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The map label for this gene is gltT [H]

Identifier: 87198507

GI number: 87198507

Start: 524457

End: 525746

Strand: Direct

Name: gltT [H]

Synonym: Saro_0482

Alternate gene names: 87198507

Gene position: 524457-525746 (Clockwise)

Preceding gene: 87198503

Following gene: 87198508

Centisome position: 14.73

GC content: 69.3

Gene sequence:

>1290_bases
ATGAAACAATCCGAACTTGCCACGAGCGACCAGGCGCCGGCCGCGCCGCCGATTTCCACGATCCGCGCCGGGTGGATCTT
TGCCGCGCTGGTGGGCGGGCTGGCGCTGGGCCTTGGACTGGCCTTCGCAGCGCCAGCCGCGCTGGAGTCGGTGCTGCTGG
TGGTGGAGCCCATCGGCAATCTCTGGTTGCAGGCCTTGCGTGGGACGATCGTTCCGCTGGTTGTCGCCCTGCTGTTTACC
GGCATCGTGCAGACGGTGGCGGCAGCGCGGGCTGGCGCCCTTGCGCGGCGGGCGCTGCTGTTCTTCGCGTCGGTGCTGGC
GGGCGGGTGCGCAATGGCCGCGGTGCTGGTGCCCGCGATGCTGGCCGCGTTCCCGATGCCCCAGGCGGCGGCGGATGCGC
TGCGACAGGGCGTAGCGCAGATTCACGACAAGGCGGACGTGCCGGGCTTTGCCGCGTTCCTCCAATCCATAGTGCCCGCC
AACGTGCTGCAATCGGCCGCGTCCGACCAGATCCTGCCGGTGATCCTGTTCACGTCGGTCTTCGCGCTGGCGGCGACGCG
GCTGACCGATGTGCAGCGCCGGACGCTTGCGACGTTCTTCGAGGCGACCGCCAATGCGATGCTGGTGGTGATCGGATGGG
TCCTGCTGGCCGCGCCGGTCGGCGTGTTCTGCCTTAGCCTTGCCGTCGCCGCGCATAGCGGCACGGCGGCGATCGGGGCG
CTGGCGCATTATGTGCTGGTGGTGACGGCGGCGGGTGTCGTTGTCTTTCTTGCGGCTTACGCCGTGGCCGTCGTGGCGGC
ACGGCAGCCTTTCGGGCGGTTCGCCCGCGCGATGTTGCCCGCACAGGCGCTGGCGCTTTCGACGCAATCGTCGCTGGCGA
CCTTGCCCGCGATGCTCGGCGTGTGCCGTACGCTTGGTGTGCGGGCGCAGACTGCCGATCTGGTACTGCCGCTGGCCGTC
GCCCTGTTCCGCGCGACGGGGCCGGCGATGAACCTCGCGGTGGCGATCTACGTGGCGCACTGGTTCGGGATGGAACTGAC
GCCCTCGATGCTCGTCGCGGGGTTTGCAGTCGCGACCCTGACCACGCTGGGCGCGGTCAGCCTGCCCGGGGCAATCAGCT
TCGTGACCTCCATCGGCCCCATTGCAATTGCGATGGGTGTCCCGGTCGAACCGCTGGCGCTGCTGGTTGCGGTCGAGGTC
TTGCCCGACCTCATGCGTACCTTGGGTAACGTGACCATGGACGTTGCCGTCACTGCGGCGGTCGACCGCGCCCACGGGCC
CGGCGAGTAG

Upstream 100 bases:

>100_bases
GCCATCGGTGCCGAAGAACTTGCGTGCCATGAAACGTCCCGTGCCTGTTTGCGCTGCAATGCGTTGCATTGCCCGCCTAC
ACCAATATTGTCACCAGCGC

Downstream 100 bases:

>100_bases
CGTTTACTGCAACTGCCTTTCCGAAAATTTCAACGCAAAATCAGTACGTAACGGCTCTATCTGGCGCAACCGGCGCGCGC
CTTGCGCGTTGGTATGCGAA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKQSELATSDQAPAAPPISTIRAGWIFAALVGGLALGLGLAFAAPAALESVLLVVEPIGNLWLQALRGTIVPLVVALLFT
GIVQTVAAARAGALARRALLFFASVLAGGCAMAAVLVPAMLAAFPMPQAAADALRQGVAQIHDKADVPGFAAFLQSIVPA
NVLQSAASDQILPVILFTSVFALAATRLTDVQRRTLATFFEATANAMLVVIGWVLLAAPVGVFCLSLAVAAHSGTAAIGA
LAHYVLVVTAAGVVVFLAAYAVAVVAARQPFGRFARAMLPAQALALSTQSSLATLPAMLGVCRTLGVRAQTADLVLPLAV
ALFRATGPAMNLAVAIYVAHWFGMELTPSMLVAGFAVATLTTLGAVSLPGAISFVTSIGPIAIAMGVPVEPLALLVAVEV
LPDLMRTLGNVTMDVAVTAAVDRAHGPGE

