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The map label for this gene is fabA

Identifier: 86747739

GI number: 86747739

Start: 691805

End: 692335

Strand: Reverse

Name: fabA

Synonym: RPB_0613

Alternate gene names: 86747739

Gene position: 692335-691805 (Counterclockwise)

Preceding gene: 86747741

Following gene: 86747738

Centisome position: 12.99

GC content: 64.22

Gene sequence:

>531_bases
ATGCAGGACCGTCGTTCCAGCTACGATTACGAAGACTTGCTGGCCTGCGGCCGCGGCGAACTGTTCGGCGCCGGCAACGC
GCAATTGCCGCTGCCGCCGATGCTGATGTTCGACCGCATCACCGAGATCAACGACAGCGGCGGCGAGCACGGCAAGGGGC
TGATCCGCGCCGAGCTGGATGTGAACCCGGACCTGTGGTTCTTCGCCTGCCACTTCAAGGGCGATCCGGTGATGCCGGGC
TGTCTCGGGCTGGATGCGATGTGGCAGCTGGTCGGCTTCTTTCTCGGCTGGTCCGGCGGCCTCGGCCCCGGCCGCGCGCT
CGGCCTCGGCGAGCTGAAATTTTCCGGCCAGGTTCAGCCGAACATCAAGAAGGTCGTGTACAACATCGACGTCAAGCGGG
TGATGCGGTCGAAACTGTGGCTCGGCATCGCCGACGGAACCATGGCGGCCGACGGCGAGATTTTCTATCGCGCCAAGGAT
CTGAAAGTCGGTCTGTTCAGGCAGGACGCCGCAGTTCAGCCTGCCGTCTAG

Upstream 100 bases:

>100_bases
GCCGTTGCACAAGGAACGGGCGGGCGCCGACCGTTCGATCGCGGGGGCTGGAGCAGCCCTGTCGCGGCCGGAGTCCGGGA
AACTGAAGAGGCAGAGCTGC

Downstream 100 bases:

>100_bases
GCTAAGCACCGAAATCCGTTCGAGCCGTCCCGGTTCGACCAACGACAAGCAATGAACGAGGCGAGCATGAGACGGGTTGT
TGTCACGGGGATGGGGATCG

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MQDRRSSYDYEDLLACGRGELFGAGNAQLPLPPMLMFDRITEINDSGGEHGKGLIRAELDVNPDLWFFACHFKGDPVMPG
CLGLDAMWQLVGFFLGWSGGLGPGRALGLGELKFSGQVQPNIKKVVYNIDVKRVMRSKLWLGIADGTMAADGEIFYRAKD
LKVGLFRQDAAVQPAV

Sequences:

>Translated_176_residues
MQDRRSSYDYEDLLACGRGELFGAGNAQLPLPPMLMFDRITEINDSGGEHGKGLIRAELDVNPDLWFFACHFKGDPVMPG
CLGLDAMWQLVGFFLGWSGGLGPGRALGLGELKFSGQVQPNIKKVVYNIDVKRVMRSKLWLGIADGTMAADGEIFYRAKD
LKVGLFRQDAAVQPAV
>Mature_176_residues
MQDRRSSYDYEDLLACGRGELFGAGNAQLPLPPMLMFDRITEINDSGGEHGKGLIRAELDVNPDLWFFACHFKGDPVMPG
CLGLDAMWQLVGFFLGWSGGLGPGRALGLGELKFSGQVQPNIKKVVYNIDVKRVMRSKLWLGIADGTMAADGEIFYRAKD
LKVGLFRQDAAVQPAV

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=171, Percent_Identity=63.1578947368421, Blast_Score=229, Evalue=8e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_RHOP2 (Q2J2I6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484235.1
- ProteinModelPortal:   Q2J2I6
- SMR:   Q2J2I6
- STRING:   Q2J2I6
- GeneID:   3908306
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_0613
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BioCyc:   RPAL316058:RPB_0613-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 19310; Mature: 19310

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDRRSSYDYEDLLACGRGELFGAGNAQLPLPPMLMFDRITEINDSGGEHGKGLIRAELD
CCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEC
VNPDLWFFACHFKGDPVMPGCLGLDAMWQLVGFFLGWSGGLGPGRALGLGELKFSGQVQP
CCCCEEEEEEEECCCCCCCCHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCC
NIKKVVYNIDVKRVMRSKLWLGIADGTMAADGEIFYRAKDLKVGLFRQDAAVQPAV
CCEEEEEECCHHHHHHHHHEEEECCCCEECCCEEEEEEECCEEEEEECCCCCCCCC
>Mature Secondary Structure
MQDRRSSYDYEDLLACGRGELFGAGNAQLPLPPMLMFDRITEINDSGGEHGKGLIRAELD
CCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEC
VNPDLWFFACHFKGDPVMPGCLGLDAMWQLVGFFLGWSGGLGPGRALGLGELKFSGQVQP
CCCCEEEEEEEECCCCCCCCHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCC
NIKKVVYNIDVKRVMRSKLWLGIADGTMAADGEIFYRAKDLKVGLFRQDAAVQPAV
CCEEEEEECCHHHHHHHHHEEEECCCCEECCCEEEEEEECCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA