Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 87198830

GI number: 87198830

Start: 859691

End: 861217

Strand: Direct

Name: pccB [H]

Synonym: Saro_0808

Alternate gene names: 87198830

Gene position: 859691-861217 (Clockwise)

Preceding gene: 87198828

Following gene: 87198831

Centisome position: 24.14

GC content: 63.92

Gene sequence:

>1527_bases
ATGTCCGCCAATATTGCCGAGATGGAAAAGCGCCGGGAAGCCGCGCGACTGGGTGGCGGGCAGAAGCGCATCGATGCGCA
GCACGCCAAGGGCAAGCTGACCGCGCGCGAACGCCTCGAAGTACTGCTTGACGAAGGCAGCTTCGAGGAAGTGGACATGT
ACGTCGAGCATAATTGCGTCGACTTCGGCATGCCCGACACGGTGATCCCTGGCGACGGCGTGGTGACGGGTTCGGGCACG
ATCAACGGCCGCCTGGTCTATGTGTTCAGCCAGGACTTCACCGTGTTCGGCGGCTCGCTTTCCGAGCGTCACGCGCAGAA
GATCTGCAAGATCATGGACATGGCGCTCAAGGTCGGGGCTCCGGTGATCGGGCTCAACGATTCGGGCGGCGCGCGCATCC
AGGAAGGCGTGGCATCGCTTGGCGGCTATGCCGAAGTGTTCCAGCGCAACGTGCTGGCATCGGGCGTGGTGCCGCAGCTT
TCGCTGATCATGGGGCCTTGCGCGGGCGGTGCGGTCTACAGCCCCGCGATGACCGACTTCATCTTCATGGTGAAGGACAG
CTCGTACATGTTCGTGACCGGGCCGGACGTGGTCAAGACGGTGACGAACGAGATCGTGACGCAGGAGGAACTGGGTGGCG
CGGTGACGCACACGACCAAGACCTCGGTCGCGGACCTTGCGCTCGAGAACGACATCGAGGCGCTTCTCGCCGCGCGCGAC
TTCTTCGATTACCTGCCGCTGTCGAACCGGCAGGAAGTGCCCGAGCGGCCGACTTCGGACCCATACGACCGTCTGGAGCC
GAGCCTCGACAGCATCGTGCCGGCTTCGGCGACGCAGCCCTATGACATGCACGAAGTGATCCGCAAGACGGTGGACGAAG
GCGAGTTCTTCGAGATCCAGCCCAAGCATGCGGGCAACATCATCTGCGGTTTCGGCCGCGTCGAAGGGCGTACCGTGGGC
GTGGTCGCCAACCAGCCGATGGTGCTGGCGGGCGTGCTCGACATCAATTCGTCGAAGAAGGCGGCGCGGTTCGTTCGCTT
CTGTGATGCGTTCAACATTCCGATCGTGACCTTCGTCGACGTTCCGGGCTTCCTTCCCGGCACCGCGCAGGAGCACAACG
GCATTATCAAGCACGGCGCGAAGCTGCTGTTCGCCTATGCCGAGGCGACCGTGCCGAAGATCACCGTGATCACCCGCAAG
GCCTATGGCGGCGCCTATGACGTGATGGCCTCGAAGCACCTGCGCGGCGACCTCAACTACGCCTGGCCCACCGCCGAGAT
CGCGGTGATGGGCGCGAAGGGCGCGGTCGAGATCATCTTCCGCGGGCTTTCGGCGGAAGAGCAGGCGGTGAAGACCAGGG
AATACGAGGACCGCTTCGCCAACCCGTTCGTGGCGGCGAGCAAGGGCTTCGTCGACGAGGTGATCCATCCGCACTCGACC
CGTCGCCGCGTGGCGCTCGGCCTGCGCAAGCTGCGCAACAAGAGCCTCGAGAATCCGTGGAAGAAGCACGACAACATTCC
GCTCTGA

Upstream 100 bases:

>100_bases
CAGATGCGGGCCCGGTTCCGGTCCGCACCCCGGGGAGGGGGAACGGGCCGGAGCCGGGCGCCAGTTTTTGGTCATCACCG
TTCAAGAGAGGGTGCGTAGA

Downstream 100 bases:

>100_bases
CGAGCGCTTCAGTCTGGAAGAACTGACATGACCGACATCTACATCGTCTCGGGCGCGCGTACCGCCATCGGCTCGTTCGG
CGGCGGGCTCGCTTCGCTGC

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSANIAEMEKRREAARLGGGQKRIDAQHAKGKLTARERLEVLLDEGSFEEVDMYVEHNCVDFGMPDTVIPGDGVVTGSGT
INGRLVYVFSQDFTVFGGSLSERHAQKICKIMDMALKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQL
SLIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEIVTQEELGGAVTHTTKTSVADLALENDIEALLAARD
FFDYLPLSNRQEVPERPTSDPYDRLEPSLDSIVPASATQPYDMHEVIRKTVDEGEFFEIQPKHAGNIICGFGRVEGRTVG
VVANQPMVLAGVLDINSSKKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRGLSAEEQAVKTREYEDRFANPFVAASKGFVDEVIHPHST
RRRVALGLRKLRNKSLENPWKKHDNIPL

Sequences:

>Translated_508_residues
MSANIAEMEKRREAARLGGGQKRIDAQHAKGKLTARERLEVLLDEGSFEEVDMYVEHNCVDFGMPDTVIPGDGVVTGSGT
INGRLVYVFSQDFTVFGGSLSERHAQKICKIMDMALKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQL
SLIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEIVTQEELGGAVTHTTKTSVADLALENDIEALLAARD
FFDYLPLSNRQEVPERPTSDPYDRLEPSLDSIVPASATQPYDMHEVIRKTVDEGEFFEIQPKHAGNIICGFGRVEGRTVG
VVANQPMVLAGVLDINSSKKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRK
AYGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRGLSAEEQAVKTREYEDRFANPFVAASKGFVDEVIHPHST
RRRVALGLRKLRNKSLENPWKKHDNIPL
>Mature_507_residues
SANIAEMEKRREAARLGGGQKRIDAQHAKGKLTARERLEVLLDEGSFEEVDMYVEHNCVDFGMPDTVIPGDGVVTGSGTI
NGRLVYVFSQDFTVFGGSLSERHAQKICKIMDMALKVGAPVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQLS
LIMGPCAGGAVYSPAMTDFIFMVKDSSYMFVTGPDVVKTVTNEIVTQEELGGAVTHTTKTSVADLALENDIEALLAARDF
FDYLPLSNRQEVPERPTSDPYDRLEPSLDSIVPASATQPYDMHEVIRKTVDEGEFFEIQPKHAGNIICGFGRVEGRTVGV
VANQPMVLAGVLDINSSKKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKA
YGGAYDVMASKHLRGDLNYAWPTAEIAVMGAKGAVEIIFRGLSAEEQAVKTREYEDRFANPFVAASKGFVDEVIHPHSTR
RRVALGLRKLRNKSLENPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=504, Percent_Identity=70.2380952380952, Blast_Score=734, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=523, Percent_Identity=67.6864244741874, Blast_Score=721, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=519, Percent_Identity=31.5992292870906, Blast_Score=224, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=66.9980119284294, Blast_Score=713, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=66.9980119284294, Blast_Score=711, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=530, Percent_Identity=31.3207547169811, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24586065, Length=513, Percent_Identity=32.943469785575, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55307; Mature: 55176

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANIAEMEKRREAARLGGGQKRIDAQHAKGKLTARERLEVLLDEGSFEEVDMYVEHNCV
CCCCHHHHHHHHHHHHCCCCHHHHCHHHHCCCCCHHHHHHHHHCCCCCHHHHEEEECCEE
DFGMPDTVIPGDGVVTGSGTINGRLVYVFSQDFTVFGGSLSERHAQKICKIMDMALKVGA
ECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQLSLIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPDVVKTVTNEIVTQEELGGAVTHTTKTSVADLALENDIEALLAARD
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHH
FFDYLPLSNRQEVPERPTSDPYDRLEPSLDSIVPASATQPYDMHEVIRKTVDEGEFFEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PKHAGNIICGFGRVEGRTVGVVANQPMVLAGVLDINSSKKAARFVRFCDAFNIPIVTFVD
CCCCCCEEEEECCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDLNY
CCCCCCCCCHHCCCHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGAVEIIFRGLSAEEQAVKTREYEDRFANPFVAASKGFVDEVIHPHST
CCCCEEEEEECCCCCEEHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHCCCCCH
RRRVALGLRKLRNKSLENPWKKHDNIPL
HHHHHHHHHHHHHCCCCCCHHHCCCCCC
>Mature Secondary Structure 
SANIAEMEKRREAARLGGGQKRIDAQHAKGKLTARERLEVLLDEGSFEEVDMYVEHNCV
CCCHHHHHHHHHHHHCCCCHHHHCHHHHCCCCCHHHHHHHHHCCCCCHHHHEEEECCEE
DFGMPDTVIPGDGVVTGSGTINGRLVYVFSQDFTVFGGSLSERHAQKICKIMDMALKVGA
ECCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCC
PVIGLNDSGGARIQEGVASLGGYAEVFQRNVLASGVVPQLSLIMGPCAGGAVYSPAMTDF
CEEEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHEE
IFMVKDSSYMFVTGPDVVKTVTNEIVTQEELGGAVTHTTKTSVADLALENDIEALLAARD
EEEEECCCEEEEECHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHH
FFDYLPLSNRQEVPERPTSDPYDRLEPSLDSIVPASATQPYDMHEVIRKTVDEGEFFEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PKHAGNIICGFGRVEGRTVGVVANQPMVLAGVLDINSSKKAARFVRFCDAFNIPIVTFVD
CCCCCCEEEEECCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEHNGIIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMASKHLRGDLNY
CCCCCCCCCHHCCCHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGAVEIIFRGLSAEEQAVKTREYEDRFANPFVAASKGFVDEVIHPHST
CCCCEEEEEECCCCCEEHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHHCCCCCH
RRRVALGLRKLRNKSLENPWKKHDNIPL
HHHHHHHHHHHHHCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]