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The map label for this gene is fabB [H]

Identifier: 86747738

GI number: 86747738

Start: 690512

End: 691738

Strand: Reverse

Name: fabB [H]

Synonym: RPB_0612

Alternate gene names: 86747738

Gene position: 691738-690512 (Counterclockwise)

Preceding gene: 86747739

Following gene: 86747737

Centisome position: 12.97

GC content: 67.81

Gene sequence:

>1227_bases
ATGAGACGGGTTGTTGTCACGGGGATGGGGATCGTCTCATCGATCGGAAACAACACACAGGAGGTGCTGGCGAGTCTGCA
CGACGCCAAGTCGGGCATCACCCGCGCCGAGAAGCACGCCGAGCTGGGGTTCCGCTCGCAGGTCCAGGGCCTGCCGTCGC
TGAATCCGGCCGACGTGGTGGATCGCCGCGCGATGCGGTTCCTCGGCGAGGGCGCGGCGTGGAACCACGTCGCGATGGAA
CAGGCGCTGGCCGATTCCGGGCTGGAGGAGAAAGACATCTCCAATCCGCGCACCGGCATCGTGATGGGCTCCGGCGGCCC
GTCGGCGCGCACCATCGTCGAGGCCGCCGACACCACGCGGACCAAGGGCCCGAAGCGCGTCGGCCCGTTCGCGGTGCCGA
AGGCGATGAGCTCGACCGCGTCGGCGACGCTCGCCACCTGGTTCAAGATCAAGGGCGTCAACTACTCGATCTCGTCGGCC
TGCGCGACCTCCAACCACTGCATCGGCAACGCCTACGAGCTGATCCAGTGGGGCAAGCAGGACGTGGTGTTCGCCGGCGG
CTGCGAGGAACTCGACTGGTCGCTGTCGGTGCTGTTCGACGCGATGGGGGCGATGAGCTCCAAGTACAACGACACCCCGG
CCACCGCGTCGCGCCCCTACGACGTGTCGCGCGACGGCTTCGTGATCGCCGGCGGCGCCGGCGTGCTGGTGCTGGAAGAG
CTGGAACACGCCAAGGCGCGCGGCGCCAAGATCTACGGCGAGATCATCGGCTACGGCGCCACCTCGGACGGCTACGACAT
GGTGGCGCCCTCGGGCGAAGGCGCCGAGCGCTGCATGCAGATGGCGCTCGCCACCACCGGCGGCATCAAGATCGACTACA
TCAACCCGCACGCGACCTCGACGCCGGCCGGCGACCCGCCGGAACTGCAGGCGCTCCGCAACGTGTTCGGCGTCGGCGAC
AAATGCCCGCCGATTTCCGCCACCAAGGCGCTGACCGGGCATTCGCTCGGCGCCACCGGCGTGCAGGAGGCGATCTATTC
GCTGTTGATGATGCAGAACGGCTTCATCTGCGAGAGCGCCAACATCACCGAGCTCGACCCGGCCTTCGCCGACATGCCGA
TCGTGCGCAAGCGGATCGACAACGCCCAGCTCGGCGCGGTGCTGTCGAATTCGTTCGGCTTCGGCGGCACCAATGCGACG
CTGGTGTTCAAGCGGCTGGACGCGTGA

Upstream 100 bases:

>100_bases
CAGGCAGGACGCCGCAGTTCAGCCTGCCGTCTAGGCTAAGCACCGAAATCCGTTCGAGCCGTCCCGGTTCGACCAACGAC
AAGCAATGAACGAGGCGAGC

Downstream 100 bases:

>100_bases
TTATTTAACCTCTCCCCGCCCTGCGCGGGGAGAGGTCGACCTTGGCGCGCCAGCGCGAAGGTCGGGTGAGGGGCCGGGCA
CTGCCCTCACCTCGCCAGCA

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MRRVVVTGMGIVSSIGNNTQEVLASLHDAKSGITRAEKHAELGFRSQVQGLPSLNPADVVDRRAMRFLGEGAAWNHVAME
QALADSGLEEKDISNPRTGIVMGSGGPSARTIVEAADTTRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYELIQWGKQDVVFAGGCEELDWSLSVLFDAMGAMSSKYNDTPATASRPYDVSRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEIIGYGATSDGYDMVAPSGEGAERCMQMALATTGGIKIDYINPHATSTPAGDPPELQALRNVFGVGD
KCPPISATKALTGHSLGATGVQEAIYSLLMMQNGFICESANITELDPAFADMPIVRKRIDNAQLGAVLSNSFGFGGTNAT
LVFKRLDA

Sequences:

>Translated_408_residues
MRRVVVTGMGIVSSIGNNTQEVLASLHDAKSGITRAEKHAELGFRSQVQGLPSLNPADVVDRRAMRFLGEGAAWNHVAME
QALADSGLEEKDISNPRTGIVMGSGGPSARTIVEAADTTRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYELIQWGKQDVVFAGGCEELDWSLSVLFDAMGAMSSKYNDTPATASRPYDVSRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEIIGYGATSDGYDMVAPSGEGAERCMQMALATTGGIKIDYINPHATSTPAGDPPELQALRNVFGVGD
KCPPISATKALTGHSLGATGVQEAIYSLLMMQNGFICESANITELDPAFADMPIVRKRIDNAQLGAVLSNSFGFGGTNAT
LVFKRLDA
>Mature_408_residues
MRRVVVTGMGIVSSIGNNTQEVLASLHDAKSGITRAEKHAELGFRSQVQGLPSLNPADVVDRRAMRFLGEGAAWNHVAME
QALADSGLEEKDISNPRTGIVMGSGGPSARTIVEAADTTRTKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSA
CATSNHCIGNAYELIQWGKQDVVFAGGCEELDWSLSVLFDAMGAMSSKYNDTPATASRPYDVSRDGFVIAGGAGVLVLEE
LEHAKARGAKIYGEIIGYGATSDGYDMVAPSGEGAERCMQMALATTGGIKIDYINPHATSTPAGDPPELQALRNVFGVGD
KCPPISATKALTGHSLGATGVQEAIYSLLMMQNGFICESANITELDPAFADMPIVRKRIDNAQLGAVLSNSFGFGGTNAT
LVFKRLDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=36.0189573459716, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=23.2142857142857, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI223972627, Length=165, Percent_Identity=38.1818181818182, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=61.7647058823529, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=37.8640776699029, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=32.9383886255924, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=273, Percent_Identity=37.3626373626374, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=27.6978417266187, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212642053, Length=362, Percent_Identity=24.0331491712707, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=32.7354260089686, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=36.8794326241135, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=26.4094955489614, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=26.4094955489614, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24581345, Length=337, Percent_Identity=21.9584569732938, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42872; Mature: 42872

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGMGIVSSIGNNTQEVLASLHDAKSGITRAEKHAELGFRSQVQGLPSLNPADVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHH
DRRAMRFLGEGAAWNHVAMEQALADSGLEEKDISNPRTGIVMGSGGPSARTIVEAADTTR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEECCCCCCHHHEEEHHHCCC
TKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYELIQWGKQ
CCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCEEHHHHHCCCCCCCCHHHHHHHCCCC
DVVFAGGCEELDWSLSVLFDAMGAMSSKYNDTPATASRPYDVSRDGFVIAGGAGVLVLEE
CEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHH
LEHAKARGAKIYGEIIGYGATSDGYDMVAPSGEGAERCMQMALATTGGIKIDYINPHATS
HHHHHHCCCEEEEHHEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
TPAGDPPELQALRNVFGVGDKCPPISATKALTGHSLGATGVQEAIYSLLMMQNGFICESA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCC
NITELDPAFADMPIVRKRIDNAQLGAVLSNSFGFGGTNATLVFKRLDA
CCCCCCHHHHCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRRVVVTGMGIVSSIGNNTQEVLASLHDAKSGITRAEKHAELGFRSQVQGLPSLNPADVV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHH
DRRAMRFLGEGAAWNHVAMEQALADSGLEEKDISNPRTGIVMGSGGPSARTIVEAADTTR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCEEEECCCCCCHHHEEEHHHCCC
TKGPKRVGPFAVPKAMSSTASATLATWFKIKGVNYSISSACATSNHCIGNAYELIQWGKQ
CCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCEEHHHHHCCCCCCCCHHHHHHHCCCC
DVVFAGGCEELDWSLSVLFDAMGAMSSKYNDTPATASRPYDVSRDGFVIAGGAGVLVLEE
CEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHH
LEHAKARGAKIYGEIIGYGATSDGYDMVAPSGEGAERCMQMALATTGGIKIDYINPHATS
HHHHHHCCCEEEEHHEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCC
TPAGDPPELQALRNVFGVGDKCPPISATKALTGHSLGATGVQEAIYSLLMMQNGFICESA
CCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEECCC
NITELDPAFADMPIVRKRIDNAQLGAVLSNSFGFGGTNATLVFKRLDA
CCCCCCHHHHCCHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]