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The map label for this gene is fumC [H]

Identifier: 86749153

GI number: 86749153

Start: 2309647

End: 2311065

Strand: Reverse

Name: fumC [H]

Synonym: RPB_2030

Alternate gene names: 86749153

Gene position: 2311065-2309647 (Counterclockwise)

Preceding gene: 86749154

Following gene: 86749152

Centisome position: 43.35

GC content: 67.44

Gene sequence:

>1419_bases
ATGGCCCGTAAGCCCGATGCCCCCAAGCTGGGGGCGACCCGCAGCGAAACCGACAGCTTCGGTCCGATCGAGGTCGCCGC
CGACCGCTACTGGGGCGCGCAGACCGAACGCTCGCGGCAGAACTTCCGGATCGGCCGGGAGCGGATGCCGATCGGCCTCG
TGCACGCGCTCGGCATCGTCAAGCTCGCCGCCGCCGAGACCAATCGCGAACTCGGCCTGCTCGACCAGCGCCGCGCCGGC
GCCATCGTCCGCGCGGCACGCGAAGTGATCGACGGCAAGCTCGACGATCACTTCCCGCTGGTGGTGTGGCAGACCGGCTC
CGGCACCCAGACCAACATGAACCTCAACGAGGTGATCGCCAACCGCGCCAACGAGCTGCTCGGCGGCGAGCGCGGCAGCA
AGACGCCGGTCCATCCCAACGACCACGTCAACATGAGCCAGTCGTCGAACGACTCGTTCCCGACCGCGATGCACATCGCC
GCCGCGCAGGCGATCGTCGCCGATCTGATCCCCGGCCTGACGATGCTGCACGACGCGCTGCGCGCCAAGGAGAAAGCCTT
CGCCAAGATCGTCAAGATCGGCCGCACCCATACCCAGGACGCCACCCCGCTGACGCTCGGCCAGGAGTTTTCCGGCTACG
CCGCGCAGGTCGCGAGCAGCCTGGCCCGGCTGAAGCTCGCGGTGAAGGAACTGTATCCGCTGGCGCAGGGCGGCACCGCG
GTCGGCACCGGCCTCAACACCCACCCGAAATTCGCCAAGGCGTTCGCCAAGCGCGCCGCCGCGCTGACCGAGCTGCCGTT
CGTCACCGCGCCGAACAAATTCGAGGCGCTGGCGAGTAACGACGCTTACGTCTCGGTGCACGGCGCAATCAACGCCGCCG
CGACCGCGCTGTTCAAGATCGCCAACGATATCCGCCTGCTCGGCTCAGGGCCACGCTCGGGACTCGGCGAGCTGATCCTG
CCGGAGAACGAGCCGGGCTCCTCGATCATGCCCGGCAAGGTCAACCCGACGCAATGCGAAGCGCTGACGATGGTGTGCTG
CCAGGTGTTCGGCAATCACACCACCATCACCGTCGCCGGCAGCCAGGGTCACTTCGAACTCAACGTCTACAAGCCGGTGA
TGGCGCAGGCGATGCTGCAGTCGGTCGGGCTGCTGGCCGACGCCGCGCGGTCGTTCACCACCCATTGCGTCGACGGCATT
CGCGCCGACGAAGTCCGGATCGGCGAACTGATGCAGCGCTCCTTGATGCTGGTGACCGCGCTGGCGCCGAAGATCGGCTA
CGACAACGCCGCGAAGATCGCCAAATCCGCGCATCAGCGCGGCACCACCCTGAAACAGGAGGCGTTGCGGCTCGGCCTGG
TGAGCGAAGCCGAGTTCGACCGGCTGGTCCGTCCGGACAATATGACGCATCCTGGATGA

Upstream 100 bases:

>100_bases
AGAAATAGGGTTTCGCGCAGCCGTCGCGCCCCCTCCGCCGGCCGCGGCGCGGCCTGCGGGGTTCTTTACGATTCCCCCGC
TGACCGACAGGACGACCGCG

Downstream 100 bases:

>100_bases
GCCGTGCCGTCGCGCAGACTGACCAAAAATGCCATTTTGGAAATTGATGTAAATCATATCCCTTGCTCGTGCGGATTGAT
CAACTTGATCTCGCAGCGTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MARKPDAPKLGATRSETDSFGPIEVAADRYWGAQTERSRQNFRIGRERMPIGLVHALGIVKLAAAETNRELGLLDQRRAG
AIVRAAREVIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANELLGGERGSKTPVHPNDHVNMSQSSNDSFPTAMHIA
AAQAIVADLIPGLTMLHDALRAKEKAFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVASSLARLKLAVKELYPLAQGGTA
VGTGLNTHPKFAKAFAKRAAALTELPFVTAPNKFEALASNDAYVSVHGAINAAATALFKIANDIRLLGSGPRSGLGELIL
PENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTTITVAGSQGHFELNVYKPVMAQAMLQSVGLLADAARSFTTHCVDGI
RADEVRIGELMQRSLMLVTALAPKIGYDNAAKIAKSAHQRGTTLKQEALRLGLVSEAEFDRLVRPDNMTHPG

Sequences:

>Translated_472_residues
MARKPDAPKLGATRSETDSFGPIEVAADRYWGAQTERSRQNFRIGRERMPIGLVHALGIVKLAAAETNRELGLLDQRRAG
AIVRAAREVIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANELLGGERGSKTPVHPNDHVNMSQSSNDSFPTAMHIA
AAQAIVADLIPGLTMLHDALRAKEKAFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVASSLARLKLAVKELYPLAQGGTA
VGTGLNTHPKFAKAFAKRAAALTELPFVTAPNKFEALASNDAYVSVHGAINAAATALFKIANDIRLLGSGPRSGLGELIL
PENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTTITVAGSQGHFELNVYKPVMAQAMLQSVGLLADAARSFTTHCVDGI
RADEVRIGELMQRSLMLVTALAPKIGYDNAAKIAKSAHQRGTTLKQEALRLGLVSEAEFDRLVRPDNMTHPG
>Mature_471_residues
ARKPDAPKLGATRSETDSFGPIEVAADRYWGAQTERSRQNFRIGRERMPIGLVHALGIVKLAAAETNRELGLLDQRRAGA
IVRAAREVIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIANRANELLGGERGSKTPVHPNDHVNMSQSSNDSFPTAMHIAA
AQAIVADLIPGLTMLHDALRAKEKAFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVASSLARLKLAVKELYPLAQGGTAV
GTGLNTHPKFAKAFAKRAAALTELPFVTAPNKFEALASNDAYVSVHGAINAAATALFKIANDIRLLGSGPRSGLGELILP
ENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTTITVAGSQGHFELNVYKPVMAQAMLQSVGLLADAARSFTTHCVDGIR
ADEVRIGELMQRSLMLVTALAPKIGYDNAAKIAKSAHQRGTTLKQEALRLGLVSEAEFDRLVRPDNMTHPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=472, Percent_Identity=64.6186440677966, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=60, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=40.1301518438178, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=64.0086206896552, Blast_Score=613, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=63.302752293578, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=64.5652173913044, Blast_Score=592, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=63.1236442516269, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=63.1236442516269, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=61.3390928725702, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=59.0909090909091, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=52.9157667386609, Blast_Score=494, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50481; Mature: 50350

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKPDAPKLGATRSETDSFGPIEVAADRYWGAQTERSRQNFRIGRERMPIGLVHALGIV
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHCCHHCCCHHHHHHHHHH
KLAAAETNRELGLLDQRRAGAIVRAAREVIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
NRANELLGGERGSKTPVHPNDHVNMSQSSNDSFPTAMHIAAAQAIVADLIPGLTMLHDAL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKEKAFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVASSLARLKLAVKELYPLAQGGTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VGTGLNTHPKFAKAFAKRAAALTELPFVTAPNKFEALASNDAYVSVHGAINAAATALFKI
ECCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHCCCCCEEEECCHHHHHHHHHHHH
ANDIRLLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTTITVAG
HHHHHEECCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
SQGHFELNVYKPVMAQAMLQSVGLLADAARSFTTHCVDGIRADEVRIGELMQRSLMLVTA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAPKIGYDNAAKIAKSAHQRGTTLKQEALRLGLVSEAEFDRLVRPDNMTHPG
HHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ARKPDAPKLGATRSETDSFGPIEVAADRYWGAQTERSRQNFRIGRERMPIGLVHALGIV
CCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHCCHHCCCHHHHHHHHHH
KLAAAETNRELGLLDQRRAGAIVRAAREVIDGKLDDHFPLVVWQTGSGTQTNMNLNEVIA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
NRANELLGGERGSKTPVHPNDHVNMSQSSNDSFPTAMHIAAAQAIVADLIPGLTMLHDAL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKEKAFAKIVKIGRTHTQDATPLTLGQEFSGYAAQVASSLARLKLAVKELYPLAQGGTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VGTGLNTHPKFAKAFAKRAAALTELPFVTAPNKFEALASNDAYVSVHGAINAAATALFKI
ECCCCCCCHHHHHHHHHHHHHHHHCCCEECCCHHHHHCCCCCEEEECCHHHHHHHHHHHH
ANDIRLLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEALTMVCCQVFGNHTTITVAG
HHHHHEECCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEC
SQGHFELNVYKPVMAQAMLQSVGLLADAARSFTTHCVDGIRADEVRIGELMQRSLMLVTA
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LAPKIGYDNAAKIAKSAHQRGTTLKQEALRLGLVSEAEFDRLVRPDNMTHPG
HHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]