Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 86750467

GI number: 86750467

Start: 3837465

End: 3838745

Strand: Direct

Name: fabF [H]

Synonym: RPB_3356

Alternate gene names: 86750467

Gene position: 3837465-3838745 (Clockwise)

Preceding gene: 86750466

Following gene: 86750468

Centisome position: 71.98

GC content: 67.92

Gene sequence:

>1281_bases
ATGACCGCGACGCACGACAAATTCGGCAGGCCGATCGTGGTCGTCACCGGCATGGGCGTGGTTACATCACTCGGCGCCGG
CAAGACCGACAATTGGGCCAAGCTCACGGCGGGCGAATCCGGCATCCGCACCATCACCCGGTTTCCGATCGACGGCCTCA
AGACGACGATGGCCGGCACCGTGGACTTCGTCCCGGTCGAGCCGTTCTCCTCCACGGTGCTCGGCGAGAAGCTCGCCGAC
ATCGCCACCGAGGAAGCGATCGCGCAGGCCGGCATCGGCCGCAAGGGCGACTTCCCCGGCCCGCTGTTTCTCGCGGTGGC
GCCGGTCGAACTGGAGTGGCAGCCGCGGCAGGAACTGGCGCGCGCCACCGGCGCCAACACCGCGATCGACTACGACGCCC
TGCTCCGCGTCAGCGGCGGCGGACGCTTCGCCAACTATCACCACCGCTTCCTGTTCGGATCGGTCGCCGATCATCTCGCC
GAAACGTTCGGCACCAAGGGCTCGCCGATCTCGCTGTCGACCGCATGCGCCTCGGGCGCGAGCGCGATCCAGCTCGGCGT
CGAAGCGATCCGCCGCGGCGAGGCCGACGCCGCTTTGTGCGTCGCGACCGACGGCTCGGTCAACGCCGAAGCGCTGATCC
GCTTCTCGCTGCTGTCGGCGCTGTCGACCCAGAACGATCCGCCGCAGGCCTCTGCAAAGCCGTTCGCCAAGAATCGCGAC
GGCTTCGTGATGGCGGAAGGCGCCGGCGCGCTGGTGCTGGAAAGCTACCAATCCGCCGTGGCGCGCGGCGCGGCGATTCT
CGGCGTCGTCGCCGGCTGCGGCGAACTCGCCGACTCGTTTCACCGCACCCGCTCGAGCCCCGACGGCAAGCCGATCATCG
GCTGCATCAAGAAGACGCTCGCCGACGCCGGCCTCGGCGTCGAGCAGATCGACTACATCAATGCCCACGGCACCGGCACG
CCCGAAAACGACAAGATGGAATACAACGGCATCTCCGCGATGTTCGGCGAACGCGCCTCGACGATTCCGGTGTCCTCGAA
CAAGTCGATGGTCGGCCACACACTGTCCGCCGCCGGTGCGGTCGAGGCGATCTTCTCGCTGCTGACGCTCGAGCATCAGC
GAATCCCGCCGACCATCAACTACGACGTGCCCGACCCGGCGATCCCGCTCGACGTGGTGCCGAACAAGGCGCGCGACGCC
CGCGTCACCGCGGTGATGTCGAACTCGTTCGGGTTCGGCGGCCAGAACGCTTCCCTGATTCTGACGCGCGAGCCGGTCTA
G

Upstream 100 bases:

>100_bases
GACCAGATTGTGGTGGTCGGCGCCGGCCATTGGCGCGGCGAAGGCATGGCACTGGTCGAGGCCATTCGGTGAGCTCGGTC
GACCGAGCGAGGGGGACGCG

Downstream 100 bases:

>100_bases
CCGCGCCAGAACACAACTGTTTCGGACACGATACATGCGCGCGCTCACTCTCGTTGCCGACCGCGATCTCGCGGTCTCCG
ATCTGCCGCCGCCGCCGCCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTATHDKFGRPIVVVTGMGVVTSLGAGKTDNWAKLTAGESGIRTITRFPIDGLKTTMAGTVDFVPVEPFSSTVLGEKLAD
IATEEAIAQAGIGRKGDFPGPLFLAVAPVELEWQPRQELARATGANTAIDYDALLRVSGGGRFANYHHRFLFGSVADHLA
ETFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASAKPFAKNRD
GFVMAEGAGALVLESYQSAVARGAAILGVVAGCGELADSFHRTRSSPDGKPIIGCIKKTLADAGLGVEQIDYINAHGTGT
PENDKMEYNGISAMFGERASTIPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNKARDA
RVTAVMSNSFGFGGQNASLILTREPV

