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The map label for this gene is metH [H]

Identifier: 86748887

GI number: 86748887

Start: 2018819

End: 2022733

Strand: Reverse

Name: metH [H]

Synonym: RPB_1764

Alternate gene names: 86748887

Gene position: 2022733-2018819 (Counterclockwise)

Preceding gene: 86748888

Following gene: 86748885

Centisome position: 37.94

GC content: 66.44

Gene sequence:

>3915_bases
ATGAACTCCATGACCAAGCCGACATCCCCGAAGCGGACCGAACTGCTGGCGCTGACCCGCGAGCGCATCCTCGTGCTCGA
CGGCGCGATGGGCACGATGATCCAGGCGCTGCAGTTCGACGAGGCTGCGTTCCGCGGCGAGCGCTTCAAGGATTTCCATC
GCGACCTGCGCGGCAACAACGACCTGTTGATCCTGACCCAGCCGCAGGCGATCGAGGACATCCACGCGCAATATCTGCGC
GCCGGCGCCGACATCGTCGCCACCAACACCTTCTCCTCGACCTCGATCGCGCAGGCGGACTACGACCTGTCCGAGATCGC
CTATGAAATGAGCCGTGACGGCGCCCGCCTCGCCCGCAACGCCGCCGACACGGTGCAGGCCGAGGACGGCAAGCCGCGCT
TCGTCGCCGGCGCGATCGGCCCGACCAACCGCACCGCCTCGATCTCGCCCGATGTCGCCAATCCGGGCTATCGCGCGGTG
ACCTTCGACGATCTGCGCATCGCCTATGGCGAGCAGATCAACGGGCTGCTCGACGGCGGCGCCGACCTGCTGCTGGTCGA
GACTATTTTCGACACGCTCAATGCCAAGGCGGCGCTCTACGCGATCGCCGAGATCAGCGAGGCGCGCGGCATCGACGTGC
CGGTGATGATCTCCGGCACCATCACCGACAAATCCGGACGGCTCTTGTCCGGGCAATTGCCGGAAGCGTTCTGGAATTCG
GTGCGACATGCCAAGCCGATCACCATCGGCTTCAACTGCGCGCTCGGCGCCAAGGATCTGCGCGCGCACATCGCCGATAT
CGGCCGCGTCGCCGATACGCTGGTCTGCGCCTATCCCAACGCCGGCCTGCCCAACGAATTCGGCCAGTACGACGAGAGCC
CGGACTACATGGCATCGCTGGTCGGCGAATTCGCAGAGGCCGGCCTCGTCAACATCGTCGGCGGCTGCTGCGGCACCACG
CCGGCGCATATCGCGGCGATCGCCAAGGCCGTGGCGCCGCACAAGCCGCGCGTCGTGCCCGTGATCGAACCGCGGCTGCG
ATTGAGCGGGCTCGAGCCGTTCGAACTCACCCAAGCTATTCCGTTCGTCAATGTCGGCGAGCGCACCAACGTCACGGGCT
CTGCGAAATTCCGCAAGCTGATCACCGCCGGCGACTACGCCGCGGCGCTACAGGTGGCGCGCGACCAGGTCGAGAACGGC
GCGCAGATCATCGACGTCAACATGGACGAAGGGCTTCTGGATTCCGAAGCCGCGATGGTGACCTTCCTCAACCTGGTCGC
CGCCGAGCCGGACATCGCCAAGGTGCCGGTGATGGTCGATAGTTCGAAGTTCGCCGTGATCGAGGCCGGCCTGAAATGCG
TTCAGGGCAAGCCGGTGGTGAACTCGATCTCGCTGAAGGAAGGCGAGGACAAGTTCCTGCACGAGGCCAGGATCGCGCGC
CGCCACGGCGCCGCGGTCGTCGTCATGGCGTTCGACGAACAGGGCCAAGCCGACACTTACGCGCGCAAGACCGAGATCTG
CAAACGCGCCTACGACATTCTGGTCGAGCGGATCGGCTTCCCGCCGGAAGACATCATCTTCGATCCGAATATCTTCGCGA
TCGCGACCGGGCTGGAAGAACACAACAATTACGGCGTCGACTTCATCGAGGCGACGCGCTGGATCCGCCAGAACCTGCCG
CACGCGCATATCTCCGGCGGCGTCTCGAATCTCTCGTTCTCGTTCCGCGGCAACGAGCCGGTGCGCGAGGCGATGCACTC
GGTGTTCCTGTATCACGCCATCAAGGCCGGCATGGACATGGGCATCGTCAATGCCGGGCAGATGATCGTGTATGACGACA
TCGATCCCGAACTGCGCCAAACTTGCGAGGACGTCATCCTCAATCGCGACCCGGGCGCCTCCGAGCGGCTGCTGGCGCTC
GCCGAAAAGTATCGCGGCCAGGGCAAGGCGGTGAAGGAGCAGGACCTCGCCTGGCGTTCGTGGCCGGTCGAGCAGCGGCT
CAGCCACGCGCTGGTGCACGGCATCACCGAATATATCGAGACCGATACCGAGGAAGCCCGCGCCAAAGCAGAACGACCGC
TGCACGTGATCGAAGGCCCGCTGATGGCCGGCATGAACGTCGTCGGCGATCTGTTCGGCGACGGCAAGATGTTCCTGCCG
CAGGTGGTGAAATCCGCTCGCGTGATGAAGCAGGCGGTCGCCTATCTGATGCCGTTCATGGAAGCCGAGAAGGCCGCCCA
GCTTGCCGCCGGCACCCACACCGGCGAGCGCGCCACCGCCGGCAAGATCGTGCTCGCCACCGTCAAGGGCGACGTCCACG
ACATCGGCAAGAACATCGTCGGCATCGTGCTCCAGTGCAACAATTTCGAGGTGATCGACCTCGGCGTGATGGTGCCCGCC
GCGAAGATCATCGAGACCGCGATCGCCGAGCAGGCGGACATCATCGGCCTGTCCGGCCTGATCACGCCGTCGCTCGATGA
AATGAGCTTCCTCGCCTCCGAGATGCAGCGCAACGGCCTCGACATGCCGCTGCTGATCGGCGGCGCCACCACCAGCCGGG
TCCACACCGCGGTGAAGATCGACCCGTCCTATCCGGCCGGCAGCGTCGTGCACGTCAATGACGCCAGCCGCGCGGTCGGC
GTCGCATCGTCGCTGCTGTCGCGCGAGCGCGGCCCGGCCTACGCCGCCGAGATCCGCGCCGACTACGCCCGGATCACCGC
GGCGCATCTGCGCGCGCAGGCCGACAAGAAGCGCGTCGCGCTGAAAGACGCCCGCGCCAATGCGACGAAGATCGACTGGT
CGGCGGCGAAGCCGGTGAAGCCGTCGTTCCTCGGCGTCCGCAGCTTCATCAACTATCCACTCGCCGAACTGGCCGAGACC
ATCGACTGGACGCCGTTCTTCCAGAGCTGGGAGCTCGCCGGGCGCTTCCCCGCGATCCTCGACGACAAGGTGGTCGGCGA
GGCCGCGCGCTCGCTCTATGCCGACGCCCGCAAGATGCTTGAGCGGATCGTCGCCGAGAACTGGTTCACCGCCAAGGCGG
TGATCGGATTCTGGCCGGCGAATGCGGTCGGCGACGACATCATCCTGTATGCCGACGACGACCGCGACGCCTCGATCGGC
GCGCTGCACACGCTGCGCCAGCAGTTGGTCAAGCGCGAGGGCCGCGCCAATGCGGCGCTGTCGGATTTCATCGCGCCGCG
CGGCGTGCAGGACTATATCGGCGCCTTCGTCGTCACCGCCGGGATCGGCGAGGACGTGATCGCCGACAAATTCAAGGCCG
ACAATGACGACTATTCGTCGATCATGGTCAAGGCGCTGGCCGATCGTCTGGCGGAGGCCTTCGCCGAGCGGATGCACGCC
CGCGTTCGCCGCGAATTCTGGGGCTACGCGCCGGACGAGAGCCTGTCGGTGGATGAGCTGATCCTCGAGAAGTATCAGGG
CATCCGCCCGGCGCCGGGCTATCCGGCGCAGCCCGACCACACCGAGAAGGCGACGCTGTTCAAGCTGCTCGAAGCCGAGG
TCAATGCCGGCGTGACGCTGACCGAGTCATATGCGATGTGGCCCGGCTCGTCGGTGTCGGGGCTGTATTTCAGCCATCCG
CAGAGCGCCTATTTCGGCGTCGGCAAGATCGAGCGCGACCAGGTCGAGGACTACGCGCTGCGCAAGGGCTGGAGCGTCAC
CGAGGCCGAGCGCTGGCTCGCCCCGGTGCTGAACTACATCCCCGAGCCGCAGCCCGCCGGTGCCCGCGCCCAGGAGCCGA
TGCCGCCGCTGGCGCCGTCCGGCGACCTGCTGCCGACCGAGCCGCCCGCCGATGCGGCGTTCACCGCGAACGACGCCGCC
CTCGCCGCCCACCCCGCCGGCTGCAACTGCGCGGTGCATCTGATGTGGCGGAAGACGGCGGTCGGGGCGAAGTAG

Upstream 100 bases:

>100_bases
GCGTCGACACCTTCCACTTCTACACCATGAACCGCGCGGACCTGGTGTTCGCGATCAGCCACCTGCTCGGCCTTCGGCCG
CAGGCGGCGCAGAAAGCCGC

Downstream 100 bases:

>100_bases
GCGCTGTCGCTTTCGCCGGCGTTCTGAACAAGCTCGTGGGCAAAGCGAAGCGTGCCCACGGCGTCTGCCGCCACGCAACA
GCCTGCCGCAACACGTACAG

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1304; Mature: 1304

Protein sequence:

>1304_residues
MNSMTKPTSPKRTELLALTRERILVLDGAMGTMIQALQFDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQYLR
AGADIVATNTFSSTSIAQADYDLSEIAYEMSRDGARLARNAADTVQAEDGKPRFVAGAIGPTNRTASISPDVANPGYRAV
TFDDLRIAYGEQINGLLDGGADLLLVETIFDTLNAKAALYAIAEISEARGIDVPVMISGTITDKSGRLLSGQLPEAFWNS
VRHAKPITIGFNCALGAKDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDESPDYMASLVGEFAEAGLVNIVGGCCGTT
PAHIAAIAKAVAPHKPRVVPVIEPRLRLSGLEPFELTQAIPFVNVGERTNVTGSAKFRKLITAGDYAAALQVARDQVENG
AQIIDVNMDEGLLDSEAAMVTFLNLVAAEPDIAKVPVMVDSSKFAVIEAGLKCVQGKPVVNSISLKEGEDKFLHEARIAR
RHGAAVVVMAFDEQGQADTYARKTEICKRAYDILVERIGFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRQNLP
HAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASERLLAL
AEKYRGQGKAVKEQDLAWRSWPVEQRLSHALVHGITEYIETDTEEARAKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLP
QVVKSARVMKQAVAYLMPFMEAEKAAQLAAGTHTGERATAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPA
AKIIETAIAEQADIIGLSGLITPSLDEMSFLASEMQRNGLDMPLLIGGATTSRVHTAVKIDPSYPAGSVVHVNDASRAVG
VASSLLSRERGPAYAAEIRADYARITAAHLRAQADKKRVALKDARANATKIDWSAAKPVKPSFLGVRSFINYPLAELAET
IDWTPFFQSWELAGRFPAILDDKVVGEAARSLYADARKMLERIVAENWFTAKAVIGFWPANAVGDDIILYADDDRDASIG
ALHTLRQQLVKREGRANAALSDFIAPRGVQDYIGAFVVTAGIGEDVIADKFKADNDDYSSIMVKALADRLAEAFAERMHA
RVRREFWGYAPDESLSVDELILEKYQGIRPAPGYPAQPDHTEKATLFKLLEAEVNAGVTLTESYAMWPGSSVSGLYFSHP
QSAYFGVGKIERDQVEDYALRKGWSVTEAERWLAPVLNYIPEPQPAGARAQEPMPPLAPSGDLLPTEPPADAAFTANDAA
LAAHPAGCNCAVHLMWRKTAVGAK

Sequences:

>Translated_1304_residues
MNSMTKPTSPKRTELLALTRERILVLDGAMGTMIQALQFDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQYLR
AGADIVATNTFSSTSIAQADYDLSEIAYEMSRDGARLARNAADTVQAEDGKPRFVAGAIGPTNRTASISPDVANPGYRAV
TFDDLRIAYGEQINGLLDGGADLLLVETIFDTLNAKAALYAIAEISEARGIDVPVMISGTITDKSGRLLSGQLPEAFWNS
VRHAKPITIGFNCALGAKDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDESPDYMASLVGEFAEAGLVNIVGGCCGTT
PAHIAAIAKAVAPHKPRVVPVIEPRLRLSGLEPFELTQAIPFVNVGERTNVTGSAKFRKLITAGDYAAALQVARDQVENG
AQIIDVNMDEGLLDSEAAMVTFLNLVAAEPDIAKVPVMVDSSKFAVIEAGLKCVQGKPVVNSISLKEGEDKFLHEARIAR
RHGAAVVVMAFDEQGQADTYARKTEICKRAYDILVERIGFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRQNLP
HAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASERLLAL
AEKYRGQGKAVKEQDLAWRSWPVEQRLSHALVHGITEYIETDTEEARAKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLP
QVVKSARVMKQAVAYLMPFMEAEKAAQLAAGTHTGERATAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPA
AKIIETAIAEQADIIGLSGLITPSLDEMSFLASEMQRNGLDMPLLIGGATTSRVHTAVKIDPSYPAGSVVHVNDASRAVG
VASSLLSRERGPAYAAEIRADYARITAAHLRAQADKKRVALKDARANATKIDWSAAKPVKPSFLGVRSFINYPLAELAET
IDWTPFFQSWELAGRFPAILDDKVVGEAARSLYADARKMLERIVAENWFTAKAVIGFWPANAVGDDIILYADDDRDASIG
ALHTLRQQLVKREGRANAALSDFIAPRGVQDYIGAFVVTAGIGEDVIADKFKADNDDYSSIMVKALADRLAEAFAERMHA
RVRREFWGYAPDESLSVDELILEKYQGIRPAPGYPAQPDHTEKATLFKLLEAEVNAGVTLTESYAMWPGSSVSGLYFSHP
QSAYFGVGKIERDQVEDYALRKGWSVTEAERWLAPVLNYIPEPQPAGARAQEPMPPLAPSGDLLPTEPPADAAFTANDAA
LAAHPAGCNCAVHLMWRKTAVGAK
>Mature_1304_residues
MNSMTKPTSPKRTELLALTRERILVLDGAMGTMIQALQFDEAAFRGERFKDFHRDLRGNNDLLILTQPQAIEDIHAQYLR
AGADIVATNTFSSTSIAQADYDLSEIAYEMSRDGARLARNAADTVQAEDGKPRFVAGAIGPTNRTASISPDVANPGYRAV
TFDDLRIAYGEQINGLLDGGADLLLVETIFDTLNAKAALYAIAEISEARGIDVPVMISGTITDKSGRLLSGQLPEAFWNS
VRHAKPITIGFNCALGAKDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDESPDYMASLVGEFAEAGLVNIVGGCCGTT
PAHIAAIAKAVAPHKPRVVPVIEPRLRLSGLEPFELTQAIPFVNVGERTNVTGSAKFRKLITAGDYAAALQVARDQVENG
AQIIDVNMDEGLLDSEAAMVTFLNLVAAEPDIAKVPVMVDSSKFAVIEAGLKCVQGKPVVNSISLKEGEDKFLHEARIAR
RHGAAVVVMAFDEQGQADTYARKTEICKRAYDILVERIGFPPEDIIFDPNIFAIATGLEEHNNYGVDFIEATRWIRQNLP
HAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDMGIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASERLLAL
AEKYRGQGKAVKEQDLAWRSWPVEQRLSHALVHGITEYIETDTEEARAKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLP
QVVKSARVMKQAVAYLMPFMEAEKAAQLAAGTHTGERATAGKIVLATVKGDVHDIGKNIVGIVLQCNNFEVIDLGVMVPA
AKIIETAIAEQADIIGLSGLITPSLDEMSFLASEMQRNGLDMPLLIGGATTSRVHTAVKIDPSYPAGSVVHVNDASRAVG
VASSLLSRERGPAYAAEIRADYARITAAHLRAQADKKRVALKDARANATKIDWSAAKPVKPSFLGVRSFINYPLAELAET
IDWTPFFQSWELAGRFPAILDDKVVGEAARSLYADARKMLERIVAENWFTAKAVIGFWPANAVGDDIILYADDDRDASIG
ALHTLRQQLVKREGRANAALSDFIAPRGVQDYIGAFVVTAGIGEDVIADKFKADNDDYSSIMVKALADRLAEAFAERMHA
RVRREFWGYAPDESLSVDELILEKYQGIRPAPGYPAQPDHTEKATLFKLLEAEVNAGVTLTESYAMWPGSSVSGLYFSHP
QSAYFGVGKIERDQVEDYALRKGWSVTEAERWLAPVLNYIPEPQPAGARAQEPMPPLAPSGDLLPTEPPADAAFTANDAA
LAAHPAGCNCAVHLMWRKTAVGAK

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1261, Percent_Identity=56.8596352101507, Blast_Score=1405, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1236, Percent_Identity=61.2459546925566, Blast_Score=1518, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=326, Percent_Identity=25.7668711656442, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535405, Length=1242, Percent_Identity=55.5555555555556, Blast_Score=1333, Evalue=0.0,
Organism=Drosophila melanogaster, GI24585077, Length=284, Percent_Identity=25.3521126760563, Blast_Score=68, Evalue=5e-11,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 141401; Mature: 141401

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSMTKPTSPKRTELLALTRERILVLDGAMGTMIQALQFDEAAFRGERFKDFHRDLRGNN
CCCCCCCCCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
DLLILTQPQAIEDIHAQYLRAGADIVATNTFSSTSIAQADYDLSEIAYEMSRDGARLARN
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHH
AADTVQAEDGKPRFVAGAIGPTNRTASISPDVANPGYRAVTFDDLRIAYGEQINGLLDGG
HHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCHHHHHHHCCC
ADLLLVETIFDTLNAKAALYAIAEISEARGIDVPVMISGTITDKSGRLLSGQLPEAFWNS
CCEEHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEECCCCCHHHHHH
VRHAKPITIGFNCALGAKDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDESPDYMASL
HCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCHHHHHHH
VGEFAEAGLVNIVGGCCGTTPAHIAAIAKAVAPHKPRVVPVIEPRLRLSGLEPFELTQAI
HHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCHHHHHHHC
PFVNVGERTNVTGSAKFRKLITAGDYAAALQVARDQVENGAQIIDVNMDEGLLDSEAAMV
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
TFLNLVAAEPDIAKVPVMVDSSKFAVIEAGLKCVQGKPVVNSISLKEGEDKFLHEARIAR
HHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
RHGAAVVVMAFDEQGQADTYARKTEICKRAYDILVERIGFPPEDIIFDPNIFAIATGLEE
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCEEEEECHHH
HNNYGVDFIEATRWIRQNLPHAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDM
CCCCCCHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
GIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASERLLALAEKYRGQGKAVKEQDLAWRS
CEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHC
WPVEQRLSHALVHGITEYIETDTEEARAKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLP
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCHHH
QVVKSARVMKQAVAYLMPFMEAEKAAQLAAGTHTGERATAGKIVLATVKGDVHDIGKNIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCEE
GIVLQCNNFEVIDLGVMVPAAKIIETAIAEQADIIGLSGLITPSLDEMSFLASEMQRNGL
EEEEEECCEEEEEECHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCC
DMPLLIGGATTSRVHTAVKIDPSYPAGSVVHVNDASRAVGVASSLLSRERGPAYAAEIRA
CCCEEEECCCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHH
DYARITAAHLRAQADKKRVALKDARANATKIDWSAAKPVKPSFLGVRSFINYPLAELAET
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHH
IDWTPFFQSWELAGRFPAILDDKVVGEAARSLYADARKMLERIVAENWFTAKAVIGFWPA
CCCCCCHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHEEEECCC
NAVGDDIILYADDDRDASIGALHTLRQQLVKREGRANAALSDFIAPRGVQDYIGAFVVTA
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCC
GIGEDVIADKFKADNDDYSSIMVKALADRLAEAFAERMHARVRREFWGYAPDESLSVDEL
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ILEKYQGIRPAPGYPAQPDHTEKATLFKLLEAEVNAGVTLTESYAMWPGSSVSGLYFSHP
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCEEECCC
QSAYFGVGKIERDQVEDYALRKGWSVTEAERWLAPVLNYIPEPQPAGARAQEPMPPLAPS
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GDLLPTEPPADAAFTANDAALAAHPAGCNCAVHLMWRKTAVGAK
CCCCCCCCCCCCEEECCCCEEEECCCCCCEEEEEEEHHHCCCCC
>Mature Secondary Structure
MNSMTKPTSPKRTELLALTRERILVLDGAMGTMIQALQFDEAAFRGERFKDFHRDLRGNN
CCCCCCCCCCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
DLLILTQPQAIEDIHAQYLRAGADIVATNTFSSTSIAQADYDLSEIAYEMSRDGARLARN
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHCCHHHHHHH
AADTVQAEDGKPRFVAGAIGPTNRTASISPDVANPGYRAVTFDDLRIAYGEQINGLLDGG
HHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCHHHHHHHCCC
ADLLLVETIFDTLNAKAALYAIAEISEARGIDVPVMISGTITDKSGRLLSGQLPEAFWNS
CCEEHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEECCCCCHHHHHH
VRHAKPITIGFNCALGAKDLRAHIADIGRVADTLVCAYPNAGLPNEFGQYDESPDYMASL
HCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHCCCCCHHHHHHH
VGEFAEAGLVNIVGGCCGTTPAHIAAIAKAVAPHKPRVVPVIEPRLRLSGLEPFELTQAI
HHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCHHHHHHHC
PFVNVGERTNVTGSAKFRKLITAGDYAAALQVARDQVENGAQIIDVNMDEGLLDSEAAMV
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHH
TFLNLVAAEPDIAKVPVMVDSSKFAVIEAGLKCVQGKPVVNSISLKEGEDKFLHEARIAR
HHHHHHHCCCCCCCCCEEECCCCEEHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
RHGAAVVVMAFDEQGQADTYARKTEICKRAYDILVERIGFPPEDIIFDPNIFAIATGLEE
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCCEEEEECHHH
HNNYGVDFIEATRWIRQNLPHAHISGGVSNLSFSFRGNEPVREAMHSVFLYHAIKAGMDM
CCCCCCHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
GIVNAGQMIVYDDIDPELRQTCEDVILNRDPGASERLLALAEKYRGQGKAVKEQDLAWRS
CEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCHHC
WPVEQRLSHALVHGITEYIETDTEEARAKAERPLHVIEGPLMAGMNVVGDLFGDGKMFLP
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCHHH
QVVKSARVMKQAVAYLMPFMEAEKAAQLAAGTHTGERATAGKIVLATVKGDVHDIGKNIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCCCEE
GIVLQCNNFEVIDLGVMVPAAKIIETAIAEQADIIGLSGLITPSLDEMSFLASEMQRNGL
EEEEEECCEEEEEECHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHCCC
DMPLLIGGATTSRVHTAVKIDPSYPAGSVVHVNDASRAVGVASSLLSRERGPAYAAEIRA
CCCEEEECCCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHH
DYARITAAHLRAQADKKRVALKDARANATKIDWSAAKPVKPSFLGVRSFINYPLAELAET
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHH
IDWTPFFQSWELAGRFPAILDDKVVGEAARSLYADARKMLERIVAENWFTAKAVIGFWPA
CCCCCCHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHEEEECCC
NAVGDDIILYADDDRDASIGALHTLRQQLVKREGRANAALSDFIAPRGVQDYIGAFVVTA
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHCC
GIGEDVIADKFKADNDDYSSIMVKALADRLAEAFAERMHARVRREFWGYAPDESLSVDEL
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
ILEKYQGIRPAPGYPAQPDHTEKATLFKLLEAEVNAGVTLTESYAMWPGSSVSGLYFSHP
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEECCCCCCCCEEECCC
QSAYFGVGKIERDQVEDYALRKGWSVTEAERWLAPVLNYIPEPQPAGARAQEPMPPLAPS
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GDLLPTEPPADAAFTANDAALAAHPAGCNCAVHLMWRKTAVGAK
CCCCCCCCCCCCEEECCCCEEEECCCCCCEEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]