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The map label for this gene is phoQ [H]

Identifier: 86751791

GI number: 86751791

Start: 5312621

End: 5313979

Strand: Reverse

Name: phoQ [H]

Synonym: RPB_4693

Alternate gene names: 86751791

Gene position: 5313979-5312621 (Counterclockwise)

Preceding gene: 86751792

Following gene: 86751790

Centisome position: 99.67

GC content: 73.73

Gene sequence:

>1359_bases
GTGACGCGACATTCGCTGCGGCTGCGGCTGATCGCCGGCGGCGCCGCGGCGATCCTGGTCGCGCTCAGCATCGCCGGCAT
CGCGCTCATCATCCTGTTCGAGCGTCACGTCACCCGCACCATCGCCGACGACCTCGACGTCTCGCTGAAGCAGTTGATCG
CCGGCGTCGAGGCCGGGCCGGACGGCCGCCTGGTGCTGGCGCGGTCGCCGACCGATCCGCGCTTCTCCGAGCCGCTGTCC
GGTCTGTACTGGCAGGTCGGCGACGACCACGACCGGCTGCTGCGGTCGCGCTCGCTGTGGGACGACCGGCTGAGCGTGCC
GATCGACCAGCCCGGCCCGGGCGAGATGCATCATCACGACATCGCCGGCCCCGCCGGCGCGCGGCTGTCGATCGTCGAGC
GCCAGGTGCTTCTCACCATCGCCGGCAAGCCGGTGCCGATCCGCGCCGCGGTCGCGGTCGATCTGGCCCGGGTCAGCGCC
GCCGGCCGGGCCTTCGCGCGCGATCTGATGATCGCGCTCGGTCTTCTCGGCGCGGTGCTGGCGCTCGCCACGTCGGTGCA
GGTGATGCTCGGGCTGCGACCGCTCGGTGCGTTGCGCGACGGCGTCGCCGAGATCCGCTCCGGCCGGCGGCATCGCCTGC
CCGACGCGGTGCCGGACGAGGTGCAGCCGCTGGTCGAGGAGGTCAACGCGCTGCTCGACGCCCAGGCGCGCGAGATCGCC
CGCTCGCGCGACCGCGCCGCCGATCTTGCCCATGGCCTGAAGACGCCACTCGCAGCTTTGGCCGCCGACGCCGCGCGGCT
GCGCGAGCGCGGCGAGGACAAGCTCGCCCGCGACATCGAGGCGGTCGGCAGCGCGATGAGCCGCCATGTCGATCGCGAGC
TGGCGCGCGCCCGGCTGCGCGGCGACGCCCGCCGCGGCGAAAGCGTCACCGTCGATCTGGCGCCGCTGGTGCGCTCGCTG
GTGACGATCCAGTCGCGCACCCCGGCCGGCCGGCGCATCGCGTTCGACGCGCAGATCGCCGACTACGTCTCGGTGCCGCT
CGACCGCGCCGATCTGGCCGAGGTGCTCGGCAATCTGCTCGACAACGCGGTGCGCCACGCCCGCAGTCGCGTCCGCATCG
GCACCGCCTGCGATTCGGACGGCTTCCGCATCGCGATCGAGGACGACGGCGACGGCCTCGACGAGGCCGCTTGCGCCACG
GTGCTCGGACGCGGCATCCGCCTCGACCAGCGCGGCGAAGGCGCCGGCCTCGGCCTCGCCATCGTGCAGGACGTGCTCGA
GGCCTATGGCTGGACGCTGCATCTGTCCCGCTCCGACCTCGGCGGCCTGAAAGCGAGCTGCTGCACGGCGGTGGCGTAG

Upstream 100 bases:

>100_bases
ACGCCATCGAGGTGCTGGTCGGCCGTGTCCGCAAGAAGCTCGGCCCCGAGCTGATCGAGACCAGGCGCGGCTTCGGCTAC
ATCGTGCCCGGGGACGGCAC

Downstream 100 bases:

>100_bases
TTGGTCGGACGTCTCGACGCTGCGCAGCGATGCGTCTCTCGTTCGTCATGCGCGGGCTTGACCCGCGCATCCATCGCGCG
CAAAGCGCGCCGAATAAAGC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTRHSLRLRLIAGGAAAILVALSIAGIALIILFERHVTRTIADDLDVSLKQLIAGVEAGPDGRLVLARSPTDPRFSEPLS
GLYWQVGDDHDRLLRSRSLWDDRLSVPIDQPGPGEMHHHDIAGPAGARLSIVERQVLLTIAGKPVPIRAAVAVDLARVSA
AGRAFARDLMIALGLLGAVLALATSVQVMLGLRPLGALRDGVAEIRSGRRHRLPDAVPDEVQPLVEEVNALLDAQAREIA
RSRDRAADLAHGLKTPLAALAADAARLRERGEDKLARDIEAVGSAMSRHVDRELARARLRGDARRGESVTVDLAPLVRSL
VTIQSRTPAGRRIAFDAQIADYVSVPLDRADLAEVLGNLLDNAVRHARSRVRIGTACDSDGFRIAIEDDGDGLDEAACAT
VLGRGIRLDQRGEGAGLGLAIVQDVLEAYGWTLHLSRSDLGGLKASCCTAVA

