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The map label for this gene is moaB [H]

Identifier: 86748200

GI number: 86748200

Start: 1235091

End: 1235639

Strand: Direct

Name: moaB [H]

Synonym: RPB_1075

Alternate gene names: 86748200

Gene position: 1235091-1235639 (Clockwise)

Preceding gene: 86748199

Following gene: 86748201

Centisome position: 23.17

GC content: 67.58

Gene sequence:

>549_bases
ATGGCCTCCTCCGAACAGCCGAAGACTTTCATCCCGCTCAACATCGCGGTGCTCACCGTGTCCGATACGCGTTCGCTCGA
CGACGACAAGTCGGGCGCGACGCTGGTCGAGCGGCTGACGGCGGCGGGACACCATCTCGCGGCGCGGGAGATCGTGAAGG
ACGATATCGCGGCGATTCGCGATGTCGTGCGGCGCTGGATCGCCGACGATGGCGTCGACGCGATCATCACCACCGGCGGC
ACCGGCTTCACCGGCCGCGACGTCACGCCGGAGGCGATCGAGCCGCTGTTCGAAAAGCGCATGGACGGCTTCTCGATCGC
GTTCCACATGATGAGCTACGCCAAGATCGGCACCTCGACGATCCAGTCGCGCGCCACCGCCGGCGTCGCCGGCGCGACCT
ACCTCTTCTGCCTGCCGGGCTCGCCCGGCGCCTGCCGCGACGGCTGGGACGGCATTCTGGCCGCACAGCTCGATTACCGC
ACCCGGCCGTGCAACTTCGTCGAGATCATGCCGCGACTCGACGAACACCTGCGCCGCGACAAGGCCTAA

Upstream 100 bases:

>100_bases
TCGAAGGATGGAAAACGCGCACAGCATTCATCCTTCGAGGCTCGCTTCGCTCGCACCTCAGGATGACGGCCGCAGAGTTG
AGATGCAGCAAGGACCGATG

Downstream 100 bases:

>100_bases
TCCCGCCGCATGCGTGGTGAGCGGCGCCGCGGCTTGACAGTTCCGCCGGCTCACGAAACCATCCGTCCCAACGACAGCCG
CGACCACGCGGCGACGAGGG

Product: molybdopterin binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 182; Mature: 181

Protein sequence:

>182_residues
MASSEQPKTFIPLNIAVLTVSDTRSLDDDKSGATLVERLTAAGHHLAAREIVKDDIAAIRDVVRRWIADDGVDAIITTGG
TGFTGRDVTPEAIEPLFEKRMDGFSIAFHMMSYAKIGTSTIQSRATAGVAGATYLFCLPGSPGACRDGWDGILAAQLDYR
TRPCNFVEIMPRLDEHLRRDKA

Sequences:

>Translated_182_residues
MASSEQPKTFIPLNIAVLTVSDTRSLDDDKSGATLVERLTAAGHHLAAREIVKDDIAAIRDVVRRWIADDGVDAIITTGG
TGFTGRDVTPEAIEPLFEKRMDGFSIAFHMMSYAKIGTSTIQSRATAGVAGATYLFCLPGSPGACRDGWDGILAAQLDYR
TRPCNFVEIMPRLDEHLRRDKA
>Mature_181_residues
ASSEQPKTFIPLNIAVLTVSDTRSLDDDKSGATLVERLTAAGHHLAAREIVKDDIAAIRDVVRRWIADDGVDAIITTGGT
GFTGRDVTPEAIEPLFEKRMDGFSIAFHMMSYAKIGTSTIQSRATAGVAGATYLFCLPGSPGACRDGWDGILAAQLDYRT
RPCNFVEIMPRLDEHLRRDKA

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=35.1351351351351, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=35.1351351351351, Blast_Score=87, Evalue=8e-18,
Organism=Escherichia coli, GI1787000, Length=163, Percent_Identity=51.5337423312883, Blast_Score=173, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17564954, Length=145, Percent_Identity=40, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136978, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24638841, Length=146, Percent_Identity=35.6164383561644, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19769; Mature: 19637

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSEQPKTFIPLNIAVLTVSDTRSLDDDKSGATLVERLTAAGHHLAAREIVKDDIAAIR
CCCCCCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
DVVRRWIADDGVDAIITTGGTGFTGRDVTPEAIEPLFEKRMDGFSIAFHMMSYAKIGTST
HHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IQSRATAGVAGATYLFCLPGSPGACRDGWDGILAAQLDYRTRPCNFVEIMPRLDEHLRRD
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHC
KA
CC
>Mature Secondary Structure 
ASSEQPKTFIPLNIAVLTVSDTRSLDDDKSGATLVERLTAAGHHLAAREIVKDDIAAIR
CCCCCCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
DVVRRWIADDGVDAIITTGGTGFTGRDVTPEAIEPLFEKRMDGFSIAFHMMSYAKIGTST
HHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IQSRATAGVAGATYLFCLPGSPGACRDGWDGILAAQLDYRTRPCNFVEIMPRLDEHLRRD
HHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]