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The map label for this gene is hisE

Identifier: 87199033

GI number: 87199033

Start: 1053185

End: 1053508

Strand: Direct

Name: hisE

Synonym: Saro_1011

Alternate gene names: 87199033

Gene position: 1053185-1053508 (Clockwise)

Preceding gene: 87199032

Following gene: 87199034

Centisome position: 29.57

GC content: 66.36

Gene sequence:

>324_bases
ATGGAACACGGTGAAATCCTCGCCCGGCTCGAAGCCACGATCGCAGAACGTCGCCTCGGCGATCCGTCGGCCAGCTACGT
CGCCAAGCTGAACGCCAAGGGGCTGGCCAAGATCGCGCAGAAGGTCGGGGAAGAGGGCACCGAGACCGTCATTGCCGCGC
TGGCCGGGGACCGCAAGGAACTGGTCGGCGAAGCGGCGGACCTCATCTTCCACCTGATGGTGCTGTTGTCGGCCAAGGAC
GTGCCGTTCGCCGAAGTCCTGGCCGAACTCGCGCGCCGCGAAGGCACCTCGGGCATCGCCGAGAAAGCCAGCCGGAGCAA
CTGA

Upstream 100 bases:

>100_bases
TCGGCAAGCTGGACCCTGAAACAAGTTCAGGATGACGGTTGAGCAAGAGTTCCCCTGTTACCCTTGACCGCCCCCCTCCA
TCCGCGCCATTGCGCTTGCC

Downstream 100 bases:

>100_bases
CATGGCCGTTGACGCTACCCTGCCTTATGACGACCAGAACATCTTTGCGAGGATCCTGCGCGGCGAGATCCCCAATCGCA
CGGTCTATGAAGACGATTTC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MEHGEILARLEATIAERRLGDPSASYVAKLNAKGLAKIAQKVGEEGTETVIAALAGDRKELVGEAADLIFHLMVLLSAKD
VPFAEVLAELARREGTSGIAEKASRSN

Sequences:

>Translated_107_residues
MEHGEILARLEATIAERRLGDPSASYVAKLNAKGLAKIAQKVGEEGTETVIAALAGDRKELVGEAADLIFHLMVLLSAKD
VPFAEVLAELARREGTSGIAEKASRSN
>Mature_107_residues
MEHGEILARLEATIAERRLGDPSASYVAKLNAKGLAKIAQKVGEEGTETVIAALAGDRKELVGEAADLIFHLMVLLSAKD
VPFAEVLAELARREGTSGIAEKASRSN

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=50, Blast_Score=89, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_NOVAD (Q2G9L7)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496290.1
- ProteinModelPortal:   Q2G9L7
- SMR:   Q2G9L7
- STRING:   Q2G9L7
- GeneID:   3915793
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1011
- NMPDR:   fig|48935.1.peg.3115
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   NARO279238:SARO_1011-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11327; Mature: 11327

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHGEILARLEATIAERRLGDPSASYVAKLNAKGLAKIAQKVGEEGTETVIAALAGDRKE
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LVGEAADLIFHLMVLLSAKDVPFAEVLAELARREGTSGIAEKASRSN
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MEHGEILARLEATIAERRLGDPSASYVAKLNAKGLAKIAQKVGEEGTETVIAALAGDRKE
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LVGEAADLIFHLMVLLSAKDVPFAEVLAELARREGTSGIAEKASRSN
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA