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The map label for this gene is ndk

Identifier: 87198916

GI number: 87198916

Start: 950467

End: 950889

Strand: Direct

Name: ndk

Synonym: Saro_0894

Alternate gene names: 87198916

Gene position: 950467-950889 (Clockwise)

Preceding gene: 87198914

Following gene: 87198917

Centisome position: 26.69

GC content: 62.41

Gene sequence:

>423_bases
ATGGCGGTTACCCGCACCTTCTCGATCATCAAGCCCGATGCCACGCGCCGCAACCTGACGGGCGCTGTCACCAAGATGCT
GGAAGAGGCCGGCCTGCGCGTCGTCGCTTCCAAGCGCATCCACATGAGCCGCGAGCAGGCCGAAGGCTTCTACGCGGTCC
ACAAGGAACGCCCCTTCTTCGGCGAACTCGTCGAATTCATGATCTCGGGCCCGGTGGTCGTGCAGGTTCTCGAAGGCGAG
GACGCCGTGAAGCGCAACCGCGACATCATGGGCGCCACCAACCCCAAGGACGCCGCTCCGGGCACCATCCGCAAGGAACT
GGCTGAATCGATCGAGGCCAACTCGGTCCACGGTTCGGACAGCGAAGAGAACGCAGCGATCGAAATTGCCTACTTCTTCA
AGCCGGAAGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
GTTTGGTCCGCCATGCGTGGACCCACCAACCTTGCACCGCAGCACAAACCGGGCTAGGGGCGCGCGCAACCAAATTCCCA
CATATCGCAAGGAACGTCCC

Downstream 100 bases:

>100_bases
TCAGGCTTTCAGCCTGACACGATCAAAGGGCCGGGGCGGAAGCGCTCCGGCCATTTTGCGTTGGGGGGCACGCGCCAGGC
TGCGCCTTTCCTGCCAAGCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAVTRTFSIIKPDATRRNLTGAVTKMLEEAGLRVVASKRIHMSREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGE
DAVKRNRDIMGATNPKDAAPGTIRKELAESIEANSVHGSDSEENAAIEIAYFFKPEEIVG

Sequences:

>Translated_140_residues
MAVTRTFSIIKPDATRRNLTGAVTKMLEEAGLRVVASKRIHMSREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGE
DAVKRNRDIMGATNPKDAAPGTIRKELAESIEANSVHGSDSEENAAIEIAYFFKPEEIVG
>Mature_139_residues
AVTRTFSIIKPDATRRNLTGAVTKMLEEAGLRVVASKRIHMSREQAEGFYAVHKERPFFGELVEFMISGPVVVQVLEGED
AVKRNRDIMGATNPKDAAPGTIRKELAESIEANSVHGSDSEENAAIEIAYFFKPEEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.1851851851852, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI66392203, Length=135, Percent_Identity=47.4074074074074, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI66392227, Length=135, Percent_Identity=47.4074074074074, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI66392205, Length=135, Percent_Identity=47.4074074074074, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI4505409, Length=135, Percent_Identity=47.4074074074074, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI66392192, Length=135, Percent_Identity=47.4074074074074, Blast_Score=127, Evalue=2e-30,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=45.9259259259259, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=45.9259259259259, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.037037037037, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI37574614, Length=137, Percent_Identity=32.1167883211679, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7019465, Length=137, Percent_Identity=32.1167883211679, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=35.2941176470588, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=32.8467153284672, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI148839372, Length=136, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI4505413, Length=140, Percent_Identity=29.2857142857143, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=55.3956834532374, Blast_Score=165, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=46.2686567164179, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=42.962962962963, Blast_Score=118, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=45.1851851851852, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=32.8358208955224, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_NOVAD (Q2G9Y4)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496173.1
- ProteinModelPortal:   Q2G9Y4
- SMR:   Q2G9Y4
- STRING:   Q2G9Y4
- GeneID:   3917980
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0894
- NMPDR:   fig|48935.1.peg.1562
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q2G9Y4
- ProtClustDB:   PRK00668
- BioCyc:   NARO279238:SARO_0894-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15421; Mature: 15290

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTRTFSIIKPDATRRNLTGAVTKMLEEAGLRVVASKRIHMSREQAEGFYAVHKERPFF
CCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHCHHHCCCEEEEECCCCCH
GELVEFMISGPVVVQVLEGEDAVKRNRDIMGATNPKDAAPGTIRKELAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
SEENAAIEIAYFFKPEEIVG
CCCCCEEEEEEEECCHHHCC
>Mature Secondary Structure 
AVTRTFSIIKPDATRRNLTGAVTKMLEEAGLRVVASKRIHMSREQAEGFYAVHKERPFF
CCCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHCHHHCCCEEEEECCCCCH
GELVEFMISGPVVVQVLEGEDAVKRNRDIMGATNPKDAAPGTIRKELAESIEANSVHGSD
HHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
SEENAAIEIAYFFKPEEIVG
CCCCCEEEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA