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The map label for this gene is trpC

Identifier: 86749915

GI number: 86749915

Start: 3189641

End: 3190438

Strand: Direct

Name: trpC

Synonym: RPB_2798

Alternate gene names: 86749915

Gene position: 3189641-3190438 (Clockwise)

Preceding gene: 86749914

Following gene: 86749916

Centisome position: 59.82

GC content: 68.05

Gene sequence:

>798_bases
GTGTCCGACATCCTGACCAAGATTGAAGCCTACAAGCGCGAGGAGATCGCCGCCGCCAAGCGCGAGCGCCCGATCGCATC
GCTGGAAGCGGATGCGCGCGCTGCGCCGCCGCCGCGCGGCTTCGTCCGCGCGCTCCGCGCCAAGCACGCGGCGGGCGACT
ATGCGCTGATCGCCGAGATCAAGAAGGCGTCGCCGTCGAAAGGCCTGATCCGCGCCGATTTCGATCCGCCGGCGCTCGCG
CAGGCTTACGAACAAGGCGGCGCGGCCTGTCTCTCCGTGCTGACGGATACGCCGTCGTTCCAGGGCAGCCTCGACTATCT
CGTCGCGGCGCGCGCGGCTGTGTCGTTGCCGGCGCTGCGCAAGGACTTCATGTACGACACCTATCAGGTGGTCGAAGCCC
GCGCCCATGGCGCCGACTGCATCCTGATCATCATGGCGGCGCTCGACGATGCCGAGGCCCGCGACATCGAGGACGCCGCC
TTCGATCTCGGCATGGACGTGCTGCTCGAAGTCCACGACCGTGCCGAACTCGACCGCGCGCTGCAGTTGCGTTCGCCGAT
GATCGGCGTCAACAACCGCAATTTGCGCACTTTCGAGGTGACGCTCGCGACCAGCGAGGCGCTGGCGCCGCTGATCCCGA
AGGATCGGCTGATGGTCGGCGAAAGCGGCATCTTCACGCCCGACGACCTCGCCCGACTTGCTCGCGTTGGAATGTCGACC
TTCCTGGTCGGCGAGAGCCTGATGCGTCAGGAGGACGTCGCCACCGCGACCCGCGCGCTGCTCGCGCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
AGAACGCGGTGCACGGAGCTGGATTGCTTCGTCGCTTCGCTCCTCGCAATGACGAGCTCTTGAAACCAGTGCTTTGAGTG
ACCCTCCAGGGAGCGTGCCT

Downstream 100 bases:

>100_bases
GGCGGGGCTGATGTCGAAGAAAGCGAAGCCGACCAGAGCCGCCGCCCCCGCCCTCACCCATATCGGCACCAGCGGCGAGG
CGCGGATGGTCGACGTCTCG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSDILTKIEAYKREEIAAAKRERPIASLEADARAAPPPRGFVRALRAKHAAGDYALIAEIKKASPSKGLIRADFDPPALA
QAYEQGGAACLSVLTDTPSFQGSLDYLVAARAAVSLPALRKDFMYDTYQVVEARAHGADCILIIMAALDDAEARDIEDAA
FDLGMDVLLEVHDRAELDRALQLRSPMIGVNNRNLRTFEVTLATSEALAPLIPKDRLMVGESGIFTPDDLARLARVGMST
FLVGESLMRQEDVATATRALLARAA

Sequences:

>Translated_265_residues
MSDILTKIEAYKREEIAAAKRERPIASLEADARAAPPPRGFVRALRAKHAAGDYALIAEIKKASPSKGLIRADFDPPALA
QAYEQGGAACLSVLTDTPSFQGSLDYLVAARAAVSLPALRKDFMYDTYQVVEARAHGADCILIIMAALDDAEARDIEDAA
FDLGMDVLLEVHDRAELDRALQLRSPMIGVNNRNLRTFEVTLATSEALAPLIPKDRLMVGESGIFTPDDLARLARVGMST
FLVGESLMRQEDVATATRALLARAA
>Mature_264_residues
SDILTKIEAYKREEIAAAKRERPIASLEADARAAPPPRGFVRALRAKHAAGDYALIAEIKKASPSKGLIRADFDPPALAQ
AYEQGGAACLSVLTDTPSFQGSLDYLVAARAAVSLPALRKDFMYDTYQVVEARAHGADCILIIMAALDDAEARDIEDAAF
DLGMDVLLEVHDRAELDRALQLRSPMIGVNNRNLRTFEVTLATSEALAPLIPKDRLMVGESGIFTPDDLARLARVGMSTF
LVGESLMRQEDVATATRALLARAA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=37.9310344827586, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=38.655462184874, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_RHOP2 (Q2IWB0)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486411.1
- HSSP:   Q56319
- ProteinModelPortal:   Q2IWB0
- SMR:   Q2IWB0
- STRING:   Q2IWB0
- GeneID:   3910591
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2798
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   RPAL316058:RPB_2798-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28637; Mature: 28506

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILTKIEAYKREEIAAAKRERPIASLEADARAAPPPRGFVRALRAKHAAGDYALIAEI
CHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGLIRADFDPPALAQAYEQGGAACLSVLTDTPSFQGSLDYLVAARAAVSLPALR
HHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFMYDTYQVVEARAHGADCILIIMAALDDAEARDIEDAAFDLGMDVLLEVHDRAELDRA
HHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLRSPMIGVNNRNLRTFEVTLATSEALAPLIPKDRLMVGESGIFTPDDLARLARVGMST
HHHCCCEECCCCCCEEEEEEEEECHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHH
FLVGESLMRQEDVATATRALLARAA
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDILTKIEAYKREEIAAAKRERPIASLEADARAAPPPRGFVRALRAKHAAGDYALIAEI
HHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGLIRADFDPPALAQAYEQGGAACLSVLTDTPSFQGSLDYLVAARAAVSLPALR
HHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KDFMYDTYQVVEARAHGADCILIIMAALDDAEARDIEDAAFDLGMDVLLEVHDRAELDRA
HHHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQLRSPMIGVNNRNLRTFEVTLATSEALAPLIPKDRLMVGESGIFTPDDLARLARVGMST
HHHCCCEECCCCCCEEEEEEEEECHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHH
FLVGESLMRQEDVATATRALLARAA
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA