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The map label for this gene is guaC [H]

Identifier: 86747343

GI number: 86747343

Start: 245119

End: 246162

Strand: Reverse

Name: guaC [H]

Synonym: RPB_0217

Alternate gene names: 86747343

Gene position: 246162-245119 (Counterclockwise)

Preceding gene: 86747345

Following gene: 86747342

Centisome position: 4.62

GC content: 66.19

Gene sequence:

>1044_bases
GTGCATATCGACCTCAATCCGAAGCTGGACTTCCGCGACGTTCTGATCCGGCCGAAGCGCTCCGTGCTGTCGTCGCGGTT
CGAAGCCAATATCAGCCGCAGCTTCCGGTTTCGCCATTCCAGCCAGGCGTGGACCGGCTTCCCGCTGATCGCCTCCAACA
TGGATACGGTCGGGACCATCGAGATGGCCGAAGCGTTCCGGCCGTTCGGGGCGCTGGTCGCGCTGCACAAGTTCTACGAT
CCGGAGCGGCTCGCTCAGTATCTCGATCGCCATGAGAATCCCAACGTGTTTCTCACTGTCGGCACCGGCGCCGCCGACTG
GGAGCGGCTCGCCGCTGTCAAGGCGCAGACCCGGGTGCCGATGCTGAACATCGACGTCGCCAACGGCTACACCGAGAATT
TCGTCCGGGCGGTGGGGAAGCTGCGCGACGAGAATCCCGACGCGATCATCATGGCCGGCACGGTGGTGACGGCGGAGATG
ACCGAGGCGCTGGTGATCGCCGGCGCCGACATCGTCCGCGTCGGCATCGGCTCGGGCTCGGTGTGTACCACGCGCGATCT
CACCGGCGTCGGCTATCCGCAGCTCTCGGCCGTGATCGAATGCGCCGACGCCGCGCACGGCCTCAAGGGCCACGTCTGCT
CCGACGGCGGCTGCACCGTGCCGGGCGACATCGCCAAGGCGTATGGCGGCGGCGCCGATTTCGTGATGCTCGGCGGCATG
CTCGCGGGCCACGCCGAATGCGGCGGCGAGCTGCAATATGTCGAGGAGGACGGCCGGCAGGTGCCGAAGAGCATGACGTT
CTACGGCATGTCGTCCGAAACCGCGATGAACAAGTATCACGGCGGCGTCGCCGATTATCGCGCAGCGGAAGGCAAGACCG
TCGCGGTGCCGTATCGTGGCGAGGTGCGGGCGACGGTGGAGACCATCGCGGGCGGGCTGCGCTCGGCGATGACCTATATG
GGCGCGGAGAATCTCAAGGAGGTGCCGAAGCGGACCACCTTCATCCTGGTCAACGCCCAGCGCAACACCGTGTTCGATCG
CTGA

Upstream 100 bases:

>100_bases
GTCTCGGCGCAGGCGACGATTTGCGCATTGCGAGCGCGAACCAATGCGCAACCAATGCTTCTTATAGTGGCCGCCCACCG
ACGCAACCGAGGATCCGCGC

Downstream 100 bases:

>100_bases
TCCCGCGCGATTTGCCGCGGCTCGGAATTCGCGGCGCGCGTGTCAGGGTTGCGCTTGCCTGCGCGGCCGCAAATGGCATG
GTGCGGCGACGCGCGACGCT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MHIDLNPKLDFRDVLIRPKRSVLSSRFEANISRSFRFRHSSQAWTGFPLIASNMDTVGTIEMAEAFRPFGALVALHKFYD
PERLAQYLDRHENPNVFLTVGTGAADWERLAAVKAQTRVPMLNIDVANGYTENFVRAVGKLRDENPDAIIMAGTVVTAEM
TEALVIAGADIVRVGIGSGSVCTTRDLTGVGYPQLSAVIECADAAHGLKGHVCSDGGCTVPGDIAKAYGGGADFVMLGGM
LAGHAECGGELQYVEEDGRQVPKSMTFYGMSSETAMNKYHGGVADYRAAEGKTVAVPYRGEVRATVETIAGGLRSAMTYM
GAENLKEVPKRTTFILVNAQRNTVFDR

Sequences:

>Translated_347_residues
MHIDLNPKLDFRDVLIRPKRSVLSSRFEANISRSFRFRHSSQAWTGFPLIASNMDTVGTIEMAEAFRPFGALVALHKFYD
PERLAQYLDRHENPNVFLTVGTGAADWERLAAVKAQTRVPMLNIDVANGYTENFVRAVGKLRDENPDAIIMAGTVVTAEM
TEALVIAGADIVRVGIGSGSVCTTRDLTGVGYPQLSAVIECADAAHGLKGHVCSDGGCTVPGDIAKAYGGGADFVMLGGM
LAGHAECGGELQYVEEDGRQVPKSMTFYGMSSETAMNKYHGGVADYRAAEGKTVAVPYRGEVRATVETIAGGLRSAMTYM
GAENLKEVPKRTTFILVNAQRNTVFDR
>Mature_347_residues
MHIDLNPKLDFRDVLIRPKRSVLSSRFEANISRSFRFRHSSQAWTGFPLIASNMDTVGTIEMAEAFRPFGALVALHKFYD
PERLAQYLDRHENPNVFLTVGTGAADWERLAAVKAQTRVPMLNIDVANGYTENFVRAVGKLRDENPDAIIMAGTVVTAEM
TEALVIAGADIVRVGIGSGSVCTTRDLTGVGYPQLSAVIECADAAHGLKGHVCSDGGCTVPGDIAKAYGGGADFVMLGGM
LAGHAECGGELQYVEEDGRQVPKSMTFYGMSSETAMNKYHGGVADYRAAEGKTVAVPYRGEVRATVETIAGGLRSAMTYM
GAENLKEVPKRTTFILVNAQRNTVFDR

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=349, Percent_Identity=57.3065902578797, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI50541954, Length=349, Percent_Identity=57.3065902578797, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI50541952, Length=349, Percent_Identity=57.3065902578797, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI50541948, Length=349, Percent_Identity=57.3065902578797, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI156104880, Length=346, Percent_Identity=56.0693641618497, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI66933016, Length=236, Percent_Identity=32.6271186440678, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI217035146, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI217035152, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI217035150, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34328930, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI217035148, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156616279, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34328928, Length=233, Percent_Identity=30.4721030042918, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786293, Length=352, Percent_Identity=57.9545454545455, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788855, Length=235, Percent_Identity=36.1702127659575, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=350, Percent_Identity=54, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71994385, Length=233, Percent_Identity=30.0429184549356, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=161, Percent_Identity=36.0248447204969, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323585, Length=237, Percent_Identity=32.0675105485232, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322012, Length=259, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323464, Length=237, Percent_Identity=31.2236286919831, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641071, Length=274, Percent_Identity=29.9270072992701, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641073, Length=274, Percent_Identity=29.9270072992701, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571163, Length=274, Percent_Identity=29.9270072992701, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37480; Mature: 37480

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIDLNPKLDFRDVLIRPKRSVLSSRFEANISRSFRFRHSSQAWTGFPLIASNMDTVGTI
CEECCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEECCCCCCCHH
EMAEAFRPFGALVALHKFYDPERLAQYLDRHENPNVFLTVGTGAADWERLAAVKAQTRVP
HHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
MLNIDVANGYTENFVRAVGKLRDENPDAIIMAGTVVTAEMTEALVIAGADIVRVGIGSGS
EEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHEEEEECCCEEEEECCCCC
VCTTRDLTGVGYPQLSAVIECADAAHGLKGHVCSDGGCTVPGDIAKAYGGGADFVMLGGM
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHCCCCCCHHHHCCH
LAGHAECGGELQYVEEDGRQVPKSMTFYGMSSETAMNKYHGGVADYRAAEGKTVAVPYRG
HHCCCCCCCCEEEEHHHHHHCCCCEEEECCCCHHHHHHHCCCCHHHCCCCCCEEEECCCC
EVRATVETIAGGLRSAMTYMGAENLKEVPKRTTFILVNAQRNTVFDR
CHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MHIDLNPKLDFRDVLIRPKRSVLSSRFEANISRSFRFRHSSQAWTGFPLIASNMDTVGTI
CEECCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEECCCCCCCHH
EMAEAFRPFGALVALHKFYDPERLAQYLDRHENPNVFLTVGTGAADWERLAAVKAQTRVP
HHHHHHCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCC
MLNIDVANGYTENFVRAVGKLRDENPDAIIMAGTVVTAEMTEALVIAGADIVRVGIGSGS
EEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHEEEEECCCEEEEECCCCC
VCTTRDLTGVGYPQLSAVIECADAAHGLKGHVCSDGGCTVPGDIAKAYGGGADFVMLGGM
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHCCCCCCHHHHCCH
LAGHAECGGELQYVEEDGRQVPKSMTFYGMSSETAMNKYHGGVADYRAAEGKTVAVPYRG
HHCCCCCCCCEEEEHHHHHHCCCCEEEECCCCHHHHHHHCCCCHHHCCCCCCEEEECCCC
EVRATVETIAGGLRSAMTYMGAENLKEVPKRTTFILVNAQRNTVFDR
CHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA