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The map label for this gene is pdhB [H]

Identifier: 87199067

GI number: 87199067

Start: 1083306

End: 1085522

Strand: Direct

Name: pdhB [H]

Synonym: Saro_1045

Alternate gene names: 87199067

Gene position: 1083306-1085522 (Clockwise)

Preceding gene: 87199066

Following gene: 87199068

Centisome position: 30.42

GC content: 66.67

Gene sequence:

>2217_bases
ATGTCGCTTGATGCCGCCGAGCAGGTCCACCGGCAGTTCCTTGATGCGCTGGACAAGGGAACCGCACGACGGCGTTCCAA
CCTTGGGCTGAAGGATGTGGGGCTGGCGCCGGAGAGGGCGGCAGCGCTGTTCCGGTCGCAAGCGCTGTCGCGCCAGCTTG
ACCGGCTCAGCCGCAAATTGCAGGCGCGGGGCGAGGGGTTCTATACGATCGGATCGTCGGGCCACGAGGGCAATGCAGTG
CTGGCCGAAGTGCTGCGCATGGATGACATGGCGTTCCTTCACTATCGCGACGCCGCGTTCCAGATCCACCGCGCCCACCG
CGTGCCGGGCGAGAATCCGGCGTGGGACATGCTGCTGAGCTTCACGGCCAGCATGGAGGACCCGATTTCGGGCGGGCGCC
ACAAGGTGCTGGGATCCAAGCGGCTGTTCATTCCGCCGCAGACGTCGACCATCGCCAGCCACTTGCCCAAGGCGGTGGGC
GCGGCCTTTTCCATCGGCATCGCGCGCAGGATGGGATTCGACGACACCGTGCTGTCGAAGGACGGGGTCGTGCTGTGCAG
CTTCGGCGATGCTAGCGCGAACCATTCGACCGCGCTGGGCGCGATCAACACTGCGTGCTGGGCGGCGTTTCAGGGCACGC
CAATGCCGATCATCTTCCTGTGCGAGGACAACGGCATCGGCATCTCCACACGCACGCCGCCGGGATGGATCGAGGCGAAC
TTCTCGGGCAGGGCGGGGCTGAACTACATTCCCTGCGACGGATCGGACCTTGTCGATACCTGCGCGGCCGCAAGACAGGC
ACTGGAGATCGCGAGGCGGCAGCGAAAGCCGGTGTTCCTGCACATGAAGACGGTGCGGCTCTACGGCCACGCGGGCAATG
ACGTGCAGCTTGCCTATCGCAGCAAGGAGGAGATCCGAGCCGAGGAAGAGCGCGATCCGCTGCTGGCGAGCGCGGCCTTG
CTGATCGAGGAAGGCGTCATGTCGGCGGCGCAGGTGCGCGGCGTCTATGACGAGATCGAGGCCACGCTGGAACGGCAGGT
GGAGCTTGCCATCAAGCGCCCCAAGCTGCCCGACGCGGCGGCGGTGATGGCCAGCATCGTGCCCCCCAGGCGCGAAGGGG
CGGCGCGCCCTCAGGCTTCGGCGCACGAGCGTGCCGCGCTCTTTGCCGACGATGCCGCCGCGATGGACAAGCCGCAGCAT
ATGGCGAAGCTCATCAGTTGGGCCATGGCGGACCTGCTGTTGCAGTACCCCAACGCGATCGTCTGCGGCGAGGACGTGGG
GCCGAAGGGCGGGGTCTATGCCGCGACGCAAAAGCTGCACGCGCGGTTCGGATCGGCGCGGGTGATCAATACCCTCCTCG
ACGAGCAGGCAATTCTCGGGCTTGCCATCGGGGCTGCGCACAACGGGCTGCTGCCGATGCCCGAGATCCAGTTCCTTGCC
TATGTCCACAACGCCGAGGACCAGATCCGGGGCGAGGCGGCGACACTCTCGTTCTTTTCGAACGGGCAATACACCAACCC
GATGGTCGTGCGGATCGCGGGCCTGCCCTACCAGAAGGGGTTTGGCGGGCACTTCCACAACGACAACTCGCTGGCCGTCT
TCCGCGACATTCCGGGCGTGGTGCTGGCGGTGCCGTCGAACGGGCGCGATGCCGTGGCGATGCTGCGCGAATGCGTGAGG
CTGGCGCACGATGAAGGGCGCGTGGTCGTGTTCGTGGAGCCGATCGCGCTCTACATGACGCGCGACCTGCATGAGCCGGG
CGATGGCATGTGGTCGAGCGTCTACCAACCGCCGGGCGAGGGAGAGATCGCGTTTGGCGAGATCGGCGTTTTCGACTCTG
GGCGAGGCGAAGGCACCGACCTGGCCGTGGTGACCTATGGCAATGGCTTTTACCTTTCGCTCCAGGCGCAGAAGTTGCTG
TCAGAGCGCGGCGTTAACGTGCGGGTGATCGATCTGCGCTGGCTGGGGCCGGTGAACGAGGCGGCGGTGCTCGATGCGGT
CGCGCCGTGTTCGCGCGTGCTGGTGGTGGACGAATGCCGGATCACCGGGGGGCAGAACGAGGCGCTGATGGCCCTGCTGG
CCGAGCGAGCGCCGGGCAAGGCCATCGCGCGGATGGCGGCGACCGACAGCTTCATCCCGCTCGCGCGCGCGGCAACGCAT
ACGCTGCCGAGCCGGGACGGGATCGTGGTCAAGGTGCTGGAGATGGTGCGTGGCTAA