Sequences:

>Translated_429_residues
MKQSELATSDQAPAAPPISTIRAGWIFAALVGGLALGLGLAFAAPAALESVLLVVEPIGNLWLQALRGTIVPLVVALLFT
GIVQTVAAARAGALARRALLFFASVLAGGCAMAAVLVPAMLAAFPMPQAAADALRQGVAQIHDKADVPGFAAFLQSIVPA
NVLQSAASDQILPVILFTSVFALAATRLTDVQRRTLATFFEATANAMLVVIGWVLLAAPVGVFCLSLAVAAHSGTAAIGA
LAHYVLVVTAAGVVVFLAAYAVAVVAARQPFGRFARAMLPAQALALSTQSSLATLPAMLGVCRTLGVRAQTADLVLPLAV
ALFRATGPAMNLAVAIYVAHWFGMELTPSMLVAGFAVATLTTLGAVSLPGAISFVTSIGPIAIAMGVPVEPLALLVAVEV
LPDLMRTLGNVTMDVAVTAAVDRAHGPGE
>Mature_429_residues
MKQSELATSDQAPAAPPISTIRAGWIFAALVGGLALGLGLAFAAPAALESVLLVVEPIGNLWLQALRGTIVPLVVALLFT
GIVQTVAAARAGALARRALLFFASVLAGGCAMAAVLVPAMLAAFPMPQAAADALRQGVAQIHDKADVPGFAAFLQSIVPA
NVLQSAASDQILPVILFTSVFALAATRLTDVQRRTLATFFEATANAMLVVIGWVLLAAPVGVFCLSLAVAAHSGTAAIGA
LAHYVLVVTAAGVVVFLAAYAVAVVAARQPFGRFARAMLPAQALALSTQSSLATLPAMLGVCRTLGVRAQTADLVLPLAV
ALFRATGPAMNLAVAIYVAHWFGMELTPSMLVAGFAVATLTTLGAVSLPGAISFVTSIGPIAIAMGVPVEPLALLVAVEV
LPDLMRTLGNVTMDVAVTAAVDRAHGPGE

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=403, Percent_Identity=25.0620347394541, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4827012, Length=266, Percent_Identity=30.4511278195489, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI40254478, Length=252, Percent_Identity=30.952380952381, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790514, Length=394, Percent_Identity=26.6497461928934, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789947, Length=386, Percent_Identity=24.8704663212435, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71996953, Length=444, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=394, Percent_Identity=24.3654822335025, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71983099, Length=434, Percent_Identity=26.036866359447, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983106, Length=434, Percent_Identity=26.036866359447, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583025, Length=446, Percent_Identity=22.4215246636771, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17137668, Length=446, Percent_Identity=22.4215246636771, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583023, Length=446, Percent_Identity=22.4215246636771, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43526; Mature: 43526

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSELATSDQAPAAPPISTIRAGWIFAALVGGLALGLGLAFAAPAALESVLLVVEPIGN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWLQALRGTIVPLVVALLFTGIVQTVAAARAGALARRALLFFASVLAGGCAMAAVLVPAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAFPMPQAAADALRQGVAQIHDKADVPGFAAFLQSIVPANVLQSAASDQILPVILFTSV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FALAATRLTDVQRRTLATFFEATANAMLVVIGWVLLAAPVGVFCLSLAVAAHSGTAAIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LAHYVLVVTAAGVVVFLAAYAVAVVAARQPFGRFARAMLPAQALALSTQSSLATLPAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCRTLGVRAQTADLVLPLAVALFRATGPAMNLAVAIYVAHWFGMELTPSMLVAGFAVATL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TTLGAVSLPGAISFVTSIGPIAIAMGVPVEPLALLVAVEVLPDLMRTLGNVTMDVAVTAA
HHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VDRAHGPGE
HHCCCCCCC
>Mature Secondary Structure
MKQSELATSDQAPAAPPISTIRAGWIFAALVGGLALGLGLAFAAPAALESVLLVVEPIGN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LWLQALRGTIVPLVVALLFTGIVQTVAAARAGALARRALLFFASVLAGGCAMAAVLVPAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAFPMPQAAADALRQGVAQIHDKADVPGFAAFLQSIVPANVLQSAASDQILPVILFTSV
HHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FALAATRLTDVQRRTLATFFEATANAMLVVIGWVLLAAPVGVFCLSLAVAAHSGTAAIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LAHYVLVVTAAGVVVFLAAYAVAVVAARQPFGRFARAMLPAQALALSTQSSLATLPAMLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCRTLGVRAQTADLVLPLAVALFRATGPAMNLAVAIYVAHWFGMELTPSMLVAGFAVATL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TTLGAVSLPGAISFVTSIGPIAIAMGVPVEPLALLVAVEVLPDLMRTLGNVTMDVAVTAA
HHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VDRAHGPGE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]