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The map label for this gene is nhaK [H]

Identifier: 86747645

GI number: 86747645

Start: 580156

End: 581775

Strand: Direct

Name: nhaK [H]

Synonym: RPB_0519

Alternate gene names: 86747645

Gene position: 580156-581775 (Clockwise)

Preceding gene: 86747642

Following gene: 86747646

Centisome position: 10.88

GC content: 69.07

Gene sequence:

>1620_bases
GTGGGTCCGGTGGAAGCGAAGTTCCAGATTTTCCTGATCCTGCTCGCGGTGCTGGCGGCGACCGCGCTGCTGGCGCGCCG
TCTTCACGTGGCCCCGGCGATCCTCTGGCTGCTGGTCGGCATCGTGCTGGCGTTCATCCCCGGCATGCCGGCGATCGAGC
TGCCGCCGGACCTGATCCTGCTGCTGGTGCTGCCGCCGCTGATATATTCGGCGAGCGTGGCGATGAGCTGGCGTGAATTC
CGCGCCAATCTGCGGTCGATCGGCCTGCTGGCGATCGGCTGCGTGATCTTCACCGCCGGCGCCGTCGCGGTGGCGACGCA
CTATCTGCTCGGCCTACCATGGGCGGTCGGCTTCCTGCTCGGCGCCATCGTCGCGCCGCCCGACGTGGTGGCGCCGCTGG
CGATCGCGCGCAGGCTCGGTCTGCCGCGGCGGATCGTGGTGGTGCTGGAGGGCGAGGGGCTCGCCAACGACGCCACCGCG
CTGATCCTGTATCGCTTCGCGCTGGCCGCGATCATGACCGGGATGTTCTCTCTGCCGCAGGCGTCGGGTGCCTTCGTGGC
GATTCTCGCCGGCGAAATCGGCTTCGGCATTGCGGTCGGCTGGCTCAGCCTGCGCGCCCGGCACTCCGCGCGCGATCCGC
GGATCGAGATCACGCTGTCGCTGCTGACGCCCTACATCGCCTACTGGATTCCGGAGCATCTCGGCGGCTCCGGCGTGATC
GCGACGGTGGCGTGCGGCCTCTACATCTCTTGGAACGGCCCGCTGCTGATCCCCGCGGCGACAAGGCTGCAGGGCATCTT
CTTCTGGGACTTGATCATCTATCTGATCGAGGGGCTGCTGTTCCTGCTCACCGGCTTTCAGATGCGCGCGATCCTGGAGC
GGTCGAAAGGGCTTCCGGTCGACGACATCGTGGTCGCGACGCTGCTGGTGGCGGCGATCGTCATCGTGGCGCGGTTTCTG
TGGGTGTATCCGGCGACCTATCTGCCGCGCCTGCTGAGCAAGCGGATTCGCACGCGCGAACGGCGGCCGAGCTGGCGCGC
GGTGTTCGTGGTCGGCTTCACCGGCGTGCGCGGTGCGGTGTCGCTCGCCACCGCGCTGGCGCTGCCGTTCGCGCTGCCGG
ACGGCTCCGCCTTTCCCGATCGCGACCTGATCCTGTTCGTCGCCTTCGGCGTCATCCTGATCACGCTGGTCGGGCTCGGC
CTGACGCTGCCGGCGCTGGTCGGCGTGCTCGGACTGACCCGCGACGGCCGCAGCGAGCACATCGCCGAACACGAAGCCGA
GATCGCGGCGCGGCGCGCGGCGCTGGCGGCCGCGTTGCAATCGCTCGACGCGCTGACCAACGATCGCGCATTGTCCGACG
AGGTGGTGGCGCTGCTGCATGCGCGGCACGACATCCGCGCCCATCAATTGCCGACGGCGCTCGACGACGCCGCCTATGCG
GCGACCGCCAATGCGCGCGCGCTGGTCCGCGAACTCATCGCGGCGGAGCGGCAATTCATCCACGCCCAGCTCCGCGCCGG
CAAGATCACCGACGAAGCGCGGCGACGGATCGAGCGCGACCTCGATCTGGAAGAGGCGAGTTTGGCGAACAGGGAGTTTC
GGAGCGGAGGGCAGCGCTAA

Upstream 100 bases:

>100_bases
TCGCCGCGAGCGCGGCGGCCGGCGGCGGCGAGGCGGTTCTCTTGACCTGCCCCGGCGGCCGGGCGATGCAGTCGGCGTCG
GTCCTTCGACCGACGACATC

Downstream 100 bases:

>100_bases
CTGCTAGTGCACCGGCTAGGATGCTCCATCTATTTGGTAGGCTGTCCAAACGACAAATATGTCGACGTGCAGCGAGCGAG
TAGCTAACCTTGTTCCCGTT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MGPVEAKFQIFLILLAVLAATALLARRLHVAPAILWLLVGIVLAFIPGMPAIELPPDLILLLVLPPLIYSASVAMSWREF
RANLRSIGLLAIGCVIFTAGAVAVATHYLLGLPWAVGFLLGAIVAPPDVVAPLAIARRLGLPRRIVVVLEGEGLANDATA
LILYRFALAAIMTGMFSLPQASGAFVAILAGEIGFGIAVGWLSLRARHSARDPRIEITLSLLTPYIAYWIPEHLGGSGVI
ATVACGLYISWNGPLLIPAATRLQGIFFWDLIIYLIEGLLFLLTGFQMRAILERSKGLPVDDIVVATLLVAAIVIVARFL
WVYPATYLPRLLSKRIRTRERRPSWRAVFVVGFTGVRGAVSLATALALPFALPDGSAFPDRDLILFVAFGVILITLVGLG
LTLPALVGVLGLTRDGRSEHIAEHEAEIAARRAALAAALQSLDALTNDRALSDEVVALLHARHDIRAHQLPTALDDAAYA
ATANARALVRELIAAERQFIHAQLRAGKITDEARRRIERDLDLEEASLANREFRSGGQR

Sequences:

>Translated_539_residues
MGPVEAKFQIFLILLAVLAATALLARRLHVAPAILWLLVGIVLAFIPGMPAIELPPDLILLLVLPPLIYSASVAMSWREF
RANLRSIGLLAIGCVIFTAGAVAVATHYLLGLPWAVGFLLGAIVAPPDVVAPLAIARRLGLPRRIVVVLEGEGLANDATA
LILYRFALAAIMTGMFSLPQASGAFVAILAGEIGFGIAVGWLSLRARHSARDPRIEITLSLLTPYIAYWIPEHLGGSGVI
ATVACGLYISWNGPLLIPAATRLQGIFFWDLIIYLIEGLLFLLTGFQMRAILERSKGLPVDDIVVATLLVAAIVIVARFL
WVYPATYLPRLLSKRIRTRERRPSWRAVFVVGFTGVRGAVSLATALALPFALPDGSAFPDRDLILFVAFGVILITLVGLG
LTLPALVGVLGLTRDGRSEHIAEHEAEIAARRAALAAALQSLDALTNDRALSDEVVALLHARHDIRAHQLPTALDDAAYA
ATANARALVRELIAAERQFIHAQLRAGKITDEARRRIERDLDLEEASLANREFRSGGQR
>Mature_538_residues
GPVEAKFQIFLILLAVLAATALLARRLHVAPAILWLLVGIVLAFIPGMPAIELPPDLILLLVLPPLIYSASVAMSWREFR
ANLRSIGLLAIGCVIFTAGAVAVATHYLLGLPWAVGFLLGAIVAPPDVVAPLAIARRLGLPRRIVVVLEGEGLANDATAL
ILYRFALAAIMTGMFSLPQASGAFVAILAGEIGFGIAVGWLSLRARHSARDPRIEITLSLLTPYIAYWIPEHLGGSGVIA
TVACGLYISWNGPLLIPAATRLQGIFFWDLIIYLIEGLLFLLTGFQMRAILERSKGLPVDDIVVATLLVAAIVIVARFLW
VYPATYLPRLLSKRIRTRERRPSWRAVFVVGFTGVRGAVSLATALALPFALPDGSAFPDRDLILFVAFGVILITLVGLGL
TLPALVGVLGLTRDGRSEHIAEHEAEIAARRAALAAALQSLDALTNDRALSDEVVALLHARHDIRAHQLPTALDDAAYAA
TANARALVRELIAAERQFIHAQLRAGKITDEARRRIERDLDLEEASLANREFRSGGQR

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=446, Percent_Identity=24.6636771300448, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI41872703, Length=537, Percent_Identity=21.2290502793296, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27734935, Length=364, Percent_Identity=21.7032967032967, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI148727259, Length=434, Percent_Identity=23.963133640553, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI14211919, Length=399, Percent_Identity=22.3057644110276, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194239733, Length=386, Percent_Identity=24.3523316062176, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI294997330, Length=416, Percent_Identity=23.5576923076923, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5454070, Length=440, Percent_Identity=22.7272727272727, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI110227626, Length=416, Percent_Identity=23.3173076923077, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI27777632, Length=465, Percent_Identity=25.1612903225806, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790501, Length=558, Percent_Identity=29.5698924731183, Blast_Score=178, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25147678, Length=467, Percent_Identity=22.4839400428266, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=395, Percent_Identity=25.0632911392405, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71992107, Length=333, Percent_Identity=20.7207207207207, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=333, Percent_Identity=20.7207207207207, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25150332, Length=404, Percent_Identity=22.029702970297, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993590, Length=390, Percent_Identity=24.8717948717949, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993582, Length=390, Percent_Identity=24.8717948717949, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71990932, Length=393, Percent_Identity=24.9363867684478, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=457, Percent_Identity=21.6630196936543, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=457, Percent_Identity=21.6630196936543, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=393, Percent_Identity=24.9363867684478, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71987535, Length=406, Percent_Identity=21.6748768472906, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987537, Length=406, Percent_Identity=21.6748768472906, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=403, Percent_Identity=22.5806451612903, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281360447, Length=494, Percent_Identity=22.2672064777328, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221510734, Length=382, Percent_Identity=23.2984293193717, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221510738, Length=382, Percent_Identity=23.2984293193717, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221473212, Length=337, Percent_Identity=25.2225519287834, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281364513, Length=337, Percent_Identity=25.2225519287834, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221473215, Length=337, Percent_Identity=25.2225519287834, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221473222, Length=337, Percent_Identity=25.2225519287834, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221510732, Length=379, Percent_Identity=23.4828496042216, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221510736, Length=379, Percent_Identity=23.4828496042216, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585580, Length=379, Percent_Identity=23.4828496042216, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585578, Length=379, Percent_Identity=23.4828496042216, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510740, Length=379, Percent_Identity=23.4828496042216, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 58122; Mature: 57990

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPVEAKFQIFLILLAVLAATALLARRLHVAPAILWLLVGIVLAFIPGMPAIELPPDLIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LLVLPPLIYSASVAMSWREFRANLRSIGLLAIGCVIFTAGAVAVATHYLLGLPWAVGFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIVAPPDVVAPLAIARRLGLPRRIVVVLEGEGLANDATALILYRFALAAIMTGMFSLPQ
HHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ASGAFVAILAGEIGFGIAVGWLSLRARHSARDPRIEITLSLLTPYIAYWIPEHLGGSGVI
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHH
ATVACGLYISWNGPLLIPAATRLQGIFFWDLIIYLIEGLLFLLTGFQMRAILERSKGLPV
HHHHCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIVVATLLVAAIVIVARFLWVYPATYLPRLLSKRIRTRERRPSWRAVFVVGFTGVRGAV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
SLATALALPFALPDGSAFPDRDLILFVAFGVILITLVGLGLTLPALVGVLGLTRDGRSEH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IAEHEAEIAARRAALAAALQSLDALTNDRALSDEVVALLHARHDIRAHQLPTALDDAAYA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ATANARALVRELIAAERQFIHAQLRAGKITDEARRRIERDLDLEEASLANREFRSGGQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GPVEAKFQIFLILLAVLAATALLARRLHVAPAILWLLVGIVLAFIPGMPAIELPPDLIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LLVLPPLIYSASVAMSWREFRANLRSIGLLAIGCVIFTAGAVAVATHYLLGLPWAVGFLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIVAPPDVVAPLAIARRLGLPRRIVVVLEGEGLANDATALILYRFALAAIMTGMFSLPQ
HHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ASGAFVAILAGEIGFGIAVGWLSLRARHSARDPRIEITLSLLTPYIAYWIPEHLGGSGVI
CCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCHH
ATVACGLYISWNGPLLIPAATRLQGIFFWDLIIYLIEGLLFLLTGFQMRAILERSKGLPV
HHHHCCEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIVVATLLVAAIVIVARFLWVYPATYLPRLLSKRIRTRERRPSWRAVFVVGFTGVRGAV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHH
SLATALALPFALPDGSAFPDRDLILFVAFGVILITLVGLGLTLPALVGVLGLTRDGRSEH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IAEHEAEIAARRAALAAALQSLDALTNDRALSDEVVALLHARHDIRAHQLPTALDDAAYA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ATANARALVRELIAAERQFIHAQLRAGKITDEARRRIERDLDLEEASLANREFRSGGQR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA