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The map label for this gene is acdA [H]

Identifier: 87199662

GI number: 87199662

Start: 1720822

End: 1721985

Strand: Reverse

Name: acdA [H]

Synonym: Saro_1645

Alternate gene names: 87199662

Gene position: 1721985-1720822 (Counterclockwise)

Preceding gene: 87199664

Following gene: 87199661

Centisome position: 48.35

GC content: 64.52

Gene sequence:

>1164_bases
ATGCGCGCCACGCCTGATTTCGACTTTGGACTGACCGAAAGCGCCCTGATGATCCGCGAGGCCGCCGGTCGCTTCGCCGA
CGAGCAGATTGCCCCCCTCGCCGCCGAGATCGACCGCAACGACCGCTTCCCAAGGGAACTGTGGGAGCCGATGGGCGCGC
TCGGTCTGCATGGCATCACGGTGGAGGAAGAATTCGGCGGCCTTGGCCTGGGCTATCTCGATCACGTCATCGCGGTCGAG
GAAGTGAGCCGGGCAAGCGGTTCGGTTGGGCTGTCCTACGGCGCGCACTCGAACCTCTGCGTCAACCAGATACGGCGCTG
GGGCAACGACGAGCAGAAGGCGAAGTACCTGCCGAAGCTGATCTCGGGCGAACACGTCGGCAGCCTGGCCATGTCGGAAG
CAGGCGCCGGGTCTGACGTGGTCTCGATGAAGCTGCGCGCCGATGCGGTAGCCGGCGGCTTCCGCCTCAACGGAACGAAA
TTCTGGATCACCAACGGCACTTATGCCGATACGCTGGTGGTCTACGCCAAGACCTCGCCCGAAGCGGGCAGCCGGGGCAT
CTCCGCCTTCCTGATCGAGAAGGACATGCCCGGCTTCTCCATCGGCCAGAAGATCGACAAGATGGGCCTGCGCGGCTCGC
CCACCTGCGAACTGGTGTTCGACGACTGCTTCGTTCCGGAAGAAAACGTAATGGGTCCGCTCCACGGCGGCGTCGGCGTG
TTGATGAGCGGGCTGGACTATGAACGCGTGGTGCTGGCAGGCATGCAGATCGGCATCATGCAGGCATGCCTCGACACGGT
CATCCCCTACGTGCGCGAACGCAAGCAGTTCGGCCAGCCGATCGGCACGTTCCAGCTGATGCAGGCCAAGGTCGCCGACA
TGTATGTCGCGATTCAGTCGGCCCGGGCCTATGTCTATGCCGTGGCCAAGGCTTGCGATGCAGGCCAGACCACGCGGTTC
GACGCCGCCGGGGCCATCCTTCTGGCGAGCGAGAACGCCTTCCGCGTTTCGGGCGAGGCCGTGCAGGCGCTCGGCGGCGC
GGGCTATACCAAGGACTGGCCGGTGGAACGCTACCTGCGCGATGCCAAACTGCTCGACATCGGCGCCGGAACCAATGAAA
TCCGCAGGATGCTGATCGGCAGGGAGCTGATCGGCGCACGATAA

Upstream 100 bases:

>100_bases
ATAGGAAAAATCTATCGCAAATCCCGGATCAAATCAATTTTGATCGCGACTTTGGCAATGGTATCGTTGGCCCCGAAAAG
AGTTGCGAGAGGATGCCGAA

Downstream 100 bases:

>100_bases
CGGACCTTGCGGAGAGAACGATGCGCCTGAAAACGATCCTTGCCTGCGCTGCCACGCTTTGCCTTGCCCAACCCGCACTT
GCGCGGGTGGAGAAGGCGAC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRATPDFDFGLTESALMIREAAGRFADEQIAPLAAEIDRNDRFPRELWEPMGALGLHGITVEEEFGGLGLGYLDHVIAVE
EVSRASGSVGLSYGAHSNLCVNQIRRWGNDEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLRADAVAGGFRLNGTK
FWITNGTYADTLVVYAKTSPEAGSRGISAFLIEKDMPGFSIGQKIDKMGLRGSPTCELVFDDCFVPEENVMGPLHGGVGV
LMSGLDYERVVLAGMQIGIMQACLDTVIPYVRERKQFGQPIGTFQLMQAKVADMYVAIQSARAYVYAVAKACDAGQTTRF
DAAGAILLASENAFRVSGEAVQALGGAGYTKDWPVERYLRDAKLLDIGAGTNEIRRMLIGRELIGAR

Sequences:

>Translated_387_residues
MRATPDFDFGLTESALMIREAAGRFADEQIAPLAAEIDRNDRFPRELWEPMGALGLHGITVEEEFGGLGLGYLDHVIAVE
EVSRASGSVGLSYGAHSNLCVNQIRRWGNDEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLRADAVAGGFRLNGTK
FWITNGTYADTLVVYAKTSPEAGSRGISAFLIEKDMPGFSIGQKIDKMGLRGSPTCELVFDDCFVPEENVMGPLHGGVGV
LMSGLDYERVVLAGMQIGIMQACLDTVIPYVRERKQFGQPIGTFQLMQAKVADMYVAIQSARAYVYAVAKACDAGQTTRF
DAAGAILLASENAFRVSGEAVQALGGAGYTKDWPVERYLRDAKLLDIGAGTNEIRRMLIGRELIGAR
>Mature_387_residues
MRATPDFDFGLTESALMIREAAGRFADEQIAPLAAEIDRNDRFPRELWEPMGALGLHGITVEEEFGGLGLGYLDHVIAVE
EVSRASGSVGLSYGAHSNLCVNQIRRWGNDEQKAKYLPKLISGEHVGSLAMSEAGAGSDVVSMKLRADAVAGGFRLNGTK
FWITNGTYADTLVVYAKTSPEAGSRGISAFLIEKDMPGFSIGQKIDKMGLRGSPTCELVFDDCFVPEENVMGPLHGGVGV
LMSGLDYERVVLAGMQIGIMQACLDTVIPYVRERKQFGQPIGTFQLMQAKVADMYVAIQSARAYVYAVAKACDAGQTTRF
DAAGAILLASENAFRVSGEAVQALGGAGYTKDWPVERYLRDAKLLDIGAGTNEIRRMLIGRELIGAR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=58.2446808510638, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=60.1769911504425, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=38.0697050938338, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=39.0374331550802, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=36.4864864864865, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=35.4922279792746, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=35.4922279792746, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=33.5135135135135, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=33.420365535248, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=35.0785340314136, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=35.0785340314136, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=395, Percent_Identity=31.1392405063291, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=31.6216216216216, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI48976061, Length=285, Percent_Identity=29.1228070175439, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI211971008, Length=285, Percent_Identity=29.1228070175439, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI218563752, Length=340, Percent_Identity=25.5882352941176, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786223, Length=378, Percent_Identity=28.8359788359788, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.9090909090909, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87081702, Length=291, Percent_Identity=25.7731958762887, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=25.1908396946565, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=55.5263157894737, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=34.7708894878706, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=34.7708894878706, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=34.4647519582245, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=34.0369393139842, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=34.1207349081365, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=32.3607427055703, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=38.0434782608696, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=358, Percent_Identity=32.9608938547486, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=32.8467153284672, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=36.5217391304348, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=29.5698924731183, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=27.5862068965517, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=28.2258064516129, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=31.9298245614035, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=228, Percent_Identity=27.6315789473684, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI86563381, Length=278, Percent_Identity=24.4604316546763, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=278, Percent_Identity=24.4604316546763, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=56.8062827225131, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=39.8395721925134, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=36.8700265251989, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=36.6310160427808, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=35.0785340314136, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=34.8441926345609, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=28.0927835051546, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41704; Mature: 41704

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRATPDFDFGLTESALMIREAAGRFADEQIAPLAAEIDRNDRFPRELWEPMGALGLHGIT
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
VEEEFGGLGLGYLDHVIAVEEVSRASGSVGLSYGAHSNLCVNQIRRWGNDEQKAKYLPKL
EECCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
ISGEHVGSLAMSEAGAGSDVVSMKLRADAVAGGFRLNGTKFWITNGTYADTLVVYAKTSP
HCCCCCCHHHHHCCCCCCCEEEEEEEHHHHCCCEEECCEEEEEECCCEEEEEEEEEECCC
EAGSRGISAFLIEKDMPGFSIGQKIDKMGLRGSPTCELVFDDCFVPEENVMGPLHGGVGV
CCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCCCCHHH
LMSGLDYERVVLAGMQIGIMQACLDTVIPYVRERKQFGQPIGTFQLMQAKVADMYVAIQS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ARAYVYAVAKACDAGQTTRFDAAGAILLASENAFRVSGEAVQALGGAGYTKDWPVERYLR
HHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCEEECHHHHHHHCCCCCCCCCCHHHHHC
DAKLLDIGAGTNEIRRMLIGRELIGAR
CCCEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRATPDFDFGLTESALMIREAAGRFADEQIAPLAAEIDRNDRFPRELWEPMGALGLHGIT
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
VEEEFGGLGLGYLDHVIAVEEVSRASGSVGLSYGAHSNLCVNQIRRWGNDEQKAKYLPKL
EECCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCHHHHHHHHHHH
ISGEHVGSLAMSEAGAGSDVVSMKLRADAVAGGFRLNGTKFWITNGTYADTLVVYAKTSP
HCCCCCCHHHHHCCCCCCCEEEEEEEHHHHCCCEEECCEEEEEECCCEEEEEEEEEECCC
EAGSRGISAFLIEKDMPGFSIGQKIDKMGLRGSPTCELVFDDCFVPEENVMGPLHGGVGV
CCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCCCCHHH
LMSGLDYERVVLAGMQIGIMQACLDTVIPYVRERKQFGQPIGTFQLMQAKVADMYVAIQS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ARAYVYAVAKACDAGQTTRFDAAGAILLASENAFRVSGEAVQALGGAGYTKDWPVERYLR
HHHHHHHHHHHCCCCCCCEECCCCEEEEECCCCEEECHHHHHHHCCCCCCCCCCHHHHHC
DAKLLDIGAGTNEIRRMLIGRELIGAR
CCCEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]