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The map label for this gene is celR [H]

Identifier: 87199904

GI number: 87199904

Start: 1993798

End: 1994832

Strand: Reverse

Name: celR [H]

Synonym: Saro_1887

Alternate gene names: 87199904

Gene position: 1994832-1993798 (Counterclockwise)

Preceding gene: 87199916

Following gene: 87199903

Centisome position: 56.01

GC content: 66.09

Gene sequence:

>1035_bases
ATGGGGCGTAAGCCATCCAACAAGCCGACGAGTTTCGACATTGCCTACCTCGCCGGCGTGTCCCAACCTACCGTCAGCCG
TGCGCTCAGGGGCAGCAAGTCGGTCAGCCTCGCCACGCGCCAGAAGATCGAGGCGATCGCGCGCCAGCTCAACTATACGG
TCGACAAGAACGCTTCGTCATTGCGCTCGCAGCGATCGAACACCCTCGCCCTGCTGTTCTTCGAGGACCCGACGCCGGAC
GAATCGAACATCAACCCGTTCTTCCTCGCCATGCTCGGCTCGATCACCCGGCACTGCGCCAATCGCGGCCTCGACCTGCT
GATCTCGTTCCAGAAGCTCGATGACGACTGGCACAAGCGCTACCAGGACAGTCATCGCGCCGACGGGCTGATCCTGCTCG
GCTACGGTGACTACACTCTCTACGGATCCCGCCTGCGCCAGCTCATCCGCTCGGGCACGCATTTCGTGCGCTGGGGCTCG
GTAGACGAAGGCACCATCGGGGCGACAATCGGGTCCGACAACTTCGGCGCCGGACGCCTGGCGGGCGAGCACCTCCTTGC
CCGGGGCCGCAAGCGCATTGCCTTCCTCGGCCAGGCGGATTCGCACTATCCAGAGTTCGAGCAGCGCTACGCAGGCCTGT
CCAAGGCCATCCGCACAGCCGGGCTGGAGCCCGATCCGGACCTTGTCGTCGATGCGACCTCGTCCGAGGAAATCGGCTAC
AACGCCGCGCGGGAGCTGCTGTCGCGCGGCAAAACCTTCGATGCCATCTTCGCCGCGAGCGACCTGATCGCCATCGGCGC
GATGCGCGCGCTTGCCGAAGCCGGTCGTTCCGTGCCCGCCGATGTCGCGGTCGTCGGTTTCGACGACATCCCGGCCGCCA
GCCTGACCACGCCGCCATTGACCACCATCATGCAGGATACGCGGCTTGCCGGTGAGGCTCTGGTCGATTGCGTGCTCGGG
CAGGTCGAAGGCCGCCCACCCAGCCCGCGCATCCTCCCCGCACGACTTGTCGTCAGGGCCAGCAGCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCGTTCTGACGGGCCGATTGCATGACGCGTGGTTCAGGCATACAACCTGCAGCTGCCGACTGCGGGGACACACCGG
GCGGCGGGAGAACAGGGGAA

Downstream 100 bases:

>100_bases
ATCGGGACCACTGCGGGCCTTTCGGCTTTGGTATTCGTATGCGCATCGATTGCGGGCGCGGCCGGATTCTGCGACCAGCC
TCGGCAAGACCGCTGAACGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MGRKPSNKPTSFDIAYLAGVSQPTVSRALRGSKSVSLATRQKIEAIARQLNYTVDKNASSLRSQRSNTLALLFFEDPTPD
ESNINPFFLAMLGSITRHCANRGLDLLISFQKLDDDWHKRYQDSHRADGLILLGYGDYTLYGSRLRQLIRSGTHFVRWGS
VDEGTIGATIGSDNFGAGRLAGEHLLARGRKRIAFLGQADSHYPEFEQRYAGLSKAIRTAGLEPDPDLVVDATSSEEIGY
NAARELLSRGKTFDAIFAASDLIAIGAMRALAEAGRSVPADVAVVGFDDIPAASLTTPPLTTIMQDTRLAGEALVDCVLG
QVEGRPPSPRILPARLVVRASSGG

Sequences:

>Translated_344_residues
MGRKPSNKPTSFDIAYLAGVSQPTVSRALRGSKSVSLATRQKIEAIARQLNYTVDKNASSLRSQRSNTLALLFFEDPTPD
ESNINPFFLAMLGSITRHCANRGLDLLISFQKLDDDWHKRYQDSHRADGLILLGYGDYTLYGSRLRQLIRSGTHFVRWGS
VDEGTIGATIGSDNFGAGRLAGEHLLARGRKRIAFLGQADSHYPEFEQRYAGLSKAIRTAGLEPDPDLVVDATSSEEIGY
NAARELLSRGKTFDAIFAASDLIAIGAMRALAEAGRSVPADVAVVGFDDIPAASLTTPPLTTIMQDTRLAGEALVDCVLG
QVEGRPPSPRILPARLVVRASSGG
>Mature_343_residues
GRKPSNKPTSFDIAYLAGVSQPTVSRALRGSKSVSLATRQKIEAIARQLNYTVDKNASSLRSQRSNTLALLFFEDPTPDE
SNINPFFLAMLGSITRHCANRGLDLLISFQKLDDDWHKRYQDSHRADGLILLGYGDYTLYGSRLRQLIRSGTHFVRWGSV
DEGTIGATIGSDNFGAGRLAGEHLLARGRKRIAFLGQADSHYPEFEQRYAGLSKAIRTAGLEPDPDLVVDATSSEEIGYN
AARELLSRGKTFDAIFAASDLIAIGAMRALAEAGRSVPADVAVVGFDDIPAASLTTPPLTTIMQDTRLAGEALVDCVLGQ
VEGRPPSPRILPARLVVRASSGG

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=316, Percent_Identity=30.6962025316456, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790369, Length=348, Percent_Identity=28.735632183908, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=27.0588235294118, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=30.3206997084548, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788474, Length=297, Percent_Identity=29.6296296296296, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789202, Length=296, Percent_Identity=28.3783783783784, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789456, Length=349, Percent_Identity=27.5071633237822, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787580, Length=334, Percent_Identity=27.2455089820359, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787906, Length=353, Percent_Identity=26.628895184136, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994940, Length=329, Percent_Identity=25.531914893617, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789068, Length=315, Percent_Identity=27.3015873015873, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790715, Length=300, Percent_Identity=28.3333333333333, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790689, Length=359, Percent_Identity=25.3481894150418, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37160; Mature: 37029

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKPSNKPTSFDIAYLAGVSQPTVSRALRGSKSVSLATRQKIEAIARQLNYTVDKNASS
CCCCCCCCCCCEEEHEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
LRSQRSNTLALLFFEDPTPDESNINPFFLAMLGSITRHCANRGLDLLISFQKLDDDWHKR
HHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHH
YQDSHRADGLILLGYGDYTLYGSRLRQLIRSGTHFVRWGSVDEGTIGATIGSDNFGAGRL
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHH
AGEHLLARGRKRIAFLGQADSHYPEFEQRYAGLSKAIRTAGLEPDPDLVVDATSSEEIGY
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCH
NAARELLSRGKTFDAIFAASDLIAIGAMRALAEAGRSVPADVAVVGFDDIPAASLTTPPL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCH
TTIMQDTRLAGEALVDCVLGQVEGRPPSPRILPARLVVRASSGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCC
>Mature Secondary Structure 
GRKPSNKPTSFDIAYLAGVSQPTVSRALRGSKSVSLATRQKIEAIARQLNYTVDKNASS
CCCCCCCCCCEEEHEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHH
LRSQRSNTLALLFFEDPTPDESNINPFFLAMLGSITRHCANRGLDLLISFQKLDDDWHKR
HHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHCCHHHHHH
YQDSHRADGLILLGYGDYTLYGSRLRQLIRSGTHFVRWGSVDEGTIGATIGSDNFGAGRL
HHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHH
AGEHLLARGRKRIAFLGQADSHYPEFEQRYAGLSKAIRTAGLEPDPDLVVDATSSEEIGY
HHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCH
NAARELLSRGKTFDAIFAASDLIAIGAMRALAEAGRSVPADVAVVGFDDIPAASLTTPPL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCH
TTIMQDTRLAGEALVDCVLGQVEGRPPSPRILPARLVVRASSGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]