPGILATRLHADGAHNELLYVDGGPSTTGTVGKLRMKGREVFRHAVTNLANVLKEVLETTG
HDAEEIDWVVPHQANFRILDATARKLDLPADKVIVTVDHHANTSAASVPLAYDTAVRDGRIKPGDLVMFEAMGGGFTWGA
SLARV

Sequences:

>Translated_325_residues
MSVRSVIRGSGSALPRRAVSNAEMTTMVDTTDEWIVERTGIRNRYIAGEGETTSTLATEAARKALEAAGVDASRIDLIVL
ATATPDQTFPATATIVQHNLGCNGGIAFDVAAVCSGFLYALATADSMIRSGMARCALVIGAETMSRLLDWEDRTTCVLFG
DGAGAVVLEAVDVDETDPKAPGILATRLHADGAHNELLYVDGGPSTTGTVGKLRMKGREVFRHAVTNLANVLKEVLETTG
HDAEEIDWVVPHQANFRILDATARKLDLPADKVIVTVDHHANTSAASVPLAYDTAVRDGRIKPGDLVMFEAMGGGFTWGA
SLARV
>Mature_324_residues
SVRSVIRGSGSALPRRAVSNAEMTTMVDTTDEWIVERTGIRNRYIAGEGETTSTLATEAARKALEAAGVDASRIDLIVLA
TATPDQTFPATATIVQHNLGCNGGIAFDVAAVCSGFLYALATADSMIRSGMARCALVIGAETMSRLLDWEDRTTCVLFGD
GAGAVVLEAVDVDETDPKAPGILATRLHADGAHNELLYVDGGPSTTGTVGKLRMKGREVFRHAVTNLANVLKEVLETTGH
DAEEIDWVVPHQANFRILDATARKLDLPADKVIVTVDHHANTSAASVPLAYDTAVRDGRIKPGDLVMFEAMGGGFTWGAS
LARV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=51.41065830721, Blast_Score=321, Evalue=3e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_NOVAD (Q2G5S1)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497636.1
- ProteinModelPortal:   Q2G5S1
- SMR:   Q2G5S1
- STRING:   Q2G5S1
- GeneID:   3915711
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2366
- NMPDR:   fig|48935.1.peg.1448
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q2G5S1
- ProtClustDB:   CLSK844009
- BioCyc:   NARO279238:SARO_2366-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34404; Mature: 34273

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 252-252 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRSVIRGSGSALPRRAVSNAEMTTMVDTTDEWIVERTGIRNRYIAGEGETTSTLATEA
CCHHHHHCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHCCCCCEEECCCCCCHHHHHHHH
ARKALEAAGVDASRIDLIVLATATPDQTFPATATIVQHNLGCNGGIAFDVAAVCSGFLYA
HHHHHHHCCCCCHHEEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
LATADSMIRSGMARCALVIGAETMSRLLDWEDRTTCVLFGDGAGAVVLEAVDVDETDPKA
HHHHHHHHHHHHHHHEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCCC
PGILATRLHADGAHNELLYVDGGPSTTGTVGKLRMKGREVFRHAVTNLANVLKEVLETTG
CCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HDAEEIDWVVPHQANFRILDATARKLDLPADKVIVTVDHHANTSAASVPLAYDTAVRDGR
CCHHHCCEECCCCCCEEEEECCHHHCCCCCCEEEEEEECCCCCCCCCCCEEEHHHCCCCC
IKPGDLVMFEAMGGGFTWGASLARV
CCCCCEEEEEECCCCEECCCHHCCC
>Mature Secondary Structure 
SVRSVIRGSGSALPRRAVSNAEMTTMVDTTDEWIVERTGIRNRYIAGEGETTSTLATEA
CHHHHHCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHCCCCCEEECCCCCCHHHHHHHH
ARKALEAAGVDASRIDLIVLATATPDQTFPATATIVQHNLGCNGGIAFDVAAVCSGFLYA
HHHHHHHCCCCCHHEEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
LATADSMIRSGMARCALVIGAETMSRLLDWEDRTTCVLFGDGAGAVVLEAVDVDETDPKA
HHHHHHHHHHHHHHHEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCCC
PGILATRLHADGAHNELLYVDGGPSTTGTVGKLRMKGREVFRHAVTNLANVLKEVLETTG
CCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HDAEEIDWVVPHQANFRILDATARKLDLPADKVIVTVDHHANTSAASVPLAYDTAVRDGR
CCHHHCCEECCCCCCEEEEECCHHHCCCCCCEEEEEEECCCCCCCCCCCEEEHHHCCCCC
IKPGDLVMFEAMGGGFTWGASLARV
CCCCCEEEEEECCCCEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA