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The map label for this gene is pleC [H]

Identifier: 86750547

GI number: 86750547

Start: 3935569

End: 3937884

Strand: Direct

Name: pleC [H]

Synonym: RPB_3436

Alternate gene names: 86750547

Gene position: 3935569-3937884 (Clockwise)

Preceding gene: 86750546

Following gene: 86750549

Centisome position: 73.82

GC content: 65.11

Gene sequence:

>2316_bases
ATGGCGCGCGTGCAGGGCGCGAGCGCCTGCGCTCAATCCGATTCGATCAAAGGATTGGCGCAGTCGATCGCTAAACCGGC
CTACCATCGACTGTTGACGGCCGAGCCTGTGCTCCGCCGCGCCGTCCCGATCCTCATCATCGCCTTCCTCATCACGATCT
GCTTCGGCGCCGCCGTGCAGTTCATCGATCAGAGCCGGCAGAAGCGCGCTGCGCTCAATCGCGATCTCTGCGCCCTCGCC
GATCTGCTCGCCGAGCGGCTCGAACATATCGGCGTCGTGCGGCTCGATCGTCCGGCTTCGATCGAACGCCTGCAGAATTT
GCTACCAGGCCTGATCCCGTCCTGGGGCATCGCCGCCGGGCGCCACGTCATCGTCACCAGCGCCGATCAGCGCGTCCTGG
CGCGCGTACCCGGCGACGAAGGCACCAGCGCCGCCAGCAGTTTCCTCGACATCATCAGCGCCACCCCGCCGCTGACACGG
TCCGCGCAGCAAGGCACCATCACCCAGATCATCCTGCCGAGCGGCGCCTCGGCGCTGGCGACGTTGCACACCGTCAAGTC
GCTGCCCGGCCAAGTCATCGTCATTCACGAAGACACCGGGTCGATCCTGCGTTCCGATGCGGCGCTGCAGATCACGCTGT
CGGCTACCACCGGCTTCGTCGTGCTGATCCTCGGCTTCGCCTTTCACTGGCAGTCGACCCGCGCCCAGGAGGGCGACCTC
ATCAACGATGCCGTGCGCAGCCGGATCGACACCGCGCTCAATCGCGGTCGCTGCGGGCTGTGGGACTGGGACCTGTCGCG
CGGCCGGATCTTCTGGTCGCAATCGATGTTCACTTTGCTCGGCCTGGAGAGTCGCAACGACCTCCTGACCTTCGGCGAGG
TCAACGCGCTGGTGAACAGCGACGACATCGACCTGTTCGCGATCGGCGACCAGTTGATCGCCGGCAACACCGATCACATC
GACCACAGCTTCCGGATGCGCCACGCCAACGGCCACTGGATCTGGCTGCGGATGCGCTGCGAACTCAGCCAGGAAACCCA
ATCCGACAACAAGCACCTGATCGGCATCGCGGTCGACGTCACCGAGCAGAAGAGCCTCGCCGAGCGCACCGTCGAAGCCG
ATCTGCGGCTGCGCGACGCGATCGAGACCATCCCCGAGGCCTTCGTACTGTGGGACGCCGACAATCGCCTGGTGCTGTGC
AATTCGCACTTCCAGCGGCTGCACAAGCTGCCCGACATCGCGGTCGCGCCCGGCACCTCCTACGAGACGGTGATCGAGGT
CGGACAGATGCCCGAGATCCGCACCCGTCTCTGCGACAACAGCGGAGGATCGTCCCCCGGCGCGCGGACCTTCGAGGCCC
AGCTCGCCGACGGCAGCTGGCTGCACATCAGCGAACGCCGCACCAAGGACGGCGGCTACGTCGCGGTCGGCACCGACATC
ACCCGGATCAAGGCTCACGAACAGAAGCTCGTCGACAACGACCTGCGGCTGCGCGCCACCGTCGCCGACCTCAAGATCTC
GCAATACAAGCTGGAGCGTCAGGCGATCGAACTCGCCGATCTGGCGCGGAAATATTCCGAGGAGAAGACCCGCGCCGAGG
AAGCCAATCAGACCAAATCCAAATTCCTCGCCAATATGAGCCACGAGCTGCGCACGCCGCTCAACGCCATCATCGGTTTT
TCCGAGATCATGGGCAGCGGCATGTTCGGCACGCTGGGCTCGGAGAAGTATCAGGAATACTGCCACGACATCATGACCAG
CGGGCACTATCTGCTGGAAGTGATCAACGACATTCTCGACATGTCGAAGATCGAGGCAGGTCGGATGCGGCTCGACATGG
AGGAGCTCGATCTCGCTCGCACCCTCGGCGAATCCCTCAAGGTCGTCGCCGGCCGCGCCGAGCACAAGCAGCTCGAACTG
CTCTCGGAGATCGAGGACGACATTCCGATCGTGGCGGACCGCCGGGCGGTCAAGCAGATCCTGATCAATTTGTTGTCCAA
CGCCGTGAAATTCACCCCCGACGGCGGACGGGTCACGGTCCGCAGCCGGACGCTGCCGAACGCCATCGTGTTGATGATCG
CCGATTCCGGCATCGGCATCGCGCCGCAATCGCTGCGCCGTCTCGGCCAGCCGTTCGAGCAGGTCGAGAGCCAGCTCAGC
AAGACCTATCATGGCTCCGGCCTGGGTCTGGCGATCGCCAAATCGCTCACCACGCTGCACGGCGGCTCGATGCGGCTGCG
CTCCACGCTCGGCGCCGGCACGGTGGTGATGGTGACGCTGCCGCGCGACTGCCAGCGCCGCCGGCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CTCGACAGCCCGACAAAAGTGGATTCAAATCAGCTCGTGATTCGAATGGCGAAACGTCGTTCGAACGGGGTGCTGACGGA
CATTTGGTGGGGACCACGGT

Downstream 100 bases:

>100_bases
TCGGTGCGCAGGCCGGCTTCAGCCGACGCTCAGTCGATTTGATGCGATGAAGACGGCACCGCCCGCGACCAGCGCGGGCG
TTTTTTTTCGAACCTTCGAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MARVQGASACAQSDSIKGLAQSIAKPAYHRLLTAEPVLRRAVPILIIAFLITICFGAAVQFIDQSRQKRAALNRDLCALA
DLLAERLEHIGVVRLDRPASIERLQNLLPGLIPSWGIAAGRHVIVTSADQRVLARVPGDEGTSAASSFLDIISATPPLTR
SAQQGTITQIILPSGASALATLHTVKSLPGQVIVIHEDTGSILRSDAALQITLSATTGFVVLILGFAFHWQSTRAQEGDL
INDAVRSRIDTALNRGRCGLWDWDLSRGRIFWSQSMFTLLGLESRNDLLTFGEVNALVNSDDIDLFAIGDQLIAGNTDHI
DHSFRMRHANGHWIWLRMRCELSQETQSDNKHLIGIAVDVTEQKSLAERTVEADLRLRDAIETIPEAFVLWDADNRLVLC
NSHFQRLHKLPDIAVAPGTSYETVIEVGQMPEIRTRLCDNSGGSSPGARTFEAQLADGSWLHISERRTKDGGYVAVGTDI
TRIKAHEQKLVDNDLRLRATVADLKISQYKLERQAIELADLARKYSEEKTRAEEANQTKSKFLANMSHELRTPLNAIIGF
SEIMGSGMFGTLGSEKYQEYCHDIMTSGHYLLEVINDILDMSKIEAGRMRLDMEELDLARTLGESLKVVAGRAEHKQLEL
LSEIEDDIPIVADRRAVKQILINLLSNAVKFTPDGGRVTVRSRTLPNAIVLMIADSGIGIAPQSLRRLGQPFEQVESQLS
KTYHGSGLGLAIAKSLTTLHGGSMRLRSTLGAGTVVMVTLPRDCQRRRLAA

Sequences:

>Translated_771_residues
MARVQGASACAQSDSIKGLAQSIAKPAYHRLLTAEPVLRRAVPILIIAFLITICFGAAVQFIDQSRQKRAALNRDLCALA
DLLAERLEHIGVVRLDRPASIERLQNLLPGLIPSWGIAAGRHVIVTSADQRVLARVPGDEGTSAASSFLDIISATPPLTR
SAQQGTITQIILPSGASALATLHTVKSLPGQVIVIHEDTGSILRSDAALQITLSATTGFVVLILGFAFHWQSTRAQEGDL
INDAVRSRIDTALNRGRCGLWDWDLSRGRIFWSQSMFTLLGLESRNDLLTFGEVNALVNSDDIDLFAIGDQLIAGNTDHI
DHSFRMRHANGHWIWLRMRCELSQETQSDNKHLIGIAVDVTEQKSLAERTVEADLRLRDAIETIPEAFVLWDADNRLVLC
NSHFQRLHKLPDIAVAPGTSYETVIEVGQMPEIRTRLCDNSGGSSPGARTFEAQLADGSWLHISERRTKDGGYVAVGTDI
TRIKAHEQKLVDNDLRLRATVADLKISQYKLERQAIELADLARKYSEEKTRAEEANQTKSKFLANMSHELRTPLNAIIGF
SEIMGSGMFGTLGSEKYQEYCHDIMTSGHYLLEVINDILDMSKIEAGRMRLDMEELDLARTLGESLKVVAGRAEHKQLEL
LSEIEDDIPIVADRRAVKQILINLLSNAVKFTPDGGRVTVRSRTLPNAIVLMIADSGIGIAPQSLRRLGQPFEQVESQLS
KTYHGSGLGLAIAKSLTTLHGGSMRLRSTLGAGTVVMVTLPRDCQRRRLAA
>Mature_770_residues
ARVQGASACAQSDSIKGLAQSIAKPAYHRLLTAEPVLRRAVPILIIAFLITICFGAAVQFIDQSRQKRAALNRDLCALAD
LLAERLEHIGVVRLDRPASIERLQNLLPGLIPSWGIAAGRHVIVTSADQRVLARVPGDEGTSAASSFLDIISATPPLTRS
AQQGTITQIILPSGASALATLHTVKSLPGQVIVIHEDTGSILRSDAALQITLSATTGFVVLILGFAFHWQSTRAQEGDLI
NDAVRSRIDTALNRGRCGLWDWDLSRGRIFWSQSMFTLLGLESRNDLLTFGEVNALVNSDDIDLFAIGDQLIAGNTDHID
HSFRMRHANGHWIWLRMRCELSQETQSDNKHLIGIAVDVTEQKSLAERTVEADLRLRDAIETIPEAFVLWDADNRLVLCN
SHFQRLHKLPDIAVAPGTSYETVIEVGQMPEIRTRLCDNSGGSSPGARTFEAQLADGSWLHISERRTKDGGYVAVGTDIT
RIKAHEQKLVDNDLRLRATVADLKISQYKLERQAIELADLARKYSEEKTRAEEANQTKSKFLANMSHELRTPLNAIIGFS
EIMGSGMFGTLGSEKYQEYCHDIMTSGHYLLEVINDILDMSKIEAGRMRLDMEELDLARTLGESLKVVAGRAEHKQLELL
SEIEDDIPIVADRRAVKQILINLLSNAVKFTPDGGRVTVRSRTLPNAIVLMIADSGIGIAPQSLRRLGQPFEQVESQLSK
TYHGSGLGLAIAKSLTTLHGGSMRLRSTLGAGTVVMVTLPRDCQRRRLAA

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=38.9312977099237, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=36.9477911646586, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI145693157, Length=264, Percent_Identity=32.9545454545455, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=34.1085271317829, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=34.9137931034483, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=31.063829787234, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=28.8, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=27.6679841897233, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=28.6885245901639, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=26.2948207171315, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=252, Percent_Identity=25, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1789808, Length=257, Percent_Identity=27.6264591439689, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=246, Percent_Identity=24.7967479674797, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=24.6636771300448, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=23.5294117647059, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=25.2212389380531, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84722; Mature: 84591

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVQGASACAQSDSIKGLAQSIAKPAYHRLLTAEPVLRRAVPILIIAFLITICFGAAVQ
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIDQSRQKRAALNRDLCALADLLAERLEHIGVVRLDRPASIERLQNLLPGLIPSWGIAAG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCCCCCCCC
RHVIVTSADQRVLARVPGDEGTSAASSFLDIISATPPLTRSAQQGTITQIILPSGASALA
CEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHH
TLHTVKSLPGQVIVIHEDTGSILRSDAALQITLSATTGFVVLILGFAFHWQSTRAQEGDL
HHHHHHHCCCCEEEEECCCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCH
INDAVRSRIDTALNRGRCGLWDWDLSRGRIFWSQSMFTLLGLESRNDLLTFGEVNALVNS
HHHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCHHHHHHCCCCCCCEEEEECHHHEECC
DDIDLFAIGDQLIAGNTDHIDHSFRMRHANGHWIWLRMRCELSQETQSDNKHLIGIAVDV
CCEEEEEECCEEECCCCCCCCCCEEEEECCCCEEEEEEEECCCHHCCCCCCEEEEEEEEC
TEQKSLAERTVEADLRLRDAIETIPEAFVLWDADNRLVLCNSHFQRLHKLPDIAVAPGTS
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECHHHHHHHCCCCEEECCCCC
YETVIEVGQMPEIRTRLCDNSGGSSPGARTFEAQLADGSWLHISERRTKDGGYVAVGTDI
HHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCH
TRIKAHEQKLVDNDLRLRATVADLKISQYKLERQAIELADLARKYSEEKTRAEEANQTKS
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLANMSHELRTPLNAIIGFSEIMGSGMFGTLGSEKYQEYCHDIMTSGHYLLEVINDILD
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
MSKIEAGRMRLDMEELDLARTLGESLKVVAGRAEHKQLELLSEIEDDIPIVADRRAVKQI
HHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECHHHHHHH
LINLLSNAVKFTPDGGRVTVRSRTLPNAIVLMIADSGIGIAPQSLRRLGQPFEQVESQLS
HHHHHHHHEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHH
KTYHGSGLGLAIAKSLTTLHGGSMRLRSTLGAGTVVMVTLPRDCQRRRLAA
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECCCHHHHHCCCC
>Mature Secondary Structure 
ARVQGASACAQSDSIKGLAQSIAKPAYHRLLTAEPVLRRAVPILIIAFLITICFGAAVQ
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIDQSRQKRAALNRDLCALADLLAERLEHIGVVRLDRPASIERLQNLLPGLIPSWGIAAG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCCCCCCCC
RHVIVTSADQRVLARVPGDEGTSAASSFLDIISATPPLTRSAQQGTITQIILPSGASALA
CEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHH
TLHTVKSLPGQVIVIHEDTGSILRSDAALQITLSATTGFVVLILGFAFHWQSTRAQEGDL
HHHHHHHCCCCEEEEECCCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCH
INDAVRSRIDTALNRGRCGLWDWDLSRGRIFWSQSMFTLLGLESRNDLLTFGEVNALVNS
HHHHHHHHHHHHHCCCCCCCEECCCCCCEEEECCHHHHHHCCCCCCCEEEEECHHHEECC
DDIDLFAIGDQLIAGNTDHIDHSFRMRHANGHWIWLRMRCELSQETQSDNKHLIGIAVDV
CCEEEEEECCEEECCCCCCCCCCEEEEECCCCEEEEEEEECCCHHCCCCCCEEEEEEEEC
TEQKSLAERTVEADLRLRDAIETIPEAFVLWDADNRLVLCNSHFQRLHKLPDIAVAPGTS
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECHHHHHHHCCCCEEECCCCC
YETVIEVGQMPEIRTRLCDNSGGSSPGARTFEAQLADGSWLHISERRTKDGGYVAVGTDI
HHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEECCCH
TRIKAHEQKLVDNDLRLRATVADLKISQYKLERQAIELADLARKYSEEKTRAEEANQTKS
HHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLANMSHELRTPLNAIIGFSEIMGSGMFGTLGSEKYQEYCHDIMTSGHYLLEVINDILD
HHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
MSKIEAGRMRLDMEELDLARTLGESLKVVAGRAEHKQLELLSEIEDDIPIVADRRAVKQI
HHHCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECHHHHHHH
LINLLSNAVKFTPDGGRVTVRSRTLPNAIVLMIADSGIGIAPQSLRRLGQPFEQVESQLS
HHHHHHHHEEECCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHH
KTYHGSGLGLAIAKSLTTLHGGSMRLRSTLGAGTVVMVTLPRDCQRRRLAA
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEECCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]