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The map label for this gene is nuoD [H]

Identifier: 86749693

GI number: 86749693

Start: 2956157

End: 2957362

Strand: Direct

Name: nuoD [H]

Synonym: RPB_2575

Alternate gene names: 86749693

Gene position: 2956157-2957362 (Clockwise)

Preceding gene: 86749692

Following gene: 86749694

Centisome position: 55.45

GC content: 63.27

Gene sequence:

>1206_bases
ATGGCTGACGCCGCTACCGAGGCCGCCGGTCTCCGCAACTTCACCATCAATTTCGGCCCTCAACATCCGGCGGCGCACGG
CGTGCTGCGGCTGGTGCTGGAGCTCGACGGCGAAGTGGTCGAGCGGGTCGATCCGCATATCGGACTGCTGCATCGCGGCA
CCGAAAAGCTGATCGAGCAGAAGACTTATCTGCAGGCGATCCCGTATTTTGACCGGCTCGATTACGTCGCGCCGATGAAC
CAGGAACACGCATTCTGCCTCGCCGCCGAGAAGTTGCTCGGCATCGAGGCGCCGCGGCGCGCGCAATTGATCCGCGTGCT
GTACTGCGAAATCGGCCGCATTCTCTCGCACCTTCTCAACGTCACCACCCAGGCGATGGACGTCGGCGCGCTGACGCCGC
CGCTGTGGGGGTTCGAGGAGCGCGAGAAACTGATGATGTTCTACGAGCGCGCCTCCGGCAGCCGGATGCACGCGGCGTAT
TTCCGCATCGGCGGCGTGCATCAGGACCTGCCGCCGAAGCTGATCGACGACATCGACAATTGGTGCGACAATTTCATCCA
GACGGTCGACGATCTGGAGACACTGCTGACCGACAACCGCATCTTCAAGCAGCGCAACGTCGACATCGGCGTGGTGACGC
TGGAGCAGGCGTGGGAGTGGGGTTTCTCCGGCGTGATGGTGCGCGGCTCGGGCGCCGCGTGGGATCTGCGCAAGTCGCAG
CCCTACGAATGCTACGCCGAGATGGATTTCGACGTGCCGATCGGGAAGAACGGCGACTGCTACGACCGCTACTGCATCCG
GGTCGAGGAGATGCGACAGTCGGTGCGGATCATGAAGCAGTGCATCGCCAAGATGCGAGAACCCGCCGGGCAGGGCCGTG
TCGCGGTCGACGACAACAAGATCTTCCCGCCGCGGCGTGGCGAGATGAAGCGGTCGATGGAATCCCTGATCCATCACTTC
AAGCTGTATACCGAAGGCTTCCGCGTGCCGGCCGGCGAAGTCTATGTCGCGGTCGAGGCGCCGAAGGGTGAGTTCGGCGT
GTATCTGGTCTCCGACGGCACCAACAAGCCTTACAAGTGCAAGGTCCGCGCTCCCGGCTTCGCGCATCTGCAGGCGATGG
ACTTCATCTGCCGCGGCCATCTGCTCGCCGACGTCTCGGCCATTCTCGGTTCGCTCGACATCGTGTTCGGAGAGGTCGAT
CGGTGA

Upstream 100 bases:

>100_bases
CGACGAGAAGGCGGGGGTGAAGCCGTGACGCCGATCGCCATGAACCACTCGCCATTCGCTACTCGCCCATCGCTGTTCGC
CCGTGTGCGGAGCTTGCCCC

Downstream 100 bases:

>100_bases
TCGCACCCAAGCCCATCCAGTTCGACCGCGCCACCGGCGCTCTCGAGGGCGCCAGCCCTCTCGAGCGCATGGCGGCGTAT
GCGCTGGTGATGGGCGCGCG

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MADAATEAAGLRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQKTYLQAIPYFDRLDYVAPMN
QEHAFCLAAEKLLGIEAPRRAQLIRVLYCEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAY
FRIGGVHQDLPPKLIDDIDNWCDNFIQTVDDLETLLTDNRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKSQ
PYECYAEMDFDVPIGKNGDCYDRYCIRVEEMRQSVRIMKQCIAKMREPAGQGRVAVDDNKIFPPRRGEMKRSMESLIHHF
KLYTEGFRVPAGEVYVAVEAPKGEFGVYLVSDGTNKPYKCKVRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVD
R

Sequences:

>Translated_401_residues
MADAATEAAGLRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQKTYLQAIPYFDRLDYVAPMN
QEHAFCLAAEKLLGIEAPRRAQLIRVLYCEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAY
FRIGGVHQDLPPKLIDDIDNWCDNFIQTVDDLETLLTDNRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKSQ
PYECYAEMDFDVPIGKNGDCYDRYCIRVEEMRQSVRIMKQCIAKMREPAGQGRVAVDDNKIFPPRRGEMKRSMESLIHHF
KLYTEGFRVPAGEVYVAVEAPKGEFGVYLVSDGTNKPYKCKVRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVD
R
>Mature_400_residues
ADAATEAAGLRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQKTYLQAIPYFDRLDYVAPMNQ
EHAFCLAAEKLLGIEAPRRAQLIRVLYCEIGRILSHLLNVTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAYF
RIGGVHQDLPPKLIDDIDNWCDNFIQTVDDLETLLTDNRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKSQP
YECYAEMDFDVPIGKNGDCYDRYCIRVEEMRQSVRIMKQCIAKMREPAGQGRVAVDDNKIFPPRRGEMKRSMESLIHHFK
LYTEGFRVPAGEVYVAVEAPKGEFGVYLVSDGTNKPYKCKVRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=66.4961636828644, Blast_Score=540, Evalue=1e-154,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=65.7142857142857, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=40.5684754521964, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1789076, Length=397, Percent_Identity=25.6926952141058, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788832, Length=388, Percent_Identity=26.0309278350515, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=391, Percent_Identity=62.9156010230179, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=63.0102040816327, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=64.2857142857143, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221459469, Length=391, Percent_Identity=57.5447570332481, Blast_Score=480, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45384; Mature: 45253

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAATEAAGLRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQ
CCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHH
KTYLQAIPYFDRLDYVAPMNQEHAFCLAAEKLLGIEAPRRAQLIRVLYCEIGRILSHLLN
HHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAYFRIGGVHQDLPPKLIDDIDN
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHEEECCCCCCCCHHHHHHHHH
WCDNFIQTVDDLETLLTDNRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKSQ
HHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEHHHHHCCCCCCEEEECCCCEEECCCCC
PYECYAEMDFDVPIGKNGDCYDRYCIRVEEMRQSVRIMKQCIAKMREPAGQGRVAVDDNK
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
IFPPRRGEMKRSMESLIHHFKLYTEGFRVPAGEVYVAVEAPKGEFGVYLVSDGTNKPYKC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEE
KVRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVDR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC
>Mature Secondary Structure 
ADAATEAAGLRNFTINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEQ
CCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHH
KTYLQAIPYFDRLDYVAPMNQEHAFCLAAEKLLGIEAPRRAQLIRVLYCEIGRILSHLLN
HHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTTQAMDVGALTPPLWGFEEREKLMMFYERASGSRMHAAYFRIGGVHQDLPPKLIDDIDN
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHEEECCCCCCCCHHHHHHHHH
WCDNFIQTVDDLETLLTDNRIFKQRNVDIGVVTLEQAWEWGFSGVMVRGSGAAWDLRKSQ
HHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEEEHHHHHCCCCCCEEEECCCCEEECCCCC
PYECYAEMDFDVPIGKNGDCYDRYCIRVEEMRQSVRIMKQCIAKMREPAGQGRVAVDDNK
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
IFPPRRGEMKRSMESLIHHFKLYTEGFRVPAGEVYVAVEAPKGEFGVYLVSDGTNKPYKC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEE
KVRAPGFAHLQAMDFICRGHLLADVSAILGSLDIVFGEVDR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA