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The map label for this gene is pepA [H]

Identifier: 87199134

GI number: 87199134

Start: 1159505

End: 1160887

Strand: Direct

Name: pepA [H]

Synonym: Saro_1112

Alternate gene names: 87199134

Gene position: 1159505-1160887 (Clockwise)

Preceding gene: 87199128

Following gene: 87199135

Centisome position: 32.56

GC content: 67.68

Gene sequence:

>1383_bases
ATGACGGACAAGAACGCGCTGATCCAGCCTGATCGCGGCCAGCAGGCCATTGCCCTCCACCTTGTCGACAAGGCGACGCT
GCCGGATTTTCTCAAGGGAATCAATGCAGGCCAGCGCGCCAGCCTTGTTGCGCAGAAGTTCGAGGGCGGAGGGTACGAAC
ATGCGATCGTGCCCGATGGCGACGGCTGGTTCGCAGTCGCCGGGGTGGCCAACGTCGATGACCTTTCGTCGTGGTGCATG
GCCAGGCTGGCGGACGTTCTGCCGGGCGGCACATATCGCCGCGCTGGCGGGGAGCCGGGCAAGGCGCTGCACGGATGGAT
TACCGGGCAATACCGGTTCGACCGTTATCGCAAGGACGCGACAGAGAGCGAGCCGCGCATCCTCCTGACCAAGGACGTGG
CGCTGATCGAACCGGCCATTGCGGAAGCATCGGCCGTCCTGATGGTGCGCGACCTGGTAAATACGCCGGCCGAGGACATG
GGCCCCGCGCAGCTTGAGGCGGAAGCGCGGGCGCTGGCCAAGACCTGGCACGCTGAGGTCCACGTCGTGTCGGGCGACGC
GCTGGAGCGGGACTATCCGATGGTCCACGCCGTCGGCCGAGCCGCGGCGCGCAGCCATGCGCCGCGCCTGATCGAACTGG
AATGGGGCGATCCGAAGCATCCCCGCGTCGCGATCGTCGGCAAGGGCGTCTGCTTCGATTCGGGGGGGCTCGACATCAAG
CCCTCGAGCGGCATGGCGCTGATGAAGAAGGACATGGGCGGCGCCGCCCATGCCCTCGCACTGGCGGGCCTGGTCATGGC
GATGGGCCTGAAGGTGCGCCTGCACGTGCTGTTGCCGGCGGTAGAAAACGCGATATCCGGCCACGCCTTCCGTCCTGGCG
ACATCCTGCGCGGGCGCAACGGACTGTCGGTCGAGGTCACGAATACCGACGCCGAAGGCCGGCTGGTGCTTGGCGATGCG
CTAGTACGCGCAAGTGAGATGAAGCCGGAACTGGTCATCGATTTCGCTACCCTGACGGGGGCGGCACGCGTGGCGCTGGG
CCCGGACTTGCCCGCCATGTTCGCGCGCAAGGACGAGACGGCGAATGGACTGCTCGTCGCCGGCATCGAGCGCGACGACC
CGTGCTGGCGCCTGCCGCTGTTCGAAGGGTACCGCGAATACCTCAAGTCCGACGTAGCCGACCTGCAGAACTCGCCTGCC
AACGGCTTTGCCGGAGCCAGCGTGGCGGCGCTGTTTCTCGACCGCTTCGTGGGCGAGGGGATCGACTGGGCGCACTTCGA
TACCTTCGCCTGGCGCCCCGCGGCGAAGCCCGGGCGCCCCAAGGGGGGAGACGCCCTTGGACTGCGCGCGGCGTGGGGGC
TGCTCAAGGCGCGATACGGCTGA

Upstream 100 bases:

>100_bases
GAACAGGCCGCGAGCAGCGCGAGGGGCAGGAGCGTGGTCGGGCGCATGGGGCAATTTCCTCTCGCAACGGGCCGCGCTCT
GCGGCATTGTCCGATGCAAG

Downstream 100 bases:

>100_bases
GAATGCGCGATAGCTTGCCTGACTGCGCCGACGCCGCTAATCGCCCGGCTTTCCTGTTCCGGGGACAACCTGAATTGACC
GTCGAAGCCACGCCTCTTCC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTDKNALIQPDRGQQAIALHLVDKATLPDFLKGINAGQRASLVAQKFEGGGYEHAIVPDGDGWFAVAGVANVDDLSSWCM
ARLADVLPGGTYRRAGGEPGKALHGWITGQYRFDRYRKDATESEPRILLTKDVALIEPAIAEASAVLMVRDLVNTPAEDM
GPAQLEAEARALAKTWHAEVHVVSGDALERDYPMVHAVGRAAARSHAPRLIELEWGDPKHPRVAIVGKGVCFDSGGLDIK
PSSGMALMKKDMGGAAHALALAGLVMAMGLKVRLHVLLPAVENAISGHAFRPGDILRGRNGLSVEVTNTDAEGRLVLGDA
LVRASEMKPELVIDFATLTGAARVALGPDLPAMFARKDETANGLLVAGIERDDPCWRLPLFEGYREYLKSDVADLQNSPA
NGFAGASVAALFLDRFVGEGIDWAHFDTFAWRPAAKPGRPKGGDALGLRAAWGLLKARYG

Sequences:

>Translated_460_residues
MTDKNALIQPDRGQQAIALHLVDKATLPDFLKGINAGQRASLVAQKFEGGGYEHAIVPDGDGWFAVAGVANVDDLSSWCM
ARLADVLPGGTYRRAGGEPGKALHGWITGQYRFDRYRKDATESEPRILLTKDVALIEPAIAEASAVLMVRDLVNTPAEDM
GPAQLEAEARALAKTWHAEVHVVSGDALERDYPMVHAVGRAAARSHAPRLIELEWGDPKHPRVAIVGKGVCFDSGGLDIK
PSSGMALMKKDMGGAAHALALAGLVMAMGLKVRLHVLLPAVENAISGHAFRPGDILRGRNGLSVEVTNTDAEGRLVLGDA
LVRASEMKPELVIDFATLTGAARVALGPDLPAMFARKDETANGLLVAGIERDDPCWRLPLFEGYREYLKSDVADLQNSPA
NGFAGASVAALFLDRFVGEGIDWAHFDTFAWRPAAKPGRPKGGDALGLRAAWGLLKARYG
>Mature_459_residues
TDKNALIQPDRGQQAIALHLVDKATLPDFLKGINAGQRASLVAQKFEGGGYEHAIVPDGDGWFAVAGVANVDDLSSWCMA
RLADVLPGGTYRRAGGEPGKALHGWITGQYRFDRYRKDATESEPRILLTKDVALIEPAIAEASAVLMVRDLVNTPAEDMG
PAQLEAEARALAKTWHAEVHVVSGDALERDYPMVHAVGRAAARSHAPRLIELEWGDPKHPRVAIVGKGVCFDSGGLDIKP
SSGMALMKKDMGGAAHALALAGLVMAMGLKVRLHVLLPAVENAISGHAFRPGDILRGRNGLSVEVTNTDAEGRLVLGDAL
VRASEMKPELVIDFATLTGAARVALGPDLPAMFARKDETANGLLVAGIERDDPCWRLPLFEGYREYLKSDVADLQNSPAN
GFAGASVAALFLDRFVGEGIDWAHFDTFAWRPAAKPGRPKGGDALGLRAAWGLLKARYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=338, Percent_Identity=35.5029585798817, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI47155554, Length=313, Percent_Identity=31.3099041533546, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=44.0625, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1790710, Length=347, Percent_Identity=37.1757925072046, Blast_Score=181, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=287, Percent_Identity=36.2369337979094, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17565172, Length=218, Percent_Identity=29.8165137614679, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221379063, Length=340, Percent_Identity=33.8235294117647, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221379062, Length=340, Percent_Identity=33.8235294117647, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357381, Length=340, Percent_Identity=33.8235294117647, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24661038, Length=335, Percent_Identity=30.4477611940298, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24662227, Length=295, Percent_Identity=30.1694915254237, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21355725, Length=292, Percent_Identity=30.4794520547945, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129969, Length=297, Percent_Identity=30.3030303030303, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21355645, Length=336, Percent_Identity=26.7857142857143, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662223, Length=336, Percent_Identity=26.7857142857143, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129963, Length=333, Percent_Identity=27.6276276276276, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161077148, Length=290, Percent_Identity=28.6206896551724, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130057, Length=290, Percent_Identity=28.6206896551724, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19922386, Length=353, Percent_Identity=27.4787535410765, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646701, Length=371, Percent_Identity=29.3800539083558, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646703, Length=371, Percent_Identity=29.3800539083558, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358201, Length=371, Percent_Identity=29.3800539083558, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49134; Mature: 49003

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKNALIQPDRGQQAIALHLVDKATLPDFLKGINAGQRASLVAQKFEGGGYEHAIVPDG
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECC
DGWFAVAGVANVDDLSSWCMARLADVLPGGTYRRAGGEPGKALHGWITGQYRFDRYRKDA
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCHHHHHHCCC
TESEPRILLTKDVALIEPAIAEASAVLMVRDLVNTPAEDMGPAQLEAEARALAKTWHAEV
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCEE
HVVSGDALERDYPMVHAVGRAAARSHAPRLIELEWGDPKHPRVAIVGKGVCFDSGGLDIK
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCEEECCCCCEEC
PSSGMALMKKDMGGAAHALALAGLVMAMGLKVRLHVLLPAVENAISGHAFRPGDILRGRN
CCCCCEEHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCHHHCCCC
GLSVEVTNTDAEGRLVLGDALVRASEMKPELVIDFATLTGAARVALGPDLPAMFARKDET
CCEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEEEEHHCCCEEEEECCCCHHHHHCCCCC
ANGLLVAGIERDDPCWRLPLFEGYREYLKSDVADLQNSPANGFAGASVAALFLDRFVGEG
CCCEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
IDWAHFDTFAWRPAAKPGRPKGGDALGLRAAWGLLKARYG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDKNALIQPDRGQQAIALHLVDKATLPDFLKGINAGQRASLVAQKFEGGGYEHAIVPDG
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECC
DGWFAVAGVANVDDLSSWCMARLADVLPGGTYRRAGGEPGKALHGWITGQYRFDRYRKDA
CCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCHHHHHHCCC
TESEPRILLTKDVALIEPAIAEASAVLMVRDLVNTPAEDMGPAQLEAEARALAKTWHAEV
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCEE
HVVSGDALERDYPMVHAVGRAAARSHAPRLIELEWGDPKHPRVAIVGKGVCFDSGGLDIK
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCEEECCCCCEEC
PSSGMALMKKDMGGAAHALALAGLVMAMGLKVRLHVLLPAVENAISGHAFRPGDILRGRN
CCCCCEEHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCHHHCCCC
GLSVEVTNTDAEGRLVLGDALVRASEMKPELVIDFATLTGAARVALGPDLPAMFARKDET
CCEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEEEEHHCCCEEEEECCCCHHHHHCCCCC
ANGLLVAGIERDDPCWRLPLFEGYREYLKSDVADLQNSPANGFAGASVAALFLDRFVGEG
CCCEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
IDWAHFDTFAWRPAAKPGRPKGGDALGLRAAWGLLKARYG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA