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The map label for this gene is wecA [H]

Identifier: 86748730

GI number: 86748730

Start: 1809716

End: 1810735

Strand: Reverse

Name: wecA [H]

Synonym: RPB_1605

Alternate gene names: 86748730

Gene position: 1810735-1809716 (Counterclockwise)

Preceding gene: 86748731

Following gene: 86748726

Centisome position: 33.96

GC content: 64.61

Gene sequence:

>1020_bases
ATGACTCTGTCGCCCGGGTTGCTCGCGCTCGTAGTGCTCACGACGGCTTCGTTGTGCTGCGCGGCGCTCATCGTGGCGAC
GATGCCCCTGCTTCGCCGATACGCACTGGCGCGTCCGAATGCACGCTCGTCCCACCGCACTCCGACTCCGCAGGGCGCCG
GTATCGCAGTCGTTTGCGCGACCCTCGCGGTCGCCGGATCGGCGATTGCTGTCGGCACGCCGTCGACGCAGCTCCCGCTG
TTGCTCTTCTTCTCCACTGTGGTCATCGCTGTGGTGGGAGCGATCGACGACATCAGGCCGTTGCCGGTGCTTCCAAGGCT
GGTGCTTCAGGCGTTCTCCGTCGGCGCCGTCGTCTTCGCCCTTCCCGACCAGCTGCAACTGGTCCCGTTGCTGCCGGTCG
TCGTGGAGCGCATCGTGCTTCTGGTCGCCGGCCTGTGGTTCGTCAATCTCGTCAATTTCATGGACGGCCTGGATCTGATC
ACGGTGGCCGAGATCGTTCCGGTCTCTCTGACGCTGGTGGCGATCGGCCTGCTGCTCGACTCACCTTCCACCGGGATTCT
CGTCGCAGCTGCGCTCGCCGGCTCGATGCTGGGCTTTGCGCCGTTCAATCGGCCCGTGGCCAAGGTTTTCCTGGGCGATG
TCGGAAGCCTACCGATCGGATTGTTGCTGGGCTGGTGCTTGCTGCAACTGGCGTTCGACGGACACATCGCGGCAGCGTTC
CTGCTTCCGCTCTATTATCTCGCGGACAGTTCGATCACTTTGCTGAGGCGGCTGGTCCGGCGTGAAGCTTTCTGGCGCGC
CCACCGCTCCCATTTCTATCAACGCGCCACCGACAACGGCTACTCGGTCATCGACGTCGTGGTTCGGGTTTTCCTGACCA
ACCTCGCGTTGGCGGCGCTGGCAATCGCCTCTGTCGTCCTGTCGTCGCCGGCCGCGGACGCTGTCGCGCTGGTCTGCGGA
GTCGGTCTCGTGGCGGTTCTGCTCACTCGCTTTGCCCGGCCGCGGCGATCACAAAGCTAA

Upstream 100 bases:

>100_bases
CGCAGAGAAGGCCGCCAAGGGCGACGTCGCGATCGAGGTTCGGGAGTGAAGCCATGATCGCAGCGCTGCCATCGCCGGAT
CGCGCGACGAGCGCCGCGCC

Downstream 100 bases:

>100_bases
CTTGCCTGACGCACTGCTGTTCTGGTCCTGGGCGGCGTCGCCGGCCTGATACTCCGGAACCGCGTCCTTGAGAATGGCAA
CGACGCAGTCGTAGCGCCCT

Product: glycosyl transferase family protein

Products: Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine; UMP [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTLSPGLLALVVLTTASLCCAALIVATMPLLRRYALARPNARSSHRTPTPQGAGIAVVCATLAVAGSAIAVGTPSTQLPL
LLFFSTVVIAVVGAIDDIRPLPVLPRLVLQAFSVGAVVFALPDQLQLVPLLPVVVERIVLLVAGLWFVNLVNFMDGLDLI
TVAEIVPVSLTLVAIGLLLDSPSTGILVAAALAGSMLGFAPFNRPVAKVFLGDVGSLPIGLLLGWCLLQLAFDGHIAAAF
LLPLYYLADSSITLLRRLVRREAFWRAHRSHFYQRATDNGYSVIDVVVRVFLTNLALAALAIASVVLSSPAADAVALVCG
VGLVAVLLTRFARPRRSQS

Sequences:

>Translated_339_residues
MTLSPGLLALVVLTTASLCCAALIVATMPLLRRYALARPNARSSHRTPTPQGAGIAVVCATLAVAGSAIAVGTPSTQLPL
LLFFSTVVIAVVGAIDDIRPLPVLPRLVLQAFSVGAVVFALPDQLQLVPLLPVVVERIVLLVAGLWFVNLVNFMDGLDLI
TVAEIVPVSLTLVAIGLLLDSPSTGILVAAALAGSMLGFAPFNRPVAKVFLGDVGSLPIGLLLGWCLLQLAFDGHIAAAF
LLPLYYLADSSITLLRRLVRREAFWRAHRSHFYQRATDNGYSVIDVVVRVFLTNLALAALAIASVVLSSPAADAVALVCG
VGLVAVLLTRFARPRRSQS
>Mature_338_residues
TLSPGLLALVVLTTASLCCAALIVATMPLLRRYALARPNARSSHRTPTPQGAGIAVVCATLAVAGSAIAVGTPSTQLPLL
LFFSTVVIAVVGAIDDIRPLPVLPRLVLQAFSVGAVVFALPDQLQLVPLLPVVVERIVLLVAGLWFVNLVNFMDGLDLIT
VAEIVPVSLTLVAIGLLLDSPSTGILVAAALAGSMLGFAPFNRPVAKVFLGDVGSLPIGLLLGWCLLQLAFDGHIAAAFL
LPLYYLADSSITLLRRLVRREAFWRAHRSHFYQRATDNGYSVIDVVVRVFLTNLALAALAIASVVLSSPAADAVALVCGV
GLVAVLLTRFARPRRSQS

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.13 [C]

Molecular weight: Translated: 35647; Mature: 35516

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPGLLALVVLTTASLCCAALIVATMPLLRRYALARPNARSSHRTPTPQGAGIAVVCA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
TLAVAGSAIAVGTPSTQLPLLLFFSTVVIAVVGAIDDIRPLPVLPRLVLQAFSVGAVVFA
HHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEE
LPDQLQLVPLLPVVVERIVLLVAGLWFVNLVNFMDGLDLITVAEIVPVSLTLVAIGLLLD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
SPSTGILVAAALAGSMLGFAPFNRPVAKVFLGDVGSLPIGLLLGWCLLQLAFDGHIAAAF
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LLPLYYLADSSITLLRRLVRREAFWRAHRSHFYQRATDNGYSVIDVVVRVFLTNLALAAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AIASVVLSSPAADAVALVCGVGLVAVLLTRFARPRRSQS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TLSPGLLALVVLTTASLCCAALIVATMPLLRRYALARPNARSSHRTPTPQGAGIAVVCA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
TLAVAGSAIAVGTPSTQLPLLLFFSTVVIAVVGAIDDIRPLPVLPRLVLQAFSVGAVVFA
HHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEE
LPDQLQLVPLLPVVVERIVLLVAGLWFVNLVNFMDGLDLITVAEIVPVSLTLVAIGLLLD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
SPSTGILVAAALAGSMLGFAPFNRPVAKVFLGDVGSLPIGLLLGWCLLQLAFDGHIAAAF
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LLPLYYLADSSITLLRRLVRREAFWRAHRSHFYQRATDNGYSVIDVVVRVFLTNLALAAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AIASVVLSSPAADAVALVCGVGLVAVLLTRFARPRRSQS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Undecaprenyl phosphate; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine [C]

Specific reaction: Undecaprenyl phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine --> Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP [C]

General reaction: Substituted phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]