Click here to switch to the map view.

The map label for this gene is dcp [H]

Identifier: 86751643

GI number: 86751643

Start: 5139349

End: 5141433

Strand: Reverse

Name: dcp [H]

Synonym: RPB_4545

Alternate gene names: 86751643

Gene position: 5141433-5139349 (Counterclockwise)

Preceding gene: 86751651

Following gene: 86751642

Centisome position: 96.43

GC content: 68.3

Gene sequence:

>2085_bases
ATGTCTGAAAGCTCCGGACCGATTGCCGCGCCCACGGGCAATCCGCTGTTGCAGGCCTGGACCACGCCGTTCGAAACCCC
GCCCTTCACCGAGATCGTGCCCGAGCATTTCCTGCCGGCGTTCGAGCGGGCGTTCACCGACCATGCCGCCGAGATCGCCG
CGATCGCCAACGATCCGACCGAGCCGGACTTCGCCAACACCATCACGGCGCTGGAGCGCTCCGGCAAGCTGCTCAACCGG
GTCGCCGCGGTGTTCTACGACCTGGTCTCGGCGCACTCCAATCCGGCGCTGCTGGAGATCGACAAGGACGTGTCGCTGCG
GATGGCGCGACACTGGAATCCGATCATGATGAACGCCGTGCTGTTCGGCCGCATCGCGGCGCTGCACGACAAGCGCGCCG
AGCTGAAGCTGACCTCGGAAGAGCGTCGCCTGCTGGAGCGCACCTACACCCGCTTCCACCGCTCCGGCGCCGGCCTCGAC
GAGGCCGCGAAGGCGCGGATGGCCGAGATCAACGAGCGGCTGGCGCAGCTCGGCACCAACTTCAGCCACCATCTGCTCGG
CGACGAGCAGGACTGGTTCATGGAGATCGGCGAGGGCGATACCGAGGGGCTGCCGGACAGCTTCGTCGCCGCCGCGCGCG
CTGCGGCGGACGAGCGTGGCCTGCCCGGCAAGGCGGTGGTGACGCTGTCGCGCTCCTCGGTCGAGCCGTTCCTGAAGATG
TCCGGCCGCCGCGATCTGCGCGAGAAGGTCTACCGCGCCTTCATCGCCCGCGGCGACAACGGCAACGCCAACGACAACAA
CGCGCTGATCGGCGAGATCCTCGGCCTGCGCGAGGAGAGCGCCAAGCTGCTCGGCTATCCGACCTTCGCGGCCTACCGGC
TGGAGGATTCGATGGCCAAGACGCCGGAAGCGGTGCGCGGCCTGCTGGAGCGGGTGTGGAAGCCGGCGCGCGCCCGCGCG
ATGGCCGACCGCGACGCGCTGCAGGAGCTGGTCACGGAGGAGGGCGGCAATTTCGAGCTGGCGCCGTGGGACTGGCGCTT
CTACGCCGAGAAGCTGCGCCAGCGCCGCGCCAATTTCGACGACGCCGCGATCAAGCCGTATCTGTCGCTCGACAACATGA
TCGTCGCGGCCTTCGACACCGCGACCCGGCTGTTCGGCGTCACGTTCGCCGAGCGCAAGGACGTGCCGGTGTGGCACCCG
GACGTCCGGGTCTGGGAAGTGAAGGATGCCGACGGCAGCCATCGCGGGCTGTTCTACGGCGATTACTATGCCCGGCCGTC
GAAGCGCTCCGGCGCCTGGATGACGTCGCTGCGCGACCAGCAGAAGCTCGACGGCGCGGTGGCGCCGCTGATCATCAATG
TCTGCAATTTTTCGAAGGGCGCCGACGGCGAACCGTCGCTGCTGTCGCCCGACGACGCCCGCACGCTGTTCCACGAATTC
GGCCACGGCCTGCACGGCATGATGTCGGACGTGACCTATCCGTCGCTGTCCGGCACCAGCGTGTTCACCGATTTCGTCGA
ACTGCCCTCGCAGCTCTACGAGCACTGGCAGGAGCGGCCCGAGGTGCTGCGGCGTTTCGCCCGGCACTACCAGACCGGCG
AGCCGCTGCCCGACGATCTGCTGCAGCGCTTCATCGCCGCGCGCAAATTCAACCAGGGCTTCGCCACGGTGGAATTCGTG
TCCTCGGCGCTGCTCGACCTCGAATTCCACACCCAGCCGGCCGCGAGCGTCGGCGATATCCGCGATTTCGAGCGCCGCGA
GCTCGACAAGATCGGCATGCCGGACGAGATCGCGCTGCGCCACCGGCCGACCCAGTTCGGCCACATCTTCTCCGGCGATC
ACTACGCCTCGGGCTATTACAGCTACATGTGGTCCGAAGTGATGGACGCCGACGCCTTCGGCGCCTTCGAGGAGGCCGGC
GACATCTTCGACCCCAAGGTGGCGAAGCGGCTGCGCGACGACATCTACGCCTCGGGCGGCTCACGCGATCCGGAGGAGGC
CTATATCGCCTTCCGCGGCCGTGCGCCGGAGCCCGACGCGCTGCTGCGCCGGCGCGGCCTGCTCGAAACCCCGGAGGCGG
CGTAG

Upstream 100 bases:

>100_bases
CGGGGTGAATAATCCGTGACCGGGCGGCGGTCGGGGCGCAAAAAAGCCCCACCCGGTGCTATATGTTCGCAATTCGCGAC
GCCCAACGCAGGAATTCTAG

Downstream 100 bases:

>100_bases
CGCCATGCTCGGCTTGCTTCGCCTAGCCGTCATTCGAACCGCGCTCGCGGCCGCGCTGACGCTGTCGGCAGGCGTCGCCG
CGGCCCACGCCCATCCGCAC

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MSESSGPIAAPTGNPLLQAWTTPFETPPFTEIVPEHFLPAFERAFTDHAAEIAAIANDPTEPDFANTITALERSGKLLNR
VAAVFYDLVSAHSNPALLEIDKDVSLRMARHWNPIMMNAVLFGRIAALHDKRAELKLTSEERRLLERTYTRFHRSGAGLD
EAAKARMAEINERLAQLGTNFSHHLLGDEQDWFMEIGEGDTEGLPDSFVAAARAAADERGLPGKAVVTLSRSSVEPFLKM
SGRRDLREKVYRAFIARGDNGNANDNNALIGEILGLREESAKLLGYPTFAAYRLEDSMAKTPEAVRGLLERVWKPARARA
MADRDALQELVTEEGGNFELAPWDWRFYAEKLRQRRANFDDAAIKPYLSLDNMIVAAFDTATRLFGVTFAERKDVPVWHP
DVRVWEVKDADGSHRGLFYGDYYARPSKRSGAWMTSLRDQQKLDGAVAPLIINVCNFSKGADGEPSLLSPDDARTLFHEF
GHGLHGMMSDVTYPSLSGTSVFTDFVELPSQLYEHWQERPEVLRRFARHYQTGEPLPDDLLQRFIAARKFNQGFATVEFV
SSALLDLEFHTQPAASVGDIRDFERRELDKIGMPDEIALRHRPTQFGHIFSGDHYASGYYSYMWSEVMDADAFGAFEEAG
DIFDPKVAKRLRDDIYASGGSRDPEEAYIAFRGRAPEPDALLRRRGLLETPEAA

Sequences:

>Translated_694_residues
MSESSGPIAAPTGNPLLQAWTTPFETPPFTEIVPEHFLPAFERAFTDHAAEIAAIANDPTEPDFANTITALERSGKLLNR
VAAVFYDLVSAHSNPALLEIDKDVSLRMARHWNPIMMNAVLFGRIAALHDKRAELKLTSEERRLLERTYTRFHRSGAGLD
EAAKARMAEINERLAQLGTNFSHHLLGDEQDWFMEIGEGDTEGLPDSFVAAARAAADERGLPGKAVVTLSRSSVEPFLKM
SGRRDLREKVYRAFIARGDNGNANDNNALIGEILGLREESAKLLGYPTFAAYRLEDSMAKTPEAVRGLLERVWKPARARA
MADRDALQELVTEEGGNFELAPWDWRFYAEKLRQRRANFDDAAIKPYLSLDNMIVAAFDTATRLFGVTFAERKDVPVWHP
DVRVWEVKDADGSHRGLFYGDYYARPSKRSGAWMTSLRDQQKLDGAVAPLIINVCNFSKGADGEPSLLSPDDARTLFHEF
GHGLHGMMSDVTYPSLSGTSVFTDFVELPSQLYEHWQERPEVLRRFARHYQTGEPLPDDLLQRFIAARKFNQGFATVEFV
SSALLDLEFHTQPAASVGDIRDFERRELDKIGMPDEIALRHRPTQFGHIFSGDHYASGYYSYMWSEVMDADAFGAFEEAG
DIFDPKVAKRLRDDIYASGGSRDPEEAYIAFRGRAPEPDALLRRRGLLETPEAA
>Mature_693_residues
SESSGPIAAPTGNPLLQAWTTPFETPPFTEIVPEHFLPAFERAFTDHAAEIAAIANDPTEPDFANTITALERSGKLLNRV
AAVFYDLVSAHSNPALLEIDKDVSLRMARHWNPIMMNAVLFGRIAALHDKRAELKLTSEERRLLERTYTRFHRSGAGLDE
AAKARMAEINERLAQLGTNFSHHLLGDEQDWFMEIGEGDTEGLPDSFVAAARAAADERGLPGKAVVTLSRSSVEPFLKMS
GRRDLREKVYRAFIARGDNGNANDNNALIGEILGLREESAKLLGYPTFAAYRLEDSMAKTPEAVRGLLERVWKPARARAM
ADRDALQELVTEEGGNFELAPWDWRFYAEKLRQRRANFDDAAIKPYLSLDNMIVAAFDTATRLFGVTFAERKDVPVWHPD
VRVWEVKDADGSHRGLFYGDYYARPSKRSGAWMTSLRDQQKLDGAVAPLIINVCNFSKGADGEPSLLSPDDARTLFHEFG
HGLHGMMSDVTYPSLSGTSVFTDFVELPSQLYEHWQERPEVLRRFARHYQTGEPLPDDLLQRFIAARKFNQGFATVEFVS
SALLDLEFHTQPAASVGDIRDFERRELDKIGMPDEIALRHRPTQFGHIFSGDHYASGYYSYMWSEVMDADAFGAFEEAGD
IFDPKVAKRLRDDIYASGGSRDPEEAYIAFRGRAPEPDALLRRRGLLETPEAA

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=611, Percent_Identity=31.0965630114566, Blast_Score=255, Evalue=1e-67,
Organism=Homo sapiens, GI14149738, Length=594, Percent_Identity=30.8080808080808, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI156105687, Length=657, Percent_Identity=27.0928462709285, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1787819, Length=681, Percent_Identity=40.8223201174743, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1789913, Length=683, Percent_Identity=34.8462664714495, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI32565901, Length=566, Percent_Identity=22.6148409893993, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71999758, Length=470, Percent_Identity=21.4893617021277, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319793, Length=624, Percent_Identity=29.4871794871795, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6322715, Length=688, Percent_Identity=24.7093023255814, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356111, Length=738, Percent_Identity=24.7967479674797, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20129717, Length=554, Percent_Identity=26.173285198556, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 77855; Mature: 77724

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSGPIAAPTGNPLLQAWTTPFETPPFTEIVPEHFLPAFERAFTDHAAEIAAIANDPT
CCCCCCCEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EPDFANTITALERSGKLLNRVAAVFYDLVSAHSNPALLEIDKDVSLRMARHWNPIMMNAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCHHHHHHH
LFGRIAALHDKRAELKLTSEERRLLERTYTRFHRSGAGLDEAAKARMAEINERLAQLGTN
HHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
FSHHLLGDEQDWFMEIGEGDTEGLPDSFVAAARAAADERGLPGKAVVTLSRSSVEPFLKM
CHHHHCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHH
SGRRDLREKVYRAFIARGDNGNANDNNALIGEILGLREESAKLLGYPTFAAYRLEDSMAK
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHC
TPEAVRGLLERVWKPARARAMADRDALQELVTEEGGNFELAPWDWRFYAEKLRQRRANFD
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCC
DAAIKPYLSLDNMIVAAFDTATRLFGVTFAERKDVPVWHPDVRVWEVKDADGSHRGLFYG
CHHHCCHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
DYYARPSKRSGAWMTSLRDQQKLDGAVAPLIINVCNFSKGADGEPSLLSPDDARTLFHEF
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
GHGLHGMMSDVTYPSLSGTSVFTDFVELPSQLYEHWQERPEVLRRFARHYQTGEPLPDDL
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQRFIAARKFNQGFATVEFVSSALLDLEFHTQPAASVGDIRDFERRELDKIGMPDEIALR
HHHHHHHHHHCCCHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHC
HRPTQFGHIFSGDHYASGYYSYMWSEVMDADAFGAFEEAGDIFDPKVAKRLRDDIYASGG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCC
SRDPEEAYIAFRGRAPEPDALLRRRGLLETPEAA
CCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SESSGPIAAPTGNPLLQAWTTPFETPPFTEIVPEHFLPAFERAFTDHAAEIAAIANDPT
CCCCCCEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EPDFANTITALERSGKLLNRVAAVFYDLVSAHSNPALLEIDKDVSLRMARHWNPIMMNAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCHHHHHHH
LFGRIAALHDKRAELKLTSEERRLLERTYTRFHRSGAGLDEAAKARMAEINERLAQLGTN
HHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
FSHHLLGDEQDWFMEIGEGDTEGLPDSFVAAARAAADERGLPGKAVVTLSRSSVEPFLKM
CHHHHCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHH
SGRRDLREKVYRAFIARGDNGNANDNNALIGEILGLREESAKLLGYPTFAAYRLEDSMAK
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHC
TPEAVRGLLERVWKPARARAMADRDALQELVTEEGGNFELAPWDWRFYAEKLRQRRANFD
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCC
DAAIKPYLSLDNMIVAAFDTATRLFGVTFAERKDVPVWHPDVRVWEVKDADGSHRGLFYG
CHHHCCHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
DYYARPSKRSGAWMTSLRDQQKLDGAVAPLIINVCNFSKGADGEPSLLSPDDARTLFHEF
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
GHGLHGMMSDVTYPSLSGTSVFTDFVELPSQLYEHWQERPEVLRRFARHYQTGEPLPDDL
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LQRFIAARKFNQGFATVEFVSSALLDLEFHTQPAASVGDIRDFERRELDKIGMPDEIALR
HHHHHHHHHHCCCHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHC
HRPTQFGHIFSGDHYASGYYSYMWSEVMDADAFGAFEEAGDIFDPKVAKRLRDDIYASGG
CCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCC
SRDPEEAYIAFRGRAPEPDALLRRRGLLETPEAA
CCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]