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The map label for this gene is panC

Identifier: 86749508

GI number: 86749508

Start: 2739620

End: 2740471

Strand: Reverse

Name: panC

Synonym: RPB_2388

Alternate gene names: 86749508

Gene position: 2740471-2739620 (Counterclockwise)

Preceding gene: 86749513

Following gene: 86749503

Centisome position: 51.4

GC content: 67.14

Gene sequence:

>852_bases
ATGCCCCGTCCTCCCGTCGTCGCCCGCACCCTCCCCGCCCTTCGCCGCGCGCTCGACGATCTGCGGCGCCGCAACGCCAC
CGTGGCGCTGGTTCCGACCATGGGCGCCCTGCACGACGGCCATCTGTCGCTGGTGCGGCTGGCGAAGCGCCGCGCCGCCA
AGGTCGTGGTGTCGGTGTTCGTCAATCCCACCCAGTTCGCGCCGCACGAGGATTTCGGCTCCTATCCGCGGACCTGGAAG
GCCGACGTCGCCAAGCTCGCCGCCGAGAATGTCGACCTGATCTGGAATCCCGATGTCAAGACGATGTACCCAGAGGGCTT
CGCGACGAGGATCGGAGTCGATGGCCCCGCGATCGCCGGGCTCGAGGATCGTTTCCGTCCACATTTTTTCGGCGGCGTCG
CCACCGTCGTCGGCAAACTGTTCCTGCAGGTCCGGCCGGACGTCGCGATCTTCGGCTCGAAGGATTTCCAGCAGCTCCGC
GTCGTGACGCGGATGGCGGCCGACCTCGACTTGGGCGTCAAGGTGATCGGCGCACCGACGATCCGCGAACGCGATGGCCT
CGCGATGTCGTCGCGCAACGTCTACCTGACGCCGGAGCAGCGCCAGGTGGCGCCGACGCTGTATCGCGCGATGAAGGAGA
CCGCCAAATTGTTGAAAGCCGGCAGGAGCGCGGAAGCGGCGTTGGCAGCGGGCGCGAAGATGATCACCGACGCCGGCTTC
GCGCTCGACTATCTCGAAGCTCGCCATGCCGAGTCGCTGGCGCCGGTCGGATCGATCAAGGATGGCCCGATCCGTCTGCT
GGTCGCCGCCAAGCTCGGCAACACAAGGCTGATCGACAACGTCGCGGTGTAG

Upstream 100 bases:

>100_bases
CTTGGGATTGGCTTGGGATTGGCGGCGGAACGCGGGCTTTGATAAGATCGAAATCCTCGACGCCGCCATCCGGCGGCTCT
CTTCACGCCCGCGAGCCCCC

Downstream 100 bases:

>100_bases
TCAGAGCAATCCGAGTTCGCGCAATTCGCGGCGCATCGGCTCCGGCATCGCGGCGATGCTCTCGGCGGCCTTGCCGAGGT
CGGGCGGCGCGTCGGCGGTG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVFVNPTQFAPHEDFGSYPRTWK
ADVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAGLEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLR
VVTRMAADLDLGVKVIGAPTIRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGF
ALDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV

Sequences:

>Translated_283_residues
MPRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVFVNPTQFAPHEDFGSYPRTWK
ADVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAGLEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLR
VVTRMAADLDLGVKVIGAPTIRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGF
ALDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV
>Mature_282_residues
PRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVFVNPTQFAPHEDFGSYPRTWKA
DVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAGLEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLRV
VTRMAADLDLGVKVIGAPTIRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGFA
LDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=280, Percent_Identity=46.4285714285714, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322046, Length=288, Percent_Identity=36.4583333333333, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_RHOP2 (Q2IXG7)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486004.1
- ProteinModelPortal:   Q2IXG7
- SMR:   Q2IXG7
- STRING:   Q2IXG7
- GeneID:   3909388
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2388
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- ProtClustDB:   PRK00380
- BioCyc:   RPAL316058:RPB_2388-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30720; Mature: 30589

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: NA

Important sites: ACT_SITE 41-41 BINDING 65-65 BINDING 65-65 BINDING 158-158 BINDING 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVF
CCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEE
VNPTQFAPHEDFGSYPRTWKADVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAG
ECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEECCCCCEEEECCCCCCCCC
LEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLRVVTRMAADLDLGVKVIGAPT
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
IRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGF
CCCCCCCEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCH
ALDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHCCCC
>Mature Secondary Structure 
PRPPVVARTLPALRRALDDLRRRNATVALVPTMGALHDGHLSLVRLAKRRAAKVVVSVF
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEE
VNPTQFAPHEDFGSYPRTWKADVAKLAAENVDLIWNPDVKTMYPEGFATRIGVDGPAIAG
ECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEECCCCCEEEECCCCCCCCC
LEDRFRPHFFGGVATVVGKLFLQVRPDVAIFGSKDFQQLRVVTRMAADLDLGVKVIGAPT
HHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
IRERDGLAMSSRNVYLTPEQRQVAPTLYRAMKETAKLLKAGRSAEAALAAGAKMITDAGF
CCCCCCCEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHCCH
ALDYLEARHAESLAPVGSIKDGPIRLLVAAKLGNTRLIDNVAV
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA