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The map label for this gene is adh [H]

Identifier: 86749594

GI number: 86749594

Start: 2830363

End: 2831421

Strand: Reverse

Name: adh [H]

Synonym: RPB_2474

Alternate gene names: 86749594

Gene position: 2831421-2830363 (Counterclockwise)

Preceding gene: 86749595

Following gene: 86749593

Centisome position: 53.11

GC content: 64.12

Gene sequence:

>1059_bases
ATGACGCAGATGCGTCGCCAATCGCTGGTGAAATTCGACGCCCCGCTGTGCGAGACCATTATCGACACGCCGAAGCCGCA
AGGCCGCGAAGTGCTGGTCCGGATCGAACGCTGCGGGTTGTGTCATTCCGATCTCCACATCCAGGACGGCTACGCCGATC
TCGGCGGCGGCAAGAAGCTCGACACCACGCGCGGCATGACGCTGCCCTTCACGCTCGGCCACGAGATCGCCGGCATCGTC
GACGAGGTCGGCCCCGATGCACCGGCCGAACTGATCGGCAAGAAGAAGGCGGTGTTTCCCTGGATCGGCTGCGGCAAGTG
CCGCGATTGCCTCGCCGGTGACGAGAACCTGTGCACCAAGAACCGCTTCCTCGGCGTCGCGATCGACGGCGGCTTCGCCA
CGCACGTGCTGGTACCCGACGCGAAATATCTGCTCGACTACGATCCGCTGCCGACCAATGTCGCGGCGACGCTGATGTGC
TCCGGTATCACCGCCTACGGCGCGCTGAAGCGGCTGGTCGATCAGCCGCGCCAGCGCAACATCCTGCTGATCGGTCTCGG
TGGCGTCGGCATGATGGGCCTGTCGCTGGCGCAGACGATGTTCAAGCAGCCGATCTCGGTCGCCGATCTCAGCCCTGCAG
CGCGCGAAGCCGCTCTGCAGAACGGCGCCACGACCGCCTACGATCCGTCCGAGCCCGACGTGATCAAGCGCATCGTCAAG
GAGAACGACGGCGGTTTCGACTGCATCGTGGATTTCGCCGGCAACGACAAGTCGATGAACTTCGCCGTCGGCACTGTCGC
GCGCGGCGGCAAGATCGTCGTCTCCGGGCTGATGGGCGGTCAGTTCAGCCTGCCGATGGTGCAGTGGATCTACAAGCGCA
TGACGATCGAAGGCTTCATGGTCGGGACCCTCGAGGAGACCAAGGAACTGCTGGCGCTGGCGCGCGCCGGCAAGATCAAG
CCGACGCCGATGAAAGAAGAACCGATGACGGACGTGCAGAAGTGGATCGATCAGTTGCGCGCCGGCAAGGTGGTCGGCCG
CATCATGCTGACGAACTAA

Upstream 100 bases:

>100_bases
CGCCGCGCCGAGACCGTCCCGGTTTCCGGCTTTGTTGCCATGGCGAACGAATTGATCGATATACGAGATACAAAAAACAC
ACCCTAAGGGAGAGACCGAC

Downstream 100 bases:

>100_bases
TCGCGCTTCCGACGCGCCCACGGAACTGCGTTGCGGGTTCCCGTTTCACCCGCAATGCAGGCCCGATTCTTGTCCCAACC
GCACCGGAATTGCGGCTTAT

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTQMRRQSLVKFDAPLCETIIDTPKPQGREVLVRIERCGLCHSDLHIQDGYADLGGGKKLDTTRGMTLPFTLGHEIAGIV
DEVGPDAPAELIGKKKAVFPWIGCGKCRDCLAGDENLCTKNRFLGVAIDGGFATHVLVPDAKYLLDYDPLPTNVAATLMC
SGITAYGALKRLVDQPRQRNILLIGLGGVGMMGLSLAQTMFKQPISVADLSPAAREAALQNGATTAYDPSEPDVIKRIVK
ENDGGFDCIVDFAGNDKSMNFAVGTVARGGKIVVSGLMGGQFSLPMVQWIYKRMTIEGFMVGTLEETKELLALARAGKIK
PTPMKEEPMTDVQKWIDQLRAGKVVGRIMLTN

Sequences:

>Translated_352_residues
MTQMRRQSLVKFDAPLCETIIDTPKPQGREVLVRIERCGLCHSDLHIQDGYADLGGGKKLDTTRGMTLPFTLGHEIAGIV
DEVGPDAPAELIGKKKAVFPWIGCGKCRDCLAGDENLCTKNRFLGVAIDGGFATHVLVPDAKYLLDYDPLPTNVAATLMC
SGITAYGALKRLVDQPRQRNILLIGLGGVGMMGLSLAQTMFKQPISVADLSPAAREAALQNGATTAYDPSEPDVIKRIVK
ENDGGFDCIVDFAGNDKSMNFAVGTVARGGKIVVSGLMGGQFSLPMVQWIYKRMTIEGFMVGTLEETKELLALARAGKIK
PTPMKEEPMTDVQKWIDQLRAGKVVGRIMLTN
>Mature_351_residues
TQMRRQSLVKFDAPLCETIIDTPKPQGREVLVRIERCGLCHSDLHIQDGYADLGGGKKLDTTRGMTLPFTLGHEIAGIVD
EVGPDAPAELIGKKKAVFPWIGCGKCRDCLAGDENLCTKNRFLGVAIDGGFATHVLVPDAKYLLDYDPLPTNVAATLMCS
GITAYGALKRLVDQPRQRNILLIGLGGVGMMGLSLAQTMFKQPISVADLSPAAREAALQNGATTAYDPSEPDVIKRIVKE
NDGGFDCIVDFAGNDKSMNFAVGTVARGGKIVVSGLMGGQFSLPMVQWIYKRMTIEGFMVGTLEETKELLALARAGKIKP
TPMKEEPMTDVQKWIDQLRAGKVVGRIMLTN

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI18379349, Length=349, Percent_Identity=26.0744985673352, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565154, Length=298, Percent_Identity=28.1879194630872, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501929, Length=285, Percent_Identity=23.5087719298246, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4501933, Length=285, Percent_Identity=24.2105263157895, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=32.1981424148607, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI226510992, Length=299, Percent_Identity=29.0969899665552, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790718, Length=358, Percent_Identity=27.3743016759777, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790045, Length=353, Percent_Identity=23.7960339943343, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788073, Length=279, Percent_Identity=27.2401433691756, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787863, Length=264, Percent_Identity=26.8939393939394, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082401, Length=335, Percent_Identity=26.2686567164179, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788407, Length=290, Percent_Identity=24.4827586206897, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786518, Length=313, Percent_Identity=28.7539936102236, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082125, Length=263, Percent_Identity=27.7566539923954, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=29.0697674418605, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562582, Length=348, Percent_Identity=29.0229885057471, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=24.9266862170088, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=293, Percent_Identity=26.6211604095563, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=190, Percent_Identity=29.4736842105263, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=283, Percent_Identity=25.7950530035336, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=285, Percent_Identity=25.2631578947368, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=356, Percent_Identity=26.123595505618, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=25.5952380952381, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=25, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=382, Percent_Identity=24.0837696335079, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=337, Percent_Identity=24.6290801186944, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=270, Percent_Identity=26.2962962962963, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=317, Percent_Identity=27.1293375394322, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=338, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=365, Percent_Identity=25.7534246575342, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=23.8095238095238, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=23.8095238095238, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573965, Length=312, Percent_Identity=23.3974358974359, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586287, Length=312, Percent_Identity=23.3974358974359, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586285, Length=312, Percent_Identity=23.3974358974359, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=295, Percent_Identity=26.4406779661017, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137530, Length=300, Percent_Identity=26, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=305, Percent_Identity=25.5737704918033, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38055; Mature: 37924

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQMRRQSLVKFDAPLCETIIDTPKPQGREVLVRIERCGLCHSDLHIQDGYADLGGGKKL
CCCHHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEEHHCCCCCCCCEEECCCCCCCCCCEE
DTTRGMTLPFTLGHEIAGIVDEVGPDAPAELIGKKKAVFPWIGCGKCRDCLAGDENLCTK
CCCCCCEEEEECCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCC
NRFLGVAIDGGFATHVLVPDAKYLLDYDPLPTNVAATLMCSGITAYGALKRLVDQPRQRN
CCEEEEEEECCEEEEEECCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ILLIGLGGVGMMGLSLAQTMFKQPISVADLSPAAREAALQNGATTAYDPSEPDVIKRIVK
EEEEECCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ENDGGFDCIVDFAGNDKSMNFAVGTVARGGKIVVSGLMGGQFSLPMVQWIYKRMTIEGFM
CCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEE
VGTLEETKELLALARAGKIKPTPMKEEPMTDVQKWIDQLRAGKVVGRIMLTN
EECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHEEEEEECC
>Mature Secondary Structure 
TQMRRQSLVKFDAPLCETIIDTPKPQGREVLVRIERCGLCHSDLHIQDGYADLGGGKKL
CCHHHHHHHHCCCHHHHHHHCCCCCCCHHEEEEEHHCCCCCCCCEEECCCCCCCCCCEE
DTTRGMTLPFTLGHEIAGIVDEVGPDAPAELIGKKKAVFPWIGCGKCRDCLAGDENLCTK
CCCCCCEEEEECCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCC
NRFLGVAIDGGFATHVLVPDAKYLLDYDPLPTNVAATLMCSGITAYGALKRLVDQPRQRN
CCEEEEEEECCEEEEEECCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ILLIGLGGVGMMGLSLAQTMFKQPISVADLSPAAREAALQNGATTAYDPSEPDVIKRIVK
EEEEECCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
ENDGGFDCIVDFAGNDKSMNFAVGTVARGGKIVVSGLMGGQFSLPMVQWIYKRMTIEGFM
CCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHEE
VGTLEETKELLALARAGKIKPTPMKEEPMTDVQKWIDQLRAGKVVGRIMLTN
EECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]