Sequences:

>Translated_426_residues
MTATHDKFGRPIVVVTGMGVVTSLGAGKTDNWAKLTAGESGIRTITRFPIDGLKTTMAGTVDFVPVEPFSSTVLGEKLAD
IATEEAIAQAGIGRKGDFPGPLFLAVAPVELEWQPRQELARATGANTAIDYDALLRVSGGGRFANYHHRFLFGSVADHLA
ETFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASAKPFAKNRD
GFVMAEGAGALVLESYQSAVARGAAILGVVAGCGELADSFHRTRSSPDGKPIIGCIKKTLADAGLGVEQIDYINAHGTGT
PENDKMEYNGISAMFGERASTIPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNKARDA
RVTAVMSNSFGFGGQNASLILTREPV
>Mature_425_residues
TATHDKFGRPIVVVTGMGVVTSLGAGKTDNWAKLTAGESGIRTITRFPIDGLKTTMAGTVDFVPVEPFSSTVLGEKLADI
ATEEAIAQAGIGRKGDFPGPLFLAVAPVELEWQPRQELARATGANTAIDYDALLRVSGGGRFANYHHRFLFGSVADHLAE
TFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASAKPFAKNRDG
FVMAEGAGALVLESYQSAVARGAAILGVVAGCGELADSFHRTRSSPDGKPIIGCIKKTLADAGLGVEQIDYINAHGTGTP
ENDKMEYNGISAMFGERASTIPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNKARDAR
VTAVMSNSFGFGGQNASLILTREPV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=432, Percent_Identity=34.2592592592593, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=42.8571428571429, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI41872631, Length=275, Percent_Identity=31.6363636363636, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=37.1428571428571, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=32.8605200945626, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71983541, Length=280, Percent_Identity=35.7142857142857, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=36.5019011406844, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=281, Percent_Identity=29.1814946619217, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=27.2388059701493, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=29.6213808463252, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24644341, Length=435, Percent_Identity=33.5632183908046, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=30.8243727598566, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=30.8243727598566, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24581345, Length=274, Percent_Identity=28.1021897810219, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44325; Mature: 44193

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATHDKFGRPIVVVTGMGVVTSLGAGKTDNWAKLTAGESGIRTITRFPIDGLKTTMAGT
CCCCCCCCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCHHHHHCCCCHHHHHHCCC
VDFVPVEPFSSTVLGEKLADIATEEAIAQAGIGRKGDFPGPLFLAVAPVELEWQPRQELA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEECCCCHHHHH
RATGANTAIDYDALLRVSGGGRFANYHHRFLFGSVADHLAETFGTKGSPISLSTACASGA
HHCCCCCEECHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
SAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASAKPFAKNRD
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAGALVLESYQSAVARGAAILGVVAGCGELADSFHRTRSSPDGKPIIGCIKKTL
CEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ADAGLGVEQIDYINAHGTGTPENDKMEYNGISAMFGERASTIPVSSNKSMVGHTLSAAGA
HHCCCCHHHEEEEECCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNKARDARVTAVMSNSFGFGGQNASLI
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTREPV
EEECCC
>Mature Secondary Structure 
TATHDKFGRPIVVVTGMGVVTSLGAGKTDNWAKLTAGESGIRTITRFPIDGLKTTMAGT
CCCCCCCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCHHHHHCCCCHHHHHHCCC
VDFVPVEPFSSTVLGEKLADIATEEAIAQAGIGRKGDFPGPLFLAVAPVELEWQPRQELA
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEECCCCHHHHH
RATGANTAIDYDALLRVSGGGRFANYHHRFLFGSVADHLAETFGTKGSPISLSTACASGA
HHCCCCCEECHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
SAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASAKPFAKNRD
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAGALVLESYQSAVARGAAILGVVAGCGELADSFHRTRSSPDGKPIIGCIKKTL
CEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ADAGLGVEQIDYINAHGTGTPENDKMEYNGISAMFGERASTIPVSSNKSMVGHTLSAAGA
HHCCCCHHHEEEEECCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNKARDARVTAVMSNSFGFGGQNASLI
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTREPV
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]