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The map label for this gene is pyrC [H]

Identifier: 86749543

GI number: 86749543

Start: 2779053

End: 2780363

Strand: Reverse

Name: pyrC [H]

Synonym: RPB_2423

Alternate gene names: 86749543

Gene position: 2780363-2779053 (Counterclockwise)

Preceding gene: 86749544

Following gene: 86749542

Centisome position: 52.15

GC content: 68.12

Gene sequence:

>1311_bases
ATGCTGATCGACCGCCGCCCGATCCTGCTCGCCAACGCCCGCCTGATCGATCCGGCGCGCGACTTCGACGGCCTCGGCGA
CGTGCTGATCGCCGACGGCGTGATCCGCGACGCGCGCCGCGGCATCGGCGCCGCCGGCGTGCCCGAGGGCACCGACATTA
TTAATTGCGCCGGCATGGTGGTCGCCCCCGGGCTGGTCGATATGCGCGCCTTCGTCGGCGAGCCCGGCGCCAGCCACCGC
GAGACCTTCGCCTCGGCCAGCCAGGCCGCCGCCGCCGGCGGCATCACCACCATCATCTGCCAGCCCAACACCTCGCCGGT
GATCGACAATTCGGCGACGGTCGATTTCGTGATGCGTCGCGCCCGCGACACCGCGATCGTCAACATCCATCCGATGGCCG
CGCTGACCAAGGGTCTGAACGGAATCGAGATGACCGAGATCGGGCTGTTGAAGGCCGCCGGCGCCGTGGCGTTCAGCGAC
GGCGACCGCAGTGTGATGAATGCGCGGGTGATGCGCAGCGCGCTGACCTATGCGCGCGATTTCGATGCGCTGATCGTCCA
TCACACCGAAGACCCCGATCTGGTTGCCGAAGGCGTGATGAACGAAAGCGAGTTCGCCACCCGCCTCGGCCTGTCCGGCG
TGCCGAGTGCCGCAGAAGCCGTGGTGCTGGAGCGCGACGTCCGCCTCGCCGCATTGACCGGCGGGCGCTATCACGCCGCC
TCGCTGACCTGCATCGAGTCGCTGGAGATCCTGCAGCGCGCTCGCGACGCCGGGATCAACGTCTCGGCGTCGGTGTCGAT
CAATCACGTCACGCTCAACGAGAACGACATCGGCCCGTATCGCACCTTCCTCAAGCTGTCGCCGCCGCTGCGCAGCGAGG
ACGACCGCAAGGCGCTGATCGCCGCGGTCTCGTCCGGTCTGATCGACGTCATCATGTCGGACCACAATCCGCAGGATGTC
GAGGTCAAGCGGCTGCCCTTCGCCGAGGCCGCCGCCGGCGCGATCGGGCTGGAGACGATGCTGCCGGCCGGCCTGCGATT
GCTGCACGCCGGCGAACTCGATCTCTTGAGTCTGATCCGCGCGATGTCGACCCGCCCGGCCGAACTGCTCGGCCTGCCCG
GCGGCACGCTGCGCGCAGGCAGCCCGGCCGACCTGATCGTGATCGACCTCGACACGCCGTGGATCGTCGATCCGAACGAA
CTGAAATCGAAGTGCAAGAACACCCCGTTCGACGAGGCGCGGTTCTCCGGACGGGTGGTCCGCACCATCGTCGGCGGACG
CACGGTGTACGAGCACGTCAGCGCACATTGA

Upstream 100 bases:

>100_bases
ATCCGCGAACAGGTCGAAATGGGCGTGGCGGTGCGGATGGCGGTGCTCGAAGCGCTCGCCCGCAACCTGCCCAACGCCTG
AAGCTGGAACTGGACCGACA

Downstream 100 bases:

>100_bases
GGGAACCACGACGATGTTGATCGGCATCTACATCGCAGCGCTGCTGCTCGGCTATCTGTTCGGTTCGATTCCGTTCGGGC
TGATCCTGACCAAGATCGCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLIDRRPILLANARLIDPARDFDGLGDVLIADGVIRDARRGIGAAGVPEGTDIINCAGMVVAPGLVDMRAFVGEPGASHR
ETFASASQAAAAGGITTIICQPNTSPVIDNSATVDFVMRRARDTAIVNIHPMAALTKGLNGIEMTEIGLLKAAGAVAFSD
GDRSVMNARVMRSALTYARDFDALIVHHTEDPDLVAEGVMNESEFATRLGLSGVPSAAEAVVLERDVRLAALTGGRYHAA
SLTCIESLEILQRARDAGINVSASVSINHVTLNENDIGPYRTFLKLSPPLRSEDDRKALIAAVSSGLIDVIMSDHNPQDV
EVKRLPFAEAAAGAIGLETMLPAGLRLLHAGELDLLSLIRAMSTRPAELLGLPGGTLRAGSPADLIVIDLDTPWIVDPNE
LKSKCKNTPFDEARFSGRVVRTIVGGRTVYEHVSAH

Sequences:

>Translated_436_residues
MLIDRRPILLANARLIDPARDFDGLGDVLIADGVIRDARRGIGAAGVPEGTDIINCAGMVVAPGLVDMRAFVGEPGASHR
ETFASASQAAAAGGITTIICQPNTSPVIDNSATVDFVMRRARDTAIVNIHPMAALTKGLNGIEMTEIGLLKAAGAVAFSD
GDRSVMNARVMRSALTYARDFDALIVHHTEDPDLVAEGVMNESEFATRLGLSGVPSAAEAVVLERDVRLAALTGGRYHAA
SLTCIESLEILQRARDAGINVSASVSINHVTLNENDIGPYRTFLKLSPPLRSEDDRKALIAAVSSGLIDVIMSDHNPQDV
EVKRLPFAEAAAGAIGLETMLPAGLRLLHAGELDLLSLIRAMSTRPAELLGLPGGTLRAGSPADLIVIDLDTPWIVDPNE
LKSKCKNTPFDEARFSGRVVRTIVGGRTVYEHVSAH
>Mature_436_residues
MLIDRRPILLANARLIDPARDFDGLGDVLIADGVIRDARRGIGAAGVPEGTDIINCAGMVVAPGLVDMRAFVGEPGASHR
ETFASASQAAAAGGITTIICQPNTSPVIDNSATVDFVMRRARDTAIVNIHPMAALTKGLNGIEMTEIGLLKAAGAVAFSD
GDRSVMNARVMRSALTYARDFDALIVHHTEDPDLVAEGVMNESEFATRLGLSGVPSAAEAVVLERDVRLAALTGGRYHAA
SLTCIESLEILQRARDAGINVSASVSINHVTLNENDIGPYRTFLKLSPPLRSEDDRKALIAAVSSGLIDVIMSDHNPQDV
EVKRLPFAEAAAGAIGLETMLPAGLRLLHAGELDLLSLIRAMSTRPAELLGLPGGTLRAGSPADLIVIDLDTPWIVDPNE
LKSKCKNTPFDEARFSGRVVRTIVGGRTVYEHVSAH

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=26.3565891472868, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4503377, Length=454, Percent_Identity=22.4669603524229, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=22.2466960352423, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786722, Length=400, Percent_Identity=25, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=24.8888888888889, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=383, Percent_Identity=27.6762402088773, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI86575075, Length=447, Percent_Identity=24.3847874720358, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=24.6851385390428, Blast_Score=106, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24642586, Length=405, Percent_Identity=25.1851851851852, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18859883, Length=444, Percent_Identity=26.1261261261261, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46163; Mature: 46163

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDRRPILLANARLIDPARDFDGLGDVLIADGVIRDARRGIGAAGVPEGTDIINCAGMV
CCCCCCCEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHH
VAPGLVDMRAFVGEPGASHRETFASASQAAAAGGITTIICQPNTSPVIDNSATVDFVMRR
HCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIHPMAALTKGLNGIEMTEIGLLKAAGAVAFSDGDRSVMNARVMRSALTYARD
CCCCEEEEEEHHHHHHCCCCCCEEHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHC
FDALIVHHTEDPDLVAEGVMNESEFATRLGLSGVPSAAEAVVLERDVRLAALTGGRYHAA
CCEEEEEECCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEECCCEEHH
SLTCIESLEILQRARDAGINVSASVSINHVTLNENDIGPYRTFLKLSPPLRSEDDRKALI
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHHHHEEECCCCCCCCHHHHHH
AAVSSGLIDVIMSDHNPQDVEVKRLPFAEAAAGAIGLETMLPAGLRLLHAGELDLLSLIR
HHHHCCCEEEEECCCCCCCCEEEECCCHHHHCCHHHHHHHHHHHHEEEECCCHHHHHHHH
AMSTRPAELLGLPGGTLRAGSPADLIVIDLDTPWIVDPNELKSKCKNTPFDEARFSGRVV
HHCCCCHHHEECCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHCCCCCHHHHHCCEEE
RTIVGGRTVYEHVSAH
EHHHCCHHHHHHHCCC
>Mature Secondary Structure
MLIDRRPILLANARLIDPARDFDGLGDVLIADGVIRDARRGIGAAGVPEGTDIINCAGMV
CCCCCCCEEEECCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHH
VAPGLVDMRAFVGEPGASHRETFASASQAAAAGGITTIICQPNTSPVIDNSATVDFVMRR
HCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
ARDTAIVNIHPMAALTKGLNGIEMTEIGLLKAAGAVAFSDGDRSVMNARVMRSALTYARD
CCCCEEEEEEHHHHHHCCCCCCEEHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHC
FDALIVHHTEDPDLVAEGVMNESEFATRLGLSGVPSAAEAVVLERDVRLAALTGGRYHAA
CCEEEEEECCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHEEEECCCEEEEEECCCEEHH
SLTCIESLEILQRARDAGINVSASVSINHVTLNENDIGPYRTFLKLSPPLRSEDDRKALI
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHHHHEEECCCCCCCCHHHHHH
AAVSSGLIDVIMSDHNPQDVEVKRLPFAEAAAGAIGLETMLPAGLRLLHAGELDLLSLIR
HHHHCCCEEEEECCCCCCCCEEEECCCHHHHCCHHHHHHHHHHHHEEEECCCHHHHHHHH
AMSTRPAELLGLPGGTLRAGSPADLIVIDLDTPWIVDPNELKSKCKNTPFDEARFSGRVV
HHCCCCHHHEECCCCCCCCCCCCCEEEEECCCCCEECHHHHHHHHCCCCCHHHHHCCEEE
RTIVGGRTVYEHVSAH
EHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA