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The map label for this gene is mmsB [H]

Identifier: 87198883

GI number: 87198883

Start: 911487

End: 912356

Strand: Direct

Name: mmsB [H]

Synonym: Saro_0861

Alternate gene names: 87198883

Gene position: 911487-912356 (Clockwise)

Preceding gene: 87198882

Following gene: 87198885

Centisome position: 25.59

GC content: 65.98

Gene sequence:

>870_bases
ATGAAAATCGCATTCATCGGCCTCGGCAACATGGGCGGCGGCATGGCCGCGAACCTCGTCAAGGCAGGCCACGACGTCCA
CGCCTTCGACCTTGCCGAAGCGGCCCTCGAACGAGCCAGGGAAAACGGCTGCACCACCTACACTTCGGTCAAGGAAGCCG
TGCAGGGTGCCGATGCCGTCGTCTCGATGCTGCCCAACGGCGCCATCGTGAAGTCGGTCTATGCCGCCGACGTGATCGGC
CAGGCCCCGACCTCGGCGCTCCTTCTCGATTGCTCGACCATCGACGTCGCCACCGCGCGCGAAGTCGCCTCGGCAGCCGA
TACGGCGGGCTATGTCATGGTCGATGCTCCCGTTTCGGGCGGCATCGCGGCTGCCAACGGCGGCACGCTGACCTTCATGG
TCGGCGGTAGCGACGAGGCTTTCGCCCGTGCCGAGCCGATCCTTGCCGCGATGGGCAAGGCGGTGATCCACGCCGGTGCC
AGCGGTGCGGGGCAGGCGGCCAAGATCTGCAATAACATGCTGCTCGGCGCCTCGATGGTGGCCACCTGCGAGACCTTCGC
CATGGCGGAGAAGCTTGGGCTCGATCTTCAGACCTTCTACGACATCTCGTCCAAGGCTTCGGGCCAGTGCTGGTCGATGA
CGTCGTACTGCCCGGTCCCCGGTGTCGGCCCGCAGAGCCCCGCCGACAACGGCTACCAGGGTGGCTTTGCCACCGCGCTG
ATGCTGAAGGACCTCAAGCTTGCGATGGCGGCTGCCCAGGATGCCGGAGCGCAGGTTCCGATGGGCGCGCGTGCGGAAGA
GCTTTACGAAGCCTTCGCCAACGCCGGCAACGCCGGGCTGGATTTCTCGGCGATCATCAAGTCGCTCTAG

Upstream 100 bases:

>100_bases
CGCCGCGTGTTCCAGATCCTCACCGCCAGCGAGGACAAGGCCGAAGGCATGAAGGCCTTCATCGAAAAGCGCCCCGGCGT
GTGGAAGGGACGTTAAGCCC

Downstream 100 bases:

>100_bases
AATGGCGTTCCGTTGCGCCCCCGCCCAATGCGGGGCGCAACGGCAGGTCAGCGCATCTTCGCGGCGATGATGCGGCCAAT
GGGGTCGTCGGCCAGTTTCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKIAFIGLGNMGGGMAANLVKAGHDVHAFDLAEAALERARENGCTTYTSVKEAVQGADAVVSMLPNGAIVKSVYAADVIG
QAPTSALLLDCSTIDVATAREVASAADTAGYVMVDAPVSGGIAAANGGTLTFMVGGSDEAFARAEPILAAMGKAVIHAGA
SGAGQAAKICNNMLLGASMVATCETFAMAEKLGLDLQTFYDISSKASGQCWSMTSYCPVPGVGPQSPADNGYQGGFATAL
MLKDLKLAMAAAQDAGAQVPMGARAEELYEAFANAGNAGLDFSAIIKSL

Sequences:

>Translated_289_residues
MKIAFIGLGNMGGGMAANLVKAGHDVHAFDLAEAALERARENGCTTYTSVKEAVQGADAVVSMLPNGAIVKSVYAADVIG
QAPTSALLLDCSTIDVATAREVASAADTAGYVMVDAPVSGGIAAANGGTLTFMVGGSDEAFARAEPILAAMGKAVIHAGA
SGAGQAAKICNNMLLGASMVATCETFAMAEKLGLDLQTFYDISSKASGQCWSMTSYCPVPGVGPQSPADNGYQGGFATAL
MLKDLKLAMAAAQDAGAQVPMGARAEELYEAFANAGNAGLDFSAIIKSL
>Mature_289_residues
MKIAFIGLGNMGGGMAANLVKAGHDVHAFDLAEAALERARENGCTTYTSVKEAVQGADAVVSMLPNGAIVKSVYAADVIG
QAPTSALLLDCSTIDVATAREVASAADTAGYVMVDAPVSGGIAAANGGTLTFMVGGSDEAFARAEPILAAMGKAVIHAGA
SGAGQAAKICNNMLLGASMVATCETFAMAEKLGLDLQTFYDISSKASGQCWSMTSYCPVPGVGPQSPADNGYQGGFATAL
MLKDLKLAMAAAQDAGAQVPMGARAEELYEAFANAGNAGLDFSAIIKSL

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=289, Percent_Identity=41.522491349481, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI40556376, Length=288, Percent_Identity=25.3472222222222, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=33.7931034482759, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=32.7526132404181, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786719, Length=291, Percent_Identity=29.2096219931272, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=31.8493150684932, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=272, Percent_Identity=43.0147058823529, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24655230, Length=283, Percent_Identity=39.9293286219081, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19922568, Length=283, Percent_Identity=39.9293286219081, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=46.875, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29062; Mature: 29062

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGLGNMGGGMAANLVKAGHDVHAFDLAEAALERARENGCTTYTSVKEAVQGADAV
CEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VSMLPNGAIVKSVYAADVIGQAPTSALLLDCSTIDVATAREVASAADTAGYVMVDAPVSG
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCC
GIAAANGGTLTFMVGGSDEAFARAEPILAAMGKAVIHAGASGAGQAAKICNNMLLGASMV
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ATCETFAMAEKLGLDLQTFYDISSKASGQCWSMTSYCPVPGVGPQSPADNGYQGGFATAL
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
MLKDLKLAMAAAQDAGAQVPMGARAEELYEAFANAGNAGLDFSAIIKSL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MKIAFIGLGNMGGGMAANLVKAGHDVHAFDLAEAALERARENGCTTYTSVKEAVQGADAV
CEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VSMLPNGAIVKSVYAADVIGQAPTSALLLDCSTIDVATAREVASAADTAGYVMVDAPVSG
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCC
GIAAANGGTLTFMVGGSDEAFARAEPILAAMGKAVIHAGASGAGQAAKICNNMLLGASMV
CEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ATCETFAMAEKLGLDLQTFYDISSKASGQCWSMTSYCPVPGVGPQSPADNGYQGGFATAL
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
MLKDLKLAMAAAQDAGAQVPMGARAEELYEAFANAGNAGLDFSAIIKSL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]