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The map label for this gene is fps [H]

Identifier: 86747642

GI number: 86747642

Start: 576819

End: 577745

Strand: Direct

Name: fps [H]

Synonym: RPB_0516

Alternate gene names: 86747642

Gene position: 576819-577745 (Clockwise)

Preceding gene: 86747638

Following gene: 86747645

Centisome position: 10.82

GC content: 70.55

Gene sequence:

>927_bases
ATGGCCACCGGCACTTCCACCATCGACTTTGCCAAACGGCTCGACGCCACCGCCGAGGATACCGAAGCCCTGCTCGGACG
ATTGTTGTCCGACGATCTGCTCCCCGACGAGATCGCCCGCCCCCGCCGGCTGATGGAGGCGATCCGCTATTCGACGCTCG
GCGGCGGCAAGCGGCTGCGGCCGTTTCTGGCGGTGGAGAGCGCGGCGGTGTTCGGCGTCGATCGCGCCGGCGCGCTGCTG
GTCGGCGCGGCGCTGGAGTGCATCCATTGCTATTCGCTGATCCACGACGATCTGCCAGCAATGGACAATTCCGATCTGCG
CCGCGGCCGGCCGACGCTGCACAAGGCCTATGACGACGCCACCGCGATCCTGGCCGGCGACGCGCTGCTGACGCTGGCCT
TCGACATCATCACCCGTGACGAGGTGCACCAGGACGCAAAGGTACGGCTCGATCTCAACCGCGTGCTGGCGCGTTGCGCC
GGGCTCGGCGGCATGGTCGGCGGCCAGATGCTCGACCTCGCCGGCGAGGGCCGGTTCGGCGACCGCGAGCCGGTCGACGT
TGCCCGCTTGCAGCAGATGAAGACCGGCGCGCTGCTGCGCTACGGCTGCGTCGCCGGCGCCATCCTGGGCCAGGCGTCGC
CGGAGCACTACAAGGCGCTGGACGATTACGGCCGCGCGCTCGGCGAGGCGTTCCAGATCGCCGACGATCTGCTCGACGTC
GAGGGCGACGCCGCAGCGCTCGGCAAGCCGGCCGGCGCCGATGCCGCGCTCGGCAAGACCACGTTCGTCACCCAGCTCGG
CGTCGATGGCGCCAAGCAGCGGGTGCGCGATCTGATCGCGCGCGCCGACGAGGCGCTGGCGCCGTTCGGCGCCAAAGGCG
AGGTGCTGCGGGCCGCCGCCCGGTTCGTCGCCGAACGCAAGAACTGA

Upstream 100 bases:

>100_bases
CATCTTTGCGCCCCCTGATGCACCGCCCGGTCGAGCGCCGAATTGACGAAGCCGGTGCCATGATGAATGGTCCGGCCGAA
TTTATCTGGAGCACTTCCGA

Downstream 100 bases:

>100_bases
TCGGCCACGCCACGCCCGGTCGCGGCGCGGCGACCGGACTACTCGGTGGCCAGCGCGCGGACGATGTCGAGCAGGCGCCG
GGCTTCGGGATGGGTCGCGC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MATGTSTIDFAKRLDATAEDTEALLGRLLSDDLLPDEIARPRRLMEAIRYSTLGGGKRLRPFLAVESAAVFGVDRAGALL
VGAALECIHCYSLIHDDLPAMDNSDLRRGRPTLHKAYDDATAILAGDALLTLAFDIITRDEVHQDAKVRLDLNRVLARCA
GLGGMVGGQMLDLAGEGRFGDREPVDVARLQQMKTGALLRYGCVAGAILGQASPEHYKALDDYGRALGEAFQIADDLLDV
EGDAAALGKPAGADAALGKTTFVTQLGVDGAKQRVRDLIARADEALAPFGAKGEVLRAAARFVAERKN

Sequences:

>Translated_308_residues
MATGTSTIDFAKRLDATAEDTEALLGRLLSDDLLPDEIARPRRLMEAIRYSTLGGGKRLRPFLAVESAAVFGVDRAGALL
VGAALECIHCYSLIHDDLPAMDNSDLRRGRPTLHKAYDDATAILAGDALLTLAFDIITRDEVHQDAKVRLDLNRVLARCA
GLGGMVGGQMLDLAGEGRFGDREPVDVARLQQMKTGALLRYGCVAGAILGQASPEHYKALDDYGRALGEAFQIADDLLDV
EGDAAALGKPAGADAALGKTTFVTQLGVDGAKQRVRDLIARADEALAPFGAKGEVLRAAARFVAERKN
>Mature_307_residues
ATGTSTIDFAKRLDATAEDTEALLGRLLSDDLLPDEIARPRRLMEAIRYSTLGGGKRLRPFLAVESAAVFGVDRAGALLV
GAALECIHCYSLIHDDLPAMDNSDLRRGRPTLHKAYDDATAILAGDALLTLAFDIITRDEVHQDAKVRLDLNRVLARCAG
LGGMVGGQMLDLAGEGRFGDREPVDVARLQQMKTGALLRYGCVAGAILGQASPEHYKALDDYGRALGEAFQIADDLLDVE
GDAAALGKPAGADAALGKTTFVTQLGVDGAKQRVRDLIARADEALAPFGAKGEVLRAAARFVAERKN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=240, Percent_Identity=28.75, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786623, Length=307, Percent_Identity=41.3680781758958, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789578, Length=259, Percent_Identity=33.2046332046332, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=282, Percent_Identity=25.886524822695, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651612, Length=220, Percent_Identity=30.4545454545455, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32739; Mature: 32608

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGTSTIDFAKRLDATAEDTEALLGRLLSDDLLPDEIARPRRLMEAIRYSTLGGGKRLR
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
PFLAVESAAVFGVDRAGALLVGAALECIHCYSLIHDDLPAMDNSDLRRGRPTLHKAYDDA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHCCH
TAILAGDALLTLAFDIITRDEVHQDAKVRLDLNRVLARCAGLGGMVGGQMLDLAGEGRFG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHEECHHHHHHHHHCCCCHHCCHHHHHCCCCCCC
DREPVDVARLQQMKTGALLRYGCVAGAILGQASPEHYKALDDYGRALGEAFQIADDLLDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGDAAALGKPAGADAALGKTTFVTQLGVDGAKQRVRDLIARADEALAPFGAKGEVLRAAA
CCCHHHCCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RFVAERKN
HHHHHCCC
>Mature Secondary Structure 
ATGTSTIDFAKRLDATAEDTEALLGRLLSDDLLPDEIARPRRLMEAIRYSTLGGGKRLR
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
PFLAVESAAVFGVDRAGALLVGAALECIHCYSLIHDDLPAMDNSDLRRGRPTLHKAYDDA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHCCH
TAILAGDALLTLAFDIITRDEVHQDAKVRLDLNRVLARCAGLGGMVGGQMLDLAGEGRFG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHEECHHHHHHHHHCCCCHHCCHHHHHCCCCCCC
DREPVDVARLQQMKTGALLRYGCVAGAILGQASPEHYKALDDYGRALGEAFQIADDLLDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGDAAALGKPAGADAALGKTTFVTQLGVDGAKQRVRDLIARADEALAPFGAKGEVLRAAA
CCCHHHCCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
RFVAERKN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]