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The map label for this gene is degP [H]

Identifier: 86748144

GI number: 86748144

Start: 1167546

End: 1169123

Strand: Direct

Name: degP [H]

Synonym: RPB_1019

Alternate gene names: 86748144

Gene position: 1167546-1169123 (Clockwise)

Preceding gene: 86748143

Following gene: 86748145

Centisome position: 21.9

GC content: 68.5

Gene sequence:

>1578_bases
ATGAATCAGAACAAGACGGATCGCAACGACATCGACGACACCCCGAAATCCGAGGCGCAACTACGCCGGATCATGAGGCC
GCGGCGCTTTGCTCTGCTGGCGTCCGCCGCAGCGCTGAGCGCCGCGCTGGTCACCGGCGGATATATGACGCACGAGTTTC
CGTCGTTCGCGTCGCCCGCGCTCGCGGCCGAAGCGGCTGCGCCGACCGGCATGCCTTCCGGCTTCGGCGATCTCGTCAGC
AAGGTGAAGCCGGCGGTGATCTCGGTGCGCGTCAAGATCGACGAGGACAGCCGCACCACGCCGCTGATCCGCAACGACGA
CAGCGACGACAATGCCAATCCGGGGATGGGCGACGATCAGTTGCGTCCGTTCCTCAAGCAGTTCGGCTTCCGCGGCGAAG
GCGCCATGCCGAAGCGGCACGAGATGATCACCGGCGAGGGCTCCGGCTTCTTCATCTCGCCGGACGGCTACGCGGTCACC
AACTATCACGTCGTCGATCACGCCAAGTCGGTGCAGGTCACGACCGATGACGGCGCCGTCCACACCGCCAAGGTCGTCGG
CACCGACAAGAAGACCGATCTGGCGCTGATCAAGGTCGACGGCAAGAGCGACTTCACTTACGTGAAATTCGCCGATCAGC
CGGCGCGGGTCGGCGACTGGGTGGTGGCGGTCGGCAATCCGTTCGGCCTCGGCGGCACCGTCACGGCCGGCATCGTCTCG
GCGCGCGGCCGCGACATCGGCTCCGGTCCCTATGACGACTACGTCCAGATCGACGCGCCGATCAACAAGGGCAATTCCGG
CGGCCCGGCGTTCGACACCAGCGGCAACGTCATCGGCGTCAACACCGCGATCTATTCGCCCTCCGGCGGCTCGGTCGGCA
TCGGCTTCGACATTCCGGCGGCGACCGCCAAGCTCGTCATCGCGCAGTTGAAGGACAAGGGCGTGGTGACGCGCGGTTGG
CTCGGCGTGCAGGTGCAGCCGGTGACCGCCGAGATCGCCGACAGCATGGGGCTGAAGCAGGCCCGCGGCGCGCTGGTCGA
CAGCCCGCAGGACGGCAGCCCGGCCGCCAAGGCGGGGATCGCCGCCGGCGACGTCATCACCGCGGTCAATGGCGCGGAGA
TCAAGGACTCGCGCGCGCTGGCGCGGACCATCAGCATGATGGCGCCGGGCAGCGCGGTGAAGCTCGACGTGCTGCACAAG
GGTGACAGCAAGACTGTGACGCTCAGCCTGGCGGAGATGCCGAACGAGAGCGCGAAAGTCGCCGACAGCGGCGATGCCGG
GCGCGAGTCCGGCCGGCCCTATCTCGGCCTGCGCGTCGCGCCGGCCAGCGAGGTTGGCGACTCCGGCCAGAAGGGCGTCG
TCGTCACCGGCGTCGACCCCGAAGGCCCGGCGGCCGATCGCGGGCTGCGCAGCGGCGACGTCATCCTCGACGTCGGCGGC
AAGCCGGTCGCCAATTCCGGCGACGTCCGCGACGCGCTGAAGCAGGCCAGCGAGCACGGCAAGAAGACCGTGCTGATGCG
GGTCAAGACCGCGGATTCCGCCGCGCGCTTCGTCGCGGTGCCGATCGCCAAAGGCTGA

Upstream 100 bases:

>100_bases
CTGTCCAAAGATTAATTCGCCAAACAGCTTCGCGTAATGTCGGTCAACTATATTCCAGCGAGTAGTTCACGCCCCGTTCA
CCACTCACTGGAGCCTCGCC

Downstream 100 bases:

>100_bases
TCGAACTCCGCATCGCCGATACGCCGAGGGCGGCCGCGAGGCCGCCCTTTGTGCGTGCTGCACGCCCGATGCGACGCCGA
GCGGCCACGGTGCTGTCAGC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNQNKTDRNDIDDTPKSEAQLRRIMRPRRFALLASAAALSAALVTGGYMTHEFPSFASPALAAEAAAPTGMPSGFGDLVS
KVKPAVISVRVKIDEDSRTTPLIRNDDSDDNANPGMGDDQLRPFLKQFGFRGEGAMPKRHEMITGEGSGFFISPDGYAVT
NYHVVDHAKSVQVTTDDGAVHTAKVVGTDKKTDLALIKVDGKSDFTYVKFADQPARVGDWVVAVGNPFGLGGTVTAGIVS
ARGRDIGSGPYDDYVQIDAPINKGNSGGPAFDTSGNVIGVNTAIYSPSGGSVGIGFDIPAATAKLVIAQLKDKGVVTRGW
LGVQVQPVTAEIADSMGLKQARGALVDSPQDGSPAAKAGIAAGDVITAVNGAEIKDSRALARTISMMAPGSAVKLDVLHK
GDSKTVTLSLAEMPNESAKVADSGDAGRESGRPYLGLRVAPASEVGDSGQKGVVVTGVDPEGPAADRGLRSGDVILDVGG
KPVANSGDVRDALKQASEHGKKTVLMRVKTADSAARFVAVPIAKG

Sequences:

>Translated_525_residues
MNQNKTDRNDIDDTPKSEAQLRRIMRPRRFALLASAAALSAALVTGGYMTHEFPSFASPALAAEAAAPTGMPSGFGDLVS
KVKPAVISVRVKIDEDSRTTPLIRNDDSDDNANPGMGDDQLRPFLKQFGFRGEGAMPKRHEMITGEGSGFFISPDGYAVT
NYHVVDHAKSVQVTTDDGAVHTAKVVGTDKKTDLALIKVDGKSDFTYVKFADQPARVGDWVVAVGNPFGLGGTVTAGIVS
ARGRDIGSGPYDDYVQIDAPINKGNSGGPAFDTSGNVIGVNTAIYSPSGGSVGIGFDIPAATAKLVIAQLKDKGVVTRGW
LGVQVQPVTAEIADSMGLKQARGALVDSPQDGSPAAKAGIAAGDVITAVNGAEIKDSRALARTISMMAPGSAVKLDVLHK
GDSKTVTLSLAEMPNESAKVADSGDAGRESGRPYLGLRVAPASEVGDSGQKGVVVTGVDPEGPAADRGLRSGDVILDVGG
KPVANSGDVRDALKQASEHGKKTVLMRVKTADSAARFVAVPIAKG
>Mature_525_residues
MNQNKTDRNDIDDTPKSEAQLRRIMRPRRFALLASAAALSAALVTGGYMTHEFPSFASPALAAEAAAPTGMPSGFGDLVS
KVKPAVISVRVKIDEDSRTTPLIRNDDSDDNANPGMGDDQLRPFLKQFGFRGEGAMPKRHEMITGEGSGFFISPDGYAVT
NYHVVDHAKSVQVTTDDGAVHTAKVVGTDKKTDLALIKVDGKSDFTYVKFADQPARVGDWVVAVGNPFGLGGTVTAGIVS
ARGRDIGSGPYDDYVQIDAPINKGNSGGPAFDTSGNVIGVNTAIYSPSGGSVGIGFDIPAATAKLVIAQLKDKGVVTRGW
LGVQVQPVTAEIADSMGLKQARGALVDSPQDGSPAAKAGIAAGDVITAVNGAEIKDSRALARTISMMAPGSAVKLDVLHK
GDSKTVTLSLAEMPNESAKVADSGDAGRESGRPYLGLRVAPASEVGDSGQKGVVVTGVDPEGPAADRGLRSGDVILDVGG
KPVANSGDVRDALKQASEHGKKTVLMRVKTADSAARFVAVPIAKG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=252, Percent_Identity=34.9206349206349, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI24308541, Length=244, Percent_Identity=36.0655737704918, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI22129776, Length=262, Percent_Identity=33.206106870229, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI7019477, Length=269, Percent_Identity=31.9702602230483, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786356, Length=447, Percent_Identity=38.255033557047, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI1789629, Length=466, Percent_Identity=36.0515021459227, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=33.448275862069, Blast_Score=149, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24646839, Length=254, Percent_Identity=32.6771653543307, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 54243; Mature: 54243

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNKTDRNDIDDTPKSEAQLRRIMRPRRFALLASAAALSAALVTGGYMTHEFPSFASPA
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCH
LAAEAAAPTGMPSGFGDLVSKVKPAVISVRVKIDEDSRTTPLIRNDDSDDNANPGMGDDQ
HHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHHH
LRPFLKQFGFRGEGAMPKRHEMITGEGSGFFISPDGYAVTNYHVVDHAKSVQVTTDDGAV
HHHHHHHCCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEEEEEECCCEEEEECCCCCE
HTAKVVGTDKKTDLALIKVDGKSDFTYVKFADQPARVGDWVVAVGNPFGLGGTVTAGIVS
EEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHC
ARGRDIGSGPYDDYVQIDAPINKGNSGGPAFDTSGNVIGVNTAIYSPSGGSVGIGFDIPA
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCH
ATAKLVIAQLKDKGVVTRGWLGVQVQPVTAEIADSMGLKQARGALVDSPQDGSPAAKAGI
HHHHHHHHHHCCCCCEEECEEEEEEEECHHHHHHHCCHHHHCCCCCCCCCCCCCHHHCCC
AAGDVITAVNGAEIKDSRALARTISMMAPGSAVKLDVLHKGDSKTVTLSLAEMPNESAKV
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEHHHCCCCCCCC
ADSGDAGRESGRPYLGLRVAPASEVGDSGQKGVVVTGVDPEGPAADRGLRSGDVILDVGG
CCCCCCCHHCCCCEEEEEECCHHHCCCCCCCCEEEECCCCCCCCHHCCCCCCCEEEECCC
KPVANSGDVRDALKQASEHGKKTVLMRVKTADSAARFVAVPIAKG
CCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCC
>Mature Secondary Structure
MNQNKTDRNDIDDTPKSEAQLRRIMRPRRFALLASAAALSAALVTGGYMTHEFPSFASPA
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCH
LAAEAAAPTGMPSGFGDLVSKVKPAVISVRVKIDEDSRTTPLIRNDDSDDNANPGMGDDQ
HHHHHCCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCHHH
LRPFLKQFGFRGEGAMPKRHEMITGEGSGFFISPDGYAVTNYHVVDHAKSVQVTTDDGAV
HHHHHHHCCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEEEEEECCCEEEEECCCCCE
HTAKVVGTDKKTDLALIKVDGKSDFTYVKFADQPARVGDWVVAVGNPFGLGGTVTAGIVS
EEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHC
ARGRDIGSGPYDDYVQIDAPINKGNSGGPAFDTSGNVIGVNTAIYSPSGGSVGIGFDIPA
CCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCH
ATAKLVIAQLKDKGVVTRGWLGVQVQPVTAEIADSMGLKQARGALVDSPQDGSPAAKAGI
HHHHHHHHHHCCCCCEEECEEEEEEEECHHHHHHHCCHHHHCCCCCCCCCCCCCHHHCCC
AAGDVITAVNGAEIKDSRALARTISMMAPGSAVKLDVLHKGDSKTVTLSLAEMPNESAKV
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEHHHCCCCCCCC
ADSGDAGRESGRPYLGLRVAPASEVGDSGQKGVVVTGVDPEGPAADRGLRSGDVILDVGG
CCCCCCCHHCCCCEEEEEECCHHHCCCCCCCCEEEECCCCCCCCHHCCCCCCCEEEECCC
KPVANSGDVRDALKQASEHGKKTVLMRVKTADSAARFVAVPIAKG
CCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]