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The map label for this gene is lpd [H]

Identifier: 87199962

GI number: 87199962

Start: 2060883

End: 2062295

Strand: Reverse

Name: lpd [H]

Synonym: Saro_1945

Alternate gene names: 87199962

Gene position: 2062295-2060883 (Counterclockwise)

Preceding gene: 87199963

Following gene: 87199961

Centisome position: 57.9

GC content: 62.35

Gene sequence:

>1413_bases
GTGGCTGAACAGTATGACGTCATCGTCCTCGGATCGGGCCCCGGCGGCTATGTCGCGGCGATCCGCTGCGCCCAGCTTGG
CCTGAAGACGGCCATCGTCGAGCGCGAGAACCTCGGCGGCATCTGCCTTAACTGGGGTTGTATCCCGACCAAGGCGCTCC
TGCGCTCGGCCGAAGTGCTGAACCATATGAAGCATGCCGCCGCCTACGGTCTTGCGGCCGACAACATCCGTGCGGACCTC
GACGCGGTGGTCAAGCGGTCCCGCGGAGTTGCCAAGCAGCTCAACCAGGGCGTCACGCACCTGATGAAGAAGAACAAGAT
TACCGTGCACATGGGCAACGGTATTCTGAAGTCGGCCACGTCGGTGGAAGTCACTGGCGACAAGGGTTCCGAAACCATCT
CGGCCAAGCATGTGATCGTCGCCACCGGAGCCCGCGCCCGCGACTTGCCGTTCGCCAAGGCCGACGGCGAGCGCGTGTGG
ACCTATCGCCACGCGATGACGCCCAAGGAGATGCCAACCAAGCTTCTGGTCATCGGATCGGGTGCGATCGGCATAGAATT
TGCCAGCTTCTACAATGATATGGGGGCAGAAGTTACTGTCGTCGAGATGATGGACCGGGTGGTGCCCGTGGAAGATGCCG
ACGTTTCGGCCTTCCTCGAAAAGGCGCTAACCAAGCAGGGCATGAAGATCATGACCGGCGCAGGCGTCGAAAGCCTGGCC
GTTTCGGCCTCGGGCGTGAAGGCGAAGATCAAGGGCAAGGATGGCAAGGTCGCGGAAGGCGATTACAGCCATGTCATCGT
TGCGGTCGGCATCGTGCCGAATACCGAGCACATCGGCCTCGAAGCGCTGGGGGTGAAGGCTGAGCGCGGGATCATCGCCA
TCGACGGTTATGGCCGCACGAACGTCAAGGGCCTGTGGGCCATCGGCGACGTTACGCCGGGGCCATGGCTGGCGCACAAG
GCCAGCCATGAAGGCGTGATCGCTGCTGAGGCCATCGCCGCGGAACTGGGCAACAAGGAGGTTCACCCGCACCCGATGGA
CCGGGGGAACATCCCGGGATGCACCTACTGTCACCCGCAGATCGCAAGCGTCGGCCTGACCGAGGCCAAGGCCAAGGAAG
CAGGCTACGCGGTGAAGGTCGGGACCTTCCCCTTCATCGGCAATGGCAAGGCTATCGCGCTGGGCGAGCCCGAGGGCTTC
GTGAAGACCGTGTTCGATGCCAAGACCGGCGAATTGCTCGGTGCGCACATGATCGGCGCTGAAGTGACCGAGATGATTCA
AGGCTATGTGGTCGGCAAGACGCTGGAGACGACAGAGGCCGAACTGATGCACACGGTGTTCCCGCATCCGACCATCAGCG
AATCGATGCACGAAAGCGTTCTGGCTGCTTACGGACGCGCCATCCACATCTGA

Upstream 100 bases:

>100_bases
CGCTCGGCCTGGTCGCCTGACGCCTGACCATTCTGCGAGCGGCAGCATGCCGCCCGCTTCGCTAGATCATGGGCCGAAAA
TGGCCTGAAGGAGCATTTGC

Downstream 100 bases:

>100_bases
GGTTTCCACCTCAAACCATTGACAGCCATGAAAAGGCGCGGAGGGGCAACCTCCGCGCCTTTTTGCCGGGGATGCCCCGC
CAGGTTGTGACTGACGACGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAEQYDVIVLGSGPGGYVAAIRCAQLGLKTAIVERENLGGICLNWGCIPTKALLRSAEVLNHMKHAAAYGLAADNIRADL
DAVVKRSRGVAKQLNQGVTHLMKKNKITVHMGNGILKSATSVEVTGDKGSETISAKHVIVATGARARDLPFAKADGERVW
TYRHAMTPKEMPTKLLVIGSGAIGIEFASFYNDMGAEVTVVEMMDRVVPVEDADVSAFLEKALTKQGMKIMTGAGVESLA
VSASGVKAKIKGKDGKVAEGDYSHVIVAVGIVPNTEHIGLEALGVKAERGIIAIDGYGRTNVKGLWAIGDVTPGPWLAHK
ASHEGVIAAEAIAAELGNKEVHPHPMDRGNIPGCTYCHPQIASVGLTEAKAKEAGYAVKVGTFPFIGNGKAIALGEPEGF
VKTVFDAKTGELLGAHMIGAEVTEMIQGYVVGKTLETTEAELMHTVFPHPTISESMHESVLAAYGRAIHI

Sequences:

>Translated_470_residues
MAEQYDVIVLGSGPGGYVAAIRCAQLGLKTAIVERENLGGICLNWGCIPTKALLRSAEVLNHMKHAAAYGLAADNIRADL
DAVVKRSRGVAKQLNQGVTHLMKKNKITVHMGNGILKSATSVEVTGDKGSETISAKHVIVATGARARDLPFAKADGERVW
TYRHAMTPKEMPTKLLVIGSGAIGIEFASFYNDMGAEVTVVEMMDRVVPVEDADVSAFLEKALTKQGMKIMTGAGVESLA
VSASGVKAKIKGKDGKVAEGDYSHVIVAVGIVPNTEHIGLEALGVKAERGIIAIDGYGRTNVKGLWAIGDVTPGPWLAHK
ASHEGVIAAEAIAAELGNKEVHPHPMDRGNIPGCTYCHPQIASVGLTEAKAKEAGYAVKVGTFPFIGNGKAIALGEPEGF
VKTVFDAKTGELLGAHMIGAEVTEMIQGYVVGKTLETTEAELMHTVFPHPTISESMHESVLAAYGRAIHI
>Mature_469_residues
AEQYDVIVLGSGPGGYVAAIRCAQLGLKTAIVERENLGGICLNWGCIPTKALLRSAEVLNHMKHAAAYGLAADNIRADLD
AVVKRSRGVAKQLNQGVTHLMKKNKITVHMGNGILKSATSVEVTGDKGSETISAKHVIVATGARARDLPFAKADGERVWT
YRHAMTPKEMPTKLLVIGSGAIGIEFASFYNDMGAEVTVVEMMDRVVPVEDADVSAFLEKALTKQGMKIMTGAGVESLAV
SASGVKAKIKGKDGKVAEGDYSHVIVAVGIVPNTEHIGLEALGVKAERGIIAIDGYGRTNVKGLWAIGDVTPGPWLAHKA
SHEGVIAAEAIAAELGNKEVHPHPMDRGNIPGCTYCHPQIASVGLTEAKAKEAGYAVKVGTFPFIGNGKAIALGEPEGFV
KTVFDAKTGELLGAHMIGAEVTEMIQGYVVGKTLETTEAELMHTVFPHPTISESMHESVLAAYGRAIHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=36.2869198312236, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=28.0172413793103, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI22035672, Length=481, Percent_Identity=27.6507276507277, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI33519430, Length=487, Percent_Identity=25.8726899383984, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519428, Length=487, Percent_Identity=25.8726899383984, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI33519426, Length=487, Percent_Identity=25.8726899383984, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148277065, Length=487, Percent_Identity=25.8726899383984, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI148277071, Length=487, Percent_Identity=25.8726899383984, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI291045266, Length=479, Percent_Identity=26.0960334029228, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI291045268, Length=351, Percent_Identity=27.9202279202279, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=37.3626373626374, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87082354, Length=472, Percent_Identity=27.5423728813559, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789915, Length=469, Percent_Identity=29.2110874200426, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=27.765726681128, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788892, Length=232, Percent_Identity=28.448275862069, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=477, Percent_Identity=36.4779874213836, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=26.9709543568465, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=465, Percent_Identity=26.8817204301075, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=465, Percent_Identity=26.8817204301075, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=491, Percent_Identity=24.0325865580448, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17559934, Length=330, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=484, Percent_Identity=36.9834710743802, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=27.4633123689727, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=478, Percent_Identity=27.1966527196653, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21358499, Length=476, Percent_Identity=38.655462184874, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=26.7080745341615, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=27.2536687631027, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=27.2536687631027, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=27.3109243697479, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49550; Mature: 49419

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQYDVIVLGSGPGGYVAAIRCAQLGLKTAIVERENLGGICLNWGCIPTKALLRSAEVL
CCCCEEEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCEEEECCCCCHHHHHHHHHHH
NHMKHAAAYGLAADNIRADLDAVVKRSRGVAKQLNQGVTHLMKKNKITVHMGNGILKSAT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCEECCCC
SVEVTGDKGSETISAKHVIVATGARARDLPFAKADGERVWTYRHAMTPKEMPTKLLVIGS
EEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEC
GAIGIEFASFYNDMGAEVTVVEMMDRVVPVEDADVSAFLEKALTKQGMKIMTGAGVESLA
CCCCEEHHHHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHEE
VSASGVKAKIKGKDGKVAEGDYSHVIVAVGIVPNTEHIGLEALGVKAERGIIAIDGYGRT
EECCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCEEEECEECCCCEEEEECCCCC
NVKGLWAIGDVTPGPWLAHKASHEGVIAAEAIAAELGNKEVHPHPMDRGNIPGCTYCHPQ
CCCEEEEECCCCCCCCEEECCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
IASVGLTEAKAKEAGYAVKVGTFPFIGNGKAIALGEPEGFVKTVFDAKTGELLGAHMIGA
HHHCCCCHHHHHHCCCEEEECCEEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHH
EVTEMIQGYVVGKTLETTEAELMHTVFPHPTISESMHESVLAAYGRAIHI
HHHHHHHCEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure 
AEQYDVIVLGSGPGGYVAAIRCAQLGLKTAIVERENLGGICLNWGCIPTKALLRSAEVL
CCCEEEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCEEEECCCCCHHHHHHHHHHH
NHMKHAAAYGLAADNIRADLDAVVKRSRGVAKQLNQGVTHLMKKNKITVHMGNGILKSAT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCEECCCC
SVEVTGDKGSETISAKHVIVATGARARDLPFAKADGERVWTYRHAMTPKEMPTKLLVIGS
EEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEC
GAIGIEFASFYNDMGAEVTVVEMMDRVVPVEDADVSAFLEKALTKQGMKIMTGAGVESLA
CCCCEEHHHHHHCCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHEE
VSASGVKAKIKGKDGKVAEGDYSHVIVAVGIVPNTEHIGLEALGVKAERGIIAIDGYGRT
EECCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCEEEECEECCCCEEEEECCCCC
NVKGLWAIGDVTPGPWLAHKASHEGVIAAEAIAAELGNKEVHPHPMDRGNIPGCTYCHPQ
CCCEEEEECCCCCCCCEEECCCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCH
IASVGLTEAKAKEAGYAVKVGTFPFIGNGKAIALGEPEGFVKTVFDAKTGELLGAHMIGA
HHHCCCCHHHHHHCCCEEEECCEEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHH
EVTEMIQGYVVGKTLETTEAELMHTVFPHPTISESMHESVLAAYGRAIHI
HHHHHHHCEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]