Upstream 100 bases:

>100_bases
AGAGCAGCCGGGCGCGGCTCCGCTTCCGCCGGTGGAGATCGTGGACTTGCGATAGGCGGGCGGCTATCAGGCTGGTTCGT
TACGAGGGAAACCATCCGCA

Downstream 100 bases:

>100_bases
GGAAACCGTTCTGGTCGTCTGCCCCGGGCGCGGGACCTACAACGCGCCCGAGCTTGGCTATCTGGCGCGGCATCATGCAG
GGTCGGAGTGGCTCGCGCGG

Product: branched-chain alpha-keto acid dehydrogenase E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 737

Protein sequence:

>738_residues
MSLDAAEQVHRQFLDALDKGTARRRSNLGLKDVGLAPERAAALFRSQALSRQLDRLSRKLQARGEGFYTIGSSGHEGNAV
LAEVLRMDDMAFLHYRDAAFQIHRAHRVPGENPAWDMLLSFTASMEDPISGGRHKVLGSKRLFIPPQTSTIASHLPKAVG
AAFSIGIARRMGFDDTVLSKDGVVLCSFGDASANHSTALGAINTACWAAFQGTPMPIIFLCEDNGIGISTRTPPGWIEAN
FSGRAGLNYIPCDGSDLVDTCAAARQALEIARRQRKPVFLHMKTVRLYGHAGNDVQLAYRSKEEIRAEEERDPLLASAAL
LIEEGVMSAAQVRGVYDEIEATLERQVELAIKRPKLPDAAAVMASIVPPRREGAARPQASAHERAALFADDAAAMDKPQH
MAKLISWAMADLLLQYPNAIVCGEDVGPKGGVYAATQKLHARFGSARVINTLLDEQAILGLAIGAAHNGLLPMPEIQFLA
YVHNAEDQIRGEAATLSFFSNGQYTNPMVVRIAGLPYQKGFGGHFHNDNSLAVFRDIPGVVLAVPSNGRDAVAMLRECVR
LAHDEGRVVVFVEPIALYMTRDLHEPGDGMWSSVYQPPGEGEIAFGEIGVFDSGRGEGTDLAVVTYGNGFYLSLQAQKLL
SERGVNVRVIDLRWLGPVNEAAVLDAVAPCSRVLVVDECRITGGQNEALMALLAERAPGKAIARMAATDSFIPLARAATH
TLPSRDGIVVKVLEMVRG

Sequences:

>Translated_738_residues
MSLDAAEQVHRQFLDALDKGTARRRSNLGLKDVGLAPERAAALFRSQALSRQLDRLSRKLQARGEGFYTIGSSGHEGNAV
LAEVLRMDDMAFLHYRDAAFQIHRAHRVPGENPAWDMLLSFTASMEDPISGGRHKVLGSKRLFIPPQTSTIASHLPKAVG
AAFSIGIARRMGFDDTVLSKDGVVLCSFGDASANHSTALGAINTACWAAFQGTPMPIIFLCEDNGIGISTRTPPGWIEAN
FSGRAGLNYIPCDGSDLVDTCAAARQALEIARRQRKPVFLHMKTVRLYGHAGNDVQLAYRSKEEIRAEEERDPLLASAAL
LIEEGVMSAAQVRGVYDEIEATLERQVELAIKRPKLPDAAAVMASIVPPRREGAARPQASAHERAALFADDAAAMDKPQH
MAKLISWAMADLLLQYPNAIVCGEDVGPKGGVYAATQKLHARFGSARVINTLLDEQAILGLAIGAAHNGLLPMPEIQFLA
YVHNAEDQIRGEAATLSFFSNGQYTNPMVVRIAGLPYQKGFGGHFHNDNSLAVFRDIPGVVLAVPSNGRDAVAMLRECVR
LAHDEGRVVVFVEPIALYMTRDLHEPGDGMWSSVYQPPGEGEIAFGEIGVFDSGRGEGTDLAVVTYGNGFYLSLQAQKLL
SERGVNVRVIDLRWLGPVNEAAVLDAVAPCSRVLVVDECRITGGQNEALMALLAERAPGKAIARMAATDSFIPLARAATH
TLPSRDGIVVKVLEMVRG
>Mature_737_residues
SLDAAEQVHRQFLDALDKGTARRRSNLGLKDVGLAPERAAALFRSQALSRQLDRLSRKLQARGEGFYTIGSSGHEGNAVL
AEVLRMDDMAFLHYRDAAFQIHRAHRVPGENPAWDMLLSFTASMEDPISGGRHKVLGSKRLFIPPQTSTIASHLPKAVGA
AFSIGIARRMGFDDTVLSKDGVVLCSFGDASANHSTALGAINTACWAAFQGTPMPIIFLCEDNGIGISTRTPPGWIEANF
SGRAGLNYIPCDGSDLVDTCAAARQALEIARRQRKPVFLHMKTVRLYGHAGNDVQLAYRSKEEIRAEEERDPLLASAALL
IEEGVMSAAQVRGVYDEIEATLERQVELAIKRPKLPDAAAVMASIVPPRREGAARPQASAHERAALFADDAAAMDKPQHM
AKLISWAMADLLLQYPNAIVCGEDVGPKGGVYAATQKLHARFGSARVINTLLDEQAILGLAIGAAHNGLLPMPEIQFLAY
VHNAEDQIRGEAATLSFFSNGQYTNPMVVRIAGLPYQKGFGGHFHNDNSLAVFRDIPGVVLAVPSNGRDAVAMLRECVRL
AHDEGRVVVFVEPIALYMTRDLHEPGDGMWSSVYQPPGEGEIAFGEIGVFDSGRGEGTDLAVVTYGNGFYLSLQAQKLLS
ERGVNVRVIDLRWLGPVNEAAVLDAVAPCSRVLVVDECRITGGQNEALMALLAERAPGKAIARMAATDSFIPLARAATHT
LPSRDGIVVKVLEMVRG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=28.3950617283951, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=28.3950617283951, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI11386135, Length=331, Percent_Identity=25.3776435045317, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI258645172, Length=339, Percent_Identity=25.0737463126844, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI156564403, Length=278, Percent_Identity=24.8201438848921, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4505685, Length=183, Percent_Identity=26.775956284153, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI291084744, Length=183, Percent_Identity=26.775956284153, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI291084742, Length=183, Percent_Identity=26.775956284153, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI4885543, Length=180, Percent_Identity=25, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI291084858, Length=273, Percent_Identity=23.4432234432234, Blast_Score=73, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17506935, Length=301, Percent_Identity=30.8970099667774, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=332, Percent_Identity=25.3012048192771, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI86563355, Length=332, Percent_Identity=25.3012048192771, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538422, Length=279, Percent_Identity=27.2401433691756, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536047, Length=343, Percent_Identity=23.0320699708455, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32564172, Length=343, Percent_Identity=23.0320699708455, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=342, Percent_Identity=27.7777777777778, Blast_Score=104, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=201, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=28.9230769230769, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=29.4478527607362, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355903, Length=333, Percent_Identity=24.3243243243243, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358145, Length=374, Percent_Identity=24.5989304812834, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24650940, Length=374, Percent_Identity=24.5989304812834, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24639744, Length=369, Percent_Identity=24.9322493224932, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571106, Length=369, Percent_Identity=24.9322493224932, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639740, Length=369, Percent_Identity=24.9322493224932, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24639748, Length=205, Percent_Identity=27.8048780487805, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639746, Length=183, Percent_Identity=28.9617486338798, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 79642; Mature: 79511

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDAAEQVHRQFLDALDKGTARRRSNLGLKDVGLAPERAAALFRSQALSRQLDRLSRKL
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QARGEGFYTIGSSGHEGNAVLAEVLRMDDMAFLHYRDAAFQIHRAHRVPGENPAWDMLLS
HHCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
FTASMEDPISGGRHKVLGSKRLFIPPQTSTIASHLPKAVGAAFSIGIARRMGFDDTVLSK
HHHCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
DGVVLCSFGDASANHSTALGAINTACWAAFQGTPMPIIFLCEDNGIGISTRTPPGWIEAN
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCEEEEC
FSGRAGLNYIPCDGSDLVDTCAAARQALEIARRQRKPVFLHMKTVRLYGHAGNDVQLAYR
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEEEEC
SKEEIRAEEERDPLLASAALLIEEGVMSAAQVRGVYDEIEATLERQVELAIKRPKLPDAA
CHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AVMASIVPPRREGAARPQASAHERAALFADDAAAMDKPQHMAKLISWAMADLLLQYPNAI
HHHHHCCCCCCCCCCCCCCCCHHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHCCCEE
VCGEDVGPKGGVYAATQKLHARFGSARVINTLLDEQAILGLAIGAAHNGLLPMPEIQFLA
EECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHH
YVHNAEDQIRGEAATLSFFSNGQYTNPMVVRIAGLPYQKGFGGHFHNDNSLAVFRDIPGV
EECCCHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
VLAVPSNGRDAVAMLRECVRLAHDEGRVVVFVEPIALYMTRDLHEPGDGMWSSVYQPPGE
EEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHCCCCCC
GEIAFGEIGVFDSGRGEGTDLAVVTYGNGFYLSLQAQKLLSERGVNVRVIDLRWLGPVNE
CCEEEEEEEEEECCCCCCCEEEEEEECCCEEEEEEHHHHHHHCCCEEEEEEEEECCCCCH
AAVLDAVAPCSRVLVVDECRITGGQNEALMALLAERAPGKAIARMAATDSFIPLARAATH
HHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHH
TLPSRDGIVVKVLEMVRG
CCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SLDAAEQVHRQFLDALDKGTARRRSNLGLKDVGLAPERAAALFRSQALSRQLDRLSRKL
CCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QARGEGFYTIGSSGHEGNAVLAEVLRMDDMAFLHYRDAAFQIHRAHRVPGENPAWDMLLS
HHCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCHHHHHHH
FTASMEDPISGGRHKVLGSKRLFIPPQTSTIASHLPKAVGAAFSIGIARRMGFDDTVLSK
HHHCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
DGVVLCSFGDASANHSTALGAINTACWAAFQGTPMPIIFLCEDNGIGISTRTPPGWIEAN
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCEEEEC
FSGRAGLNYIPCDGSDLVDTCAAARQALEIARRQRKPVFLHMKTVRLYGHAGNDVQLAYR
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCEEEEEC
SKEEIRAEEERDPLLASAALLIEEGVMSAAQVRGVYDEIEATLERQVELAIKRPKLPDAA
CHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
AVMASIVPPRREGAARPQASAHERAALFADDAAAMDKPQHMAKLISWAMADLLLQYPNAI
HHHHHCCCCCCCCCCCCCCCCHHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHCCCEE
VCGEDVGPKGGVYAATQKLHARFGSARVINTLLDEQAILGLAIGAAHNGLLPMPEIQFLA
EECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHH
YVHNAEDQIRGEAATLSFFSNGQYTNPMVVRIAGLPYQKGFGGHFHNDNSLAVFRDIPGV
EECCCHHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
VLAVPSNGRDAVAMLRECVRLAHDEGRVVVFVEPIALYMTRDLHEPGDGMWSSVYQPPGE
EEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCHHHHHCCCCCC
GEIAFGEIGVFDSGRGEGTDLAVVTYGNGFYLSLQAQKLLSERGVNVRVIDLRWLGPVNE
CCEEEEEEEEEECCCCCCCEEEEEEECCCEEEEEEHHHHHHHCCCEEEEEEEEECCCCCH
AAVLDAVAPCSRVLVVDECRITGGQNEALMALLAERAPGKAIARMAATDSFIPLARAATH
HHHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHH
TLPSRDGIVVKVLEMVRG
CCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]