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The map label for this gene is fumC

Identifier: 87199713

GI number: 87199713

Start: 1782016

End: 1783392

Strand: Reverse

Name: fumC

Synonym: Saro_1696

Alternate gene names: 87199713

Gene position: 1783392-1782016 (Counterclockwise)

Preceding gene: 87199714

Following gene: 87199701

Centisome position: 50.07

GC content: 66.23

Gene sequence:

>1377_bases
ATGCACCGGATCGAAACCGACAGCCTGGGCGAAGTGCGCGTGCCCGCAGATGCCTATTGGGGCGCCCAGACGCAGCGAAG
CATCGAGAACTTTCCGTTCGGCGAGATGGAGCGGATGCCGATTGGCATCATTCGCGCACTGGCGCTGGTAAAACGGGCAG
CGGCGGGGGTGAACCGGGCACACGGGCTAGACCCGACGCTGGCCGACGCCATCGAACGGGCCGCCGCCGAAGTGGTCGAC
GGCAAGCTGGACGACCAGTTCCCGCTGGTCATCTGGCAGACCGGCAGCGGCACCCAGTCCAACATGAACGCCAACGAAGT
CATCGCAGGGCGCGCCAACGAGATCCTTACCGGCAAGCGCGGAGGCAAGAGCCCGGTCCATCCCAATGACCACGTAAACA
TGGGCCAGTCCTCGAACGACACCTTCCCTACCGCGCTGCACGTCGCGGCCGTCGAGGCGCTGAACCGAGACCTGCTGCCC
GCGCTGGGACGGCTGCGGGGCGCGCTGGCGGGCGCGGCGCTCGCGTGGAAGGATATCGTCAAGATCGGGCGAACCCACTT
GCAGGATGCGACCCCGCTGACACTGGGGCAGGAGTTTTCCGGCTATGCCGAGCAGTTGCGCGGCATCGAAGCGCACCTGA
AGGCCGCCGAGACGCACCTTCTGCGACTGGCGCAAGGCGGGACTGCGGTGGGGACCGGGCTCAATGCGCCGGAAGGCTTT
GGCGACGCCATGGCGGCAGAAATCGCCGCATTGACCGGCAGGCCCTTCGTTTCCGCGCCGAACAAGTTCGAAGCGCTCGC
CAGCAACGACGCTCTTGTCCAGTTTTCGGGGACGCTTTCGACGCTGGCGGTGGCGCTGACCAAGATTGCCAACGACATCC
GCCTGCTGGGTTCCGGCCCGCGCTCAGGCCTTGGCGAGCTGGAATTGCCGGCCAACGAACCGGGCAGTTCGATCATGCCC
GGCAAGGTCAACCCGACGCAGGCCGAAATGCTCACGATGGTGGCGGCGCAGGTGATCGGCAATCATCAGGCCGTGACCGT
GGGAGGGATGCAGGGGCATCTGGAACTCAACGTGTTCAAGCCGATGATCGGCGCCGCCGTGCTGCGATCGGTCCACCTGC
TGTCGACCGGCATGACAAGCTTTGCCACCCGCTGCGTCGAAGGGATCGAGCCGAACCGGCGGCGGATCGCGGACCTTGTC
GAACGCTCGCTCATGCTTGTGACCGCGCTGGCGCCGGAGATCGGGTACGACAACGCGGCGAAGATCGCCAAGCACGCGCA
CGAGCATGACCTGAGCCTGCGACAGGCGGCGCTGGCGCTGGGACTGGTTGACGAGGCGACGTTCGACCGGCTTATCCGAC
CGGGGGACATGGTCTAG

Upstream 100 bases:

>100_bases
AACGGGAAGTCGGGATCGCGACCGACAAGCAGTCGACGACTGACGATTCGGTCGAGCGTCTGCTAGACCGCACCTGACAC
TGGCGCGGAGAGCATCGAGA

Downstream 100 bases:

>100_bases
ACCTGCGTCCTGCCCCTAAACGTCCGGGAGGGACTGTTGGGCCATTCCCCAGCCGCGCAGCGACTTGCCTTCGCTACGCT
TGAGTAGTCCTGCCGTATCG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MHRIETDSLGEVRVPADAYWGAQTQRSIENFPFGEMERMPIGIIRALALVKRAAAGVNRAHGLDPTLADAIERAAAEVVD
GKLDDQFPLVIWQTGSGTQSNMNANEVIAGRANEILTGKRGGKSPVHPNDHVNMGQSSNDTFPTALHVAAVEALNRDLLP
ALGRLRGALAGAALAWKDIVKIGRTHLQDATPLTLGQEFSGYAEQLRGIEAHLKAAETHLLRLAQGGTAVGTGLNAPEGF
GDAMAAEIAALTGRPFVSAPNKFEALASNDALVQFSGTLSTLAVALTKIANDIRLLGSGPRSGLGELELPANEPGSSIMP
GKVNPTQAEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPMIGAAVLRSVHLLSTGMTSFATRCVEGIEPNRRRIADLV
ERSLMLVTALAPEIGYDNAAKIAKHAHEHDLSLRQAALALGLVDEATFDRLIRPGDMV

Sequences:

>Translated_458_residues
MHRIETDSLGEVRVPADAYWGAQTQRSIENFPFGEMERMPIGIIRALALVKRAAAGVNRAHGLDPTLADAIERAAAEVVD
GKLDDQFPLVIWQTGSGTQSNMNANEVIAGRANEILTGKRGGKSPVHPNDHVNMGQSSNDTFPTALHVAAVEALNRDLLP
ALGRLRGALAGAALAWKDIVKIGRTHLQDATPLTLGQEFSGYAEQLRGIEAHLKAAETHLLRLAQGGTAVGTGLNAPEGF
GDAMAAEIAALTGRPFVSAPNKFEALASNDALVQFSGTLSTLAVALTKIANDIRLLGSGPRSGLGELELPANEPGSSIMP
GKVNPTQAEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPMIGAAVLRSVHLLSTGMTSFATRCVEGIEPNRRRIADLV
ERSLMLVTALAPEIGYDNAAKIAKHAHEHDLSLRQAALALGLVDEATFDRLIRPGDMV
>Mature_458_residues
MHRIETDSLGEVRVPADAYWGAQTQRSIENFPFGEMERMPIGIIRALALVKRAAAGVNRAHGLDPTLADAIERAAAEVVD
GKLDDQFPLVIWQTGSGTQSNMNANEVIAGRANEILTGKRGGKSPVHPNDHVNMGQSSNDTFPTALHVAAVEALNRDLLP
ALGRLRGALAGAALAWKDIVKIGRTHLQDATPLTLGQEFSGYAEQLRGIEAHLKAAETHLLRLAQGGTAVGTGLNAPEGF
GDAMAAEIAALTGRPFVSAPNKFEALASNDALVQFSGTLSTLAVALTKIANDIRLLGSGPRSGLGELELPANEPGSSIMP
GKVNPTQAEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFKPMIGAAVLRSVHLLSTGMTSFATRCVEGIEPNRRRIADLV
ERSLMLVTALAPEIGYDNAAKIAKHAHEHDLSLRQAALALGLVDEATFDRLIRPGDMV

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=457, Percent_Identity=60.8315098468271, Blast_Score=547, Evalue=1e-156,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=59.3220338983051, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=58.8621444201313, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI87082375, Length=454, Percent_Identity=40.9691629955947, Blast_Score=326, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=457, Percent_Identity=61.7067833698031, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=60, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=57.7342047930283, Blast_Score=522, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24640179, Length=458, Percent_Identity=60.0436681222707, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640177, Length=458, Percent_Identity=60.0436681222707, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=58.6056644880174, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI78710009, Length=459, Percent_Identity=57.0806100217865, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24583245, Length=459, Percent_Identity=52.2875816993464, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48410; Mature: 48410

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRIETDSLGEVRVPADAYWGAQTQRSIENFPFGEMERMPIGIIRALALVKRAAAGVNRA
CCCCCCCCCCCEECCCHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
HGLDPTLADAIERAAAEVVDGKLDDQFPLVIWQTGSGTQSNMNANEVIAGRANEILTGKR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHEECCCCCHHEECCC
GGKSPVHPNDHVNMGQSSNDTFPTALHVAAVEALNRDLLPALGRLRGALAGAALAWKDIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEFSGYAEQLRGIEAHLKAAETHLLRLAQGGTAVGTGLNAPEGF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
GDAMAAEIAALTGRPFVSAPNKFEALASNDALVQFSGTLSTLAVALTKIANDIRLLGSGP
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHEECCCC
RSGLGELELPANEPGSSIMPGKVNPTQAEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFK
CCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHH
PMIGAAVLRSVHLLSTGMTSFATRCVEGIEPNRRRIADLVERSLMLVTALAPEIGYDNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
KIAKHAHEHDLSLRQAALALGLVDEATFDRLIRPGDMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHRIETDSLGEVRVPADAYWGAQTQRSIENFPFGEMERMPIGIIRALALVKRAAAGVNRA
CCCCCCCCCCCEECCCHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
HGLDPTLADAIERAAAEVVDGKLDDQFPLVIWQTGSGTQSNMNANEVIAGRANEILTGKR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHEECCCCCHHEECCC
GGKSPVHPNDHVNMGQSSNDTFPTALHVAAVEALNRDLLPALGRLRGALAGAALAWKDIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEFSGYAEQLRGIEAHLKAAETHLLRLAQGGTAVGTGLNAPEGF
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
GDAMAAEIAALTGRPFVSAPNKFEALASNDALVQFSGTLSTLAVALTKIANDIRLLGSGP
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHEECCCC
RSGLGELELPANEPGSSIMPGKVNPTQAEMLTMVAAQVIGNHQAVTVGGMQGHLELNVFK
CCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHH
PMIGAAVLRSVHLLSTGMTSFATRCVEGIEPNRRRIADLVERSLMLVTALAPEIGYDNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
KIAKHAHEHDLSLRQAALALGLVDEATFDRLIRPGDMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA