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The map label for this gene is envZ [H]

Identifier: 86749493

GI number: 86749493

Start: 2727053

End: 2728423

Strand: Reverse

Name: envZ [H]

Synonym: RPB_2373

Alternate gene names: 86749493

Gene position: 2728423-2727053 (Counterclockwise)

Preceding gene: 86749494

Following gene: 86749491

Centisome position: 51.17

GC content: 70.82

Gene sequence:

>1371_bases
ATGAGCCGCCGCAGGCCGCGCAGCCTTCTCACCCAGGTGGCGCTGCTCAGCTTCGCAGCGCTCCTCGTCGCCCAGTTCGT
CAGTTTCTGGCTGTTCACAGCCGACCACGCCAAGCGGATTCGCGTCGCCCAGCGCATCGAGGTGGTCGAACGCGTCGCCG
CCGTCGCCGCATTGCTGGACAAGGCCCCGGCGACGGCGCGCGACGACCTGCTCGAAGCGGCCAGTTCACGCTCGACACGG
TTCGAGGTGGCCACGGCACCGACCGTCGATCGGCCCGTCGACCTGCTCGGGTCCGATTGCGGCCAGCGCGATTGCGCCGA
TCTCGGCTTGCCCGCGGGACTGCGGATGCAAGAGGACTTCGTTTCGCCGCGTGATGGCGGCCGGTTCAGCGATCCGCCAC
CCCGGTTCCGCGATCGGCTCGTGAAATCCAACCTGGCACCGGTCGCGTTCAAGCTGTCGCTGCCGCTGCGCGACGCGCAG
TGGCTCAACGTCACCTCGCGCTTCGAGCGGCCGGCCATTCAACTGCCCCCGCAGGTGATGGGCACCACGCTGGTTTCGCT
GGCGCTGGTGCTGGCGGCGCTGTGGTTCGCGCTGCGGCGCGTCACCCGGCCGCTCGATCAGCTCGCCTCGGCGGCCGACG
GGTTCGGCCTCGACGCCCCGCCTCCCCGGATGCCGACCGGCGGACCGCGCGAAGTCCGTGCGCTGTCGGATGCGCTGGCG
CGGATGCACGAGCGGCTGGCGCGGATGCTGGGAGAGCGCACGAGGATGCTGGCGGCGCTCGGCCACGATCTGCGCTCGCC
GATCACCGCGCTGCGCGTCCGCGCCGAAATGGTCGACGACGCCGAGAACAAGGAGCGGATGATCGCGACGCTCGACGAGA
TGCAGCAGATGGTGGAAGCCACGCTGGCCTTCGCCCGCGGCGTCTCGACCGACCAGCCGACCGAACCTGTCGACCTCGCC
GCGCTGGCGTCGGAGCTGGCCGCCGAGCTGAGCGCGATCGGACCACCGATCCGGATCACGTCGGCAACCCCGATCGTGCT
GCCGCTGCGGCGCGTGCCGCTGCGGCGCGCGCTGCGCAACATCCTGGAAAACGCCCAGCGCTATGGCGGCGGCGCCGAGG
TTCGGGTCGAGCAAGACGGCACCGAAGTCCGAATGGTGATCGAGGATCGCGGCCCCGGTCTGCCGGACAGTGACCTCACG
CGGGTGTTCGAACCGTTCGTCAGGCTGGAGACCTCACGGTCGCGGGAAACCGGCGGCACCGGTCTCGGCCTGCCGATCGC
GCGCGCCATTCTGCAGGCGCACGGCGCCACCATCGCCTTGGCCAACCGGCCCGAAGGCGGTCTGCGCGCGACGGTGACGT
TCGCAGGATAG

Upstream 100 bases:

>100_bases
GGCTGCGTCGCAAGATCGAGGACGATCCGGCGCATCCGAAGATCATCACCACGGTTCGCTCCGGCGGCTACAGCCTCGCC
GCCGACGTCCGGGAGCTGCC

Downstream 100 bases:

>100_bases
GTCGGCGGCGACTCGGTGAGGATGGGTGGACGACACGCGCCGGCTGGGCTGCTTTCCCGCCAATTCGCGGGAGGCCGGAC
CGTGCATGTTCGAAGAGAAT

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSRRRPRSLLTQVALLSFAALLVAQFVSFWLFTADHAKRIRVAQRIEVVERVAAVAALLDKAPATARDDLLEAASSRSTR
FEVATAPTVDRPVDLLGSDCGQRDCADLGLPAGLRMQEDFVSPRDGGRFSDPPPRFRDRLVKSNLAPVAFKLSLPLRDAQ
WLNVTSRFERPAIQLPPQVMGTTLVSLALVLAALWFALRRVTRPLDQLASAADGFGLDAPPPRMPTGGPREVRALSDALA
RMHERLARMLGERTRMLAALGHDLRSPITALRVRAEMVDDAENKERMIATLDEMQQMVEATLAFARGVSTDQPTEPVDLA
ALASELAAELSAIGPPIRITSATPIVLPLRRVPLRRALRNILENAQRYGGGAEVRVEQDGTEVRMVIEDRGPGLPDSDLT
RVFEPFVRLETSRSRETGGTGLGLPIARAILQAHGATIALANRPEGGLRATVTFAG

Sequences:

>Translated_456_residues
MSRRRPRSLLTQVALLSFAALLVAQFVSFWLFTADHAKRIRVAQRIEVVERVAAVAALLDKAPATARDDLLEAASSRSTR
FEVATAPTVDRPVDLLGSDCGQRDCADLGLPAGLRMQEDFVSPRDGGRFSDPPPRFRDRLVKSNLAPVAFKLSLPLRDAQ
WLNVTSRFERPAIQLPPQVMGTTLVSLALVLAALWFALRRVTRPLDQLASAADGFGLDAPPPRMPTGGPREVRALSDALA
RMHERLARMLGERTRMLAALGHDLRSPITALRVRAEMVDDAENKERMIATLDEMQQMVEATLAFARGVSTDQPTEPVDLA
ALASELAAELSAIGPPIRITSATPIVLPLRRVPLRRALRNILENAQRYGGGAEVRVEQDGTEVRMVIEDRGPGLPDSDLT
RVFEPFVRLETSRSRETGGTGLGLPIARAILQAHGATIALANRPEGGLRATVTFAG
>Mature_455_residues
SRRRPRSLLTQVALLSFAALLVAQFVSFWLFTADHAKRIRVAQRIEVVERVAAVAALLDKAPATARDDLLEAASSRSTRF
EVATAPTVDRPVDLLGSDCGQRDCADLGLPAGLRMQEDFVSPRDGGRFSDPPPRFRDRLVKSNLAPVAFKLSLPLRDAQW
LNVTSRFERPAIQLPPQVMGTTLVSLALVLAALWFALRRVTRPLDQLASAADGFGLDAPPPRMPTGGPREVRALSDALAR
MHERLARMLGERTRMLAALGHDLRSPITALRVRAEMVDDAENKERMIATLDEMQQMVEATLAFARGVSTDQPTEPVDLAA
LASELAAELSAIGPPIRITSATPIVLPLRRVPLRRALRNILENAQRYGGGAEVRVEQDGTEVRMVIEDRGPGLPDSDLTR
VFEPFVRLETSRSRETGGTGLGLPIARAILQAHGATIALANRPEGGLRATVTFAG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=273, Percent_Identity=31.5018315018315, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787894, Length=300, Percent_Identity=28, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=30.4195804195804, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=29.957805907173, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=29.045643153527, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=33.0612244897959, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=26.1744966442953, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=28.3276450511945, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081816, Length=327, Percent_Identity=28.1345565749235, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=287, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=26.9058295964126, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=25.7918552036199, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=235, Percent_Identity=21.7021276595745, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=28.1938325991189, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49630; Mature: 49499

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRPRSLLTQVALLSFAALLVAQFVSFWLFTADHAKRIRVAQRIEVVERVAAVAALLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAPATARDDLLEAASSRSTRFEVATAPTVDRPVDLLGSDCGQRDCADLGLPAGLRMQEDF
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCHHHHCCCCCCCCCHHHC
VSPRDGGRFSDPPPRFRDRLVKSNLAPVAFKLSLPLRDAQWLNVTSRFERPAIQLPPQVM
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHH
GTTLVSLALVLAALWFALRRVTRPLDQLASAADGFGLDAPPPRMPTGGPREVRALSDALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RMHERLARMLGERTRMLAALGHDLRSPITALRVRAEMVDDAENKERMIATLDEMQQMVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TLAFARGVSTDQPTEPVDLAALASELAAELSAIGPPIRITSATPIVLPLRRVPLRRALRN
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
ILENAQRYGGGAEVRVEQDGTEVRMVIEDRGPGLPDSDLTRVFEPFVRLETSRSRETGGT
HHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GLGLPIARAILQAHGATIALANRPEGGLRATVTFAG
CCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure 
SRRRPRSLLTQVALLSFAALLVAQFVSFWLFTADHAKRIRVAQRIEVVERVAAVAALLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAPATARDDLLEAASSRSTRFEVATAPTVDRPVDLLGSDCGQRDCADLGLPAGLRMQEDF
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCCCCHHHHCCCCCCCCCHHHC
VSPRDGGRFSDPPPRFRDRLVKSNLAPVAFKLSLPLRDAQWLNVTSRFERPAIQLPPQVM
CCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHH
GTTLVSLALVLAALWFALRRVTRPLDQLASAADGFGLDAPPPRMPTGGPREVRALSDALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RMHERLARMLGERTRMLAALGHDLRSPITALRVRAEMVDDAENKERMIATLDEMQQMVEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TLAFARGVSTDQPTEPVDLAALASELAAELSAIGPPIRITSATPIVLPLRRVPLRRALRN
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
ILENAQRYGGGAEVRVEQDGTEVRMVIEDRGPGLPDSDLTRVFEPFVRLETSRSRETGGT
HHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GLGLPIARAILQAHGATIALANRPEGGLRATVTFAG
CCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]