Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 86749484

GI number: 86749484

Start: 2718807

End: 2720270

Strand: Reverse

Name: phr [H]

Synonym: RPB_2364

Alternate gene names: 86749484

Gene position: 2720270-2718807 (Counterclockwise)

Preceding gene: 86749490

Following gene: 86749483

Centisome position: 51.02

GC content: 69.74

Gene sequence:

>1464_bases
ATGAGCAACGACATTCCCCGCCCCGTCATCGTCTGGTTCCGCGACGATCTGCGGCTCTCCGACCATCCGGCCCTGCACGC
AGCTGCGGCCTCCGGCAGCCCGCTGATCTGCATCTACGTCCATGACGAACAAAGCCCGCAACTGCGTCCGCCGCAGGCGC
GGCCGATCGGCGGCGCCGCGCGCTGGTGGTTGGCGCAGTCGTTGCGCGCGCTCGCCGCCGAGCTCGAGCAGCGTGGCGCG
CGACTGATCCTGCGCCGCGGCCCTGCCGCTGCGATCGTCGGTGAACTCGCCCGACAGGTCGACGCCGCCGCCGTGCATTG
GAACGAGATCGAGATCGCACCGCATCGCGCCATCGCCGACGACCTCGCCGAAACGCTGAGCATGTCCGGGATCGATCACC
ACCGCCACCCCGGCGACCTGTTGGTGGCCCCGTCCGAAATCCGAACCAAGGACGGCCGCGGCCTGCGCGTGTTCACGCCG
TTCTGGCGCCGCGTCCTCGGCCTCGGCGATCCACCGAAGCCGTTGCCGGCGCCGGCGATGCTGCGCGCTGGACCCGACAT
TGCAAGCGACGATCCGGCGACGTGGCAGCTGGAGCCGACCGCGCCGGATTGGGCCGGTGGACTGCGCGCGAGCTGGACGC
CGGGGGAACGCGCCGCGCACGACCTGCTCACCGCCTTCCTCGATCGCCTGCCCGGCTATGCCGCGGACCGCGACCGGCCC
GATCGCGACGCCACCTCGCTGCTGTCGCCGCATCTGCGGTTCGGCGAGATCAGTCCGCGGCAGCTCTGGTACGCGGCGCG
CTTTGCCGCCGCAAAGCGGCCGGCGATCGCCGCCGACATCGACAAATTCCTCAGCGAACTCGGCTGGCGCGAGTTCTGCC
GGCACCTTCTGCACGACCACCCCGATCTCGCCGAGCGCAATCTGCAATCGGCGTTCGACGCCTTTCCGTGGACGCGCGAC
GATGCGGCGCTCGCCGCCTGGCAGCGCGGACGCACCGGCTATCCGATCGTCGACGCCGGGATGCGCCAACTCTGGCACAC
CGGCGTGATGCACAATCGCATCCGTATGGTGGTGGCCTCGTTCCTGGTGAAGCATCTGCTGATCGACTGGCGGCTCGGCG
AAGAATGGTTCTGGGACACGCTGGTCGACGCCGATCCCGGCAGCAATCCCGGCAATTGGCAGTGGGTCGCCGGCTCCGGC
GCCGACGCCGCGCCGTATTTTCGCGTCTTCAACCCGATCCTGCAGGGCGAGAAGTTCGATCCCGCCGGCGATTATGTGCG
CCGCTGGGTGCCGGAGATCGCGGCCCTGCCGAACAAGTTCATCCACCAGCCATGGACCGCGACGCTGCTCGAACGCGCCG
CGGCGGGCGTTGCGCTCGGCGGCAATTACCCCGCGCCGATCGTGGATCACAAGGTCGGACGCGCGCGCGCGCTTGCCGCT
TACGCCGAACTGCGTCAGAGTTGA

Upstream 100 bases:

>100_bases
ATCATCCGCATCGTTCTCAATACGCTTTACTTCTTTTCCGGTTTCAAGCCCGCAACCCTCGCCACGGATCAAAATCCCTC
CTGCCGGATTGCATCTTCCG

Downstream 100 bases:

>100_bases
ACAACTGCGGTTAGCACCACTACTAACTGACGCGAATCGGCTATCGTCGATTCCATCTGTAAACCCATCTAGTGAACCTC
GGGGAATGACATGGACGACG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSNDIPRPVIVWFRDDLRLSDHPALHAAAASGSPLICIYVHDEQSPQLRPPQARPIGGAARWWLAQSLRALAAELEQRGA
RLILRRGPAAAIVGELARQVDAAAVHWNEIEIAPHRAIADDLAETLSMSGIDHHRHPGDLLVAPSEIRTKDGRGLRVFTP
FWRRVLGLGDPPKPLPAPAMLRAGPDIASDDPATWQLEPTAPDWAGGLRASWTPGERAAHDLLTAFLDRLPGYAADRDRP
DRDATSLLSPHLRFGEISPRQLWYAARFAAAKRPAIAADIDKFLSELGWREFCRHLLHDHPDLAERNLQSAFDAFPWTRD
DAALAAWQRGRTGYPIVDAGMRQLWHTGVMHNRIRMVVASFLVKHLLIDWRLGEEWFWDTLVDADPGSNPGNWQWVAGSG
ADAAPYFRVFNPILQGEKFDPAGDYVRRWVPEIAALPNKFIHQPWTATLLERAAAGVALGGNYPAPIVDHKVGRARALAA
YAELRQS

Sequences:

>Translated_487_residues
MSNDIPRPVIVWFRDDLRLSDHPALHAAAASGSPLICIYVHDEQSPQLRPPQARPIGGAARWWLAQSLRALAAELEQRGA
RLILRRGPAAAIVGELARQVDAAAVHWNEIEIAPHRAIADDLAETLSMSGIDHHRHPGDLLVAPSEIRTKDGRGLRVFTP
FWRRVLGLGDPPKPLPAPAMLRAGPDIASDDPATWQLEPTAPDWAGGLRASWTPGERAAHDLLTAFLDRLPGYAADRDRP
DRDATSLLSPHLRFGEISPRQLWYAARFAAAKRPAIAADIDKFLSELGWREFCRHLLHDHPDLAERNLQSAFDAFPWTRD
DAALAAWQRGRTGYPIVDAGMRQLWHTGVMHNRIRMVVASFLVKHLLIDWRLGEEWFWDTLVDADPGSNPGNWQWVAGSG
ADAAPYFRVFNPILQGEKFDPAGDYVRRWVPEIAALPNKFIHQPWTATLLERAAAGVALGGNYPAPIVDHKVGRARALAA
YAELRQS
>Mature_486_residues
SNDIPRPVIVWFRDDLRLSDHPALHAAAASGSPLICIYVHDEQSPQLRPPQARPIGGAARWWLAQSLRALAAELEQRGAR
LILRRGPAAAIVGELARQVDAAAVHWNEIEIAPHRAIADDLAETLSMSGIDHHRHPGDLLVAPSEIRTKDGRGLRVFTPF
WRRVLGLGDPPKPLPAPAMLRAGPDIASDDPATWQLEPTAPDWAGGLRASWTPGERAAHDLLTAFLDRLPGYAADRDRPD
RDATSLLSPHLRFGEISPRQLWYAARFAAAKRPAIAADIDKFLSELGWREFCRHLLHDHPDLAERNLQSAFDAFPWTRDD
AALAAWQRGRTGYPIVDAGMRQLWHTGVMHNRIRMVVASFLVKHLLIDWRLGEEWFWDTLVDADPGSNPGNWQWVAGSGA
DAAPYFRVFNPILQGEKFDPAGDYVRRWVPEIAALPNKFIHQPWTATLLERAAAGVALGGNYPAPIVDHKVGRARALAAY
AELRQS

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=478, Percent_Identity=29.9163179916318, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4758072, Length=476, Percent_Identity=28.3613445378151, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI188536103, Length=432, Percent_Identity=29.1666666666667, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1786926, Length=496, Percent_Identity=37.0967741935484, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324962, Length=515, Percent_Identity=29.5145631067961, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17137248, Length=490, Percent_Identity=30.8163265306122, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24585455, Length=490, Percent_Identity=30.8163265306122, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24648152, Length=526, Percent_Identity=27.7566539923954, Blast_Score=152, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54100; Mature: 53969

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDIPRPVIVWFRDDLRLSDHPALHAAAASGSPLICIYVHDEQSPQLRPPQARPIGGAA
CCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
RWWLAQSLRALAAELEQRGARLILRRGPAAAIVGELARQVDAAAVHWNEIEIAPHRAIAD
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHEECCEEEECCHHHHHH
DLAETLSMSGIDHHRHPGDLLVAPSEIRTKDGRGLRVFTPFWRRVLGLGDPPKPLPAPAM
HHHHHHHHCCCCCCCCCCCEEECCHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCCCHH
LRAGPDIASDDPATWQLEPTAPDWAGGLRASWTPGERAAHDLLTAFLDRLPGYAADRDRP
HHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DRDATSLLSPHLRFGEISPRQLWYAARFAAAKRPAIAADIDKFLSELGWREFCRHLLHDH
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHCC
PDLAERNLQSAFDAFPWTRDDAALAAWQRGRTGYPIVDAGMRQLWHTGVMHNRIRMVVAS
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLVKHLLIDWRLGEEWFWDTLVDADPGSNPGNWQWVAGSGADAAPYFRVFNPILQGEKFD
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCC
PAGDYVRRWVPEIAALPNKFIHQPWTATLLERAAAGVALGGNYPAPIVDHKVGRARALAA
CHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCEEECCCCCCCHHHCCCHHHHHHHH
YAELRQS
HHHHHCC
>Mature Secondary Structure 
SNDIPRPVIVWFRDDLRLSDHPALHAAAASGSPLICIYVHDEQSPQLRPPQARPIGGAA
CCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
RWWLAQSLRALAAELEQRGARLILRRGPAAAIVGELARQVDAAAVHWNEIEIAPHRAIAD
HHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHEECCEEEECCHHHHHH
DLAETLSMSGIDHHRHPGDLLVAPSEIRTKDGRGLRVFTPFWRRVLGLGDPPKPLPAPAM
HHHHHHHHCCCCCCCCCCCEEECCHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCCCHH
LRAGPDIASDDPATWQLEPTAPDWAGGLRASWTPGERAAHDLLTAFLDRLPGYAADRDRP
HHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DRDATSLLSPHLRFGEISPRQLWYAARFAAAKRPAIAADIDKFLSELGWREFCRHLLHDH
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHCC
PDLAERNLQSAFDAFPWTRDDAALAAWQRGRTGYPIVDAGMRQLWHTGVMHNRIRMVVAS
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLVKHLLIDWRLGEEWFWDTLVDADPGSNPGNWQWVAGSGADAAPYFRVFNPILQGEKFD
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCC
PAGDYVRRWVPEIAALPNKFIHQPWTATLLERAAAGVALGGNYPAPIVDHKVGRARALAA
CHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCEEECCCCCCCHHHCCCHHHHHHHH
YAELRQS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]