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The map label for this gene is norM [H]

Identifier: 86748798

GI number: 86748798

Start: 1906086

End: 1907459

Strand: Reverse

Name: norM [H]

Synonym: RPB_1675

Alternate gene names: 86748798

Gene position: 1907459-1906086 (Counterclockwise)

Preceding gene: 86748801

Following gene: 86748797

Centisome position: 35.78

GC content: 70.09

Gene sequence:

>1374_bases
ATGACCATCGACGCGCCGGCGGACCGGCCGCTCCCCGCCGCTTCCGCCGAGCGACTGCTCGCCGCGCCGATCCTGCCGAC
TCTGATCCGGCTGGCGATTCCGAACGTGATCGCGATGGTCGGCACCGCGGTGGTGGCGATCGCCGAAACCTCCTATATCG
GCCGTCTCGGCACCGAGCCGCTGGCGGCGATCGCGCTGGTGTTCCCGTTCGCGATGCTGACGCAGATGATGTCGGCGGGC
GCGATGGGCGGCGGGGTGTCCTCCGCCGTCAGCCGCGCACTCGGCGCCGGAGACCGCACACGCGCCGAAGTGCTGGCGCT
GCACGCGATCATCATCGGCATCGCCGCCGGGCTGGTCTTCACGCTGCTGATGCTGCTGTTCGGGCGGTCGCTCTACGCGC
TGCTCGGCGGGCGCGGCGAAGTCCTCGAACAGGCCTGCAGCTATTCGGTGGTGCTGTTCTCGGGCGCGGTGTCGATCTGG
CTGGTCAACACGCTGGCGTCGGTGCTGCGCGGCACCGGCGACATGGTGCTGCCGTCGGCGACGCTGCTCGGCGTCGCGGC
GCTGCAGATCGTGATCGGCGGCGGACTCGGGCTCGGCCTGTTCGGCCTGCCGCGGCTCGGCATGGCGGGCGTCGCGTCGG
GCCAGTTGATCGCGTTTTCGCTCGGCGCGCTGTTCCTGCTGGTCTACATGGCGAGCGGCCACGGACGGTTGACGCTGCGG
GTCAAGTCGTTCGTGTTTCAGCGGCCGATGTTCGTCGACATTCTCAAGTTCGGCGCGATGGCCTGCCTCTCGCCGCTGCA
ATCGGTGCTGACGATCCTGATCTTCACCAAAATCATCGCGAGCTACGGGGTCGCGACGCTCGCCGGCTACGGCATCGGCT
CGCGTCTGGAATTCCTGCTGATCCCGATCGCCTTCGCCTTCGGCGTCGCCTCGATCCCGATGGTCGGCATGGCGATCGGC
GCCGGTCAGGTGGCGCGGGCGCGACGCGTGGCCTGGATCGCCGGGGCGGTCTCGGCGCTGATCCTCGGGCTGGTCGGGCT
CGTGCTGGCGATCTGGCCGTCGCTGTGGGTCGCGCTGTTCACCAGCGATCCCGCGGTGGCCGCGGCGGCGAGTTCCTATT
TCAACTGGGCCGGTCCCGGCTTCGCTTTCTTCGGCCTCGGCGTGACGCTGTATTTCGCCTCGCAGGGCGCGGCGAAGGTC
GGCGGCCCGGTGCTCGCGGCGACGGCGCGACTGCTGCTGGTCGCGATCGGCGGCACCGCGCTGATCACGTCCGGCGCCCC
GGCCTCGGCGCTGTTCGCACTGGTGCTGGTGGCGATGGTGGTCTACGGACTCGGAACCGCCGCCGCGATCCACCTGACAC
GCTGGGTCAAGTGA

Upstream 100 bases:

>100_bases
CGCGAGACGCAGACCCTCCGCCTTGCGCACTGATCATATGTTGATCATAATTCAATCATCGACCGCCGCCCGTGAGCGGT
CCGCACGGGCAGGAAATCGC

Downstream 100 bases:

>100_bases
ATCGCAATCCCGCCGCACCGCCGCGGCGGCCATACCTTTGGCGCGAATCTCGTGCTCTGCTATTCAACGCGTTGCGACGC
AGCAGATTTGGCGCGGCGCC

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTIDAPADRPLPAASAERLLAAPILPTLIRLAIPNVIAMVGTAVVAIAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAG
AMGGGVSSAVSRALGAGDRTRAEVLALHAIIIGIAAGLVFTLLMLLFGRSLYALLGGRGEVLEQACSYSVVLFSGAVSIW
LVNTLASVLRGTGDMVLPSATLLGVAALQIVIGGGLGLGLFGLPRLGMAGVASGQLIAFSLGALFLLVYMASGHGRLTLR
VKSFVFQRPMFVDILKFGAMACLSPLQSVLTILIFTKIIASYGVATLAGYGIGSRLEFLLIPIAFAFGVASIPMVGMAIG
AGQVARARRVAWIAGAVSALILGLVGLVLAIWPSLWVALFTSDPAVAAAASSYFNWAGPGFAFFGLGVTLYFASQGAAKV
GGPVLAATARLLLVAIGGTALITSGAPASALFALVLVAMVVYGLGTAAAIHLTRWVK

Sequences:

>Translated_457_residues
MTIDAPADRPLPAASAERLLAAPILPTLIRLAIPNVIAMVGTAVVAIAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAG
AMGGGVSSAVSRALGAGDRTRAEVLALHAIIIGIAAGLVFTLLMLLFGRSLYALLGGRGEVLEQACSYSVVLFSGAVSIW
LVNTLASVLRGTGDMVLPSATLLGVAALQIVIGGGLGLGLFGLPRLGMAGVASGQLIAFSLGALFLLVYMASGHGRLTLR
VKSFVFQRPMFVDILKFGAMACLSPLQSVLTILIFTKIIASYGVATLAGYGIGSRLEFLLIPIAFAFGVASIPMVGMAIG
AGQVARARRVAWIAGAVSALILGLVGLVLAIWPSLWVALFTSDPAVAAAASSYFNWAGPGFAFFGLGVTLYFASQGAAKV
GGPVLAATARLLLVAIGGTALITSGAPASALFALVLVAMVVYGLGTAAAIHLTRWVK
>Mature_456_residues
TIDAPADRPLPAASAERLLAAPILPTLIRLAIPNVIAMVGTAVVAIAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAGA
MGGGVSSAVSRALGAGDRTRAEVLALHAIIIGIAAGLVFTLLMLLFGRSLYALLGGRGEVLEQACSYSVVLFSGAVSIWL
VNTLASVLRGTGDMVLPSATLLGVAALQIVIGGGLGLGLFGLPRLGMAGVASGQLIAFSLGALFLLVYMASGHGRLTLRV
KSFVFQRPMFVDILKFGAMACLSPLQSVLTILIFTKIIASYGVATLAGYGIGSRLEFLLIPIAFAFGVASIPMVGMAIGA
GQVARARRVAWIAGAVSALILGLVGLVLAIWPSLWVALFTSDPAVAAAASSYFNWAGPGFAFFGLGVTLYFASQGAAKVG
GPVLAATARLLLVAIGGTALITSGAPASALFALVLVAMVVYGLGTAAAIHLTRWVK

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=349, Percent_Identity=27.7936962750716, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46541; Mature: 46410

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDAPADRPLPAASAERLLAAPILPTLIRLAIPNVIAMVGTAVVAIAETSYIGRLGTEP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LAAIALVFPFAMLTQMMSAGAMGGGVSSAVSRALGAGDRTRAEVLALHAIIIGIAAGLVF
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TLLMLLFGRSLYALLGGRGEVLEQACSYSVVLFSGAVSIWLVNTLASVLRGTGDMVLPSA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHCCCCCEECCHH
TLLGVAALQIVIGGGLGLGLFGLPRLGMAGVASGQLIAFSLGALFLLVYMASGHGRLTLR
HHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
VKSFVFQRPMFVDILKFGAMACLSPLQSVLTILIFTKIIASYGVATLAGYGIGSRLEFLL
EHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHH
IPIAFAFGVASIPMVGMAIGAGQVARARRVAWIAGAVSALILGLVGLVLAIWPSLWVALF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSDPAVAAAASSYFNWAGPGFAFFGLGVTLYFASQGAAKVGGPVLAATARLLLVAIGGTA
CCCCHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCCCHHCCHHHHHHHHHHHHHCCCCE
LITSGAPASALFALVLVAMVVYGLGTAAAIHLTRWVK
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TIDAPADRPLPAASAERLLAAPILPTLIRLAIPNVIAMVGTAVVAIAETSYIGRLGTEP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH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EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]