Sequences:

>Translated_452_residues
MTRHSLRLRLIAGGAAAILVALSIAGIALIILFERHVTRTIADDLDVSLKQLIAGVEAGPDGRLVLARSPTDPRFSEPLS
GLYWQVGDDHDRLLRSRSLWDDRLSVPIDQPGPGEMHHHDIAGPAGARLSIVERQVLLTIAGKPVPIRAAVAVDLARVSA
AGRAFARDLMIALGLLGAVLALATSVQVMLGLRPLGALRDGVAEIRSGRRHRLPDAVPDEVQPLVEEVNALLDAQAREIA
RSRDRAADLAHGLKTPLAALAADAARLRERGEDKLARDIEAVGSAMSRHVDRELARARLRGDARRGESVTVDLAPLVRSL
VTIQSRTPAGRRIAFDAQIADYVSVPLDRADLAEVLGNLLDNAVRHARSRVRIGTACDSDGFRIAIEDDGDGLDEAACAT
VLGRGIRLDQRGEGAGLGLAIVQDVLEAYGWTLHLSRSDLGGLKASCCTAVA
>Mature_451_residues
TRHSLRLRLIAGGAAAILVALSIAGIALIILFERHVTRTIADDLDVSLKQLIAGVEAGPDGRLVLARSPTDPRFSEPLSG
LYWQVGDDHDRLLRSRSLWDDRLSVPIDQPGPGEMHHHDIAGPAGARLSIVERQVLLTIAGKPVPIRAAVAVDLARVSAA
GRAFARDLMIALGLLGAVLALATSVQVMLGLRPLGALRDGVAEIRSGRRHRLPDAVPDEVQPLVEEVNALLDAQAREIAR
SRDRAADLAHGLKTPLAALAADAARLRERGEDKLARDIEAVGSAMSRHVDRELARARLRGDARRGESVTVDLAPLVRSLV
TIQSRTPAGRRIAFDAQIADYVSVPLDRADLAEVLGNLLDNAVRHARSRVRIGTACDSDGFRIAIEDDGDGLDEAACATV
LGRGIRLDQRGEGAGLGLAIVQDVLEAYGWTLHLSRSDLGGLKASCCTAVA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=323, Percent_Identity=28.4829721362229, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786783, Length=319, Percent_Identity=25.0783699059561, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788393, Length=267, Percent_Identity=23.9700374531835, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=257, Percent_Identity=28.4046692607004, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48177; Mature: 48046

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHSLRLRLIAGGAAAILVALSIAGIALIILFERHVTRTIADDLDVSLKQLIAGVEAGP
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGRLVLARSPTDPRFSEPLSGLYWQVGDDHDRLLRSRSLWDDRLSVPIDQPGPGEMHHHD
CCCEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
IAGPAGARLSIVERQVLLTIAGKPVPIRAAVAVDLARVSAAGRAFARDLMIALGLLGAVL
CCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSVQVMLGLRPLGALRDGVAEIRSGRRHRLPDAVPDEVQPLVEEVNALLDAQAREIA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSRDRAADLAHGLKTPLAALAADAARLRERGEDKLARDIEAVGSAMSRHVDRELARARLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDARRGESVTVDLAPLVRSLVTIQSRTPAGRRIAFDAQIADYVSVPLDRADLAEVLGNLL
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHH
DNAVRHARSRVRIGTACDSDGFRIAIEDDGDGLDEAACATVLGRGIRLDQRGEGAGLGLA
HHHHHHHHHHEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
IVQDVLEAYGWTLHLSRSDLGGLKASCCTAVA
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TRHSLRLRLIAGGAAAILVALSIAGIALIILFERHVTRTIADDLDVSLKQLIAGVEAGP
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGRLVLARSPTDPRFSEPLSGLYWQVGDDHDRLLRSRSLWDDRLSVPIDQPGPGEMHHHD
CCCEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
IAGPAGARLSIVERQVLLTIAGKPVPIRAAVAVDLARVSAAGRAFARDLMIALGLLGAVL
CCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATSVQVMLGLRPLGALRDGVAEIRSGRRHRLPDAVPDEVQPLVEEVNALLDAQAREIA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSRDRAADLAHGLKTPLAALAADAARLRERGEDKLARDIEAVGSAMSRHVDRELARARLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDARRGESVTVDLAPLVRSLVTIQSRTPAGRRIAFDAQIADYVSVPLDRADLAEVLGNLL
CCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHHHH
DNAVRHARSRVRIGTACDSDGFRIAIEDDGDGLDEAACATVLGRGIRLDQRGEGAGLGLA
HHHHHHHHHHEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHH
IVQDVLEAYGWTLHLSRSDLGGLKASCCTAVA
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA