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The map label for this gene is gppA [H]

Identifier: 86749613

GI number: 86749613

Start: 2852035

End: 2853540

Strand: Direct

Name: gppA [H]

Synonym: RPB_2493

Alternate gene names: 86749613

Gene position: 2852035-2853540 (Clockwise)

Preceding gene: 86749612

Following gene: 86749616

Centisome position: 53.49

GC content: 66.0

Gene sequence:

>1506_bases
GTGACGAAGCGGGCGCGCAGGCGCGAAACCAGCGTCGCAGTGATCGACATAGGCTCGAATTCCGTGCGTCTCGTGGTCTA
CGAGTCGCTCGCGCGCAGCCTGGTCACGGTTTTCAACGAAAAGGCGCTGTGCGGGCTCGGGCGTGAAGTGCAGAGCACGG
GGCTGTTGGCGACCGATGCCGTCGACAAGGCGCTGACCGCGCTACGTCGGTTCCGCGCGTTGATTCGGGTGATGCGCGTC
GGCCGAGTCTACGCCATTGCCACGGCAGCGTGCCGCGACGCCAGCAACGGTCCCGATTTCATCGCAGCCGCAGAGCGGAT
CTGCGGTGTCACGATCGAAATCCTGTCGGGGCCGCGCGAGGCCAAGCTGTCGGCACTCGGCGTCATCGCCGGGGTTCACA
AGCCGAACGGCATCGTCGGCGATCTCGGCGGCGGATCGCTGGAACTGATCGATGTTCGCGGCAACCTGGTTCGCAAGGGC
GTAACCTTGCCGCTCGGGAGTCTGGCGCTTCAGGATGCCTCGCAGAAATCCCTGAAGCGGGCCGAACGGATCGCGAAAGA
CGCTCTCGCGGGTGCCCTCCCGCTGAAGGCGGCGAGCGGGCGGACGTTCTACGCAGTCGGGGGGACCTGGCGCGCTTTGG
CGCGGATTCACATCGCGCAGAGCGGCTACGCGCTCAAGGTGATGCATGGTTACGCGATCCCGGCCGCGGAAGCGCTGAGG
TTCGCCAAGCGGCTGCGTGTGCTGGCCTCGACCAATCAACTGGCCGATCTCGACCTCGTCGCTGATGCGCGGCGGCCGCT
GTTGGCTTACGCGGCGCTGGTGCTCGAATACGTCATCGAAGCCGCGAAGCCGAAGACCATCGTGTTCTCGACCTACGGTG
TTCGTGAGGGACTGCTTTACGAGCAATTGCCTGCCGCGGAGCGCGCCAAGGACGGCCTGATCTGCTCCGCGCAGAACCTC
AACCTGTTGTTGTCGCGCTCGGCGCGCCACGCCGAAGAACTCATCGAATGGACCGACCGGCTGTTCCGGGTCGCAAAGGT
GCGCGAGACCGAAATCGATCGACGTCTCCGCCGTGCCGCCTGCCTGATGTCCGATGTCGGCTGGCGTGTGCATCCCGACC
ATCGCGGCGAGCAGACGCTGGCGTTGATCACCAACGGCAATTTCGGCGACGTGACCCATCAGGAGCGCGCCTTCATGGCG
CTCTCGGTGTTCTATCGCTACGCGGGATTCAGCGAGCAGAACGAGCCGCCAGCTGCTGTGCGCGAGCTGGTGACGCAGGC
GATGGACGAGCGCGCGCGCCTGCTCGGCGCCGCTTTCCGGGTCGCGCATCTGATCAGTGCGGCGCGGCCGGGCGTGTTGC
CGGCGACGCATTTCCGGACCAGCGAACGCAAACTGATGCTGGTGTTCGAGCACAGGCTGGTCGACCTGGTCGCCGATCGA
GTCGGCAGCCGCTTCAAGCAGCTCGGCCGTATGGTCGGGCGCTCGGGGACGATCGTCAGGCGATAG

Upstream 100 bases:

>100_bases
TCCGAGTCTGTCCGGCCGTGGAAAGTCGCTCAAAGAATCTTCGCCGCGACGACTCACGCGCCGTTCGGAGCGCCATCAGT
CGCCTTGAGGATTTTGCACG

Downstream 100 bases:

>100_bases
CGCTCAGCCGCGGTCGACGTGGATCACGCGGCCCTTCTCGATCGCGAGCGCGAGCTGGCCGTGCTTGAGCGCCAGCGCCG
CTTCGCCGAACAATTCGCGT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTKRARRRETSVAVIDIGSNSVRLVVYESLARSLVTVFNEKALCGLGREVQSTGLLATDAVDKALTALRRFRALIRVMRV
GRVYAIATAACRDASNGPDFIAAAERICGVTIEILSGPREAKLSALGVIAGVHKPNGIVGDLGGGSLELIDVRGNLVRKG
VTLPLGSLALQDASQKSLKRAERIAKDALAGALPLKAASGRTFYAVGGTWRALARIHIAQSGYALKVMHGYAIPAAEALR
FAKRLRVLASTNQLADLDLVADARRPLLAYAALVLEYVIEAAKPKTIVFSTYGVREGLLYEQLPAAERAKDGLICSAQNL
NLLLSRSARHAEELIEWTDRLFRVAKVRETEIDRRLRRAACLMSDVGWRVHPDHRGEQTLALITNGNFGDVTHQERAFMA
LSVFYRYAGFSEQNEPPAAVRELVTQAMDERARLLGAAFRVAHLISAARPGVLPATHFRTSERKLMLVFEHRLVDLVADR
VGSRFKQLGRMVGRSGTIVRR

Sequences:

>Translated_501_residues
MTKRARRRETSVAVIDIGSNSVRLVVYESLARSLVTVFNEKALCGLGREVQSTGLLATDAVDKALTALRRFRALIRVMRV
GRVYAIATAACRDASNGPDFIAAAERICGVTIEILSGPREAKLSALGVIAGVHKPNGIVGDLGGGSLELIDVRGNLVRKG
VTLPLGSLALQDASQKSLKRAERIAKDALAGALPLKAASGRTFYAVGGTWRALARIHIAQSGYALKVMHGYAIPAAEALR
FAKRLRVLASTNQLADLDLVADARRPLLAYAALVLEYVIEAAKPKTIVFSTYGVREGLLYEQLPAAERAKDGLICSAQNL
NLLLSRSARHAEELIEWTDRLFRVAKVRETEIDRRLRRAACLMSDVGWRVHPDHRGEQTLALITNGNFGDVTHQERAFMA
LSVFYRYAGFSEQNEPPAAVRELVTQAMDERARLLGAAFRVAHLISAARPGVLPATHFRTSERKLMLVFEHRLVDLVADR
VGSRFKQLGRMVGRSGTIVRR
>Mature_500_residues
TKRARRRETSVAVIDIGSNSVRLVVYESLARSLVTVFNEKALCGLGREVQSTGLLATDAVDKALTALRRFRALIRVMRVG
RVYAIATAACRDASNGPDFIAAAERICGVTIEILSGPREAKLSALGVIAGVHKPNGIVGDLGGGSLELIDVRGNLVRKGV
TLPLGSLALQDASQKSLKRAERIAKDALAGALPLKAASGRTFYAVGGTWRALARIHIAQSGYALKVMHGYAIPAAEALRF
AKRLRVLASTNQLADLDLVADARRPLLAYAALVLEYVIEAAKPKTIVFSTYGVREGLLYEQLPAAERAKDGLICSAQNLN
LLLSRSARHAEELIEWTDRLFRVAKVRETEIDRRLRRAACLMSDVGWRVHPDHRGEQTLALITNGNFGDVTHQERAFMAL
SVFYRYAGFSEQNEPPAAVRELVTQAMDERARLLGAAFRVAHLISAARPGVLPATHFRTSERKLMLVFEHRLVDLVADRV
GSRFKQLGRMVGRSGTIVRR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=441, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788848, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321185, Length=443, Percent_Identity=25.2821670428894, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54754; Mature: 54623

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRARRRETSVAVIDIGSNSVRLVVYESLARSLVTVFNEKALCGLGREVQSTGLLATDA
CCCCHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCHHHHHCCCHHHHCCCCHHHH
VDKALTALRRFRALIRVMRVGRVYAIATAACRDASNGPDFIAAAERICGVTIEILSGPRE
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCH
AKLSALGVIAGVHKPNGIVGDLGGGSLELIDVRGNLVRKGVTLPLGSLALQDASQKSLKR
HHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AERIAKDALAGALPLKAASGRTFYAVGGTWRALARIHIAQSGYALKVMHGYAIPAAEALR
HHHHHHHHHHCCCCCEECCCCEEEEECCHHHHHHHHHEECCCCEEEEEECCCCCHHHHHH
FAKRLRVLASTNQLADLDLVADARRPLLAYAALVLEYVIEAAKPKTIVFSTYGVREGLLY
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
EQLPAAERAKDGLICSAQNLNLLLSRSARHAEELIEWTDRLFRVAKVRETEIDRRLRRAA
HHCCCHHHHCCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLMSDVGWRVHPDHRGEQTLALITNGNFGDVTHQERAFMALSVFYRYAGFSEQNEPPAAV
HHHHHCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RELVTQAMDERARLLGAAFRVAHLISAARPGVLPATHFRTSERKLMLVFEHRLVDLVADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHH
VGSRFKQLGRMVGRSGTIVRR
HHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
TKRARRRETSVAVIDIGSNSVRLVVYESLARSLVTVFNEKALCGLGREVQSTGLLATDA
CCCHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCHHHHHCCCHHHHCCCCHHHH
VDKALTALRRFRALIRVMRVGRVYAIATAACRDASNGPDFIAAAERICGVTIEILSGPRE
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCH
AKLSALGVIAGVHKPNGIVGDLGGGSLELIDVRGNLVRKGVTLPLGSLALQDASQKSLKR
HHHHHHHHHHCCCCCCCCEEECCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
AERIAKDALAGALPLKAASGRTFYAVGGTWRALARIHIAQSGYALKVMHGYAIPAAEALR
HHHHHHHHHHCCCCCEECCCCEEEEECCHHHHHHHHHEECCCCEEEEEECCCCCHHHHHH
FAKRLRVLASTNQLADLDLVADARRPLLAYAALVLEYVIEAAKPKTIVFSTYGVREGLLY
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHH
EQLPAAERAKDGLICSAQNLNLLLSRSARHAEELIEWTDRLFRVAKVRETEIDRRLRRAA
HHCCCHHHHCCCCEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLMSDVGWRVHPDHRGEQTLALITNGNFGDVTHQERAFMALSVFYRYAGFSEQNEPPAAV
HHHHHCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RELVTQAMDERARLLGAAFRVAHLISAARPGVLPATHFRTSERKLMLVFEHRLVDLVADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHH
VGSRFKQLGRMVGRSGTIVRR
HHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA