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The map label for this gene is hemA [H]

Identifier: 87199814

GI number: 87199814

Start: 1894532

End: 1895752

Strand: Reverse

Name: hemA [H]

Synonym: Saro_1797

Alternate gene names: 87199814

Gene position: 1895752-1894532 (Counterclockwise)

Preceding gene: 87199815

Following gene: 87199813

Centisome position: 53.23

GC content: 63.14

Gene sequence:

>1221_bases
GTGAATTACGATCAGGTTTTCGATTCTGCCATCGAGCGCTTGCACTCCGAAGGCCGTTACCGCGTTTTCATCGACATCCT
GCGCAACAAGGGAGCCTACCCCAACGCGCGCTGCTTTGCGGGCCACAACGGCCCCAAGCCGATCACGGTGTGGTGTTCGA
ACGACTATCTCGCAATGGGCCAGCACCCCAAGGTGATCGCGGCCATGGAAGAGGCGTTGCACAACGTCGGCGCGGGCTCG
GGCGGTACGCGCAACATCGGCGGCAACACCCACTACCACATCGAGCTTGAGCACGAGCTGGCCGACCTTCACGGCAAGGA
CGGGGCGCTGCTGTTCACGTCGGGTTACGTCTCGAACGACGCGACGCTGTCGACGCTCGCCAAGATCCTGCCTGGCTGCG
TGATCTTCTCGGACGAACTGAACCACGCATCGATGATCGCGGGCATCCGCAACTCGGGTGCGGAAAAGCGGGTGTTCCGC
CACAACGACGTGGAACACCTCGAACAGCTTCTCGCCGAGACCGACCCTGCGCTGCCAAAGCTGATCGCGTTCGAGTCGGT
CTATTCGATGGATGGCGACATTGCGCCGATCCATGCGATCTGCGACCTGGCCGAGAAGTACAACGCGCTGACCTACATCG
ATGAAGTGCATGCCGTCGGCATGTACGGACCGCGCGGCGGCGGCATCACCGATCGTGACGAGGCGGCCCACCGCATCGAC
ATCATCGAGGGCACGCTGGGCAAGGCCTTCGGCGTGATGGGCGGCTATATCGCGGCAGACACGCGGATCATCGACGTGAT
CCGATCCTATGCGCCGGGGTTCATCTTCACCACCTCGCTTTCGCCGGTTCTGGTAGCGGGCGTTCTCGCATCGGTCCGCC
ACCTCAAGGCGTCGAGCGCCGAGCGCGACGGGCAGCAGGCGGCGGCGGCCTACCTCAAGAAGGCGTTCGCCGACGCCGGC
CTTCCCGTGATGCCATCGACCACGCACATCGTGCCGCTGATGGTCGGTGATCCGGTAAAGGCCAAGAAGATCAGCGACAT
ACTTCTGGCGGAGTATGGCGTATACGTGCAGCCCATCAACTTCCCGACCGTGCCGCGCGGGACCGAGCGCCTGCGCTTCA
CTCCGGGACCGTCGCACACCGAGGCGATGATGGACGAGCTTACCGGAGCGCTGGTGGAAATCTGGCAGCGCATGGAAATG
GAACTGCAGAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
CCGGGGCAACAGGCGTAGAAGCCGCTCATTCGCCGGGTGGCCCAGAGGGATCGGGCCTCGGGGGCGCGTCTGCGCCTCTG
TTACAGGAAGGAGCGGCGGG

Downstream 100 bases:

>100_bases
GCCCAGCCTTCAATGGATGCGAAAAGCCCTCCCCCAACCGGGAGGGCTTTTTCGTTGCATTGAAGGCTTCCGAAGGCCGT
CCAAGGCGCGTCCGAAGTCG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNYDQVFDSAIERLHSEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIAAMEEALHNVGAGS
GGTRNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSNDATLSTLAKILPGCVIFSDELNHASMIAGIRNSGAEKRVFR
HNDVEHLEQLLAETDPALPKLIAFESVYSMDGDIAPIHAICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRDEAAHRID
IIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKASSAERDGQQAAAAYLKKAFADAG
LPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPSHTEAMMDELTGALVEIWQRMEM
ELQKAA

Sequences:

>Translated_406_residues
MNYDQVFDSAIERLHSEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIAAMEEALHNVGAGS
GGTRNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSNDATLSTLAKILPGCVIFSDELNHASMIAGIRNSGAEKRVFR
HNDVEHLEQLLAETDPALPKLIAFESVYSMDGDIAPIHAICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRDEAAHRID
IIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKASSAERDGQQAAAAYLKKAFADAG
LPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPSHTEAMMDELTGALVEIWQRMEM
ELQKAA
>Mature_406_residues
MNYDQVFDSAIERLHSEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMGQHPKVIAAMEEALHNVGAGS
GGTRNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSNDATLSTLAKILPGCVIFSDELNHASMIAGIRNSGAEKRVFR
HNDVEHLEQLLAETDPALPKLIAFESVYSMDGDIAPIHAICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRDEAAHRID
IIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKASSAERDGQQAAAAYLKKAFADAG
LPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPSHTEAMMDELTGALVEIWQRMEM
ELQKAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=52.2167487684729, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=52.2167487684729, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=52.2167487684729, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI4502025, Length=406, Percent_Identity=50.4926108374384, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI40316939, Length=406, Percent_Identity=50.4926108374384, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI7657118, Length=377, Percent_Identity=33.6870026525199, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.0574712643678, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=30.8108108108108, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=29.9191374663073, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI5454084, Length=251, Percent_Identity=27.4900398406374, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1790046, Length=351, Percent_Identity=35.8974358974359, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=32.8445747800587, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=34.8051948051948, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=30.8333333333333, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17560914, Length=353, Percent_Identity=28.6118980169972, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=353, Percent_Identity=28.6118980169972, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=243, Percent_Identity=27.5720164609054, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=243, Percent_Identity=27.5720164609054, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=47.1563981042654, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320267, Length=373, Percent_Identity=29.4906166219839, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=276, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17137420, Length=402, Percent_Identity=50.2487562189055, Blast_Score=420, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24662918, Length=356, Percent_Identity=35.6741573033708, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI17136286, Length=343, Percent_Identity=29.4460641399417, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653280, Length=279, Percent_Identity=27.5985663082437, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653276, Length=279, Percent_Identity=27.5985663082437, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653278, Length=279, Percent_Identity=27.5985663082437, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44053; Mature: 44053

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDQVFDSAIERLHSEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIAAMEEALHNVGAGSGGTRNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSND
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCCEEEEECCCCCCC
ATLSTLAKILPGCVIFSDELNHASMIAGIRNSGAEKRVFRHNDVEHLEQLLAETDPALPK
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCCCHH
LIAFESVYSMDGDIAPIHAICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRDEAAHRID
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEE
IIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKASSA
EHHCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
ERDGQQAAAAYLKKAFADAGLPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGVYVQPIN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPSHTEAMMDELTGALVEIWQRMEMELQKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYDQVFDSAIERLHSEGRYRVFIDILRNKGAYPNARCFAGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIAAMEEALHNVGAGSGGTRNIGGNTHYHIELEHELADLHGKDGALLFTSGYVSND
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCCEEEEECCCCCCC
ATLSTLAKILPGCVIFSDELNHASMIAGIRNSGAEKRVFRHNDVEHLEQLLAETDPALPK
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCCCHH
LIAFESVYSMDGDIAPIHAICDLAEKYNALTYIDEVHAVGMYGPRGGGITDRDEAAHRID
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEE
IIEGTLGKAFGVMGGYIAADTRIIDVIRSYAPGFIFTTSLSPVLVAGVLASVRHLKASSA
EHHCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
ERDGQQAAAAYLKKAFADAGLPVMPSTTHIVPLMVGDPVKAKKISDILLAEYGVYVQPIN
CCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPSHTEAMMDELTGALVEIWQRMEMELQKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]