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The map label for this gene is nqo13 [H]

Identifier: 86749704

GI number: 86749704

Start: 2967377

End: 2968894

Strand: Direct

Name: nqo13 [H]

Synonym: RPB_2586

Alternate gene names: 86749704

Gene position: 2967377-2968894 (Clockwise)

Preceding gene: 86749703

Following gene: 86749705

Centisome position: 55.66

GC content: 64.62

Gene sequence:

>1518_bases
ATGTCGGCTTCAATCATGACCTGGCCGGTGCTGTCGGTCGTCACCTTCCTGCCGCTGGTCGGCGCGGCGCTGGTCTATCT
CGCTCGCGGCGATGACGAGGCGGCGCGCCGCAATGCGCGCTGGATCTCGCTGTGGACTACGCTGATCACCTTCGCGGTGT
CGCTGATCCTGGTCTGGCGCTTCGACGCCGCCGACCCGGGCTTCCAGTTCGTCGAGAAGGCGCCGTGGCTCGGCGCCACC
ATCGCCTTTCACATGGGCGTCGACGGCATTTCGCTGCCGTTCGTGATCCTGACCACCGCGCTGATGCCGTTCTGCATCCT
CGCGAGCTGGAAGTCCATCACGGTGCGGGTGCGCGAATACATGATGGCGTTTCTGGTGCTGGAAACGCTGATGATCGGTA
CCTTCTCGGCGCTCGACCTGGTGCTGTTCTATCTGTTCTTCGAAGGCGGCCTGATCCCGATGTTCCTGATCATCGGCGTC
TGGGGCGGCCCGCGCCGGGTGTACGCATCGTTCAAGTTCTTCCTCTACACGCTGCTCGGCTCGGTGCTGATGCTGCTGGC
GATCATGGCGCTGTACTGGACGGCGGGCACCACTGACATCCCGACGCTGATGACCACCGCGATCCCGCGCAACCTGCAGA
CCTGGGCGTGGCTGGCGTTCTTCGCCTCGTTCGCGGTCAAGATGCCGATGTGGCCGGTGCACACCTGGCTGCCGGATGCG
CATGTCGAGGCGCCGACCGCGGGCTCCGTGGTGCTCGCCGCGATCATGCTGAAGATGGGCGGCTACGGCTTCCTGCGATT
CTCGCTGCCGATGTTCCCGGATGCCTCGGTGTATTTCGCACCGCTGGTGTTCAGCCTGTCGGTGATCGCGATCGTCTATA
CGTCGCTGGTCGCGCTGATGCAGGAGGATATCAAGAAGCTGATCGCGTACTCCTCGGTCGCGCATATGGGCTTCGTCACC
ATGGGCATCTTCGCCGGCAACACCCAGGGCGTCGCCGGCAGCGTGTTTCAGATGATCTCGCACGGCATCGTGTCGGGCGC
GCTGTTCCTCTGCGTCGGCGTGATCTACGACCGCATGCACACCCGCGAGATCGCGGCCTATGGCGGCCTCGTCAACCGGA
TGCCGATCTACGCCTTCGTGTTCCTGGTGTTCACCATGGCCAATGTCGGCCTGCCGGGCACCTCGGGCTTCGTCGGCGAG
TTCCTGACGCTGCTCGGCACCTTCCGCGTCAACGTGCCCACCGCGACCATCGCCACGCTCGGCGTGATCCTGTCGGCGGC
CTATGCGCTGTGGCTCTACCGCAAGGTGGTGTTCGGCGCGTTGACCAAGCCGGCGCTGGCCGACATCAAGGACCTGACCT
GGCGGGAGGGGATCATCCTGGCGCCGCTGGTGGTGCTCACCATTCTGTTCGGCTTCTATCCGAAGCCGGTGCTGGACATG
TCGGCCGCCTCGGTCCAGCAACTCGTCAACAATTACGCCGCCGCCGTGACTGCCGTGAAGGCAGCCGCGCTTCCGTAA

Upstream 100 bases:

>100_bases
TCAAGCTGCAGTCCGGCTATCTCTACCACTACGCATTCGCGATGCTGATCGGCGTGGCCGGTCTGATCACCTGGTTCATG
CTCGGCGGGGGAGGCCGCTA

Downstream 100 bases:

>100_bases
CCGGCAAGGACCGCAAGCTATGAATTTCGAAACTGCCGGTTATTCGCTGTTGCCGATCATGCCGGAGCTCGTGCTGGTGA
TCGGCTCGATGCTGCTGCTG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSASIMTWPVLSVVTFLPLVGAALVYLARGDDEAARRNARWISLWTTLITFAVSLILVWRFDAADPGFQFVEKAPWLGAT
IAFHMGVDGISLPFVILTTALMPFCILASWKSITVRVREYMMAFLVLETLMIGTFSALDLVLFYLFFEGGLIPMFLIIGV
WGGPRRVYASFKFFLYTLLGSVLMLLAIMALYWTAGTTDIPTLMTTAIPRNLQTWAWLAFFASFAVKMPMWPVHTWLPDA
HVEAPTAGSVVLAAIMLKMGGYGFLRFSLPMFPDASVYFAPLVFSLSVIAIVYTSLVALMQEDIKKLIAYSSVAHMGFVT
MGIFAGNTQGVAGSVFQMISHGIVSGALFLCVGVIYDRMHTREIAAYGGLVNRMPIYAFVFLVFTMANVGLPGTSGFVGE
FLTLLGTFRVNVPTATIATLGVILSAAYALWLYRKVVFGALTKPALADIKDLTWREGIILAPLVVLTILFGFYPKPVLDM
SAASVQQLVNNYAAAVTAVKAAALP

Sequences:

>Translated_505_residues
MSASIMTWPVLSVVTFLPLVGAALVYLARGDDEAARRNARWISLWTTLITFAVSLILVWRFDAADPGFQFVEKAPWLGAT
IAFHMGVDGISLPFVILTTALMPFCILASWKSITVRVREYMMAFLVLETLMIGTFSALDLVLFYLFFEGGLIPMFLIIGV
WGGPRRVYASFKFFLYTLLGSVLMLLAIMALYWTAGTTDIPTLMTTAIPRNLQTWAWLAFFASFAVKMPMWPVHTWLPDA
HVEAPTAGSVVLAAIMLKMGGYGFLRFSLPMFPDASVYFAPLVFSLSVIAIVYTSLVALMQEDIKKLIAYSSVAHMGFVT
MGIFAGNTQGVAGSVFQMISHGIVSGALFLCVGVIYDRMHTREIAAYGGLVNRMPIYAFVFLVFTMANVGLPGTSGFVGE
FLTLLGTFRVNVPTATIATLGVILSAAYALWLYRKVVFGALTKPALADIKDLTWREGIILAPLVVLTILFGFYPKPVLDM
SAASVQQLVNNYAAAVTAVKAAALP
>Mature_504_residues
SASIMTWPVLSVVTFLPLVGAALVYLARGDDEAARRNARWISLWTTLITFAVSLILVWRFDAADPGFQFVEKAPWLGATI
AFHMGVDGISLPFVILTTALMPFCILASWKSITVRVREYMMAFLVLETLMIGTFSALDLVLFYLFFEGGLIPMFLIIGVW
GGPRRVYASFKFFLYTLLGSVLMLLAIMALYWTAGTTDIPTLMTTAIPRNLQTWAWLAFFASFAVKMPMWPVHTWLPDAH
VEAPTAGSVVLAAIMLKMGGYGFLRFSLPMFPDASVYFAPLVFSLSVIAIVYTSLVALMQEDIKKLIAYSSVAHMGFVTM
GIFAGNTQGVAGSVFQMISHGIVSGALFLCVGVIYDRMHTREIAAYGGLVNRMPIYAFVFLVFTMANVGLPGTSGFVGEF
LTLLGTFRVNVPTATIATLGVILSAAYALWLYRKVVFGALTKPALADIKDLTWREGIILAPLVVLTILFGFYPKPVLDMS
AASVQQLVNNYAAAVTAVKAAALP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=362, Percent_Identity=37.292817679558, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI251831117, Length=340, Percent_Identity=25.2941176470588, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788613, Length=503, Percent_Identity=38.7673956262425, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1788827, Length=258, Percent_Identity=27.906976744186, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788831, Length=364, Percent_Identity=24.1758241758242, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=369, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI2367154, Length=253, Percent_Identity=25.6916996047431, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788829, Length=490, Percent_Identity=24.6938775510204, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI145693160, Length=358, Percent_Identity=23.7430167597765, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55158; Mature: 55026

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SASIMTWPVLSVVTFLPLVGAALVYLARGDDEAARRNARWISLWTTLITFAVSLILVWR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHC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CHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]